Synthetically valuable monofluoroalkenes can be obtained via atom- and step-economical transition metal mediated catalysis with high stereoselectivity and functional group tolerance.
This feature article summarizes the developments in fluorinated carbene transformations, and their consequent C–F functionalization in a cascade platform.
Herein, we describe a novel and efficient photo-redox catalytic difluorinated ester radical addition/defluoroalkylation coupling reaction between trifluoroacetic acid derivatives and α-trifluoromethyl alkenes.
Defluorinative alkylation and arylation between thianthrenium salts and α-trifluoromethyl alkene to afford gem-difluoroolefins by easily recycling thianthrene under visible light irradiation and free of metal photocatalyst.
A visible-light-mediated selective difluoroalkylation of α-trifluoromethyl alkenes with difluoroalkylating reagents was developed. This protocol allowed the formation of gem-difluoroalkene difluoroacetates and trifluoromethylated difluoroacetamides.