Themed collection Journal of Materials Chemistry B Emerging Investigators 2024

46 items
Profile

Contributors to the Journal of Materials Chemistry B Emerging Investigators 2024 collection

The Journal of Materials Chemistry B Emerging Investigators collection gathers some of the best research being conducted by materials scientists in the early stages of their independent career. Congratulations to all of the researchers featured.

Graphical abstract: Contributors to the Journal of Materials Chemistry B Emerging Investigators 2024 collection
Open Access Perspective

In vivo photopharmacological inhibition of hippocampal activity via multimodal probes – perspective and opening steps on experimental and computational challenges

A new perspective for the study/treatment of neurological conditions using in vivo photopharmacology is presented, including initial experimental and computational data.

Graphical abstract: In vivo photopharmacological inhibition of hippocampal activity via multimodal probes – perspective and opening steps on experimental and computational challenges
Review Article

Advancements in DNA computing: exploring DNA logic systems and their biomedical applications

DNA computing is a key molecular method in biological analysis. This review highlights advancements in DNA logic systems, material innovations, and applications in imaging, diagnosis, and treatment, addressing challenges and future directions.

Graphical abstract: Advancements in DNA computing: exploring DNA logic systems and their biomedical applications
Review Article

Nanomaterial combined engineered bacteria for intelligent tumor immunotherapy

Compared to traditional therapies, tumor immunotherapy has received a lot of attention and research focus due to its potential to activate both innate and adaptive immunity, cause low toxicity to normal tissue, and induce long-term immune activity.

Graphical abstract: Nanomaterial combined engineered bacteria for intelligent tumor immunotherapy
Review Article

Immunologically effective biomaterials enhance immunotherapy of prostate cancer

Prostate cancer (PCa) is one of the most common malignant neoplasms affecting the male population.

Graphical abstract: Immunologically effective biomaterials enhance immunotherapy of prostate cancer
Review Article

A novel method for the diagnosis of atherosclerosis based on nanotechnology

The integration of nanotechnology and medicine is a significant trend in modern healthcare, with a particular focus on its utilization in atherosclerosis imaging, presenting immense potential for advancement.

Graphical abstract: A novel method for the diagnosis of atherosclerosis based on nanotechnology
Open Access Review Article

Methods to achieve tissue-mimetic physicochemical properties in hydrogels for regenerative medicine and tissue engineering

Hydrogels are limited by their inability to recapitulate native extracellular physicochemical properties. Current efforts using advanced materials science and engineering methods seek to form hydrogels with physiologically-relevant properties.

Graphical abstract: Methods to achieve tissue-mimetic physicochemical properties in hydrogels for regenerative medicine and tissue engineering
Open Access Review Article

Wearable and implantable biosensors: mechanisms and applications in closed-loop therapeutic systems

Biosensors integrated into closed-loop systems provide patient-specific adaptive therapies. These advanced devices have significant potential for managing chronic conditions by continuously adjusting therapeutic regimens based on physiological data.

Graphical abstract: Wearable and implantable biosensors: mechanisms and applications in closed-loop therapeutic systems
Review Article

Hydrogels: a promising therapeutic platform for inflammatory skin diseases treatment

Hydrogels revolutionize treating chronic skin diseases by enhancing drug delivery and reducing side effects. This review explores hydrogel design, drug integration, and clinical trials, highlighting their potential to improve efficacy and safety.

Graphical abstract: Hydrogels: a promising therapeutic platform for inflammatory skin diseases treatment
Review Article

Building in vitro models for mechanistic understanding of liver regeneration in chronic liver diseases

The figure shows how impaired regeneration fuels CLD progression. It depicts how 3D bioprinted models can overcome the limitations of animal models and clinical/histopathological data, and provide mechanistic insights into liver regeneration.

Graphical abstract: Building in vitro models for mechanistic understanding of liver regeneration in chronic liver diseases
Review Article

Magneto-responsive biocomposites in wound healing: from characteristics to functions

Schematic illustrations of the pathways through which magneto-responsive biocomposites promote wound healing.

Graphical abstract: Magneto-responsive biocomposites in wound healing: from characteristics to functions
Review Article

A nanoparticle-assisted signal-enhancement technique for lateral flow immunoassays

This review probes the nanoparticle-assisted amplification strategies for lateral flow immunoassay.

Graphical abstract: A nanoparticle-assisted signal-enhancement technique for lateral flow immunoassays
Review Article

Recent advances in stimuli-responsive controlled release systems for neuromodulation

Stimuli-responsive controlled release systems are emerging as powerful tools for precise neuromodulation. This review summarizes the recent progress in different release mechanisms and provides insights into future research direction.

Graphical abstract: Recent advances in stimuli-responsive controlled release systems for neuromodulation
Review Article

Biological applications of lipoic acid-based polymers: an old material with new promise

This review highlights the ring-opening polymerization strategies of LA molecules and recent biomedical applications of PLA while discussing the challenges they face and future perspectives.

Graphical abstract: Biological applications of lipoic acid-based polymers: an old material with new promise
Review Article

Vaccine adjuvants: current status, research and development, licensing, and future opportunities

A comprehensive review of the current landscape and advancements in vaccine adjuvants, providing critical insights into research, development, regulatory licensing, and potential future opportunities for enhancing vaccine efficacy and safety.

Graphical abstract: Vaccine adjuvants: current status, research and development, licensing, and future opportunities
Communication

Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles

Ionizable lipids with branched tails enhance the selective mRNA delivery to spleen, particularly to antigen-presenting cells.

Graphical abstract: Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles
From the themed collection: Journal of Materials Chemistry B HOT Papers
Open Access Communication

Heparin binding induced supramolecular chirality into the self-assembly of perylenediimide bolaamphiphile

Heparin, an anionic chiral biomolecule, binds to cationic achiral perylenediimide derivative to induce supramolecular helicity, forming chiral nanostructures in both aqueous and cell culture medium.

Graphical abstract: Heparin binding induced supramolecular chirality into the self-assembly of perylenediimide bolaamphiphile
Open Access Communication

Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment

A novel drug delivery system hitchhiking albumin as a drug carrier with tuneable redox-responsive drug release.

Graphical abstract: Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment
From the themed collection: Journal of Materials Chemistry B HOT Papers
Communication

Sensing cholesterol-induced rigidity in model membranes with time-resolved fluorescence spectroscopy and microscopy

Shifting from liquid disorder to liquid order phase in liposomes restricts the microenvironment of DI-8-ANEPPS, resulting in lengthening its fluorescence lifetime.

Graphical abstract: Sensing cholesterol-induced rigidity in model membranes with time-resolved fluorescence spectroscopy and microscopy
Open Access Paper

Photopatterning of conductive hydrogels which exhibit tissue-like properties

Conductive hydrogels patterned with a confocal laser can produce complex shapes that support neuronal growth for over 7 weeks.

Graphical abstract: Photopatterning of conductive hydrogels which exhibit tissue-like properties
Paper

Highly disordered and resorbable lithiated nanoparticles with osteogenic and angiogenic properties

This study develops lithium-doped amorphous calcium phosphate nanoparticles. These bioresorbable particles promote osteogenesis and angiogenesis, effectively inducing the formation of mature ectopic bone.

Graphical abstract: Highly disordered and resorbable lithiated nanoparticles with osteogenic and angiogenic properties
Paper

Selenium nanoparticle-functionalized injectable chitosan/collagen hydrogels as a novel therapeutic strategy to enhance stem cell osteoblastic differentiation for bone regeneration

Selenium nanoparticle-functionalized injectable chitosan/collagen hydrogels for bone regeneration.

Graphical abstract: Selenium nanoparticle-functionalized injectable chitosan/collagen hydrogels as a novel therapeutic strategy to enhance stem cell osteoblastic differentiation for bone regeneration
Paper

Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation

Oxidized PVA (OPVA-1.0) obtained by one-pot method is completely degraded in soil, which is further sprayed, dipped, or brushed conformally onto different perishable fruits to delay the ripening by 5–14 days as ideal packaging materials.

Graphical abstract: Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation
Paper

Broad-spectrum degradation of fluoroquinolone antibiotics by Hemin-His-Fe nanozymes with peroxidase-like activity

A novel biomimetic peroxidase nanozymes named Hemin-His-Fe (HHF)-peroxidase nanozyme was synthesized for the broad-spectrum degradation of fluoroquinolone antibiotics.

Graphical abstract: Broad-spectrum degradation of fluoroquinolone antibiotics by Hemin-His-Fe nanozymes with peroxidase-like activity
From the themed collection: Journal of Materials Chemistry B HOT Papers
Paper

Bacteria-responsive functional electrospun membrane: simultaneous on-site visual monitoring and inhibition of bacterial infection

Visual bacterial monitoring and responsive antimicrobial ability triggered by acid.

Graphical abstract: Bacteria-responsive functional electrospun membrane: simultaneous on-site visual monitoring and inhibition of bacterial infection
Paper

On-demand activatable peroxidase-mimicking enzymatic polymer nanocomposite films

The present work reports the fabrication of nanocomposite films that demonstrated precise control and tuneable on-demand enzyme-mimicking activity, thus setting up a platform for future development of smart sensors for various applications.

Graphical abstract: On-demand activatable peroxidase-mimicking enzymatic polymer nanocomposite films
Paper

A 4D printed nanoengineered super bioactive hydrogel scaffold with programmable deformation for potential bifurcated vascular channel construction

Four-dimensional (4D) printing of hydrogels enabled the fabrication of complex scaffold geometries out of static parts.

Graphical abstract: A 4D printed nanoengineered super bioactive hydrogel scaffold with programmable deformation for potential bifurcated vascular channel construction
Paper

Dapansutrile OLT1177 suppresses foreign body response inflammation while preserving vascularisation of implanted materials

Selective immune suppression of the NLRP3 inflammasome by Dapansutrile (OLT1177) decreases fibrotic capsule formation and increases angiogenesis in a mouse subcutaneous implantation model of the foreign body response.

Graphical abstract: Dapansutrile OLT1177 suppresses foreign body response inflammation while preserving vascularisation of implanted materials
Paper

Highly sensitive detection of Salmonella typhimurium via gold and magnetic nanoparticle-mediated sandwich hybridization coupled with ICP-MS

Foodborne pathogens including Salmonella typhimurium cause millions of illnesses annually. A novel detection method using ICP-MS with magnetic and gold nanoparticles for Salmonella typhimurium shows high specificity and sensitivity.

Graphical abstract: Highly sensitive detection of Salmonella typhimurium via gold and magnetic nanoparticle-mediated sandwich hybridization coupled with ICP-MS
Paper

A separation-free paper-based hydrogel device for one-step reactive oxygen species determination by a smartphone

A hydrogel-coupled and paper-based analytical device for H2O2 colorimetric detection by a smartphone was reported with a separation-free nature in complex biological samples.

Graphical abstract: A separation-free paper-based hydrogel device for one-step reactive oxygen species determination by a smartphone
Open Access Paper

Conformal encapsulation of mammalian stem cells using modified hyaluronic acid

Conformal coatings designed using a hyaluronic acid hydrogel system are used to encapsulate cells and to assemble multicellular structures.

Graphical abstract: Conformal encapsulation of mammalian stem cells using modified hyaluronic acid
Paper

Enhancing cell adhesion in synthetic hydrogels via physical confinement of peptide-functionalized polymer clusters

A uniquely designed functional polymer cluster imparts cell adhesion characteristics to conventional synthetic hydrogels by being physically confined within the polymer network, without chemically modifying the hydrogel's polymer chains.

Graphical abstract: Enhancing cell adhesion in synthetic hydrogels via physical confinement of peptide-functionalized polymer clusters
Paper

Charge-reversal polymeric nanomodulators for ferroptosis-enhanced photodynamic therapy

The clinical application of photodynamic therapy (PDT) has some limitations including poor tumor targeting properties, a high reductive tumor microenvironment, and inefficient activation of single cell death machinery.

Graphical abstract: Charge-reversal polymeric nanomodulators for ferroptosis-enhanced photodynamic therapy
Paper

Design and development of 3D printed shape memory triphasic polymer-ceramic bioactive scaffolds for bone tissue engineering

Scaffolds for bone tissue engineering require considerable mechanical strength to repair damaged bone defects.

Graphical abstract: Design and development of 3D printed shape memory triphasic polymer-ceramic bioactive scaffolds for bone tissue engineering
Paper

Tough and elastic hydrogels based on robust hydrophobicity-assisted metal ion coordination for flexible wearable devices

A hydrogel-based flexible sensor based on hydrophobicity-assisted metal ion coordination is reported for human movement monitoring and physiological signal detection.

Graphical abstract: Tough and elastic hydrogels based on robust hydrophobicity-assisted metal ion coordination for flexible wearable devices
From the themed collection: Journal of Materials Chemistry B HOT Papers
Paper

Supramolecular assembly of isomeric SN-38 prodrugs regulated by conjugation sites

By attaching hydrophilic OEG on different conjugation sites of SN38, isomeric self-assembling prodrugs were developed and self-assembled into giant nanotubes and filamentous assemblies, revealing the critical contribution of conjugation sites.

Graphical abstract: Supramolecular assembly of isomeric SN-38 prodrugs regulated by conjugation sites
Paper

Supramolecular DNA nanogels through host–guest interaction for targeted drug delivery

Supramolecular DNA nanogel was constructed by host–guest interaction from Y-DNA modified with methyl violet, dsDNA with azobenzene, and curcubit[8]uril. It possess stimuli responses, excellent biocompatibility and targeted drug transport ability.

Graphical abstract: Supramolecular DNA nanogels through host–guest interaction for targeted drug delivery
Paper

Fluorinated BPA derivatives enhanced 10B delivery in tumors

Fluorinated BPA derivatives exhibited improved 10B accumulation in tumors, and enhanced T/B and T/N ratios compared to clinical boron drug fructose-BPA (f-BPA).

Graphical abstract: Fluorinated BPA derivatives enhanced 10B delivery in tumors
Paper

Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer

Radioactive hybrid semiconducting polymer nanoparticles are developed for imaging-guided photothermal–photodynamic–sonodynamic tri-modal therapy of breast cancer.

Graphical abstract: Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer
From the themed collection: Journal of Materials Chemistry B HOT Papers
Paper

Comparative effectiveness of myocardial patches and intramyocardial injections in treating myocardial infarction with a MitoQ/hydrogel system

Schematic illustration of the comparative effectiveness of myocardial patches and intramyocardial injections in the treatment of myocardial infarction using a MitoQ/hydrogel system.

Graphical abstract: Comparative effectiveness of myocardial patches and intramyocardial injections in treating myocardial infarction with a MitoQ/hydrogel system
Paper

Peptide nanovaccine conjugated via a retro-Diels–Alder reaction linker for overcoming the obstacle in lymph node penetration and eliciting robust cellular immunity

Nanovaccine conjugated via a retro-Diels–Alder reaction achieves lymph node deep penetration of antigens for enhancing vaccine efficacy.

Graphical abstract: Peptide nanovaccine conjugated via a retro-Diels–Alder reaction linker for overcoming the obstacle in lymph node penetration and eliciting robust cellular immunity
From the themed collection: Journal of Materials Chemistry B HOT Papers
Paper

Copper peroxide nanodot-decorated gold nanostar/silica nanorod Janus nanostructure with NIR-II photothermal and acid-triggered hydroxyl radical generation properties for the effective treatment of wound infections

A multifunctional nanostructure with synergistic MPTT/CDT antibacterial activities was designed for the effective treatment of wound infections.

Graphical abstract: Copper peroxide nanodot-decorated gold nanostar/silica nanorod Janus nanostructure with NIR-II photothermal and acid-triggered hydroxyl radical generation properties for the effective treatment of wound infections
Paper

Synthesis and characterization of a pH/temperature-dual responsive hydrogel with promising biocompatibility features for stimuli-responsive 5-FU delivery

The study focused on the fine refinement of PNIPAM-based materials, resulting in enhanced biocompatibility and drug loading for a smart hydrogel system with multi-responsive 5-FU release.

Graphical abstract: Synthesis and characterization of a pH/temperature-dual responsive hydrogel with promising biocompatibility features for stimuli-responsive 5-FU delivery
From the themed collection: Journal of Materials Chemistry B HOT Papers
Open Access Paper

Drug delivery via a 3D electro-swellable conjugated polymer hydrogel

A glycolated polythiophene, p(g3T2), enables controlled drug loading/release of molecules with molecular weight of 800–6000 Da, due to large, reversible volume changes during electrochemical doping.

Graphical abstract: Drug delivery via a 3D electro-swellable conjugated polymer hydrogel
Paper

Revelation of adhesive proteins affecting cellular contractility through reference-free traction force microscopy

Reference-free traction force microscopy with a regular microdot array was designed and proposed to reveal the effects of adhesive proteins on cellular contractility, cytoskeleton structure, morphogenesis and mechanotransduction.

Graphical abstract: Revelation of adhesive proteins affecting cellular contractility through reference-free traction force microscopy
Open Access Paper

Statistical optimization of hydrazone-crosslinked hyaluronic acid hydrogels for protein delivery

Design of experiments, a statistical optimization tool, was used to optimize the gelation time, compressive modulus, and stability of hydrazone-crosslinked hyaluronic acid hydrogels for controlled protein delivery.

Graphical abstract: Statistical optimization of hydrazone-crosslinked hyaluronic acid hydrogels for protein delivery
46 items

About this collection

Journal of Materials Chemistry B is pleased to present this themed collection highlighting the rising stars of materials chemistry research in 2024. This special collection showcases the very best work from materials chemists in the early stages of their independent career.

Each contributor was recommended by experts in their fields as carrying out work with the potential to influence future directions in materials chemistry with applications in biology and medicine. Congratulations to all the outstanding researchers featured!

See also:

Journal of Materials Chemistry A Emerging Investigators 2024

Journal of Materials Chemistry C Emerging Investigators 2024

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