Issue 10, 2016

A ratiometric, fluorescent BODIPY-based probe for transition and heavy metal ions

Abstract

A novel metal ion-sensitive fluorescent probe – 4,4-difluoro-8-(4-methylphenyl)-5-(phenylethynyl)-3-[bis(pyridin-2-ylmethyl)amino]-4-bora-3a,4a-diaza-s-indacene – based on the BODIPY platform with di(2-picolyl)amine as chelator has been synthesized and spectroscopically and photophysically characterized. The generalized treatment of the solvent effect shows that solvent dipolarity is primarily responsible for the observed shifts of the absorption and fluorescence emission maxima. Complex formation with various metal ions is investigated in acetonitrile solution by means of spectrophotometric and fluorometric titrations. The BODIPY indicator forms 1 : 1 complexes with several transition metal (Ni2+, Cu2+, Zn2+) and heavy metal (Cd2+, Hg2+) ions, producing large bathochromic shifts in the absorption and fluorescence spectra and, except for Ni2+, cation-induced fluorescence amplifications. The dissociation constants of the metal ion complexes range from 4 μM for Hg2+ to 48 μM for Zn2+.

Graphical abstract: A ratiometric, fluorescent BODIPY-based probe for transition and heavy metal ions

Supplementary files

Article information

Article type
Paper
Submitted
10 ⵏⵓⵡ 2015
Accepted
08 ⵉⵏⵏ 2016
First published
13 ⵉⵏⵏ 2016

RSC Adv., 2016,6, 7806-7816

Author version available

A ratiometric, fluorescent BODIPY-based probe for transition and heavy metal ions

W. Qin, W. Dou, V. Leen, W. Dehaen, M. Van der Auweraer and N. Boens, RSC Adv., 2016, 6, 7806 DOI: 10.1039/C5RA23751C

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