This is the first example of harmaline scaffolds as acceptor/acceptor-based N–C–C synthons and evaluation of 3at as an anticancer agent.
A reaction involving a Ru(II)-catalyzed C–H activation and annulation cascade was successfully established for constructing coumarin-fused benzo[a]quinolizin-4-ones and pyridin-2-ones.
We developed a protocol for synthesis of PDIZs from CMQZs with isocyanides. The cycloaddition of [1,4]/[1,6]/[1,2] and skeletal rearrangement were performed by heating a mixture of 1–2 in DMSO, which was promoted by Cs2CO3 and catalyzed by Ag2CO3.
New Eu(III)-based indicators enable luminescence-based detection of polyphosphate-bound Mg2+ species, a highly dynamic pool of biomolecule-bound magnesium in cells.
Azlactones are widely studied for their inherent reactivity, performing diverse chemical transformations. This review summarizes key advances, focusing on reaction mechanisms, reactivity, and some synthetic applications.