Halloysite clay nanotubes as a ceramic “skeleton” for functional biopolymer composites with sustained drug release

Abstract

Halloysite, naturally occurring clay nanotubes, is described as an additive for functional polymer composites. Due to the empty tubular lumen capable of being loaded with chemically active agents, halloysite provides additional functions (drug delivery, antibiotic, flame-retardant, anticorrosion, and crack self-healing) to polymeric composites synergistically combined with enhanced tensile, impact and adhesive strength. Doping loaded clay nanotubes into a polymeric matrix provides a kind of ceramic “skeleton”, and these “skeleton bones” are loaded with functional chemicals like real bones loaded with marrow. Tunable controlled release of active agents through synthesis of artificial nano-caps at the tube endings and halloysite lumen enlargement by selective etching allowed for tubular nanocontainers with chemicals release time from 10 to 200 h and a loading capacity of ca. 30 wt%. Halloysite is well mixable with polymers of high and medium polarities without any surface modification.