Bingchen Yu, Li Cao, Shanshan Li, Paul C. Klauser and Lei Wang
Chem. Sci., 2023,14, 7913-7921
From themed collection:
2023 Chemical Science HOT Article Collection
Abstract
Proximity-enabled SuFEx reaction between interacting proteins was found to follow a two-step mechanism. Kinetics and essential properties were thoroughly studied for SuFEx applications in protein cross-linking and covalent biotherapeutics.
Oliver L. Symes and James A. Bull
Org. Chem. Front., 2025,12, 6681-6697
From themed collection:
2025 Organic Chemistry Frontiers HOT articles
Abstract
This review examines the mechanism and stereochemical outcome of substitution reactions at chiral S(VI) electrophiles.
Meng Li, Ping Song, Shuiyuan Zhang, Xi Yan, Hui Shao, Hai-Chao Xu and Saihu Liao
Polym. Chem., 2026, Advance Article
Abstract
The good orthogonality of a sulfur(VI) fluoride exchange (SuFEx) click reaction to active ester–amine chemistry enables efficient access to functionalized polymers from a single parent reactive polymer via selective post-polymerization modification.
Joshua A. Homer, Rebecca A. Koelln, Andrew S. Barrow, Timothy L. Gialelis, Zlata Boiarska, Nikita S. Steinohrt, Erinna F. Lee, Wen-Hsuan Yang, Robert M. Johnson, Taemoon Chung, Amber N. Habowski, Dharmendra S. Vishwakarma, Debmalya Bhunia, Charlotte Avanzi, Adam D. Moorhouse, Mary Jackson, David A. Tuveson, Scott K. Lyons, Michael J. Lukey, W. Douglas Fairlie, Shozeb M. Haider, Michel O. Steinmetz, Andrea E. Prota and John E. Moses
Chem. Sci., 2024,15, 3879-3892
From themed collection:
Celebrating the scientific accomplishments of RSC Fellows
Abstract
The Accelerated SuFEx Click Chemistry (ASCC) protocol, adapted to a 96-well plate format, has been applied to the late-stage derivatization of bioactive molecules and array synthesis of anticancer agents, showcasing its potential for drug discovery.
Qidong Yan, Jiayi Jiang, Shuping Huang, Quan Zhou, Nianhua Luo and Jiapian Huang
Org. Biomol. Chem., 2026,24, 4562-4572
Abstract
This review covers advances in β-sultam synthesis via intramolecular cyclization. Ring-closure strategies enable access to strained β-sultams and functionalization, highlighting their importance in medicinal chemistry and heterocyclic design.