Issue 12, 2018

Azidoheteroarylation of unactivated olefins through distal heteroaryl migration

Abstract

The radical-mediated azidoheteroarylation of unactivated olefins has been accomplished for the first time based on the strategy of intramolecular distal heteroaryl migration. A variety of synthetically useful heteroaryl-substituted alkyl azides are readily furnished under mild reaction conditions. The utility of the protocol is manifested by readily converting the products to piperidine, β-pipecolic acid, and triazole derivatives.

Graphical abstract: Azidoheteroarylation of unactivated olefins through distal heteroaryl migration

Supplementary files

Article information

Article type
Research Article
Submitted
20 ⵎⴰⵕ 2018
Accepted
27 ⵉⴱⵔ 2018
First published
28 ⵉⴱⵔ 2018

Org. Chem. Front., 2018,5, 1896-1899

Azidoheteroarylation of unactivated olefins through distal heteroaryl migration

M. Wang, Z. Wu, B. Zhang and C. Zhu, Org. Chem. Front., 2018, 5, 1896 DOI: 10.1039/C8QO00301G

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