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Rocking- and diffusion-based culture of tumor spheroids-on-a-chip

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The vascular niche in next generation microphysiological systems

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Gravity-perfused airway-on-a-chip optimized for quantitative BSL-3 studies of SARS-CoV-2 infection: barrier permeability, cytokine production, immunohistochemistry, and viral load assays

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Reconstitution of human tissue barrier function for precision and personalized medicine

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Pumpless microfluidic devices for generating healthy and diseased endothelia

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Cancer-on-a-chip for precision cancer medicine

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Lab Chip, 2025, 25, 3314
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Rocker or pump? Transcriptomic response of endothelial cells exposed to peristaltic pump-based unidirectional flow vs. rocker-induced bidirectional flow

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Investigating the mechanotransduction of transient shear stress mediated by Piezo1 ion channel using a 3D printed dynamic gravity pump

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Lab Chip, 2022, 22, 262
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Microscale impeller pump for recirculating flow in organs-on-chip and microreactors

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Microfluidic artery-on-a-chip model with unidirectional gravity-driven flow for high-throughput applications

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Size-selective filtration of extracellular vesicles with a movable-layer device

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Lab Chip, 2022, 22, 3699
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Kinetic analysis of sequential metabolism of triazolam and its extrapolation to humans using an entero-hepatic two-organ microphysiological system

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Organ-on-a-chip: A new tool for in vitro research

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IFlowPlate—A Customized 384‐Well Plate for the Culture of Perfusable Vascularized Colon Organoids

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Innovative micro physiological systems for vaccine development

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Pump‐Less Platform Enables Long‐Term Recirculating Perfusion of 3D Printed Tubular Tissues

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Adv Healthcare Materials, 2023, 12
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A Tissue Engineering Approach to Metastatic Colon Cancer

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Recent Advances in Body-on-a-Chip Systems

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Engineering complexity in human tissue models of cancer

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Pressure-Driven Perfusion System to Control, Multiplex and Recirculate Cell Culture Medium for Organs-on-Chips

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Micromachines, 2022, 13, 1359
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Self-loading microfluidic platform with ultra-thin nanoporous membrane for organ-on-chip by wafer-level processing

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Tissue engineering of the biliary tract and modelling of cholestatic disorders

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Engineering tissue‐specific blood vessels

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Studying metabolism with multi-organ chips: new tools for disease modelling, pharmacokinetics and pharmacodynamics

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Integrating spheroid‐on‐a‐chip with tubeless rocker platform: A high‐throughput biological screening platform

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Biotechnology Journal, 2023, 18
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A Highly Programmable Magnetic Micropump

Xing Yue (Larry) Peng, Linghan Peng and Yaxin Guo

Adv Materials Technologies, 2021, 6
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A Kinetic Pump Integrated Microfluidic Plate (KIM-Plate) with High Usability for Cell Culture-Based Multiorgan Microphysiological Systems

Kenta Shinha, Wataru Nihei, Hiroko Nakamura, Tomomi Goto, Takumi Kawanishi, Naoki Ishida, Nao Yamazaki, Yuki Imakura, Shinji Mima, Kosuke Inamura, Hiroshi Arakawa, Masaki Nishikawa, Yukio Kato, Yasuyuki Sakai and Hiroshi Kimura

Micromachines, 2021, 12, 1007
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Integration of immune cells in organs-on-chips: a tutorial

Lisette Van Os, Britta Engelhardt and Olivier T. Guenat

Front. Bioeng. Biotechnol., 2023, 11
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From Model System to Therapy: Scalable Production of Perfusable Vascularized Liver Spheroids in “Open-Top“ 384-Well Plate

Dawn S. Y. Lin, Shravanthi Rajasekar, Mandeep Kaur Marway and Boyang Zhang

ACS Biomater. Sci. Eng., 2021, 7, 2964
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A guide to the organ-on-a-chip

Chak Ming Leung, Pim de Haan, Kacey Ronaldson-Bouchard, Ge-Ah Kim, Jihoon Ko, Hoon Suk Rho, Zhu Chen, Pamela Habibovic, Noo Li Jeon, Shuichi Takayama, Michael L. Shuler, Gordana Vunjak-Novakovic, Olivier Frey, Elisabeth Verpoorte and Yi-Chin Toh

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Organ-on-a-chip models for elucidating the cellular biology of infectious diseases

Fuki Yokoi, Sayaka Deguchi and Kazuo Takayama

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023, 1870, 119504
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Compelling standardized and high-throughput micro-/millifluidic plates for biomedical research: from laboratory to market

Longjun Gu, Peidi Liu, Wen Zhao, Yuhang Fan, Yuwen Wang and Pu Chen

MedMat, 2025, 2, 101
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Stem cell-derived vessels-on-chip for cardiovascular disease modeling

Maren Marder, Caroline Remmert, Julius A. Perschel, Munkhtur Otgonbayar, Christine von Toerne, Stefanie Hauck, Judith Bushe, Annette Feuchtinger, Bilal Sheikh, Michel Moussus and Matthias Meier

Cell Reports, 2024, 43, 114008
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Development of Tumor-Vasculature Interaction on Chip Mimicking Vessel Co-Option of Glioblastoma

Jinseung Bae, Min-Hyeok Kim, Seokgyu Han and Sungsu Park

BioChip J, 2023, 17, 77
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The Future Application of Organ-on-a-Chip Technologies as Proving Grounds for MicroBioRobots

Haley Fuller, Ting-Yen Wei, Michael Behrens and Warren Ruder

Micromachines, 2020, 11, 947
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A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature

Benjamin Fook Lun Lai, Rick Xing Ze Lu, Locke Davenport Huyer, Sachiro Kakinoki, Joshua Yazbeck, Erika Yan Wang, Qinghua Wu, Boyang Zhang and Milica Radisic

Nat Protoc, 2021, 16, 2158
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Engineering Organ-on-a-Chip to Accelerate Translational Research

Jihoon Ko, Dohyun Park, Somin Lee, Burcu Gumuscu and Noo Jeon

Micromachines, 2022, 13, 1200
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Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations

Yi Zhao, Ranjith Kumar Kankala, Shi-Bin Wang and Ai-Zheng Chen

Molecules, 2019, 24, 675
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Microfluidic Isolation and Enrichment of Nanoparticles

Yuliang Xie, Joseph Rufo, Ruoyu Zhong, Joseph Rich, Peng Li, Kam W. Leong and Tony Jun Huang

ACS Nano, 2020, 14, 16220
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A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke

Zhonglin Lyu, Jon Park, Kwang-Min Kim, Hye-Jin Jin, Haodi Wu, Jayakumar Rajadas, Deok-Ho Kim, Gary K. Steinberg and Wonjae Lee

Nat Biomed Eng, 2021, 5, 847
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A pump-free dual unidirectional circulation microfluidic device for tumor spheroid microenvironment modulation and motility analysis

Xiaoqing Chen, Yuanyuan Xie, Wen Sun, Ke Ning, Yirong Chen, Lingke Feng, Can Fang, Yan Li and Ling Yu

Microchemical Journal, 2025, 215, 114317
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Skin-on-a-chip technologies towards clinical translation and commercialization

Nilufar Ismayilzada, Ceren Tarar, Sajjad Rahmani Dabbagh, Begüm Kübra Tokyay, Sara Asghari Dilmani, Emel Sokullu, Hasan Erbil Abaci and Savas Tasoglu

Biofabrication, 2024, 16, 042001
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Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models

João Rodrigues, Bruno Sarmento and Catarina Leite Pereira

In vitro models, 2022, 1, 5
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Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

Scott B. Campbell, Qinghua Wu, Joshua Yazbeck, Chuan Liu, Sargol Okhovatian and Milica Radisic

ACS Biomater. Sci. Eng., 2021, 7, 2880
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Capturing physiological hemodynamic flow and mechanosensitive cell signaling in vessel-on-a-chip platforms

A. Martier, Z. Chen, H. Schaps, M. J. Mondrinos and J. S. Fang

Front. Physiol., 2024, 15
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Recent Advances in Microfluidic-Based Microphysiological Systems

Sung-Min Kang

BioChip J, 2022, 16, 13
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Passive-Flow-Based MPS: Emerging Physiological Flow-Mimetic Platforms for Studying Effects of Flow on Single Tissues and Inter-tissue Interactions

Geonho Jin, Dohyung Kim, Seonghun Mun and Seokyoung Bang

BioChip J, 2024, 18, 186
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Skin-on-a-Chip Technology: Microengineering Physiologically Relevant In Vitro Skin Models

Patrícia Zoio and Abel Oliva

Pharmaceutics, 2022, 14, 682
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Heterogenous morphogenesis of Caco‐2 cells reveals that flow induces three‐dimensional growth and maturation at high initial seeding cell densities

Asli Aybike Dogan and Martin Dufva

Biotech & Bioengineering, 2023, 120, 1667
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Gravity-driven microfluidic device placed on a slow-tilting table enables constant unidirectional perfusion culture of human induced pluripotent stem cells

Nuttakrit Limjanthong, Yoshikatsu Tohbaru, Taiga Okamoto, Riho Okajima, Yuta Kusama, Hiromu Kojima, Akira Fujimura, Toshimasa Miyazaki, Toshiyuki Kanamori, Shinji Sugiura and Kiyoshi Ohnuma

Journal of Bioscience and Bioengineering, 2023, 135, 151
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A pump-free microfluidic co-culture system for investigating NK cell-tumor spheroid interactions in flow conditions

Yuanyuan Xie, Ke Ning, Wen Sun, Lingke Feng, Yirong Chen, Wei Sun, Yan Li and Ling Yu

Journal of Biotechnology, 2025, 397, 11
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A novel valve-less piezoelectric micropump generating recirculating flow

Xiaosheng Chen, Zhenlin Chen, Zhenzhen Gui, Fan Zhang, Weirong Zhang, Xiaosi Zhou, Xi Huang and Jianhui Zhang

Engineering Applications of Computational Fluid Mechanics, 2021, 15, 1473
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Perfusion culture of endothelial cells under shear stress on microporous membrane in a pressure-driven microphysiological system

Shinji Sugiura, Kazumi Shin and Toshiyuki Kanamori

Journal of Bioscience and Bioengineering, 2023, 135, 79
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Design Artificial Stem Cell Nests for Stem Cell Niche in a Microfluidic Petri Dish Programmed by a Cell Phone

Xing Yue (Larry) Peng, Yaxin Guo, Linghan Peng and Juan Liu

Adv Materials Technologies, 2021, 6
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Engineering in vitro vascular microsystems

Qiao Liu, Guoliang Ying, Chenyan Hu, Lingyu Du, Huaiyi Zhang, Zhenye Wang, Hongyan Yue, Ali K. Yetisen, Guixue Wang, Yang Shen and Nan Jiang

Microsyst Nanoeng, 2025, 11
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Mimicking the Human Physiology with Microphysiological Systems (MPS)

Jong Hwan Sung, Jamin Koo and Michael L. Shuler

BioChip J, 2019, 13, 115
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Revolutionizing Biomedical Research: Unveiling the Power of Microphysiological Systems with Advanced Assays, Integrated Sensor Technologies, and Real-Time Monitoring

Anupama Samantasinghar, Naina Sunildutt, Faheem Ahmed, Fida Hussain Memon, Chulung Kang and Kyung Hyun Choi

ACS Omega, 2025, 10, 9869
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Sequentially suspended 3D bioprinting of multiple-layered vascular models with tunable geometries for in vitro modeling of arterial disorders initiation

Chen Pan, Jingwen Xu, Qiqi Gao, Wei Li, Tao Sun, Jiping Lu, Qing Shi, Yafeng Han, Ge Gao and Jinhua Li

Biofabrication, 2023, 15, 045017
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A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis

Mario Rothbauer, Eva I. Reihs, Anita Fischer, Reinhard Windhager, Florien Jenner and Stefan Toegel

Front. Bioeng. Biotechnol., 2022, 10
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Strategies for using mathematical modeling approaches to design and interpret multi-organ microphysiological systems (MPS)

Jong Hwan Sung, Ying Wang and Michael L. Shuler

APL Bioengineering, 2019, 3
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Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier

Nina Truong, Abir Zahra, Ryan C. V. Lintao, Rahul Chauhan, Giovana Fernanda Bento, Manuel Vidal Jr., Sungjin Kim, Po Yi Lam, Thomas Conrads, Kelly Conrads, Arum Han, Ramkumar Menon and Lauren S. Richardson

Front. Bioeng. Biotechnol., 2025, 13
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Critical design parameters to develop biomimetic organ-on-a-chip models for the evaluation of the safety and efficacy of nanoparticles

Mahmoud Abdelkarim, Luis Perez-Davalos, Yasmin Abdelkader, Amr Abostait and Hagar I. Labouta

Expert Opinion on Drug Delivery, 2023, 20, 13
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Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)

Mridu Malik, Yang Yang, Parinaz Fathi, Gretchen J. Mahler and Mandy B. Esch

Front. Cell Dev. Biol., 2021, 9
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A human-on-a-chip approach to tackling rare diseases

Camilly P. Pires de Mello, John Rumsey, Victoria Slaughter and James J. Hickman

Drug Discovery Today, 2019, 24, 2139
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Organ-on-a-Chip Applications in Microfluidic Platforms

Ling An, Yi Liu and Yaling Liu

Micromachines, 2025, 16, 201
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Gravity-driven preprogrammed microfluidic recirculation system for parallel biosensing of cell behaviors

Korakot Boonyaphon, Zhenglin Li and Sung-Jin Kim

Analytica Chimica Acta, 2022, 1233, 340456
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Development of a Microphysiological System to Model Human Cancer Metastasis From the Colon to the Liver

Paula G. Miller, Emina Huang, Robert Fisher and Michael L. Shuler

Biotech & Bioengineering, 2025, 122, 481
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Integrated Microphysiological Systems: Transferable Organ Models and Recirculating Flow

Kasper Renggli, Nassim Rousset, Christian Lohasz, Oanh T. P. Nguyen and Andreas Hierlemann

Adv. Biosys., 2019, 3
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Flow‐IMPACT: A Pumpless, High‐Throughput 3D Cell Culture Platform for Investigation of Synergistic Angiogenic Effects

Seonghyuk Park, Youngtaek Kim, Jungseub Lee, Sangmin Jung, Jongho Hong, Suryong Kim, Seung‐Ryeol Lee, Jiyoung Song, Siwan Park, Young Sun Oh, Jihoon Ko and Noo Li Jeon

Adv Materials Technologies, 2025, 10
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Vascular microphysiological systems

Sarah E. Shelton

Current Opinion in Hematology, 2024, 31, 155
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Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip

H.H.T. Middelkamp, H.J. Weener, T. Gensheimer, K. Vermeul, L.E. de Heus, H.J. Albers, A. van den Berg and A.D. van der Meer

Biomed Microdevices, 2024, 26
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A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis

Soojung Kim, Hyerin Song, Heesang Ahn, Taeyeon Kim, Jihyun Jung, Soo Kyung Cho, Dong-Myeong Shin, Jong-ryul Choi, Yoon-Hwae Hwang and Kyujung Kim

Biosensors, 2021, 11, 412
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Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance

Jungeun Lim, Hanna Ching, Jeong-Kee Yoon, Noo Li Jeon and YongTae Kim

Nano Convergence, 2021, 8
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Pumped and pumpless microphysiological systems to study (nano)therapeutics

Eun‐Jin Lee, Zachary L. Krassin, Hasan Erbil Abaci, Gretchen J. Mahler and Mandy B. Esch

WIREs Nanomed Nanobiotechnol, 2023, 15
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An on-chip capacitive liquid–air sensor for minimizing sample loss and automating microfluidic flow control

Yeram Eom and Ki-Ho Han

Sensors and Actuators B: Chemical, 2025, 443, 138280
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A User-Centric 3D-Printed Modular Peristaltic Pump for Microfluidic Perfusion Applications

Jorge A. Cataño, Steven Farthing, Zeus Mascarenhas, Nathaniel Lake, Prasad K. D. V. Yarlagadda, Zhiyong Li and Yi-Chin Toh

Micromachines, 2023, 14, 930
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A quantitative meta-analysis comparing cell models in perfused organ on a chip with static cell cultures

Martin Dufva

Sci Rep, 2023, 13
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Open-source tubing-free impeller pump platform for controlled recirculating fluid flow for microfluidics and organs-on-chip

Sophie R. Cook, Erin E. Lawrence, Parastoo Sakinejad and Rebecca R. Pompano

HardwareX, 2025, 23, e00673
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Immune cell extravasation in an organ-on-chip to model lung inflammation

Lisette van Os, Jeremy Yeoh, Guillaume Witz, Dario Ferrari, Philippe Krebs, Yashoda Chandorkar, Soheila Zeinali, Arunima Sengupta and Olivier T. Guenat

European Journal of Pharmaceutical Sciences, 2023, 187, 106485
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Pumpless, unidirectional microphysiological system for testing metabolism‐dependent chemotherapeutic toxicity

Danielle J. LaValley, Paula G. Miller and Michael L. Shuler

Biotechnology Progress, 2021, 37
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Microfluidic models of the human circulatory system: versatile platforms for exploring mechanobiology and disease modeling

Ngan Nguyen, Peter Thurgood, Nadia Chandra Sekar, Sheng Chen, Elena Pirogova, Karlheinz Peter, Sara Baratchi and Khashayar Khoshmanesh

Biophys Rev, 2021, 13, 769
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The Fluidic Shear Stress Loading Method Enables Mechanobiological Stimulation in an On-Chip Pump-Integrated Microphysiological System

Jin Hong Yap, Satoshi Ishizaki, Hiroko Nakamura, Kenta Shinha and Hiroshi Kimura

Micromachines, 2025, 16, 1051
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Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling

Hoang-Tuan Nguyen, Siiri-Liisa Rissanen, Mimosa Peltokangas, Tino Laakkonen, Jere Kettunen, Lara Barthod, Ragul Sivakumar, Anniina Palojärvi, Pauliina Junttila, Jussi Talvitie, Michele Bassis, Sarah L. Nickels, Sara Kalvala, Polina Ilina, Päivi Tammela, Sarka Lehtonen, Jens C. Schwamborn, Sebastien Mosser and Prateek Singh

Tissue Barriers, 2024, 12
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