Zinc finger peptide cleavage by a dinuclear platinum compound

Abstract

Electrospray ionisation mass spectrometry (ESI-MS) and {¹H, ¹⁵N HSQC} NMR spectroscopy has elucidated the binding of a dinuclear platinum compound to a zinc finger peptide with induced backbone cleavage. Cleavage is selective on the N-terminal side of the cysteine residue following incubation at neutral pH, and is further dependent on structure of dinuclear compound.