Issue 5, 2015

Selective NaOH-catalysed hydration of aromatic nitriles to amides

Abstract

The selective synthesis of aromatic and heteroaromatic amides through base-catalysed hydration of nitriles was achieved using inexpensive and commercially available NaOH as the only catalyst. A wide range of nitriles was selectively converted to their corresponding amides. Kinetic studies show that the double hydration of nitriles towards undesirable carboxylic acids is negligible under our reaction conditions.

Graphical abstract: Selective NaOH-catalysed hydration of aromatic nitriles to amides

Supplementary files

Article information

Article type
Paper
Submitted
03 ⵎⴰⵕ 2015
Accepted
18 ⵎⴰⵕ 2015
First published
24 ⵎⴰⵕ 2015

Catal. Sci. Technol., 2015,5, 2865-2868

Selective NaOH-catalysed hydration of aromatic nitriles to amides

T. E. Schmid, A. Gómez-Herrera, O. Songis, D. Sneddon, A. Révolte, F. Nahra and C. S. J. Cazin, Catal. Sci. Technol., 2015, 5, 2865 DOI: 10.1039/C5CY00313J

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