Synthesis and applications of fluorinated, polyfluoroalkyl- and polyfluoroaryl-substituted 1,2,3-triazoles

Abstract

This review summarises methods to synthesise and apply fluorine- and polyfluoroalkyl/aryl-substituted 1,2,3-triazoles. Focus is devoted to recent examples and those where the properties of both the 1,2,3-triazole and fluorine groups are important.

Stabilized carbon radical-mediated three-component polyfluoroalkylation of amino acid derivatives

Abstract

Enabled by captodatively stabilized carbon radical-mediated carbon–carbon bond formation, a three-component polyfluoroalkylation of amino acid derivatives with styrenes and readily available polyfluoroalkyl sources is reported.

Halogen-bond-assisted radical remote difunctionalization of bicyclo[1.1.1]butane skeletons

Abstract

Transition-metal-free radical remote difunctionalization of bicyclo[1.1.1]butane skeletons in both two- and three-component fashions is presented.

Silver or copper-catalyzed ring opening [3+2] annulation of 2-polyfluoroalkyl chromones/6-polyfluoroalkyl pyran-4H-ones with methylene isocyanides: regioselective synthesis of 3-polyfluoroalkyl pyrroles

Abstract

In this work, we present a synthetic protocol for the preparation of polysubstituted 3-trifluoromethyl(polyfluoroalkyl)pyrroles.

Aerobic biotransformation of a novel highly functionalized polyfluoroether-based surfactant using activated sludge from a wastewater treatment plant

Abstract

We incubated a novel fluorosurfactant with wastewater treatment plant sludge and identified smaller PFAS biotransformation products with lower bioaccumulation potential compared to the starting material.

CHAPTER 2
Poly/Perfluorinated Alkyl Substances (PFASs) – Synthetic Methods, Properties and Applications