Issue 31, 2006
From the journal:

Chemical Communications

Skeletal diversity construction via a branching synthetic strategy†‡

Emma E. Wyatt,a   Suzanne Fergus,a   Warren R. J. D. Galloway,a   Andreas Bender,a   David J. Fox,a   Alleyn T. Plowright,b   Alan S. Jessiman,c   Martin Welchd  and  David R. Spring*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: drspring@ch.cam.ac.uk
Fax: +44 (0)1223-336362
Tel: +44 (0)1223-336498

b AstraZeneca, Cardiovascular and Gastro-Intestinal Research Area, Alderley Park, Cheshire, UK

c Pfizer Global Research & Development, Discovery Chemistry, Sandwich, Kent, UK

d Department of Biochemistry, University of Cambridge, Downing Site, Cambridge, UK

Abstract

A branching synthetic strategy was used to efficiently generate structurally diverse scaffolds, which span a broad area of chemical descriptor space, and their biological activity against MRSA was demonstrated.

Graphical abstract: Skeletal diversity construction via a branching synthetic strategy

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Article information

DOI
https://doi.org/10.1039/B607710B
Article type
Communication
Submitted
01 ⵢⵓⵏ 2006
Accepted
28 ⵢⵓⵏ 2006
First published
10 ⵢⵓⵍ 2006

Chem. Commun., 2006, 3296-3298

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Skeletal diversity construction via a branching synthetic strategy

E. E. Wyatt, S. Fergus, W. R. J. D. Galloway, A. Bender, D. J. Fox, A. T. Plowright, A. S. Jessiman, M. Welch and D. R. Spring, Chem. Commun., 2006, 3296 DOI: 10.1039/B607710B

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