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An enzymic method to protect selected amino group of lysine has been reported. This reaction proceeds smoothly under room temperature with high regioselectivity (up to 99%) and high yields (up to 90%). This work will pave the way for simple and selective protection of amino group of lysine in industry.

Graphical abstract: Effective regioselective protection of amino groups of lysine achieved by a supramolecular enzyme-mimic approach

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