Addressing Challenges of Macrocyclic Conformational Sampling in Polar and Apolar Solvents: Lessons for Chameleonicity

Xuechen Tang, Janik Kokot, Franz Waibl, Monica L. Fernández-Quintero, Anna S. Kamenik and Klaus R. Liedl

J. Chem. Inf. Model., 2023, 63, 7107
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Making, Using, and Understanding Molecular Systems: The 57th Bürgenstock Conference

Martina Letizia Contente and Oliver Dumele

Angew Chem Int Ed, 2024, 63
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Insights on Structure–Passive Permeability Relationship in Pyrrole and Furan-Containing Macrocycles

Huy M. Ly, Michael Desgagné, Duc Tai Nguyen, Christian Comeau, Ulrike Froehlich, Éric Marsault and Pierre-Luc Boudreault

J. Med. Chem., 2024, 67, 3711
DOI: 10.1021/acs.jmedchem.3c02162

Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation

Justin H. Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F. T. Koehler, Christian N. Cunningham and R. Scott Lokey

J. Am. Chem. Soc., 2024, 146, 4582
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Development and Challenges of Cyclic Peptides for Immunomodulation

Xianqiong Jiang, Li Gao, Zhilong Li, Yan Shen and Zhi-Hua Lin

CPPS, 2024, 25, 353
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Getting bifunctional molecules into cells

R. Scott Lokey and Cameron Pye

Science, 2022, 378, 1054
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Molekulare Systeme herstellen, nutzen und verstehen: Die 57. Bürgenstock Konferenz

Martina Letizia Contente and Oliver Dumele

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202413732

Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes

Stephanie M. Linker, Christian Schellhaas, Anna S. Kamenik, Mac M. Veldhuizen, Franz Waibl, Hans-Jörg Roth, Marianne Fouché, Stephane Rodde and Sereina Riniker

J. Med. Chem., 2023, 66, 2773
DOI: 10.1021/acs.jmedchem.2c01837

Molecular chameleons in drug discovery

Vasanthanathan Poongavanam, Lianne H. E. Wieske, Stefan Peintner, Máté Erdélyi and Jan Kihlberg

Nat Rev Chem, 2023, 8, 45
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Conformational Effects on the Passive Membrane Permeability of Synthetic Macrocycles

Anna A. Rzepiela, Lauren A. Viarengo-Baker, Victor Tatarskii, Roman Kombarov and Adrian Whitty

J. Med. Chem., 2022, 65, 10300
DOI: 10.1021/acs.jmedchem.1c02090

From lead to market: chemical approaches to transform peptides into therapeutics

Caitlin L. Gare, Andrew M. White and Lara R. Malins

Trends in Biochemical Sciences, 2025
DOI: 10.1016/j.tibs.2025.01.009