Metal-free, photoredox-catalyzed aromatization-driven deconstructive functionalization of spiro-dihydroquinazolinones with α-CF3 alkenes is achieved with high chemoselectivity. Mechanistic studies suggest a radical pathway for this cascade reaction.
The aromatization-driven deconstructive coupling of spiro carbocycles with organic halides via dual photoredox/nickel catalysis is developed. An in-depth mechanism study revealed that this reaction proceeded via a radical-metal crossover pathway.
Synergistic visible-light/Brønsted-acid promoted deconstructive aminoalkylation of spiro-dihydroquinazolinones with aromatic amines and ethyl glyoxylate is presented.
An organophotoredox-catalyzed deconstructive alkylation/Truce–Smiles rearrangement of spiro-dihydroquinazolinones with activated alkenes has been reported.
K2S-mediated one-pot synthesis of quinazolinones or dihydroquinazolinones from o-aminobenzamides (or o-aminobenzonitriles) and calcium carbide offers a cost-effective and sustainable alternative.