Issue 4, 2015

Selective monoalkylation of amines with light electrophiles using a flow microreactor system

Abstract

The challenging direct monoalkylation of amines with light electrophilic reagents (C1 to C3) was performed through a flow microreactor approach. The efficiency of mixing coupled with short residence times (tR = 0.7–62 s) allows the transfer of a single alkyl group from R-OTf onto primary amines (R = Et, Pr) as well as on secondary amines (R = Me, Et, Pr, allyl, propargyl) with good selectivities.

Graphical abstract: Selective monoalkylation of amines with light electrophiles using a flow microreactor system

Supplementary files

Article information

Article type
Research Article
Submitted
22 ⴷⵓⵊ 2014
Accepted
30 ⵉⵏⵏ 2015
First published
03 ⴱⵕⴰ 2015

Org. Chem. Front., 2015,2, 324-327

Author version available

Selective monoalkylation of amines with light electrophiles using a flow microreactor system

T. Lebleu, J. Maddaluno and J. Legros, Org. Chem. Front., 2015, 2, 324 DOI: 10.1039/C4QO00342J

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