Issue 42, 2013

Tumour targeting with radiometals for diagnosis and therapy

Abstract

Use of radiometals in nuclear oncology is a rapidly growing field and encompasses a broad spectrum of radiotracers for imaging via PET (positron emission tomography) or SPECT (single-photon emission computed tomography) and therapy via α, β, or Auger electron emission. This feature article opens with a brief introduction to the imaging and therapy modalities exploited in nuclear medicine, followed by a discussion of the multi-component strategy used in radiopharmaceutical development, known as the bifunctional chelate (BFC) method. The modular assembly is dissected into its individual components and each is discussed separately. The concepts and knowledge unique to metal-based designs are outlined, giving insight into how these radiopharmaceuticals are evaluated for use in vivo. Imaging nuclides 64Cu, 68Ga, 86Y, 89Zr, and 111In, and therapeutic nuclides 90Y, 177Lu, 225Ac, 213Bi, 188Re, and 212Pb will be the focus herein. Finally, key examples have been extracted from the literature to give the reader a sense of breadth of the field.

Graphical abstract: Tumour targeting with radiometals for diagnosis and therapy

Article information

Article type
Feature Article
Submitted
28 ⴱⵕⴰ 2013
Accepted
27 ⵎⴰⵕ 2013
First published
02 ⵉⴱⵔ 2013

Chem. Commun., 2013,49, 4720-4739

Tumour targeting with radiometals for diagnosis and therapy

C. F. Ramogida and C. Orvig, Chem. Commun., 2013, 49, 4720 DOI: 10.1039/C3CC41554F

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