A novel architecture based upon multi-walled carbon nanotubes and ionic liquid to improve the electroanalytical detection of ciprofibrate

Abstract

Voltammetric studies have been carried out using a glassy carbon electrode (GCE) modified with multi-walled carbon nanotubes (MWCNTs) and the ionic liquid 1-butyl-3-methylimidazolium chloride (IL). Studies on the electrochemical properties of GCEs modified with MWCNTs and IL within different polymeric films (dihexadecylphosphate (DHP), Nafion, and chitosan (CTS)) were performed using a [Fe(CN)₆]^4−/3− electrochemical probe. The modified GCE with different polymeric films was also tested for ciprofibrate (CPF) sensing in the presence and absence of IL in the film. The presence of IL and the MWCNTs improved the electrochemical response for CPF in all cases due to a synergic effect, and the IL-MWCNTs-DHP/GCE showed a great voltammetric profile for CPF detection. The IL-MWCNTs-DHP/GCE and differential pulse voltammetry (DPV) were used for the determination of CPF. An analytical curve was obtained for CPF in the concentration range of 2.50 × 10⁻⁷ to 7.41 × 10⁻⁶ mol L⁻¹ with a detection limit of 9.20 × 10⁻⁸ mol L⁻¹. The proposed DPV method was successfully applied for CPF determination in pharmaceutical samples, and the results obtained agree with the results obtained using a spectrophotometric method at a confidence level of 95%.