3-Carboxamide indazoles have been developed using the amide coupling process. Density function theory (DFT) computations, and the assessment of binding energy using Auto Dock, illustrate the pharmaceutical effectiveness.
This study focused on the development of a novel series of 5-ethylsulfonyl-indazole-3-carboxamides (8a–l) as dual inhibitors of VEGFR-2 and EGFR. Compounds 8g and 8h emerged as the most potent derivatives against breast (MCF-7) and colorectal (HCT-116) cancer cell lines.
Palladium-catalyzed 1,4-migration associated with direct arylation is a new tool for C–H bond functionalization.
The two designed compounds 11 and 12 showed significat antifungal activity supported by molecular studies.
A one-pot N–S bond cleavage of tosyl hydrazones by arynes produced diaryl sulfones, diazomethyledenes of isatin or spiro[indazole-3,3′-indolin]-2-one and arynes and direct N-arylation products. A plausible reaction mechanism is provided.