DOI:
10.1039/C4QO00319E
(Research Article)
Org. Chem. Front., 2015,
2, 241-247
N-heterocyclic carbene-based ruthenium-catalyzed direct amidation of aldehydes with amines†
Received
5th December 2014
, Accepted 13th January 2015
First published on 13th January 2015
Abstract
The direct amide synthesis from alcohols and amines is a highly environmentally-benign and atom economic process. In situ generated NHC-based Ru halide catalytic systems are active for the amidation of alcohols with amines. However, these systems show poor activities in the amidation of aldehydes with amines, though aldehydes are the proposed reaction intermediates formed by dehydrogenation of alcohols; imines are obtained as major byproducts in this case. In this study, an improved method was developed by incorporating the idea of using a hemiaminal intermediate as the precatalyst activator, for the direct amide synthesis from aldehydes and amines using a commercially available Ru complex [Ru(p-cymene)Cl2]2, an N-heterocyclic carbene ligand, a base, and pyridine. Using this method, various amides were synthesized from several aldehydes and amines.
Introduction
The amide bond is an important functionality that plays a pivotal role in both organic and biological chemistry.1 Aldehydes are versatile starting materials because of their availability and non-toxicity. The transition-metal-catalyzed direct amidation of aldehydes with amines has been highlighted as an attractive alternative to traditional amide synthesis,2 and several groups have reported Ru-,3 Pd-,4 Cu-,5 Rh-,6 Au-,7 and lanthanide-based8 catalytic systems for this transformation. The general mechanism of this reaction is shown in Scheme 1. An aldehyde reacts with an amine to produce a hemiaminal intermediate, which is further oxidized to the corresponding amide. A major advantage of this approach is that it provides efficient and fast access to amides without the isolation of carboxylic acid intermediates. Therefore, it is especially useful for synthesizing compounds containing functional groups that are either unstable in the presence of carboxylic acids or incompatible with the reaction conditions used in the classical amide formation.2b
![image file: c4qo00319e-s1.tif](/image/article/2015/QO/c4qo00319e/c4qo00319e-s1.gif) |
| Scheme 1 Amide synthesis from aldehydes and amines. | |
Recently, the transition-metal-catalyzed direct amide synthesis from alcohols and amines has been highlighted as an attractive protocol for constructing the amide bond.9,10 Ru-,3,11 Rh-,12 and Ag-,13 based catalytic systems have been reported for this transformation. In our previous studies, the catalytic systems 1a and 1b showed excellent activities for the amidation of alcohols with amines.11o However, when we tested 1a and 1b for the reaction of benzaldehyde with benzyl amine, the amide was obtained with only 48% and 11% yields, respectively, with the corresponding imine as the major byproduct (Scheme 2).11o Later, our group developed well-defined NHC-based Ru catalysts for the amidation of alcohols with amines that also showed low activity for direct amide synthesis from aldehydes and amines.11m Interestingly, the efficient amidation of aldehydes can be realized by the addition of a catalytic amount of a primary alcohol (Scheme 3). It was demonstrated that the formation of an active Ru hydride catalytic species from precatalyst 1c, by the addition of an alcohol, is essential for the amidation of aldehydes with amines. The effective formation of a Ru-hydride was crucial for amide synthesis from both alcohols and aldehydes.11j
![image file: c4qo00319e-s2.tif](/image/article/2015/QO/c4qo00319e/c4qo00319e-s2.gif) |
| Scheme 2 Reaction of benzaldehyde with benzyl amine catalyzed by 1a and 1b. | |
![image file: c4qo00319e-s3.tif](/image/article/2015/QO/c4qo00319e/c4qo00319e-s3.gif) |
| Scheme 3 Reaction of benzaldehyde with benzyl amine catalyzed by 1c. | |
Based on a mechanistic understanding of the essential role of an alcohol in activating a Ru-halide precatalyst, to the Ru-hydride form, we envisioned that a hemiaminal, an important alcoholic intermediate for the formation of amides from aldehydes and amines, could be used to activate the Ru halide precatalyst to generate the key Ru hydride species as shown in Scheme 4. With this hypothesis, herein, we report the direct amide synthesis from aldehydes and amines by modifying the reaction conditions based on 1a.
![image file: c4qo00319e-s4.tif](/image/article/2015/QO/c4qo00319e/c4qo00319e-s4.gif) |
| Scheme 4 Proposed mechanism of aldehyde amidation with amines using a hemiaminal intermediate as an activator. | |
Results and discussion
A reaction between benzaldehyde and benzylamine was selected as the model reaction for the optimization of reaction conditions (Table 1). In our previous report, when the catalytic system 1a was used for the reaction, only a limited yield of amide 5a was obtained (48%, entry 1) with the corresponding imine as the major byproduct. Inspired by the reported work that used an alcohol to activate precatalyst 1c, we added a catalytic amount of readily available primary and secondary alcohols. Disappointingly, yields of 5a (entries 2–4) were comparable to or even lower than that of entry 1. Subsequently, we turned our attention to the role of NaH to facilitate the binding of the in situ generated hemiaminal intermediate to the Ru species by forming the corresponding alkoxide. To our delight, a dramatic improvement was achieved on changing the amount of NaH from 15 mol% to 40 mol% (87% for entry 7 vs. 48% for entry 1, entries 1, 5–7). However, further increasing the amount of NaH resulted in reduced yields of the amide (entries 8–10). Milder KOtBu was not as effective as NaH (entries 11–16). The optimized catalytic system, identified as [Ru(p-cymene)Cl2]2 (2.5 mol%), NHC precursor 2 (5 mol%), pyridine (5 mol%), NaH (40 mol%), was used for further study.
Table 1 Optimization of reaction conditionsa
![image file: c4qo00319e-u1.tif](/image/article/2015/QO/c4qo00319e/c4qo00319e-u1.gif)
|
Entry |
Base (mol%) |
Additive (10 mol%) |
Yieldb (%) |
[Ru(p-cymene)Cl2]2 (2.5 mol%), NHC precursor 2 (5 mol%), base, pyridine (5 mol%), additive (10 mol%) in toluene at reflux for 24 h.
GC yields using n-dodecane as an internal standard.
|
1 |
NaH (15) |
— |
48 |
2 |
NaH (15) |
MeOH |
35 |
3 |
NaH (15) |
iPrOH |
25 |
4 |
NaH (15) |
PhCH2CH2OH |
40 |
5 |
NaH (20) |
— |
51 |
6 |
NaH (30) |
— |
63 |
7 |
NaH (40) |
— |
87 |
8 |
NaH (50) |
— |
80 |
9 |
NaH (60) |
— |
62 |
10 |
NaH (100) |
— |
50 |
11 |
KOtBu (20) |
— |
25 |
12 |
KOtBu (30) |
— |
29 |
13 |
KOtBu (40) |
— |
42 |
14 |
KOtBu (50) |
— |
42 |
15 |
KOtBu (60) |
— |
54 |
16 |
KOtBu (100) |
— |
53 |
With the optimized reaction conditions in hand, the substrate scope and limitations of this method were investigated. A range of amides was obtained in fair to good yields (Table 2). Aromatic aldehydes are good substrates for this reaction. Benzaldehyde reacted smoothly with sterically nonhindered primary amines (entries 1, 2 and 15–16). A reduced yield was observed for a moderately hindered amine 4c (entry 3). Less basic aniline was converted to the corresponding amide in only 31% yield even at elevated temperature with p-xylene as the solvent (entry 4). Furan was more tolerant than pyridine under our reaction conditions (entries 5 and 6). Electronic effects of substituents on aldehydes were explored using different benzaldehyde derivatives and benzyl amine, and a slightly lower yield was obtained for an electron-deficient substrate (entries 1, 7 and 8). In the case of cyclic secondary amines, piperidine showed good reactivity with both electron-deficient and electron-rich aromatic aldehydes (entries 9–11). Aliphatic aldehydes were also employed, giving the desired amides in 40–50% yields (entries 12–14).
Table 2 Direct amide synthesis from aldehydes and aminesa
Conclusions
The Ru-catalyzed direct amide synthesis from aldehydes and amines was performed by incorporating the idea of using a hemiaminal intermediate for generating the active Ru-hydride species. This was achieved by using a higher amount of a strong base compared to the previously reported catalytic conditions, which was conducive for direct amide synthesis from alcohols and amines, but not for the synthesis from aldehydes and amines. A range of amides was synthesized directly from aldehydes and amines in fair to good yields.
Experimental section
General information
All reactions were carried out using standard Schlenk techniques or in an argon-filled glove box unless otherwise mentioned. Toluene, THF, and dichloromethane were dried over the PureSolv solvent purification system. NMR spectra were obtained on an Agilent 400-MR DD2 Magnetic Resonance System (400 MHz). Chemical shift values were recorded in ppm relative to tetramethylsilane (TMS) as an internal standard, and coupling constants in hertz (Hz). GC analyses were carried out using the 7980A GC system from Agilent Technologies, equipped with an HP-5 column using dodecane as an internal standard. The high resolution mass spectra were recorded with Waters Q-Tof from Premier Micromass instrument, using the electrospray ionization (ESI) mode. 1,3-Diisopropylimidazolium bromide (2)11o was prepared using the procedure reported in the literature. Most substrates were obtained from commercial suppliers and used as received without further purification.
General procedure
[Ru(p-cymene)Cl2]2 (7.7 mg, 0.0125 mmol), 1,3-diisopropylimidazolium bromide (2, 5.8 mg, 0.025 mmol), NaH (4.8 mg, 0.2 mmol), pyridine (2 μL, 0.025 mmol), and toluene (0.6 mL) were added to an oven-dried Schlenk tube placed inside an argon-filled glovebox. The reaction mixture was heated to reflux under an argon atmosphere for 30 min. The flask was taken out of the oil bath before the aldehyde (0.5 mmol) and the amine (0.55 mmol) were added, and the mixture was heated to reflux in an open condition under an argon atmosphere for 24 h. The reaction mixture was cooled down to room temperature and the solvent was removed under reduced pressure. The residue was purified by silica gel flash column chromatography to afford the amide. N-Benzylbenzamide (5a),11oN-hexylbenzamide (5b),14N-benzyl-4-methoxybenzamide (5g),15N-benzyl-4-chlorobenzamide (5h),16 phenyl(piperidin-1-yl)methanone (5i),11o (4-methoxyphenyl)(piperidin-1-yl)methanone (5j),8d (4-chlorophenyl)(piperidin-1-yl)methanone (5k),8dN-benzylhexanamide (5l),11oN-benzyl-3-methylbutanamide (5n),17N-(4-methoxybenzyl)benzamide (5o),18 and N-(4-chlorobenzyl)benzamide (5p)18 were identified by spectral comparison with the literature data.
N-(Heptan-2-yl)benzamide (5c).
Purified by silica gel chromatography (hexane–EA 3
:
1) to afford it as a white solid, mp: 64–65 °C. Isolated yield: 57%. 1H NMR (CDCl3): δ = 7.76–7.74 (m, 2H), 7.51–7.38 (m, 3H), 6.02 (d, 1 H, J = 7.3 Hz), 4.23–4.13 (m, 1H), 1.65–1.10 (m, 11H), 0.87 (t, 3H, J = 7.1 Hz); 13C NMR (CDCl3): 167.0, 135.2, 131.4, 128.7, 127.0, 46.0, 37.2, 31.9, 26.0, 22.8, 21.2, 14.2; HR-MS (ESI): m/z = 220.1697 [MH+], calcd for C14H22NO: 220.1701.
N-Phenylbenzamide (5d).
Purified by silica gel chromatography (hexane–EA 3
:
1) to afford it as a white solid, mp: 161–163 °C. Isolated yield: 31%. 1H NMR (CDCl3): δ = 7.88 (bs, 1H), 7.89–7.77 (m, 2H), 7.69–7.60 (m, 2H), 7.58–7.50 (m, 1H), 7.48–7.42 (m, 2H), 7.40–7.30 (m, 2H), 7.20–7.11 (m, 1H); 13C NMR (CDCl3): 166.0, 138.1, 135.2, 132.0, 129.3, 129.0, 127.2, 124.8, 120.4; HR-MS (ESI): m/z = 198.0925 [MH+], calcd for C13H12NO: 198.0919.
N-Benzylpicolinamide (5e).
Purified by silica gel chromatography (hexane–EA 3
:
1) to afford it as a white solid, mp: 83–85 °C. Isolated yield: 38%. 1H NMR (CDCl3): δ 8.52 (d, 1H, J = 5.0 Hz), 8.39 (bs, 1H), 8.24 (d, 1H, J = 8.2 Hz), 7.90–7.75 (m, 1H), 7.50–7.20 (m, 6H), 4.67 (d, 2H, J = 6.0 Hz); 13C NMR (CDCl3): 164.4, 150.0, 148.2, 138.4, 137.5, 128.9, 128.0, 127.6, 126.4, 122.5, 43.6; HR-MS (ESI): m/z = 213.1028 [MH+], calcd for C13H13N2O: 213.1028.
N-Benzylfuran-2-carboxamide (5f).
Purified by silica gel chromatography (hexane–EA 3
:
1) to afford it as a white solid, mp: 111–113 °C. Isolated yield: 60%. 1H NMR (CDCl3): δ 7.40 (s, 1H), 7.38–7.20 (m, 5H), 7.13 (m, 1H), 6.74 (bs, 1H), 6.49 (m, 1H), 4.60 (d, 2H, J = 5.9 Hz); 13C NMR (CDCl3): 158.4, 148.0, 144.1, 138.2, 128.9, 128.0, 127.8, 114.5, 112.3, 43.3; HR-MS (ESI): m/z = 202.0872 [MH+], calcd for C12H12NO2: 202.0868.
N-Benzylnonanamide (5m).
Purified by silica gel chromatography (hexane–EA 3
:
1) to afford it as a white solid, mp: 66 °C. Isolated yield: 52%. 1H NMR (CDCl3): δ 7.40–7.15 (m, 5H), 5.75 (bs, 1H), 4.44 (d, 2H, J = 5.5 Hz), 2.21 (t, 2H, J = 7.8 Hz), 1.65 (m, 2H), 1.40–1.10 (m, 10H), 0.88 (t, 3H, J = 6.9 Hz); 13C NMR (CDCl3): 173.2, 138.6, 128.9, 128.0, 127.7, 43.8, 37.0, 32.0, 29.5, 29.4, 26.0, 22.9, 14.3; HR-MS (ESI): m/z = 248.2020 [MH+], calcd for C16H26NO: 248.2014.
Acknowledgements
This work was supported by the National Research Foundation funded by the Korean Government (NRF-2014R1A2A1A11050028; NRF-2014S1A2A2028156; NRF-2014R1A5A1011165, Center for New Directions in Organic Synthesis) and the Natural Science Foundation of Hubei Province funded by Science and Technology Department of Hubei Province (2014CFB280) and the China Postdoctoral Science Foundation (2014M562044).
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Footnote |
† Electronic supplementary information (ESI) available: 1H NMR and 13C NMR spectra of compound 5. See DOI: 10.1039/c4qo00319e |
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