Issue 34, 2015

Synthesis of functionalized γ-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems

Abstract

Two consecutive N-heterocyclic carbene (NHC) catalytic systems were combined in a one-pot cascade reaction for the assembly of aromatic aldehydes and 2-haloenals into a structurally complex γ-lactone backbone. To our knowledge, this is the first report of NHC-catalyzed [3 + 2] annulation of α,β-unsaturated acylazoliums with 1,2-bisnucleophiles.

Graphical abstract: Synthesis of functionalized γ-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems

Supplementary files

Article information

Article type
Communication
Submitted
21 ⵉⵏⵏ 2015
Accepted
06 ⵎⴰⵕ 2015
First published
06 ⵎⴰⵕ 2015

RSC Adv., 2015,5, 26972-26976

Author version available

Synthesis of functionalized γ-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems

Q. Zhao, B. Han, B. Wang, H. Leng, C. Peng and W. Huang, RSC Adv., 2015, 5, 26972 DOI: 10.1039/C5RA01254F

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