Emerging engineered nanozymes: current status and future perspectives in cancer treatments

Jiajia Zheng, Weili Peng, Houhui Shi, Jiaqi Zhang, Qinglian Hu and Jun Chen

Nanoscale Adv., 2025, 7, 1226
DOI: 10.1039/D4NA00924J

Recent advances in phototherapeutic nanosystems for oral cancer

Qingqing Pan, Haofu Tang, Li Xie, Huang Zhu, Di Wu, Rong Liu, Bin He and Yuji Pu

J. Mater. Chem. B, 2024, 12, 11560
DOI: 10.1039/D4TB01919A

Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Xin-Xin Lu, Chun Xue, Jian-Hui Dong, Yi-Zhou Zhang and Fan Gao

J. Mater. Chem. B, 2024, 12, 3209
DOI: 10.1039/D4TB00008K

Application of metal–organic framework-based reactive oxygen species therapy in cancer

Heshi Liu, Xue Wang, Pai Wang, Hongtao Liu, Quan Wang, Caina Xu and Huayu Tian

Biomater. Sci., 2025
DOI: 10.1039/D5BM00791G

Development of nanozymes for promising alleviation of COVID-19-associated arthritis

Dan Li, Baofeng Zhao, Pengfei Zhuang and Xifan Mei

Biomater. Sci., 2023, 11, 5781
DOI: 10.1039/D3BM00095H

Preparation of a high-efficiency low-toxicity CdS/C60 bactericide and investigation of the mechanism

Xiufang Wei, Yao Zhao, Shaohua Zeng, Wangyan Nie, Yifeng Zhou, Ying Xu and Pengpeng Chen

J. Mater. Chem. B, 2023, 11, 6383
DOI: 10.1039/D3TB00597F

Glutathione-sensitive mesoporous nanoparticles loaded with cinnamaldehyde for chemodynamic and immunological therapy of cancer

Lichong Zhu, Wenyue Li, Chuang Liu, Saisai Yue, Yuanyuan Qiao, Yingying Cui, Junwei Cheng, Ming Zhang, Peisen Zhang, Beibei Zhang and Yi Hou

J. Mater. Chem. B, 2023, 11, 8717
DOI: 10.1039/D3TB01094E

Exploring novel strategies to improve anti-tumour efficiency: The potential for targeting reactive oxygen species

Rumbidzai Sharon Chasara, Taiwo Oreoluwa Ajayi, Dineo Motjoadi Leshilo, Madan Sai Poka and Bwalya Angel Witika

Heliyon, 2023, 9, e19896
DOI: 10.1016/j.heliyon.2023.e19896

Antioxidant Properties of Lippia alba Essential Oil: A Potential Treatment for Oxidative Stress-Related Conditions in Plants and Cancer Cells

Ilaria Borromeo, Anastasia De Luca, Fabio Domenici, Cristiano Giordani, Luisa Rossi and Cinzia Forni

IJMS, 2024, 25, 8276
DOI: 10.3390/ijms25158276

Effect of salt stress on different tiller positions in rice and the regulatory effect of prohexadione calcium

Rongjun Zhang, Dianfeng Zheng, Naijie Feng, Linfeng Linfeng, Jinning Ma, Xiayi Yuan, Junyu Huang and Lisha Huang

PeerJ, 2024, 12, e18357
DOI: 10.7717/peerj.18357

Copper‐Based Bio‐Coordination Nanoparticle for Enhanced Pyroptosis‐Cuproptosis Cancer Immunotherapy through Redox Modulation and Glycolysis Inhibition

Ju‐E Cun, Ziyun He, Xi Fan, Qingqing Pan, Kui Luo, Bin He and Yuji Pu

Small, 2025, 21
DOI: 10.1002/smll.202409875

Nano-enabled colorectal cancer therapy

Qingqing Pan, Xi Fan, Li Xie, Di Wu, Rong Liu, Wenxia Gao, Kui Luo, Bin He and Yuji Pu

Journal of Controlled Release, 2023, 362, 548
DOI: 10.1016/j.jconrel.2023.09.014

Prussian blue nanoparticles coated with tumor cell membranes for precise photothermal therapy and subsequent inflammation reduction

Hairong Zou, Hui Wang, Yu Zhong, Zhijun Zhang, Zhigang Wang and Tingting Shang

Biochemical and Biophysical Research Communications, 2024, 723, 150173
DOI: 10.1016/j.bbrc.2024.150173

Evaluation of Environmental Radiation Exposure and Algorithms for Determining the Occupational Effective Dose During 99mTc-MDP Bone Scintigraphy: A Comprehensive Analysis

Suphalak Khamruang Marshall, Awatif Hayeeabdunromae, Nadia Noomad, Wanita Durawee, Nantakorn Sirieak, Pornchanok Karnkorn and Virunyupa Keawtong

Applied Sciences, 2024, 14, 11211
DOI: 10.3390/app142311211

Aptamer-Modified Zinc Ferrite Nanoparticles for Autophagy-Mediated Chemotherapy and MR Imaging of Ovarian Cancer

Jinli Zhu, Yi Hu, Chen Yang, Fenfen Li, Bin Yang, Rou Li, Bensheng Qiu, Yaying Li and Lin Liu

ACS Appl. Nano Mater., 2024, 7, 1055
DOI: 10.1021/acsanm.3c05036

A Comprehensive Study of Reactive Oxygen Species Explicit Dosimetry for Pleural Photodynamic Therapy

Hongjing Sun, Yihong Ong, Michele M. Kim, Andreea Dimofte, Sunil Singhal, Keith A. Cengel, Arjun G. Yodh and Timothy C. Zhu

Antioxidants, 2024, 13, 1436
DOI: 10.3390/antiox13121436

Biopiezoelectric-based nanomaterials; a promising strategy in cancer therapy

Tingting Zuo, Saikat Dewanjee, Chao Zhang, Pratik Chakraborty, Wanxia Lu, Niraj Kumar Jha, Hiranmoy Bhattacharya, Moumita Gangopadhyay, Joshua Fleishman, Saurabh Kumar Jha and Zhe-Sheng Chen

J Exp Clin Cancer Res, 2025, 44
DOI: 10.1186/s13046-025-03427-2

Release of biologically relevant substrates from prodrugs and nanocarriers using X- and γ-rays as trigger signals

Amit Kumar and Peter István Dalko

Comptes Rendus. Chimie, 2025, 26, 139
DOI: 10.5802/crchim.309

Copper(I) Complexes With Phenanthroline‐Functionalized NHC Ligands Achieve Effective Anticancer Activity via Mitochondrial and Endoplasmic Reticulum Stress

Chao Chen, Yilun Zheng, Hong Rao, Fan Huang, Chao Shen and Chunxin Lu

Applied Organom Chemis, 2025, 39
DOI: 10.1002/aoc.7756

pH- and redox-sensitive selenium-incorporated mesoporous silica nanoparticles for osteosarcoma-targeted treatment

L. He, Z. Javid Anbardan, P. Habibovic and S. van Rijt

Materials & Design, 2025, 253, 113883
DOI: 10.1016/j.matdes.2025.113883

Responsive biomaterials for tumor sensing and therapy

Ge Wang, HuiFeng Chen, Yafu Wang, Na Chen, Shikuo Fu, Xuexia Chen, Xiaoli Wang, Tianjun Ni, Kui Wang and Hua Zhang

Coordination Chemistry Reviews, 2025, 541, 216821
DOI: 10.1016/j.ccr.2025.216821

Biomimetic nanoplatform with anti-inflammation and neuroprotective effects for repairing spinal cord injury in mice

Xuechen Yin, Sen Lin, Ying Xiong, Peng Zhang and Xifan Mei

Materials Today Bio, 2023, 23, 100836
DOI: 10.1016/j.mtbio.2023.100836

Oxygen Nanobubbles Enhance ICG/Fe(III)-Mediated Dual-Modal Therapy To Induce Ferroptosis in Tumor Treatment

Li Yang, Wei-Hua Zhang, Yan Li, Yan-Li An, Ye-Ming Wu, Ning Gu and Gao-Jun Teng

ACS Appl. Mater. Interfaces, 2025, 17, 11718
DOI: 10.1021/acsami.4c19604

The synergistic potential of ultrasound and nanomaterials for enhanced diagnosis and therapy of head and neck cancers

Hua Wang, Yuankun Gao, Dawei Wang and Yulei Wan

Nanomedicine, 2025, 20, 1971
DOI: 10.1080/17435889.2025.2528593

Reactive oxygen species-sensitive chondroitin sulfate A-cholesteryl hemisuccinate micelles for targeted doxorubicin delivery in tumor therapy

Jingmou Yu, Qinglan Yuan, Chuan Li, Sile Hong, Yuting Li, Yafen Li, Jing Ren, Dengzhao Jiang, Pu Chen and Lei Zhang

Journal of Drug Delivery Science and Technology, 2024, 96, 105690
DOI: 10.1016/j.jddst.2024.105690

Tumor microenvironment responsive nanozymes for multimodal imaging of tumors

Heng Wang, Wenrui Ouyang and Hongxing Liu

Nano TransMed, 2024, 3, 100032
DOI: 10.1016/j.ntm.2024.100032

Reactive oxygen species in colorectal cancer adjuvant therapies

Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang and Hai-Ning Chen

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2024, 1870, 166922
DOI: 10.1016/j.bbadis.2023.166922

Molecular insights to in vitro biocompatibility of endodontic Pulpotec with macrophages determined by oxidative stress and apoptosis

Ankita Mohanty, Swadheena Patro, Ealisha Jha, Paritosh Patel, Aditya Nandi, Adrija Sinha, Shaikh Sheeran Naser, Antarikshya Das, Pritam Kumar Panda, Prabhat Kumar Rout, Richa Mishra, Nagendra Kumar Kaushik, Deobrat Singh, Mrutyunjay Suar and Suresh K. Verma

Biomedicine & Pharmacotherapy, 2024, 176, 116921
DOI: 10.1016/j.biopha.2024.116921

Prussian blue analogues improves the microenvironment after spinal cord injury by regulating Zn

Jinpeng Gao, ShuRui Chen, Sen Lin and Xifan Mei

International Immunopharmacology, 2024, 131, 111868
DOI: 10.1016/j.intimp.2024.111868

Photoimmunotherapy for cancer treatment based on organic small molecules: Recent strategies and future directions

Deming Zhao, Xin Wen, Jiani Wu and Feihong Chen

Translational Oncology, 2024, 49, 102086
DOI: 10.1016/j.tranon.2024.102086

Ultrasound-driven self-decomposition porphyrins as metal-free CO precursors for gas and sonodynamic synergistic therapy

Shuxin Liu, Jinjuan Ma, Xiang Xu, Aiguo Wang and Nan Zheng

Sci. China Chem., 2024, 67, 1624
DOI: 10.1007/s11426-023-1917-8

Redox Signaling Modulates Activity of Immune Checkpoint Inhibitors in Cancer Patients

Alessandro Allegra, Giuseppe Murdaca, Giuseppe Mirabile and Sebastiano Gangemi

Biomedicines, 2023, 11, 1325
DOI: 10.3390/biomedicines11051325

ROS-responsive PEGylated ferrocene polymer nanoparticles with improved stability for tumor-selective chemotherapy and imaging

Hyeryeon Oh, Eunjin Jeong, Jin Sil Lee, Jisu Kim, Donghyun Lee, Byoung Soo Kim, Daekyung Sung, Heebeom Koo, Won Il Choi and Giyoong Tae

Materials Today Bio, 2023, 22, 100774
DOI: 10.1016/j.mtbio.2023.100774

CO-delivery of paclitaxel and indocyanine green with Koliphore-elp35/folic acid nanoparticles for NIR-triggered chemo/photodynamic therapy in MCF-7 and MCF-10 cells

Nawroz Ismael Hassan, Twana Ahmad Mustafa and Yousif Mawlood Hassan

Journal of Radiation Research and Applied Sciences, 2024, 17, 101086
DOI: 10.1016/j.jrras.2024.101086

Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation

Jeong-Hoon Jang, Do-Hee Kim and Kyung-Soo Chun

Arch. Pharm. Res., 2025, 48, 115
DOI: 10.1007/s12272-025-01532-6

Cinnamaldehyde-Based ROS-Responsive Polymeric Gene Vectors for Efficient Gene Delivery and Tumor Cell Growth Inhibition

Qin-Fang Zhang, Rui-Mo Zhao, Yu Lei, Xiao-Li Tian, Yue Hu, Lan Zhang and Ji Zhang

Biomacromolecules, 2025, 26, 1362
DOI: 10.1021/acs.biomac.4c01731

Ultrathin high-entropy hydrotalcites-based injectable hydrogel with programmed bactericidal and anti-inflammatory effects to accelerate drug-resistant bacterial infected wound healing

Mingming Zhang, Huaping Jia, Liang Zhuang, Yongjie Xu, Ting Zhang, Jianwen Gu, Shan He and Dawei Li

Colloids and Surfaces B: Biointerfaces, 2025, 247, 114450
DOI: 10.1016/j.colsurfb.2024.114450

Navigating the brain: Harnessing endogenous cellular hitchhiking for targeting neoplastic and neuroinflammatory diseases

Suraj S. Wagh, Paras Famta, Saurabh Shah, Ganesh Vambhurkar, Giriraj Pandey, Anupama Sikder, Gurpreet Singh, Shalini Shukla, Abhishek Sharma, Sajja Bhanu Prasad, Akshay Shinde, Rahul Kumar, Nitin Pal Kalia, Rajeev Singh Raghuvanshi and Saurabh Srivastava

Asian Journal of Pharmaceutical Sciences, 2025, 20, 101040
DOI: 10.1016/j.ajps.2025.101040

Multicolor Hair Dyeing with Biocompatible Dark Polyphenol Complex-Integrated Shampoo with Reactive Oxygen Species Scavenging Activity

Tae Min Kim, Hyun Jeong Won, Jun-Ho Yang, Hayeon Jo, A Hyeon Kim, Dohyun Nam, Seul Gi Kim, Eun-Jung Jin, Heung Jin Bae and Sung Young Park

Biomimetics, 2023, 8, 469
DOI: 10.3390/biomimetics8060469

Nanozyme-mediated glutathione depletion for enhanced ROS-based cancer therapies: a comprehensive review

Xinyu Wang, Nan Wei, Yang Zhang, Yuan Fang, Yijun Li, Songguo Li, Zhanggui Wang and Chenglong Sun

Nanomedicine, 2025, 20, 279
DOI: 10.1080/17435889.2024.2446138

Preparation, Characterization, and Anticancer Activity Assessment of Chitosan/TPP Nanoparticles Loaded with Echis carinatus Venom

Maral Mahboubi Kancha, Mohsen Mehrabi, Fatemeh Sadat Bitaraf, Hamid Vahedi, Morteza Alizadeh and Andreas Bernkop-Schnürch

ACAMC, 2024, 24, 533
DOI: 10.2174/0118715206279731231129105221

Immunomodulatory effects of Triphala and its constituents in oral squamous cell carcinoma and oral precancer

Thayalan Dineshkumar, Nirmala Anandan, Krishnan Rajkumar and Indumathi Nandhakumar

Journal of Oral and Maxillofacial Pathology, 2024, 28, 657
DOI: 10.4103/jomfp.jomfp_53_24

A Comprehensive Review of Inorganic Sonosensitizers for Sonodynamic Therapy

Peng Chen, Ping Zhang, Navid Hussain Shah, Yanyan Cui and Yaling Wang

IJMS, 2023, 24, 12001
DOI: 10.3390/ijms241512001

Nanozyme-based cancer theranostics: A scientometric analysis and comprehensive review

Yang Xing, Feroza Yasinjan, Shuhao Sun, Jiaying Yang, Yajie Du, Haotian Zhang, Yueyang Liang, Huayue Geng, Yingtong Wang, Jicheng Sun, Zihang Yu, Dhan V. Kalvakolanu, Wei Jiang, Ling Zhang, Kelong Fan and Baofeng Guo

Nano Today, 2024, 57, 102386
DOI: 10.1016/j.nantod.2024.102386

A universal strategy of imparting metal elements into covalent organic frameworks for enhanced tumour therapy

Tianhang Feng, Jing Shi, Tao Wang, Xiangyu Lu, Chen Fan, Kaixi Shang and Guidong Gong

Inorganic Chemistry Communications, 2024, 168, 112942
DOI: 10.1016/j.inoche.2024.112942

Tumor Microenvironment-Sensitive Ca2+ Nanomodulator Combined with the Sonodynamic Process for Enhanced Cancer Therapy

Hailing Yu, Yongquan Huang, Zeyu Cai, Kaichen Huang, Ting Yu, Huimin Lan, Qianqian Zhang, Lili Wu and Hui Luo

ACS Appl. Mater. Interfaces, 2024, 16, 8275
DOI: 10.1021/acsami.3c14865

Simple preparation and high activity for cancer therapy via Zr(IO3)4 nanozyme

Jiayin Li, Runze Liu, Pengfei Liu and Hu Zhou

Journal of Molecular Structure, 2024, 1297, 136948
DOI: 10.1016/j.molstruc.2023.136948

Exploring the Antimicrobial and Antitumoral Activities of Naphthoquinone-Grafted Chitosans

Fernanda Petzold Pauli, Cyntia Silva Freitas, Patricia Ribeiro Pereira, Alviclér Magalhães, Fernando de Carvalho da Silva, Vania M. F. Paschoalin and Vitor Francisco Ferreira

Polymers, 2023, 15, 1430
DOI: 10.3390/polym15061430

Self-Assembled Drug Nanocomplexes Reverses Tumor Thermoresistance and Depletes GSH to Optimize Mild Photothermal Therapy for Osteosarcoma

Chi Zhang, Tao Ding, Tangbing Xu, Jun Chang, Yunfeng Wu, Yong Liu, Fei Huang, Xiaoyan He and Yong Hu

ACS Appl. Nano Mater., 2025, 8, 13475
DOI: 10.1021/acsanm.5c02257

Smart Nanoplatforms Responding to the Tumor Microenvironment for Precise Drug Delivery in Cancer Therapy

Yujie Wang, Tingting Deng, Xi Liu, Xueyang Fang, Yongpan Mo, Ni Xie, Guohui Nie, Bin Zhang and Xiaoqin Fan

IJN, 2024, Volume 19, 6253
DOI: 10.2147/IJN.S459710

UPLC‐ESI‐QTOF‐MS/MS Profiling, Antioxidant, and Cytotoxicity Potentials of Marrubium vulgare L. Extracts: Experimental Analysis and Computational Validation

Ines El Mannoubi, Nuha M. Alghamdi, Seham H. Bashir, Suada Alsaied Mohamed, Hedia Chaabane, Ashraf N. Abdalla, Majdi Abid, Adel Kadri and Mozaniel Santana de Oliveira

Chemistry & Biodiversity, 2025
DOI: 10.1002/cbdv.202500400

Acid-Resistant Nano-antioxidants Based on Epigallocatechin Gallate Alleviate Acute Intestinal and Kidney Inflammation

Qingqing Pan, Li Xie, Pingyang Cai, Di Wu, Huang Zhu, Long Xu, Rong Liu, Kui Luo, Bin He and Yuji Pu

ACS Appl. Mater. Interfaces, 2024, 16, 46090
DOI: 10.1021/acsami.4c09901

Micro/Nano-Structure Control and Hydrogen Sulfide Gas Sensitivity Mechanism Based on Indium Oxide

Xiaohua Wang, Yanwei Li and Guang Sun

Journal of Nanoelectronics and Optoelectronics, 2025, 20, 239
DOI: 10.1166/jno.2025.3708

Coordinating effect of ferroptosis and in situ disulfiram toxification for enhanced cancer therapy

Xiangyu Meng, Jiayi Wu, Zunfu Hu, Xiuwen Zheng and Zhifei Wang

Chemical Engineering Journal, 2024, 484, 149313
DOI: 10.1016/j.cej.2024.149313

Laser spectroscopy imaging technique coupled with nanomaterials for cancer diagnosis: A review

Zhengying Peng, Pengkun Yin, Dan Li, Youyuan Chen, Kaiqiang Shu, Qingwen Fan, Yixiang Duan and Qingyu Lin

J. Innov. Opt. Health Sci., 2024, 17
DOI: 10.1142/S1793545823300082

Fabrication of lactoferrin-chitosan-etoposide nanoparticles with melatonin via carbodiimide coupling: In-vitro & in-vivo evaluation for colon cancer

Harshvardhan Raval, Sankha Bhattacharya, Darshan Bhirud, Preeti Chidambar Sangave, Girdhari Lal Gupta, Gaurav Paraskar, Megha Jha, Satyam Sharma, Sateesh Belemkar, Devendra Kumar and Rahul Maheshwari

Journal of Controlled Release, 2025, 377, 810
DOI: 10.1016/j.jconrel.2024.11.077