Issue 30, 2013

Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions

Abstract

The efficient generation of biaryl compounds and heterocycles via the advent of the transition-metal-free coupling reaction constitutes an important development in the last few years. Although early methods for the construction of such molecules involved transition metals, recent advances in the field have witnessed a myriad of elegant reports without the use of metal sources. The serendipitous discovery and observation of synthetic chemists have realized that there lies a great potential in exploiting the inherent reactivity of molecules in absence of transition metal. The key to the success of such coupling reactions is the use of a strong base, oxidant and a catalytic amount of N-donor ligands which contribute significantly. This review aims to highlight the recent progress in the field of transition-metal-free direct C–C and C–heteroatom bond forming reactions via the use of a strong base and (or) an oxidant.

Graphical abstract: Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions

Article information

Article type
Review Article
Submitted
19 ⴱⵕⴰ 2013
Accepted
05 ⵉⴱⵔ 2013
First published
08 ⵉⴱⵔ 2013

RSC Adv., 2013,3, 11957-11986

Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions

V. P. Mehta and B. Punji, RSC Adv., 2013, 3, 11957 DOI: 10.1039/C3RA40813B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements