The modified outer membrane protein Amuc_1100 of Akkermansia muciniphila improves chronic stress-induced anxiety and depression-like behavior in mice

Rongrong Cheng, Haiyan Zhu, Yan Sun, Tianrong Hang and Min Zhang

Food Funct., 2022, 13, 10748
DOI: 10.1039/D2FO01198K

Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis

Zhenyang Gu, Wenlong Pei, Yonghua Shen, Lijuan Wang, Jun Zhu, Yi Zhang, Shengxian Fan, Qian Wu, Lei Li and Zhan Zhang

Food Funct., 2021, 12, 10184
DOI: 10.1039/D1FO02172A

The hidden language of gut-derived lipopolysaccharides: fine chemistry, huge immunological consequences

Marcello Mercogliano, Valentina Mazziotti, Alba Silipo, Antonio Molinaro and Flaviana Di Lorenzo

Chem. Sci., 2026, 17, 3894
DOI: 10.1039/D5SC09900E

Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome

Yoshiyuki Mishima and Shunji Ishihara

IJMS, 2021, 22, 10235
DOI: 10.3390/ijms221910235

The Hypolipidemic Effect of Hawthorn Leaf Flavonoids through Modulating Lipid Metabolism and Gut Microbiota in Hyperlipidemic Rats

Huiming Hu, Jiajun Weng, Can Cui, Fangrui Tang, Mengdan Yu, Yujie Zhou, Feng Shao, Yanchen Zhu and Wen Yi Kang

Evidence-Based Complementary and Alternative Medicine, 2022, 2022, 1
DOI: 10.1155/2022/3033311

Akkermansia muciniphila-derived extracellular vesicles alleviate depressive-like behaviors via hippocampal protection and gut metabolic modulation

Yushan Xu, Xinyang Chen, Ze Tao, Qiqiong Li, Shanfeng Qiao, Ying He and Junhua Xie

Food Bioscience, 2026, 80, 108904
DOI: 10.1016/j.fbio.2026.108904

The role of Akkermansia muciniphila in maintaining health: a bibliometric study

Fangfang Gao, Canyu Cheng, Runwei Li, Zongcun Chen, Ke Tang and Guankui Du

Front. Med., 2025, 12
DOI: 10.3389/fmed.2025.1484656

The Potential of Meta-Proteomics and Artificial Intelligence to Establish the Next Generation of Probiotics for Personalized Healthcare

Arpita Das, Rama N. Behera, Ayushi Kapoor and Kiran Ambatipudi

J. Agric. Food Chem., 2023, 71, 17528
DOI: 10.1021/acs.jafc.3c03834

Insights into the Functions, Characteristics, and Mechanisms of Disease-Related Proteins from Akkermansia muciniphila: A Review

Yanping Han, Juane Lu, Xueying Bu, Liying Hu, Changcheng Niu, Jianjun Qiao, Hao Wu and Qinggele Caiyin

Microorganisms, 2026, 14, 820
DOI: 10.3390/microorganisms14040820

Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior

Carolina de Weerth, Anna-Katariina Aatsinki, Meghan B. Azad, Frank F. Bartol, Lars Bode, Maria Carmen Collado, Amanda M. Dettmer, Catherine J. Field, Meagan Guilfoyle, Katie Hinde, Aniko Korosi, Hellen Lustermans, Nurul Husna Mohd Shukri, Sophie E. Moore, Shikha Pundir, Juan Miguel Rodriguez, Carolyn M. Slupsky, Sarah Turner, Johannes B. van Goudoever, Anna Ziomkiewicz and Roseriet Beijers

Critical Reviews in Food Science and Nutrition, 2023, 63, 7945
DOI: 10.1080/10408398.2022.2053058

Function of Akkermansia muciniphila in type 2 diabetes and related diseases

Jinjie Li, Ge Yang, Qihe Zhang, Zhuo Liu, Xin Jiang and Ying Xin

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1172400

Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium

Jiyeon Si, Hyena Kang, Hyun Ju You and GwangPyo Ko

Gut Microbes, 2022, 14
DOI: 10.1080/19490976.2022.2078619

The 3M roles of the gut microbiome in pharmacotherapy for diabetes: mediator, modifier, and marker

Jeong In Seo, Ara Koh, Soo Lim and Hye Hyun Yoo

Trends in Endocrinology & Metabolism, 2026
DOI: 10.1016/j.tem.2025.12.006

Molecular signalling during cross talk between gut brain axis regulation and progression of irritable bowel syndrome: A comprehensive review

Shiv Vardan Singh, Risha Ganguly, Kritika Jaiswal, Aditya Kumar Yadav, Ramesh Kumar and Abhay K Pandey

World J Clin Cases, 2023, 11, 4458
DOI: 10.12998/wjcc.v11.i19.4458

Akkermania muciniphila: a rising star in tumor immunology

Leihan Wang and Dong Tang

Clin Transl Oncol, 2024, 26, 2418
DOI: 10.1007/s12094-024-03493-6

Extracellular vesicles from Akkermansia muciniphila block NACHT, LRR, and PYD domains-containing protein 3 inflammasome activation to promote cognitive recovery in aged mice under sevoflurane anesthesia

Shili Zhang, Xiaomei Chen, Pu Tao, Hong Liu and Liang Tu

Behavioural Pharmacology, 2026, 37, 41
DOI: 10.1097/FBP.0000000000000864

Akkermansia muciniphila: The state of the art, 18 years after its first discovery

Rim Iwaza, Reham Magdy Wasfy, Grégory Dubourg, Didier Raoult and Jean-Christophe Lagier

Front. Gastroenterol., 2022, 1
DOI: 10.3389/fgstr.2022.1024393

Akkermansia muciniphila attenuates association between specific metal exposures during pregnancy and depressive symptoms in late childhood

Vishal Midya, Kiran Nagdeo, Jamil M. Lane, Libni A. Torres-Olascoaga, Gabriela Gil Martínez, Megan K. Horton, Nia McRae, Inessa Lopez, Julio Landero, Chris Gennings, Martha Maria Téllez-Rojo, Robert O. Wright, Manish Arora and Shoshannah Eggers

iScience, 2024, 27, 111335
DOI: 10.1016/j.isci.2024.111335

Pasteurized Akkermansia muciniphila mitigates 5-FU-induced intestinal mucositis in tumor-bearing mice through suppression of the cGAS-STING pathway and epithelial cell apoptosis

Yue Teng, Jiahui Li, Chunhong Yan, Ailing Wang, Xiaomeng Ren and Xiaodong Xia

Food Bioscience, 2024, 61, 104605
DOI: 10.1016/j.fbio.2024.104605

Outer membrane protein Amuc_1100 of Akkermansia muciniphila alleviates antibiotic-induced anxiety and depression-like behavior in mice

Yan Sun, Haiyan Zhu, Rongrong Cheng, Zhengquan Tang and Min Zhang

Physiology & Behavior, 2023, 258, 114023
DOI: 10.1016/j.physbeh.2022.114023

Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery

Qiaoyuan Xiang, Minhua Yu, Qi Cai, Mengjie Hu, Bo Rao, Xin Liang, Zhenxing Liu, Yu Xie, Kuan Cen, Renwei Zhang, Haibo Xu and Yumin Liu

J Transl Med, 2024, 22
DOI: 10.1186/s12967-024-05757-9

Rifaximin Ameliorates Loperamide-Induced Constipation in Rats through the Regulation of Gut Microbiota and Serum Metabolites

Mei Luo, Peiwei Xie, Xuehong Deng, Jiahui Fan and Lishou Xiong

Nutrients, 2023, 15, 4502
DOI: 10.3390/nu15214502

Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

Patrice D. Cani, Clara Depommier, Muriel Derrien, Amandine Everard and Willem M. de Vos

Nat Rev Gastroenterol Hepatol, 2022, 19, 625
DOI: 10.1038/s41575-022-00631-9

Function and therapeutic potential of Amuc_1100, an outer membrane protein of Akkermansia muciniphila: A review

Xuhui Wu, Dahai Yu, Yunkun Ma, Xuexun Fang and Pengda Sun

International Journal of Biological Macromolecules, 2025, 308, 142442
DOI: 10.1016/j.ijbiomac.2025.142442

Amuc attenuates high-fat diet-induced metabolic disorders linked to the regulation of fatty acid metabolism, bile acid metabolism, and the gut microbiota in mice

Zhuan Song, Jingqing Chen, Yun Ji, Qing Yang, Yinfeng Chen, Fengchao Wang and Zhenlong Wu

International Journal of Biological Macromolecules, 2023, 242, 124650
DOI: 10.1016/j.ijbiomac.2023.124650

Gut Microbiota Dysbiosis and Inflammation Dysfunction in Late-Life Depression: An Observational Cross-Sectional Analysis

Yan Chen, Dansheng Le, Jiaxi Xu, Piaopiao Jin, Yuhan Zhang and Zhengluan Liao

NDT, 2024, Volume 20, 399
DOI: 10.2147/NDT.S449224

Novel Candidate Microorganisms for Fermentation Technology: From Potential Benefits to Safety Issues

Duygu Ağagündüz, Birsen Yılmaz, Tevfik Koçak, Hilal Altıntaş Başar, João Rocha and Fatih Özoğul

Foods, 2022, 11, 3074
DOI: 10.3390/foods11193074

The influence of Akkermansia muciniphila on intestinal barrier function

Chunyan Mo, Xiran Lou, Jinfang Xue, Zhuange Shi, Yifang Zhao, Fuping Wang and Guobing Chen

Gut Pathog, 2024, 16
DOI: 10.1186/s13099-024-00635-7

Postbiotics and their biotherapeutic potential for chronic disease and their feature perspective: a review

Zerihun Asefa, Abera Belay, Eyuel Welelaw and Meseret Haile

Front. Microbiomes, 2025, 4
DOI: 10.3389/frmbi.2025.1489339

Role of gut microbiota-derived signals in the regulation of gastrointestinal motility

Zhipeng Zheng, Jingyi Tang, Yingnan Hu and Wei Zhang

Front. Med., 2022, 9
DOI: 10.3389/fmed.2022.961703

Extracellular Vesicles from the Probiotic Yeast Pichia kudriavzevii: Proteomic Characterization and Modulation of Immune and Defense Responses in an Induced Inflammation Model of Intestinal Epithelial Cells

Angela Maione, Monica Matuozzo, Marianna Imparato, Chiara D’Ambrosio, Elisabetta de Alteriis, Marco Guida, Andrea Scaloni and Emilia Galdiero

Nutrients, 2026, 18, 912
DOI: 10.3390/nu18060912

Pasteurized Akkermansia muciniphila ameliorates insulin resistance by reducing placental inflammation in GDM mouse model

Yi Wang, Yuting Zhu, Yan Cui, Jiali Fang, Hong Zhong, Yujie Shi, Lan Liu and Xianwei Cui

Reproductive Biology, 2025, 25, 101073
DOI: 10.1016/j.repbio.2025.101073

The immunomodulatory roles of the gut microbiome in autoimmune diseases of the central nervous system: Multiple sclerosis as a model

Kristina Hoffman, Zackariah Brownell, William J. Doyle and Javier Ochoa-Repáraz

Journal of Autoimmunity, 2023, 137, 102957
DOI: 10.1016/j.jaut.2022.102957

Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila

Miaomiao Pan, Chenglang Qian, Shaoye Huo, Yuchen Wu, Xinyi Zhao, Yueming Ying, Boyu Wang, Hao Yang, Anaguli Yeerken, Tongyao Wang, Mengwei Fu, Lihong Wang, Yuhuan Wei, Yunhua Zhao, Chunhai Shao, Huijing Wang and Chao Zhao

Gut Microbes, 2025, 17
DOI: 10.1080/19490976.2024.2447834

Intermittent Fasting and Probiotics for Gut Microbiota Modulation in Type 2 Diabetes Mellitus: A Narrative Review

Zhiwen Zhang, Shaokang Wang, Guiju Sun and Da Pan

Nutrients, 2025, 18, 119
DOI: 10.3390/nu18010119

Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning via Activating the AC3/PKA/HSL Pathway

Xifen Zheng, Wenting Huang, Qianbei Li, Yun Chen, Linyan Wu, Yifan Dong, Xinyue Huang, Xiaojing He, Zihao Ou, Yongzheng Peng and Leiliang Zhang

Microbiol Spectr, 2023, 11
DOI: 10.1128/spectrum.04323-22

The Recombinant Lactobacillus Strains with the Surface-Displayed Expression of Amuc_1100 Ameliorate Obesity in High-Fat Diet-Fed Adult Mice

Xueni Zhang, Lei Jiang, Cankun Xie, Yidi Mo, Zihao Zhang, Shengxia Xu, Xiaoping Guo, Ke Xing, Yina Wang and Zhijian Su

Bioengineering, 2024, 11, 574
DOI: 10.3390/bioengineering11060574

Interkingdom signaling between gastrointestinal hormones and the gut microbiome

Xinyu Zhao, Ye Qiu, Lanfan Liang and Xiangsheng Fu

Gut Microbes, 2025, 17
DOI: 10.1080/19490976.2025.2456592

Flavonoids from Lycium barbarum leaves attenuate obesity through modulating glycolipid levels, oxidative stress, and gut bacterial composition in high-fat diet-fed mice

JiaLe Liao, Jia Guo, YinHong Niu, Tian Fang, FangZhou Wang and YanLi Fan

Front. Nutr., 2022, 9
DOI: 10.3389/fnut.2022.972794

Akkermansia muciniphila and its outer membrane protein Amuc_1100 prevent high-fat diet-induced nonalcoholic fatty liver disease in mice

Danni Qu, Mengyun Chen, Haiyan Zhu, Xingyu Liu, Yanan Cui, Wei Zhou and Min Zhang

Biochemical and Biophysical Research Communications, 2023, 684, 149131
DOI: 10.1016/j.bbrc.2023.149131

YTHDF1 Attenuates TBI-Induced Brain-Gut Axis Dysfunction in Mice

Peizan Huang, Min Liu, Jing Zhang, Xiang Zhong and Chunlong Zhong

IJMS, 2023, 24, 4240
DOI: 10.3390/ijms24044240

Lactic acid bacteria in relieving constipation: mechanism, clinical application, challenge, and opportunity

Tong Zhang, Wenxu Liu, Huimin Lu, Ting Cheng, Linlin Wang, Gang Wang, Hao Zhang and Wei Chen

Critical Reviews in Food Science and Nutrition, 2025, 65, 551
DOI: 10.1080/10408398.2023.2278155

The biofunction of Akkermansia muciniphila in intestinal-related diseases

Ping Jiang, Siqi Ji, Dan Su, Yu Zhao, Viriania Berta Esperanca Goncalves, Guifang Xu and Mingming Zhang

Microbiome Res Rep, 2024, 3
DOI: 10.20517/mrr.2024.12

Akkermansia muciniphila extracellular vesicles: Function and theranostic potential in disease

Yu-di Wang, Wen-long Lin, Shang-yuan Wu, Xiao-jing He, Zi-hao Ou and Lei Zheng

LabMed Discovery, 2025, 2, 100060
DOI: 10.1016/j.lmd.2025.100060

Functional Proteins of Akkermansia Muciniphila: Impacts on Host Health and Metabolism

Farzad Safari, Faraz Golafshan, Elena Malekpour, Seyed Arsham Mirzaei, Hanieh Rouzbahani, Mehrab Oldin Hajarzadeh, Samira Nasir Harandi, Sara Nasirharandi and Ali Noursina

Probiotics & Antimicro. Prot., 2025
DOI: 10.1007/s12602-025-10871-1

Metformin reprograms tryptophan metabolism via gut microbiome-derived bile acid metabolites to ameliorate depression-Like behaviors in mice

Xiaoxian Xie, Wenwen Li, Ze Xiong, Junyu Xu, Tailin Liao, Lei Sun, Haoshen Xu, Mengya Zhang, Jiafeng Zhou, Wenzheng Xiong, Zhengwei Fu, Zezhi Li, Qi Han, Donghong Cui and Daniel C. Anthony

Brain, Behavior, and Immunity, 2025, 123, 442
DOI: 10.1016/j.bbi.2024.09.014

Akkermansia in the gastrointestinal tract as a modifier of human health

Maria E. Panzetta and Raphael H. Valdivia

Gut Microbes, 2024, 16
DOI: 10.1080/19490976.2024.2406379

Combining gut microbiota modulation and immunotherapy: A promising approach for treating microsatellite stable colorectal cancer

Yujie Chang, Min Long, Hanguo Shan, Logen Liu, Shangwei Zhong and Jun-Li Luo

Critical Reviews in Oncology/Hematology, 2025, 208, 104629
DOI: 10.1016/j.critrevonc.2025.104629

Drug and gut microbe relationships: Moving beyond antibiotics

Shreyas V. Kumbhare, Inti Pedroso, Juan A. Ugalde, Valeria Márquez-Miranda, Ranjan Sinha and Daniel E. Almonacid

Drug Discovery Today, 2023, 28, 103797
DOI: 10.1016/j.drudis.2023.103797

O Uter Membrane Protein Amuc_1100 of Akkermansia Muciniphila Alleviates Antibiotic-Induced Anxiety and Depression-Like Behavior in Mice

Yan Sun, Min Zhang, Haiyan Zhu and Rongrong Cheng

SSRN Journal, 2022
DOI: 10.2139/ssrn.4114992

Divergent roles of functional foods on anthropometric indices and gut microbiota in overweight and obese individuals: In silico approaches and multi-omics insights

Oladayo Emmanuel Apalowo and Isaac Duah Boateng

Trends in Food Science & Technology, 2025, 156, 104876
DOI: 10.1016/j.tifs.2025.104876

Casein-quaternary chitosan complexes induced the soft assembly of egg white peptide and curcumin for ulcerative colitis alleviation

Yajuan Li, Jingbo Liu, Xiaoxia Shi, Shanglin Li, Hui Zhang, Leiyi Zhang, Xinyi Huang, Shuaiyan Liu, Weiyi Wang, Longjiang Tian, Ting Zhang and Zhiyang Du

International Journal of Biological Macromolecules, 2024, 269, 132107
DOI: 10.1016/j.ijbiomac.2024.132107

Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?

Wenhui Lei, Yiwen Cheng, Jie Gao, Xia Liu, Li Shao, Qingming Kong, Nengneng Zheng, Zongxin Ling and Weiming Hu

Front. Cell. Infect. Microbiol., 2023, 13
DOI: 10.3389/fcimb.2023.1224155

Insights into the Mechanisms of Action of Akkermansia muciniphila in the Treatment of Non-Communicable Diseases

Honorata Mruk-Mazurkiewicz, Monika Kulaszyńska, Wiktoria Czarnecka, Albert Podkówka, Natalia Ekstedt, Piotr Zawodny, Anna Wierzbicka-Woś, Wojciech Marlicz, Błażej Skupin, Ewa Stachowska, Igor Łoniewski and Karolina Skonieczna-Żydecka

Nutrients, 2024, 16, 1695
DOI: 10.3390/nu16111695

Prokaryotic cell membrane‑based protein technologies (Review)

Mohammed Suhaib Al Huq, Kalpana Raja and Iyappan Ramalakshmi Oviya

World Acad Sci J, 2024, 6
DOI: 10.3892/wasj.2024.227

Akkermansia muciniphila plays critical roles in host health

Qixiang Zhao, Jiadong Yu, Yan Hao, Hong Zhou, Yawen Hu, Chen Zhang, Huaping Zheng, Xiaoyan Wang, Fanlian Zeng, Jing Hu, Linna Gu, Zhen Wang, Fulei Zhao, Chengcheng Yue, Pei Zhou, Haozhou Zhang, Nongyu Huang, Wenling Wu, Yifan Zhou and Jiong Li

Critical Reviews in Microbiology, 2023, 49, 82
DOI: 10.1080/1040841X.2022.2037506

The microbial revolution: Akkermansia muciniphila's role in overcoming immunotherapy challenges

Yujie Shi, Yu Fu and Dong Tang

International Immunopharmacology, 2025, 164, 115374
DOI: 10.1016/j.intimp.2025.115374

Harnessing Gut Microbiome–Brain–Liver Crosstalk: Novel Therapeutic Strategies for Metabolic Dysfunction‐Associated Steatotic Liver Disease

Xingtao Zhao, Ruolan Li, Jingdong Zhao, Ruiqi Sun, Shuo Zhang, Qiong Pan, Hongyan Lu and Jin Chai

Medicine Bulletin, 2025, 1, 136
DOI: 10.1002/mdb2.70012

An orally administered bacterial membrane protein nanodrug ameliorates doxorubicin cardiotoxicity through alleviating impaired intestinal barrier

Zhen Li, Junyue Xing, Xiaohan Ma, Wanjun Zhang, Chuan Wang, Yingying Wang, Xinkun Qi, Yanhui Liu, Dongdong Jian, Xiaolei Cheng, Yanjie Zhu, Chao Shi, Yongjun Guo, Huan Zhao, Wei Jiang and Hao Tang

Bioactive Materials, 2024, 37, 517
DOI: 10.1016/j.bioactmat.2024.03.027

Akkermansia muciniphila: A Promising Next Generation Probiotic

Muhammad Adeel Hasnain and Gi-Seong Moon

Curr. Top. Lact. Acid Bact. Probiotics, 2025, 11, 1
DOI: 10.35732/ctlabp.2025.11.1.1

New insights into natural products that target the gut microbiota: Effects on the prevention and treatment of colorectal cancer

Lu Lu, Jiahuan Dong, Yujing Liu, Yufan Qian, Guangtao Zhang, Wenjun Zhou, Aiguang Zhao, Guang Ji and Hanchen Xu

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.964793

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas and Suowen Xu

iNew Medicine, 2026
DOI: 10.1002/inm3.70028

Supplementation and Elimination of Microbiome‐Produced Metabolites in the Treatment of Human Disease

Justin Malogan, Haley Anne Hallowell, Brianna Francis and Jotham Suez

Ann NY Acad Sci, 2025, 1553, 50
DOI: 10.1111/nyas.70103

The role of the probiotic Akkermansia muciniphila in brain functions: insights underpinning therapeutic potential

Ruiling Xu, Yuxuan Zhang, Shurui Chen, Yaohui Zeng, Xuan Fu, Ti Chen, Shilin Luo and Xiaojie Zhang

Critical Reviews in Microbiology, 2023, 49, 151
DOI: 10.1080/1040841X.2022.2044286

Research progress on natural products in regulating the gut microbiota in Parkinson’s disease

Ying Jia, Yuanyuan Zhang, Xin Tai, Tengyu Zhao, Hanwen Zhang and Haichun Zhou

Front. Pharmacol., 2025, 16
DOI: 10.3389/fphar.2025.1667694

Possible application of Akkermansia muciniphila in stress management

Agata Misera, Wojciech Marlicz, Albert Podkówka, Igor Łoniewski and Karolina Skonieczna-Żydecka

Microbiome Res Rep, 2024, 3
DOI: 10.20517/mrr.2023.81

Early gut microbiota intervention in premature infants: Application perspectives

Quanhang Xiang, Xudong Yan, Wei Shi, Huiping Li and Kai Zhou

Journal of Advanced Research, 2023, 51, 59
DOI: 10.1016/j.jare.2022.11.004

Lactiplantibacillus plantarum T34 alleviates constipation by enhancing intestinal barrier and modulating gut homeostasis

Fei Shen, Huiting Zhu, Zhongyan Bao, Di Han, Juan Du, Minjie Zhao, Fengqin Feng, Guanghua He and Qiufen Mo

Food Bioscience, 2025, 66, 106195
DOI: 10.1016/j.fbio.2025.106195

The Biology of Akkermansia

Elizabeth R. Hughes, Maria E. Panzetta, Agastya Sharma and Raphael H. Valdivia

Annual Review of Microbiology, 2025, 79, 287
DOI: 10.1146/annurev-micro-051524-032131

The Impact of Akkermansia muciniphila on Mouse Models of Depression, Anxiety, and Stress: A Systematic Review and Meta-Analysis

Leila Khalili, Gwoncheol Park, Ravinder Nagpal, Pradeep Bhide and Gloria Salazar

CN, 2025, 23, 1423
DOI: 10.2174/011570159X360149250225041829

A new horizon of precision medicine: combination of the microbiome and extracellular vesicles

Jinho Yang, Tae-Seop Shin, Jong Seong Kim, Young-Koo Jee and Yoon-Keun Kim

Exp Mol Med, 2022, 54, 466
DOI: 10.1038/s12276-022-00748-6

The effects and significance of gut microbiota and its metabolites on the regulation of osteoarthritis: Close coordination of gut-bone axis

Lei Liu, Feng Tian, Guo-Yuan Li, Wei Xu and Rui Xia

Front. Nutr., 2022, 9
DOI: 10.3389/fnut.2022.1012087

Peripheral serotonin: cultivating companionship with gut microbiota in intestinal homeostasis

Yun Han Kwon and Waliul I. Khan

American Journal of Physiology-Cell Physiology, 2022, 323, C550
DOI: 10.1152/ajpcell.00433.2021

Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine

Izabella Sall, Randi Foxall, Lindsey Felth, Soren Maret, Zachary Rosa, Anirudh Gaur, Jennifer Calawa, Nadia Pavlik, Jennifer L. Whistler and Cheryl A. Whistler

Gut Microbes, 2025, 17
DOI: 10.1080/19490976.2024.2446423

Microbiome-based interventions to modulate gut ecology and the immune system

Thomas C.A. Hitch, Lindsay J. Hall, Sarah Kate Walsh, Gabriel E. Leventhal, Emma Slack, Tomas de Wouters, Jens Walter and Thomas Clavel

Mucosal Immunology, 2022, 15, 1095
DOI: 10.1038/s41385-022-00564-1

Effect of probiotic extracellular vesicles and their applications on health and disease

Guangzhao Wang, Yang Wang, Kangliang Sheng and Yongzhong Wang

J Sci Food Agric, 2025, 105, 3539
DOI: 10.1002/jsfa.14123

Gut bacteria–derived serotonin promotes immune tolerance in early life

Katherine Z. Sanidad, Stephanie L. Rager, Hannah C. Carrow, Aparna Ananthanarayanan, Ryann Callaghan, Lucy R. Hart, Tingting Li, Purnima Ravisankar, Julia A. Brown, Mohammed Amir, Jenny C. Jin, Alexandria Rose Savage, Ryan Luo, Florencia Mardorsky Rowdo, M. Laura Martin, Randi B. Silver, Chun-Jun Guo, Jan Krumsiek, Naohiro Inohara and Melody Y. Zeng

Sci. Immunol., 2024, 9
DOI: 10.1126/sciimmunol.adj4775

Probiotic attributes and safety profile of AKM Lab-01: a novel Akkermansia muciniphila strain combating obesity and metabolic disorders in diet-induced obese mice

Baojia Huang, Yibo Xian, Wenbin Xue, Zilun Pu, Ping Kong, Peifen Li, Yingying Zhao, Lihong Tai, Zhipeng Chen, Zhou Lan, Hong-Wei Liu, Xianzhi Jiang and Amanda Juan Chen

Front. Microbiol., 2026, 16
DOI: 10.3389/fmicb.2025.1627870

Anti-diabetic prospects of dietary bio-actives of millets and the significance of the gut microbiota: A case of finger millet

Vineet Singh, GyuDae Lee, HyunWoo Son, Sliti Amani, Mamta Baunthiyal and Jae-Ho Shin

Front. Nutr., 2022, 9
DOI: 10.3389/fnut.2022.1056445

A newly identified protein from Akkermansia muciniphila stimulates GLP-1 secretion

Patrice D. Cani and Claude Knauf

Cell Metabolism, 2021, 33, 1073
DOI: 10.1016/j.cmet.2021.05.004

Amuc Prevents Liver Inflammation and Oxidative Stress in Mice Challenged with Salmonella Typhimurium

Zhuan Song, Xuemeng Si, Xinyu Zhang, Jingqing Chen, Hai Jia, Yu He, Haozhen Liu, Zongyue Kou, Zhaolai Dai and Zhenlong Wu

The Journal of Nutrition, 2023, 153, 532
DOI: 10.1016/j.tjnut.2022.12.004

Serotonin and the gut microbiome: Pathways, functions, and health implications

Sarah Abubaker, Saba Miri and Riadh Hammami

The Microbe, 2026, 10, 100668
DOI: 10.1016/j.microb.2026.100668

Psychobiotics Lactiplantibacillus plantarum JYLP-326: Antidepressant-like effects on CUMS-induced depressed mouse model and alleviation of gut microbiota dysbiosis

Ruizhe Zhu, Xuanqi Zhao, Heng Wu, Xiangdi Zeng, Jing Wei and Tingtao Chen

Journal of Affective Disorders, 2024, 354, 752
DOI: 10.1016/j.jad.2024.03.136

Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases

Jose Antonio Santos-Marcos, Marina Mora-Ortiz, Manuel Tena-Sempere, Jose Lopez-Miranda and Antonio Camargo

Biol Sex Differ, 2023, 14
DOI: 10.1186/s13293-023-00490-2

Akkermansia muciniphila: A next-generation gut probiotic supporting neurorepair and functional recovery

Huiwen Yuan, Jingwei Shi, Chenlong Gu, Jinlong Yuan, Chenlei Huang, Xiaoning Li, Kailiang Zhou and Jianjun Qi

Neural Regeneration Research, 2026, 21, 3363
DOI: 10.4103/NRR.NRR-D-25-00701

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DOI: 10.3390/pathogens15010062

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Food Science and Human Wellness, 2024, 13, 830
DOI: 10.26599/FSHW.2022.9250071

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Neuropharmacology, 2023, 235, 109565
DOI: 10.1016/j.neuropharm.2023.109565

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Gut Microbes, 2026, 18
DOI: 10.1080/19490976.2025.2611546

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Rongrong Cheng, Wenjuan Xu, Junchao Wang, Zhengquan Tang and Min Zhang

Biochemical and Biophysical Research Communications, 2021, 566, 170
DOI: 10.1016/j.bbrc.2021.06.018

Serotonin signaling to regulate energy metabolism: a gut microbiota perspective

Guoli Li, Sijing Dong, Chunhao Liu, Jing Yang, Patrick C N Rensen and Yanan Wang

Life Metabolism, 2025, 4
DOI: 10.1093/lifemeta/loae039

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Ramon O. Souza, Vivian C. Miranda, Mônica F. Quintanilha, Bruno Gallotti, Samantha R. M. Oliveira, Janayne L. Silva, Jacqueline I. Alvarez-Leite, Luís C. L. Jesus, Vasco Azevedo, Kátia D. Vital, Simone O. A. Fernandes, Valbert N. Cardoso, Enio Ferreira, Jacques R. Nicoli and Flaviano S. Martins

Probiotics & Antimicro. Prot., 2024, 16, 275
DOI: 10.1007/s12602-023-10040-2

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Kairu He, Feiyu An, Henan Zhang, Danli Yan, Tong Li, Junrui Wu and Rina Wu

Foods, 2024, 14, 23
DOI: 10.3390/foods14010023

Akkermansia muciniphila: A potential target and pending issues for oncotherapy

Xu Zhao, Juanjuan Zhao, Dongmei Li, Han Yang, Chao Chen, Ming Qin, Zhenke Wen, Zhixu He and Lin Xu

Pharmacological Research, 2023, 196, 106916
DOI: 10.1016/j.phrs.2023.106916

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Aquaculture, 2026, 612, 743232
DOI: 10.1016/j.aquaculture.2025.743232

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Sharon Y. Geerlings, Kees van der Ark, Bart Nijsse, Sjef Boeren, Mark van Loosdrecht, Clara Belzer and Willem M. de Vos

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DOI: 10.20517/mrr.2024.06

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Biomolecules, 2024, 14, 1643
DOI: 10.3390/biom14121643

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Nat Microbiol, 2026, 11, 20
DOI: 10.1038/s41564-025-02222-1

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Critical Reviews in Food Science and Nutrition, 2023, 63, 9961
DOI: 10.1080/10408398.2022.2076651

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Journal of Functional Foods, 2026, 141, 107287
DOI: 10.1016/j.jff.2026.107287

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IJMS, 2022, 23, 15632
DOI: 10.3390/ijms232415632

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Microorganisms, 2023, 11, 2306
DOI: 10.3390/microorganisms11092306

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Acta Pharmacol Sin, 2024, 45, 570
DOI: 10.1038/s41401-023-01186-4

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Life Metabolism, 2023, 2
DOI: 10.1093/lifemeta/load032

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Maryam Soheilipour, Ali Noursina, Mohadese Nekookhoo, Elena Malekpour, Seyed Arsham Mirzaei, Mohammad Hossein Shafieyoun, Hanieh Rouzbahani, Mohammad Reza Chitsazi and Farzad Safari

BMC Gastroenterol, 2025, 25
DOI: 10.1186/s12876-025-04293-0

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Microbiological Research, 2026, 305, 128436
DOI: 10.1016/j.micres.2025.128436

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Molecular Nutrition Food Res, 2024, 68
DOI: 10.1002/mnfr.202300510

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Chemical Engineering Journal, 2024, 500, 157484
DOI: 10.1016/j.cej.2024.157484