Issue 25, 2016

Improving nanoparticle diffusion through tumor collagen matrix by photo-thermal gold nanorods

Abstract

Collagen (I) impairs the targeting of nanoparticles to tumor cells by obstructing their diffusion inside dense tumor interstitial matrix. This potentially makes large nanoparticles (>50 nm) reside near the tumor vessels and thereby compromises their functionality. Here we propose a strategy to locally improve nanoparticle transport inside collagen (I) component of the tumor tissue. We first used heat generating gold nanorods to alter collagen (I) matrix by local temperature elevation. We then explored this impact on the transport of 50 nm and 120 nm inorganic nanoparticles inside collagen (I). We demonstrated an increase in average diffusivity of 50 nm and 120 nm in the denatured collagen (I) by ∼14 and ∼21 fold, respectively, compared to intact untreated collagen (I) matrix. This study shows how nanoparticle-mediated hyperthermia inside tumor tissue can improve the transport of large nanoparticles through collagen (I) matrix. The ability to increase nanoparticles diffusion inside tumor stroma allows their targeting or other functionalities to take effect, thereby significantly improving cancer therapeutic or diagnostic outcome.

Graphical abstract: Improving nanoparticle diffusion through tumor collagen matrix by photo-thermal gold nanorods

Supplementary files

Article information

Article type
Communication
Submitted
29 ⵏⵓⵡ 2015
Accepted
07 ⵉⵏⵏ 2016
First published
07 ⵉⵏⵏ 2016

Nanoscale, 2016,8, 12524-12530

Author version available

Improving nanoparticle diffusion through tumor collagen matrix by photo-thermal gold nanorods

V. Raeesi and W. C. W. Chan, Nanoscale, 2016, 8, 12524 DOI: 10.1039/C5NR08463F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements