Issue 32, 2013

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

Abstract

The aggregation of human islet amyloid polypeptide (hIAPP) has been linked to beta-cell death in type II diabetes. Zinc present in secretory granules has been shown to affect this aggregation. A combination of EXAFS, NMR, and AFM experiments shows that the influence of zinc is most likely due to the stabilization of prefibrillar aggregates of hIAPP.

Graphical abstract: Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

Supplementary files

Article information

Article type
Communication
Submitted
16 ⵉⵏⵏ 2013
Accepted
06 ⵎⴰⵕ 2013
First published
06 ⵎⴰⵕ 2013

Chem. Commun., 2013,49, 3339-3341

Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide

J. R. Brender, J. Krishnamoorthy, G. M. L. Messina, A. Deb, S. Vivekanandan, C. La Rosa, J. E. Penner-Hahn and A. Ramamoorthy, Chem. Commun., 2013, 49, 3339 DOI: 10.1039/C3CC40383A

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