Molecularly imprinted polymer-integrated nanozymes for biosensing: advances and prospects

Shaemaa Hadi Abdulsada, Alvaro Garcia Cruz, Christopher Zaleski, Elena Piletska and Sergey A. Piletsky

J. Mater. Chem. B, 2025, 13, 15213
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Analytical methods for glycoRNA detection: a systematic review

Sijia Sun, Qian Liu and Zhen Liu

Anal. Methods, 2026, 18, 504
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Advances in glycan-specific biomimetic molecular recognition and its biomedical applications

Wei Li and Zhen Liu

Chem. Commun., 2025, 61, 6739
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pH-Switchable molecularly imprinted polymers for enantioselective recognition and separation of (S)-amlodipine besylate from its chiral counterpart

Hang Gong, Xiaoli Ouyang, Feng Chen, Chunyan Chen, Bin Yang, Junjie Du and Changqun Cai

Anal. Methods, 2025, 17, 9026
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Sustainable polymeric adsorbents for adsorption-based water remediation and pathogen deactivation: a review

Huda Alkhaldi, Sarah Alharthi, Salha Alharthi, Hind A. AlGhamdi, Yasmeen M. AlZahrani, Safwat A. Mahmoud, Lamia Galal Amin, Nora Hamad Al-Shaalan, Waleed E. Boraie, Mohamed S. Attia, Samera Ali Al-Gahtany, Nadiah Aldaleeli, Mohamed Mohamady Ghobashy, A. I. Sharshir, Mohamed Madani, Reem Darwesh and Sana F. Abaza

RSC Adv., 2024, 14, 33143
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Molecularly imprinted polymers for pharmaceutical and biomedical analysis

Mamajan Ovezova, Fatma Yılmaz, Ilgım Göktürk, Kıvılcım Çaktü Güler and Adil Denizli

Journal of Pharmaceutical and Biomedical Analysis Open, 2024, 4, 100038
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A Glycosyl-Imprinted Sensor Used for Accurate Classification and Quantification of Breast Cancer-Derived Exosomes by Electrochemiluminescence Detection of Two Glycoproteins at Dual Potentials

Kui Luo, Zejun Jiang, Ling Li, Lijuan Lin, Tao Qin and Jianping Li

ACS Sens., 2025, 10, 5528
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DLL4/VEGF bispecific molecularly imprinted nanomissile for robust tumor therapy

Fang Jin, Peixin Guan, Lingrui Huang, Anqi Zhang, Song Gao, Lisheng Wang and Zhen Liu

Biomaterials, 2025, 322, 123412
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Chronopotentiometric Nanopore Sensor Based on a Stimulus-Responsive Molecularly Imprinted Polymer for Label-Free Dual-Biomarker Detection

Junhao Wang, Huihui Zhou, Rongning Liang and Wei Qin

Anal. Chem., 2024, 96, 9370
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Research progress of molecular imprinting technology in the field of disease diagnosis and therapy

Ran ZHU, Ganping CAI, Haijiao ZHENG and Qiong JIA

CJCSP, 2026, 44, 2
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Recent advances in molecularly imprinted glycan-binders and their biomedical applications

Ying Li, Jingran Chen and Zhen Liu

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Functional Interface for Glycoprotein Sensing: Focusing on Biosensors

Ke Qu and Jinghong Li

Langmuir, 2024, 40, 10405
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A rapid and on-site visual sensor for tobacco mosaic virus detection based on photocatalytic molecularly imprinted ZnO nanorods

Yong Li, Lingyun Wang, Tao Pang, Ning Jiang, Changqun Cai and Hang Gong

Microchim Acta, 2026, 193
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Biologically-driven RAFT polymerization-amplified platform for electrochemical detection of antibody drugs

Jianwen Wan, Mengge Wang, Songmin Chen, Xiyao Zhang, Wenhui Xu, Di Wu, Qiong Hu and Li Niu

Talanta, 2025, 285, 127431
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Real-Time 5-Hydroxyindoleacetic Acid Monitoring in Guinea Pig Brain Using a Molecular Imprinted Polymer-Based Galvanic Redox Potentiometric Sensor

Yuxin Peng, Fenghui Zhu, Huan Wei, Jiping Ni, Xin Yang, Yichun Yao and Ying Jiang

Anal. Chem., 2025, 97, 2136
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Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications

Youlu Diao, Jia Gao, Yue Ma and Guoqing Pan

Bioactive Materials, 2025, 45, 162
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Molecularly and ionically imprinted polymers-based chemical sensors in chemical assays

Haiwen Su, Haoyu Ren, Xiayidan Maimaitikelimu, Jili Xu, Feika Bian and Huan Wang

Chemical Engineering Journal, 2024, 499, 156315
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High-sensitivity detection of glycoproteins by high-density boric acid modified metal–organic framework surface molecularly imprinted polymers resonant light scattering sensor

Hang Gong, Shuting Li, Feng Chen, Yong Li, Chunyan Chen and Changqun Cai

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 322, 124813
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Preparation and application of teamed boronate affinity magnetic protein imprinted polymer: Pollutants removal, filter resistance improvement and synergistic glycoprotein recovery under physiological pH in sequencing batch reactors

Qiming Zhang, Jiajun Hu, Chen Yang, Wenshan Guo, Jiaxiang Liu, Nan Liu, Liang Wang, Huu Hao Ngo and Jixiang Li

Chemical Engineering Journal, 2025, 518, 164868
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Gelatin-based carbon quantum dot-molecularly imprinted polymer: Safe photoluminescent core-shell nano-carrier for the pH-responsive anticancer drug delivery

Tahereh Nasiriani, Siamak Javanbakht, Ahmad Shaabani and Fahimeh Kazeminava

International Journal of Biological Macromolecules, 2024, 278, 134669
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Efficient use of imprinted nanocatalytic particles: Development and application of targeted catalytic membranes

Fumin Liu, Xitong Li, Dahua Yu, Xianghua Tang, Jingxin Huang and Huazhang Zhao

AIChE Journal, 2025, 71
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Dynamic control of integrin signaling for cell manipulation via molecularly imprinted decoy receptor

Fan Ding, Jingjing Xu, Yue Ma, Zhaoyang Yao, Jia Gao, Kangni Shang, Karsten Haupt and Guoqing Pan

Trends in Biotechnology, 2026
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Synergizing Nanosensor-Enhanced Wearable Devices with Machine Learning for Precision Health Management Benefiting Older Adult Populations

Zhihao Li, Bangshun He, Yiwei Li, Bi-Feng Liu, Guojun Zhang, Songlin Liu, Tony Ye Hu and Ying Li

ACS Nano, 2025, 19, 26273
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Biomimetic molecularly imprinted hollow fiber membranes for continuous Enantioseparation of amlodipine

Hang Gong, Xiaoli Ouyang, Chunyan Chen and Changqun Cai

Microchemical Journal, 2025, 216, 114574
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Breaking Barriers: Nucleic Acid Aptamers in Gastrointestinal (GI) Cancers Therapy

Herlina Uinarni, Enwa Felix Oghenemaro, Soumya V. Menon, Ahmed Hjazi, Fatma Magdi Ibrahim, Mandeep Kaur, Askarova Zebo Zafarjonovna, Mahamedha Deorari, Majid S. Jabir and Ahmed Hussein Zwamel

Cell Biochem Biophys, 2024, 82, 1763
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A ratio luminescent europium organometallic gel for in vitro detection of hepatocellular carcinoma marker and cellular imaging

Xiao Lian, Fang Chen, Yanmin Zhang, Juzhou Zhang, Bangben Yao and Helin Niu

Talanta, 2025, 288, 127708
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Low-Cost Polyphenol–Polypyrrole Molecularly Imprinted Sensor for Point-of-Care Alzheimer’s Detection

Ajith Mohan Arjun, Sudhaunsh Deshpande, Guoyi Liu, Daimei Miura, Krzysztof Pawlak, Tokuda Takahiko, Makoto Higuchi, Miyu Matsumoto, Tomoko Umemura, Kaori Tsukakoshi and Sanjiv Sharma

ACS Sens., 2025, 10, 8435
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Molecularly Imprinted Nanozymes with Substrate Specificity: Current Strategies and Future Direction

Zhou Zhang, Ergui Luo, Wenjuan Wang, Di Huang, Juewen Liu and Zhi Du

Small, 2025, 21
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Molecularly imprinted polymers as artificial catalysts – Recent trends and emerging applications

Sergey A. Piletsky and Stanislav S. Piletsky

TrAC Trends in Analytical Chemistry, 2025, 193, 118435
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Efficient Synthesis of Hydrophilic Hairy Semihollow Molecularly Imprinted Polymer Microcapsules with Ultrahigh Drug Loading and pH-Responsive Sustained Release Properties

Yan Zhou, Yanyan Mu and Huiqi Zhang

ACS Appl. Mater. Interfaces, 2025, 17, 65495
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Amplification by Polysaccharides for the Electrochemical Detection of Trypsin Activity

Junpeng Lv, Jingjing Xu, Yiting Chen, Wenqi Tang, Wenhui Xu, Mengge Wang, Xiyao Zhang, Ziluan Zhu, Songmin Chen, Qiong Hu and Li Niu

Anal. Chem., 2025, 97, 20549
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Protein/virus-imprinted self-assembled monolayers for real-time selective detection

Wanlan Yang, Ru Han and Xuezhong Du

Advances in Colloid and Interface Science, 2026, 351, 103793
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MoB2 nanozyme-decorated borate hydrogels with ROS-scavenging and antibacterial abilities for infected diabetic wound healing

Yueguang Fang, Chenxi Li, Ruifang He, Lanling Xiu, Dingwen Xiao, Miao Wang, Yuesheng Dong, Lin Sun and Junwei Ye

Chemical Engineering Journal, 2026, 529, 173073
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The metal- and covalent-organic frameworks-based molecularly imprinted polymer composites for sample pretreatment

Yuhao Wen, Dani Sun, Jinhua Li, Abbas Ostovan, Xiaoyan Wang, Jiping Ma, Jinmao You, Turghun Muhammad, Lingxin Chen and Maryam Arabi

TrAC Trends in Analytical Chemistry, 2024, 178, 117830
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A Resettable and Reprogrammable 3‐Input/3‐Output Biomolecular Keypad Lock Based on Stimulus‐Responsive Enzymatically Imprinted Polymer Film Electrodes

Wenjing Lian, Chengxing Cui, Junyi Lin, Menghan Wang and Hongyun Liu

Advanced Sustainable Systems, 2025, 9
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Glycan-Matchmade Multivalent Decoration of Enzyme Labels for Amplified Electrochemical Detection of Glycoproteins

Junpeng Lv, Haibiao Lin, Xiaoxia Chen, Qiong Hu and Li Niu

Anal. Chem., 2025, 97, 3171
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Advancing imprinted polymers: Pre-orientation, self-assembly, and porosity in 3D printing

Amelie Huber, Benedikt Keitel, Sherman Lesly Zambou Jiokeng, Boris Mizaikoff and Mehmet Dinc

iScience, 2026, 29, 114378
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Recent advances in molecularly imprinted polymers for the detection of microorganisms

Li Li, Shao-Bo Li, Huai-Song Wang, Yue-Jie Li, Jing-Wen Chen, Ran Chen, Meng-Xiang Su, Wen-Yuan Liu and Jing Liu

TrAC Trends in Analytical Chemistry, 2026, 199, 118786
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Fe0-MAP Prepared Glycosurfaces for Selective Cell Capture: From Adherent to Suspended Cells

Yu Duan, Xiaoliang Ma, Jiangping Guo, Fangjian Shan, Yuchun Pan, Yuru Chen, Hong Chen and Gaojian Chen

ACS Appl. Mater. Interfaces, 2024
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Imprinted probes achieve highly specific recognition of L-phenylalanine

Ziwei Wang, Jiawei Li, Zhaoxuanxuan Chen, Zhanfang Ma and Hongliang Han

Journal of Colloid and Interface Science, 2025, 697, 137987
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Online desalting of glycans labeled with 8-aminopyrene-1,3,6-trisulfonic acid via capillary electrophoresis

Chenchen Liu and Takayuki Kawai

Talanta, 2026, 296, 128429
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Rapid, efficient and highly selective separation and enrichment of glycoprotein by surface-imprinted MOF nanoparticles loaded with high-density boric acid

Hang Gong, Shuting Li, Yi Cheng, Feng Chen, Chunyan Chen and Changqun Cai

Separation and Purification Technology, 2025, 354, 128911
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Construction of pH-Responsive Drug Carrier Based on Molecularly Imprinted Polymers for Controlled Capecitabine Release

Zimeng Guo, Tianxiao He, Yuqi Lou, Guoxing Xu and Qiong Jia

J. Compos. Sci., 2025, 9, 421
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Voltammetric analysis of glycoproteins containing sialylated and neutral glycans at pyrolytic graphite electrode

Mojmír Trefulka, Hana Černocká, Tatiana Staroňová and Veronika Ostatná

Bioelectrochemistry, 2025, 163, 108851
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A Molecularly Imprinted Electrochemical Sensor for Carbendazim Detection Based on Synergy Amplified Effect of Bioelectrocatalysis and Nanocomposites

Wenjing Lian, Xinyu Zhang, Yongbin Han, Xintong Li and Hongyun Liu

Polymers, 2025, 17, 92
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Temperature-responsive molecular imprinting: From fundamental principles to cutting-edge applications

Shengwei Guo, Mimi Xu, Dan Li, Ning Wu and Yen Wei

Talanta Open, 2025, 12, 100598
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Natural bubble-blowing inspired Janus molecularly imprinted nanobowls for selective molecular capture

Lu Liu, Yanan Huang, Huan Pang, Pan Wang and Jianming Pan

Chinese Chemical Letters, 2026, 112538
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Surface-Initiated PET-RAFT Enables In Situ Glycopolymer Microarrays for Live-Cell Glycan Profiling and Programmable Biointerfaces

Al-Hassan S. Mahdy, Jixiong Zhou, Xiongzhi Ni, Yuru Chen, Jingjing Gong, Gaojian Chen and Jin Geng

Biomacromolecules, 2026
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Nanopore profiling and structure determination of oligosaccharides by fragmentation

Yunqi Xiao, Shanyu Zhang, Xinmeng Gao, Tian Li, Hanhan Zhang, Panke Zhang and Shuo Huang

Sci. Adv., 2026, 12
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Site-Directed Electrochemical Grafting for Amplified Detection of Antibody Pharmaceuticals

Jianwen Wan, Yiyan Tian, Di Wu, Zhuojun Ye, Songmin Chen, Qiong Hu, Mengge Wang, Junpeng Lv, Wenhui Xu, Xiyao Zhang, Dongxue Han and Li Niu

Anal. Chem., 2024, 96, 9278
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Development of fluorescent artificial receptors for specific recognition and rapid detection of Escherichia coli O157:H7

Qianjin Li, Rui Li, Mengdi Wang, Jinjin Wang, Tingting Wang, Yu Jin, Jianlin Li and Fenying Wang

Food Chemistry, 2025, 492, 145507
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Lanthanide-bimetallic organic frameworks: from mechanism and sensors design to ratiometric fluorescent applications

Jialing Zhou, Xiaoyun Hu, Chen Liu, Yue Liu, Na Tian, Fan Wu, Wei Li, Jianping Lei and Zhihui Dai

Coordination Chemistry Reviews, 2025, 534, 216574
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Multifunctional Self-Signaling nanoMIP and Its Application for a Washing-Free Assay of Human Angiotensin-Converting Enzyme 2

Yujian Liu, Yongcheng He, Guanghui Zhang, Jiao Yang and Yingchun Li

Anal. Chem., 2024, 96, 7602
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Nanosensor-Enabled Detection and Identification of Intracellular Bacterial Infections in Macrophages

Aritra Nath Chattopadhyay, Mingdi Jiang, Jessa Marie V. Makabenta, Jungmi Park, Yingying Geng and Vincent Rotello

Biosensors, 2024, 14, 360
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Expanding the recognition of monosaccharides and glycans: A comprehensive analytical approach using chemical-nose/tongue technology and a comparison to lectin microarrays

Shunsuke Tomita and Chiaki Nagai-Okatani

BBA Advances, 2025, 7, 100129
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Molecularly imprinted optical sensors for disease biomarker analysis: current progress and future trends

Ganping Cai, Huifeng Zhang, Ran Zhu, Yongcun Zou and Qiong Jia

TrAC Trends in Analytical Chemistry, 2026, 194, 118499
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Advances in Two-Dimensional Nanomaterials for Intelligent Biosensing and Environmental Monitoring

Gajanan M. Hingangavkar

Sens Imaging, 2025, 26
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Progress of Microneedle Electrochemical Biosensors for Interstitial Fluid Detection and Monitoring

Xinxing Gong, Yeru Wen, Yimin Pang, Song Liu and Quan Yuan

Chin. J. Chem., 2025, 43, 3016
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Molecularly imprinted polymers towards disease diagnostics

Yixin Ren, Xiaoting Fu, Xuerui Zhang, Shuo Wang and Xiaodong Bi

TrAC Trends in Analytical Chemistry, 2026, 194, 118532
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Rapid Identification of Cell Types and Phenotypic States Using a One-Polymer Multichannel Nanosensor Fabricated via Flash Nanoprecipitation

Mingdi Jiang, Junwhee Yang, Liang Liu, Aritra Nath Chattopadhyay and Vincent M. Rotello

ACS Appl. Mater. Interfaces, 2024, 16, 68928
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Deep eutectic solvent-based magnetic molecular nanomaterials coupled with fluorescent carbon dots as a new strategy to highly enrich and sensitively detect doxycycline in food matrices

Yanqiong Luo, Han Zhang, Jun Liu, Aleeza Jamil, Yujiao Hou, Qian Li, Min Zhao, Chunjie Zhao, Wenjing Li and Bo Hong

Food Chemistry: X, 2025, 25, 102202
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Advancements in Electrochemical Biosensors for Comprehensive Glycosylation Assessment of Biotherapeutics

Preety Ahuja, Manpreet Singh and Sanjeev Kumar Ujjain

Sensors, 2025, 25, 2064
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Molecular imprinting resonant light scattering sensor based on teamed boronate affinity for highly specific detection of glycoprotein

Hang Gong, Xia Wu, Feng Chen, Yong Li, Chunyan Chen and Changqun Cai

Microchemical Journal, 2024, 207, 112260
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Rapid photosynthesis of cellulose nanofibril-based imprinted membrane for selective colorimetric determination of isoniazid

Fatima Ezzahra Rejdal, Ouarda El Hani, Abderrahman Lamaoui, Youssef Habibi and Aziz Amine

Microchim Acta, 2025, 192
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Recent Advances of Optical Sensing Arrays (2019–2025): From Design of Optical Elements to Multidimensional Analysis for Applications

Xinyue Chen and Qianyu Wang

Anal. Chem., 2026, 98, 2633
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Preparation of imidazolium ionic liquid functionalized paper membrane for selective extraction of caffeic acid and its structural and functional analogues from Taraxaci Herba

Xiaohui Han, Shumin Li, Xiaoxue Sun, Jingyu Zhang, Xuerui Zhang and Xiaodong Bi

Biomedical Chromatography, 2024, 38
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Molecularly Imprinted Membranes for Selective Biomarker Recognition: Recent Advances and Emerging Strategies

Qingmei Song, Kelly Van Van, Xinhao Li, Ziman Chen and Yongqin Lv

Chem Bio Eng., 2025, 2, 713
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A “sweeter” approach to cancer immunotherapy: Glycopolymers as diverse tools for immune modulation

Kenneth Hulugalla, Oluwatosin David Abodunrin, Joshua Anderson, Adam E. Smith and Thomas Werfel

Journal of Controlled Release, 2025, 388, 114372
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Targeting protein phosphorylation with molecularly imprinted polymer receptors

Anıl Incel and Börje Sellergren

TrAC Trends in Analytical Chemistry, 2026, 199, 118781
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Biomolecule‐responsive polymers and their bio‐applications

Yuting Xiong, Minmin Li and Guangyan Qing

Interdisciplinary Materials, 2024, 3, 865
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Preparation of molecularly imprinted polymers for the selective extraction and purification of hesperidin from orange peels

Qiurui Zhao, Xinyao Yu, Mengyuan Liu, Chuansen Qin, Yahui He, Suilou Wang and Haixiang Wang

Journal of Chromatography B, 2025, 1263, 124696
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Progress in the preparation of advanced molecularly imprinted polymers via surface template-anchoring methods

Yifan Zhang, Huiqi Zhang and Linqi Shi

TrAC Trends in Analytical Chemistry, 2026, 195, 118591
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Advancements and potentials of molecularly imprinted polymer-based sensors for lysozyme determination in food and clinical samples

Vanish Kumar and Wlodzimierz Kutner

Chemical Engineering Journal, 2024, 499, 155828
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Molecularly imprinted Fe3O4 nanoparticles-based magnetic 3D photonic crystal microspheres for specific adsorption of aflatoxin B1 in grains

Qianjin Li, Xiaoxiao Hong, Menghua Dou, Shuying Guan and Jianlin Li

Food Chemistry, 2025, 477, 143530
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Molecularly Imprinted Polymers for Diagnosis and Medical Applications: Recent Advances and Progress

Maryam Shekari, Shahab Moghari, Elmuez A. Dawi and Hossein Ali Khonakdar

Polymers for Advanced Techs, 2025, 36
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