Advancing microfluidic diagnostic chips into clinical use: a review of current challenges and opportunities

Vasant Iyer, Zijian Yang, Jina Ko, Ralph Weissleder and David Issadore

Lab Chip, 2022, 22, 3110
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Antifouling hydrogel-coated magnetic nanoparticles for selective isolation and recovery of circulating tumor cells

Zhili Wang, Zeen Wu, Na Sun, Yi Cao, Xue Cai, Feng Yuan, Hanqing Zou, Chungen Xing and Renjun Pei

J. Mater. Chem. B, 2021, 9, 677
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Rapid isolation of circulating cancer associated fibroblasts by acoustic microstreaming for assessing metastatic propensity of breast cancer patients

Ruoyu Jiang, Sudhanshu Agrawal, Mohammad Aghaamoo, Ritesh Parajuli, Anshu Agrawal and Abraham P. Lee

Lab Chip, 2021, 21, 875
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A high-throughput liquid biopsy for rapid rare cell separation from large-volume samples

Yaoping Liu, Tingyu Li, Mingxin Xu, Wei Zhang, Yan Xiong, Ligong Nie, Qi Wang, Haichao Li and Wei Wang

Lab Chip, 2019, 19, 68
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Rapid liquid biopsy for Mohs surgery: rare target cell separation from surgical margin lavage fluid with a high recovery rate and selectivity

Wenbo Zhou, Yaoping Liu, Menglong Ran, Xiaofan Zhao, Hang Li, Haichao Li and Wei Wang

Lab Chip, 2019, 19, 974
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miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer

Jina Ko, Neha Bhagwat, Taylor Black, Stephanie S. Yee, Young-Ji Na, Stephen Fisher, Junhyong Kim, Erica L. Carpenter, Ben Z. Stanger and David Issadore

Cancer Research, 2018, 78, 3688
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Automatic detecting and counting magnetic beads‐labeled target cells from a suspension in a microfluidic chip

Zhenyu Song, Mengqi Li, Bao Li, Yimo Yan and Yongxin Song

Electrophoresis, 2019, 40, 897
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Recent Progress in Fast Sample Preparation Techniques

Ling Xia, Jiani Yang, Rihui Su, Wanjun Zhou, Yanshu Zhang, Yanhui Zhong, Simin Huang, Yanlong Chen and Gongke Li

Anal. Chem., 2020, 92, 34
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High-throughput and simultaneous inertial separation of tumor cells and clusters from malignant effusions using spiral-contraction-expansion channels

Zhixian Zhu, Hui Ren, Dan Wu, Zhonghua Ni and Nan Xiang

Microsyst Nanoeng, 2024, 10
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Future of Digital Assays to Resolve Clinical Heterogeneity of Single Extracellular Vesicles

Renee-Tyler T. Morales and Jina Ko

ACS Nano, 2022, 16, 11619
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Circulating Tumor Cells: How Far Have We Come with Mining These Seeds of Metastasis?

Vijay Radhakrishnan, Jussuf T. Kaifi and Kanve N. Suvilesh

Cancers, 2024, 16, 816
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Flow Homogenization Enables a Massively Parallel Fluidic Design for High‐Throughput and Multiplexed Cell Isolation

Chinchun Ooi, Christopher M. Earhart, Casey E. Hughes, Jung‐Rok Lee, Dawson J. Wong, Robert J. Wilson, Rajat Rohatgi and Shan X. Wang

Adv Materials Technologies, 2020, 5
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Multi-organ-on-chip approach in cancer research

Agnieszka Zuchowska and Sandra Skorupska

Organs-on-a-Chip, 2022, 4, 100014
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Chemical Monitoring in Clinical Settings: Recent Developments toward Real-Time Chemical Monitoring of Patients

Marsilea A. Booth, Sally A. N. Gowers, Chi Leng Leong, Michelle L. Rogers, Isabelle C. Samper, Aidan P. Wickham and Martyn G. Boutelle

Anal. Chem., 2018, 90, 2
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Stray Magnetic Field Variations and Micromagnetic Simulations: Models for Ni0.8Fe0.2 Disks Used for Microparticle Trapping

Gregory B. Vieira, Eliza Howard, Prannoy Lankapalli, Iesha Phillips, Keith Hoffmeister and Jackson Holley

Micromachines, 2024, 15, 567
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An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters

Neha Bhagwat, Keely Dulmage, Charles H. Pletcher, Ling Wang, William DeMuth, Moen Sen, David Balli, Stephanie S. Yee, Silin Sa, Frances Tong, Liping Yu, Jonni S. Moore, Ben Z. Stanger, Eric P. Dixon and Erica L. Carpenter

Sci Rep, 2018, 8
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Sorting Technology for Circulating Tumor Cells Based on Microfluidics

Dayu Hu, He Liu, Ye Tian, Zhi Li and Xiaoyu Cui

ACS Comb. Sci., 2020, 22, 701
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Biosensors for the Isolation and Detection of Circulating Tumor Cells (CTCs) in Point-of-Care Settings

Isaac Goldstein, Sobia Alyas, Waseem Asghar and Azhar Ilyas

Micromachines, 2023, 14, 1035
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High-throughput enrichment of portal venous circulating tumor cells for highly sensitive diagnosis of CA19-9-negative pancreatic cancer patients using inertial microfluidics

Zhixian Zhu, Yixuan Zhang, Wenjun Zhang, Dezhi Tang, Song Zhang, Lei Wang, Xiaoping Zou, Zhonghua Ni, Shu Zhang, Ying Lv and Nan Xiang

Biosensors and Bioelectronics, 2024, 259, 116411
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Research Progress for the Clinical Application of Circulating Tumor Cells in Prostate Cancer Diagnosis and Treatment

Mei Yang, Xiaotian Zhang, Lixia Guo, Xiumin Liu, Jing Wu, Hongquan Zhu and Eugenio Zoni

BioMed Research International, 2021, 2021
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Combining Machine Learning and Nanofluidic Technology To Diagnose Pancreatic Cancer Using Exosomes

Jina Ko, Neha Bhagwat, Stephanie S. Yee, Natalia Ortiz, Amine Sahmoud, Taylor Black, Nicole M. Aiello, Lydie McKenzie, Mark O’Hara, Colleen Redlinger, Janae Romeo, Erica L. Carpenter, Ben Z. Stanger and David Issadore

ACS Nano, 2017, 11, 11182
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Pancreatic Cancer Biomarkers: Oncogenic Mutations, Tissue and Liquid Biopsies, and Radiomics—A Review

Maria João Amaral, Rui Caetano Oliveira, Paulo Donato and José Guilherme Tralhão

Dig Dis Sci, 2023, 68, 2811
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Engineering microfluidic chip for circulating tumor cells: From enrichment, release to single cell analysis

Xu Yu, Na Wu, Feng Chen, Jing Wei and Yongxi Zhao

TrAC Trends in Analytical Chemistry, 2019, 117, 27
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Metal-mediated Fe3O4@polydopamine-aptamer capture nanoprobe coupling multifunctional MXene@Au@Pt nanozyme for direct and portable photothermal analysis of circulating breast cancer cells

Limin Yang, Heng Guo, Ting Hou, Jingang Zhang and Feng Li

Biosensors and Bioelectronics, 2023, 234, 115346
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A simple microdevice for single cell capture, array, release, and fast staining using oscillatory method

Dantong Cheng, Yang Yu, Chao Han, Mengjia Cao, Guang Yang, Jingquan Liu, Xiang Chen and Zhihai Peng

Biomicrofluidics, 2018, 12
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Multi-Dimensional Mapping of Brain-Derived Extracellular Vesicle MicroRNA Biomarker for Traumatic Brain Injury Diagnostics

Jina Ko, Matthew Hemphill, Zijian Yang, Kryshawna Beard, Emily Sewell, Jamie Shallcross, Melissa Schweizer, Danielle K. Sandsmark, Ramon Diaz-Arrastia, Junhyong Kim, David Meaney and David Issadore

Journal of Neurotrauma, 2020, 37, 2424
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Innovative Applications of Nanopore Technology in Tumor Screening: An Exosome-Centric Approach

Heng Chi, Liuxin Shi, Songlin Gan, Guangyi Fan and Yuliang Dong

Biosensors, 2025, 15, 199
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The functions of circulating tumor cells in early diagnosis and surveillance during cancer advancement

Yuqiao Wang, Ying Zhou and Zhiyuan Hu

Journal of Translational Internal Medicine, 2017, 5, 135
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Microfluidic analysis of circulating tumor cells and tumor-derived extracellular vesicles

Fei Tian, Chao Liu, Ling Lin, Qinghua Chen and Jiashu Sun

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Reviews on Current Liquid Biopsy for Detection and Management of Pancreatic Cancers

Karolina Elżbieta Kaczor-Urbanowicz, Jordan Cheng, Jonathan C. King, Alireza Sedarat, Stephen J. Pandol, James J. Farrell, David T.W. Wong and Yong Kim

Pancreas, 2020, 49, 1141
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Highly stable integration of graphene Hall sensors on a microfluidic platform for magnetic sensing in whole blood

Nishal Shah, Vasant Iyer, Zhiping Zhang, Zhaoli Gao, Juhwan Park, Venkata Yelleswarapu, Firooz Aflatouni, A. T. Charlie Johnson and David Issadore

Microsyst Nanoeng, 2023, 9
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Microsystems for Single‐Cell Analysis

Sonja M. Weiz, Mariana Medina‐Sánchez and Oliver G. Schmidt

Adv. Biosys., 2018, 2
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Isolation of circulating tumor cells

Jon F. Edd, Avanish Mishra, Kyle C. Smith, Ravi Kapur, Shyamala Maheswaran, Daniel A. Haber and Mehmet Toner

iScience, 2022, 25, 104696
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Microfluidic methods for cell separation and subsequent analysis

Tianyou Chen, Chunxia Huang, Yanran Wang and Jing Wu

Chinese Chemical Letters, 2022, 33, 1180
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Multifunctional exosome-driven pancreatic cancer diagnostics and therapeutics

Sitong Zhang, Danyang Li, Yingjia Liu, Chunlian Qin, Lingjun Tong and Lizhou Xu

Extracellular Vesicle, 2023, 2, 100022
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Microfluidics-based approaches for separation and analysis of circulating tumor cells

Jiaxiang Yin, Jinqi Deng, Chang Du, Wei Zhang and Xingyu Jiang

TrAC Trends in Analytical Chemistry, 2019, 117, 84
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Antifouling Gold-Inlaid BSA Coating for the Highly Efficient Capture of Circulating Tumor Cells

Shuming Li, Ke Wang, Shasha Hao, Fuquan Dang, Zhi-Qi Zhang and Jing Zhang

Anal. Chem., 2022, 94, 6754
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Magnetic nanotechnology for circulating tumor biomarkers screening: Rational design, microfluidics integration and applications

Nanjing Hao and John X. J. Zhang

Biomicrofluidics, 2019, 13
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