We describe the base-mediated [3 + 2] cycloaddition reaction of di/trifluoromethylated hydrazonoyl chlorides with fluoronitroalkenes for the synthesis of densely functionalized 3-di/trifluoroalkyl-5-fluoropyrazoles with potent biological activity.
A variety of pyrazoline-derived N-vinyl nitrones was prepared in moderate to good yields with high regioselectivity and diastereoselectivity through the base-promoted regioselective [3 + 2] cycloaddition of N-vinyl nitrones and hydrazonoyl chlorides.
Aromatic 1,2,4-diazaphospholes featuring distinct hybrid-mode nitrogen atoms (N(λ3σ2), N(λ3σ3)) and low-valent phosphorus atoms (λ3σ2) exhibited the characteristic of serving as unique hybrid ligands.
A chemo- and diastereoselective cyclization strategy has been developed to synthesize spiro-iminoindoline-pyrazolines with promising antioxidant properties.
A general strategy for the synthesis of multisubstituted 2,3-dihydrofurans through the intermolecular cyclization of aldehydes with acyl-stabilized sulfur ylides.