Ivan A. Volodin, Katrin Wulf, Felix Tzschoeckell, Steffi Stumpf, Stephanie Hoeppener, Nicole Fritz, Cristina F. Morales-Reyes, Thomas Wichard, Nico Ueberschaar, Christian Stolze, Martin D. Hager and Ulrich S. Schubert

J. Mater. Chem. A, 2024, 12, 4806
DOI: 10.1039/D3TA05809C

Electrostatic interactions drive phase separation in Pup protein

Narendran Sekar, Pushpkant Sahu, Swathi Sudhakar and Hema Chandra Kotamarthi

Chem. Commun., 2024, 60, 14980
DOI: 10.1039/D4CC04264F

The desalting/salting pathway: a route to form metastable aggregates with tuneable morphologies and lifetimes

Sumit Mehan, Laure Herrmann, Jean-Paul Chapel, Jacques Jestin, Jean-Francois Berret and Fabrice Cousin

Soft Matter, 2021, 17, 8496
DOI: 10.1039/D1SM00260K

A platform for the formation of uniform DNA condensate droplets using vibration-induced local vortices

Zhitai Huang, Kanji Kaneko, Ryotaro Yoneyama, Tomoya Maruyama, Takeshi Hayakawa, Masahiro Takinoue and Hiroaki Suzuki

Mater. Horiz., 2026, 13, 1777
DOI: 10.1039/D5MH01304F

Organocatalytic peptide coacervates as microreactors for aqueous aldol additions

Zhen Dai, Malcolm Meyn and Lucas Caire da Silva

Chem. Commun., 2026, 62, 2264
DOI: 10.1039/D5CC06002H

Probing the hierarchical dynamics of DNA-sperm nuclear transition protein complexes through fuzzy interaction and mesoscale condensation

Shangqiang Xie, Congran Yue, Sheng Ye and Zhenlu Li

Phys. Chem. Chem. Phys., 2024, 26, 10408
DOI: 10.1039/D3CP05957J

Ionic group-dependent structure of complex coacervate hydrogels formed by ABA triblock copolymers

Seyoung Kim, Jung-Min Kim, Kathleen Wood and Soo-Hyung Choi

Soft Matter, 2022, 18, 4146
DOI: 10.1039/D2SM00255H

Lipidation alters the phase-separation of resilin-like polypeptides

Zhe Zhang, Jingjing Ji, Md. Shahadat Hossain, Briah Bailey, Shikha Nangia and Davoud Mozhdehi

Soft Matter, 2024, 20, 4007
DOI: 10.1039/D4SM00358F

Wetting behavior of polyelectrolyte complex coacervates on solid surfaces

Christopher Balzer, Pengfei Zhang and Zhen-Gang Wang

Soft Matter, 2022, 18, 6326
DOI: 10.1039/D2SM00859A

Design principles for creating synthetic underwater adhesives

Amal Narayanan, Ali Dhinojwala and Abraham Joy

Chem. Soc. Rev., 2021, 50, 13321
DOI: 10.1039/D1CS00316J

The benefit of poor mixing: kinetics of coacervation

Whitney C. Blocher McTigue, Elizabeth Voke, Li-Wei Chang and Sarah L. Perry

Phys. Chem. Chem. Phys., 2020, 22, 20643
DOI: 10.1039/D0CP03224G

Assessing the dynamics of symmetric and asymmetric hyaluronic acid–chitosan complex coacervates

Roshan Akdar Mohamed Yunus, Roos Poelman, Abinaya Arunachalam, Marleen Kamperman and Daniele Parisi

Soft Matter, 2025, 21, 8935
DOI: 10.1039/D5SM00910C

Revealing nanoscale structure and interfaces of protein and polymer condensates via cryo-electron microscopy

Aoon Rizvi, Bruna Favetta, Nora Jaber, Yun-Kyung Lee, Jennifer Jiang, Nehal S. Idris, Benjamin S. Schuster, Wei Dai and Joseph P. Patterson

Nanoscale, 2024, 16, 16706
DOI: 10.1039/D4NR01877J

Interfacial stabilization of aqueous two-phase systems: a review

Caitlyn Fick, Zara Khan and Samanvaya Srivastava

Mater. Adv., 2023, 4, 4665
DOI: 10.1039/D3MA00307H

Temperature-dependent reentrant phase transition of RNA–polycation mixtures

Paul Pullara, Ibraheem Alshareedah and Priya R. Banerjee

Soft Matter, 2022, 18, 1342
DOI: 10.1039/D1SM01557E

Chemical reaction networks based on conjugate additions on β′-substituted Michael acceptors

Benjamin Spitzbarth and Rienk Eelkema

Chem. Commun., 2023, 59, 11174
DOI: 10.1039/D3CC02126B

Assembly of biomimetic microreactors using caged-coacervate droplets

Arjaree Jobdeedamrong, Shoupeng Cao, Iain Harley, Daniel Crespy, Katharina Landfester and Lucas Caire da Silva

Nanoscale, 2023, 15, 2561
DOI: 10.1039/D2NR05101J

Rheology and tribology of chitosan/Acacia gum complex coacervates

Amal El Abbadi and Philipp Erni

Soft Matter, 2022, 18, 7804
DOI: 10.1039/D2SM00881E

Quantitative turbidimetric characterization of stabilized complex coacervate dispersions

Advait Holkar, Shang Gao, Kathleen Villaseñor, Michael Lake and Samanvaya Srivastava

Soft Matter, 2024, 20, 5060
DOI: 10.1039/D3SM01761C

The effect of monomer polarizability on the stability and salt partitioning in model coacervates

Zuzanna M. Jedlinska and Robert A. Riggleman

Soft Matter, 2023, 19, 7000
DOI: 10.1039/D3SM00706E

Emerging trends in the dynamics of polyelectrolyte complexes

Suvesh Manoj Lalwani, Chikaodinaka I. Eneh and Jodie L. Lutkenhaus

Phys. Chem. Chem. Phys., 2020, 22, 24157
DOI: 10.1039/D0CP03696J

Theory of self-coacervation in semi-dilute and concentrated zwitterionic polymer solutions

Yury A. Budkov, Petr E. Brandyshev and Nikolai N. Kalikin

Soft Matter, 2023, 19, 3281
DOI: 10.1039/D3SM00140G

A simple simulation model for complex coacervates

Sai Vineeth Bobbili and Scott T. Milner

Soft Matter, 2021, 17, 9181
DOI: 10.1039/D1SM00881A

Adsorption of semiflexible wormlike polymers to a bar and their double-chain complex formation

A. N. Semenov and I. A. Nyrkova

Soft Matter, 2024, 20, 4366
DOI: 10.1039/D4SM00188E

Electrostatic correlation free energy for finite polymer chains

Jacob Horne and Jian Qin

Soft Matter, 2025, 21, 7243
DOI: 10.1039/D5SM00633C

Effect of cosolvents on the phase separation of polyelectrolyte complexes

Yuanchi Ma, Robert J. S. Ivancic, Jan Obrzut, Debra J. Audus and Vivek M. Prabhu

Soft Matter, 2024, 20, 7512
DOI: 10.1039/D4SM00903G

Two-dimensional polymerization-induced electrostatic self-assembly via a C12-polyelectrolyte lamellar template

Kaiwen Yu, Xiyu Wang, Caihui Luo, Ying Cao, Jie Cai, Xinhua Lu and Yuanli Cai

Chem. Commun., 2022, 58, 6793
DOI: 10.1039/D2CC02025D

Bio-inspired anti-swelling amyloid-fiber lysozyme adhesive for rapid wound closure and hemostasis

Tingwu Liu, Zilin Wang, Xu Zhang, Donghua Xu, Qiuyan Yan, Yuanwei Chen and Shifang Luan

Biomater. Sci., 2025, 13, 688
DOI: 10.1039/D4BM01494D

Coacervation of poly-electrolytes in the presence of lipid bilayers: mutual alteration of structure and morphology

Sayantan Mondal and Qiang Cui

Chem. Sci., 2022, 13, 7933
DOI: 10.1039/D2SC02013K

The effects of protein charge patterning on complex coacervation

Nicholas A. Zervoudis and Allie C. Obermeyer

Soft Matter, 2021, 17, 6637
DOI: 10.1039/D1SM00543J

Ubiquity of complex coacervation of DNA and proteins in aqueous solution

Priyanka Kaushik, Pankaj K. Pandey, V. K. Aswal and H. B. Bohidar

Soft Matter, 2020, 16, 9525
DOI: 10.1039/D0SM00543F

Coacervation-driven instant paintable underwater adhesives with tunable optical and electrochromic properties

Qiongyao Peng, Jingsi Chen, Tao Wang, Lu Gong, Xuwen Peng, Meng Wu, Yuhao Ma, Feiyi Wu, Diling Yang, Hao Zhang and Hongbo Zeng

J. Mater. Chem. A, 2021, 9, 12988
DOI: 10.1039/D1TA01658J

ATP mediated stimuli responsive supramolecular assembly

Lakshmi Priya Datta

Soft Matter, 2021, 17, 1178
DOI: 10.1039/D0SM02274H

Can oppositely charged polyelectrolyte stars form a gel? A simulational study

Andrea Tagliabue, Jonas Landsgesell, Massimo Mella and Christian Holm

Soft Matter, 2021, 17, 1574
DOI: 10.1039/D0SM01617A

Formation and properties of liposome-stabilized all-aqueous emulsions based on PEG/dextran, PEG/Ficoll, and PEG/sulfate aqueous biphasic systems

Andrew T. Rowland and Christine D. Keating

Soft Matter, 2021, 17, 3688
DOI: 10.1039/D0SM01849J

pH-Dependent complexation and polyelectrolyte chain conformation of polyzwitterion–polycation coacervates in salted water

Kehua Lin, Benxin Jing and Yingxi Zhu

Soft Matter, 2021, 17, 8937
DOI: 10.1039/D1SM00880C

Polyelectrolyte complex scaffoldings for photocrosslinked hydrogels

Defu Li, Mahsa Ghovvati, Nasim Annabi and Samanvaya Srivastava

Mol. Syst. Des. Eng., 2023, 8, 611
DOI: 10.1039/D2ME00171C

Fuel-driven macromolecular coacervation in complex coacervate core micelles

Reece W. Lewis, Benjamin Klemm, Mariano Macchione and Rienk Eelkema

Chem. Sci., 2022, 13, 4533
DOI: 10.1039/D2SC00805J

Flow-driven pattern formation during coacervation of xanthan gum with a cationic surfactant

Y. Stergiou, A. Perrakis, A. De Wit and K. Schwarzenberger

Phys. Chem. Chem. Phys., 2025, 27, 2920
DOI: 10.1039/D4CP01055H

Unravelling the polyethylenimine mediated non-monotonic stability behaviour of silica colloids: the role of competing electrostatic and entropic interactions

Swati Mehta, Jitendra Bahadur, Debasis Sen, Vinod K. Aswal and Joachim Kohlbrecher

Phys. Chem. Chem. Phys., 2022, 24, 21740
DOI: 10.1039/D2CP02699F

Theory and quantitative assessment of pH-responsive polyzwitterion–polyelectrolyte complexation

Samuel C. Hoover, Khatcher O. Margossian and Murugappan Muthukumar

Soft Matter, 2024, 20, 7199
DOI: 10.1039/D4SM00575A

Structures of cationic and anionic polyelectrolytes in aqueous solutions: the sign effect

Chengjiang Lin, Hao Wei, Hongfei Li and Xiaozheng Duan

Soft Matter, 2022, 18, 1603
DOI: 10.1039/D1SM01700D

Ultra-high molecular weight complex coacervates via polymerization-induced electrostatic self-assembly

Julia Y. Rho, Angie B. Korpusik, Miriam Hoteit, John B. Garrison and Brent S. Sumerlin

Polym. Chem., 2024, 15, 1821
DOI: 10.1039/D4PY00273C

Dendrimicelles with pH-controlled aggregation number of core-dendrimers and stability

Junyou Wang, Liu Lei, Ilja K. Voets, Martien A. Cohen Stuart and Aldrik H. Velders

Soft Matter, 2020, 16, 7893
DOI: 10.1039/D0SM00458H

Liquid–liquid phase separation induced auto-confinement

Aoon Rizvi and Joseph P. Patterson

Soft Matter, 2024, 20, 1978
DOI: 10.1039/D3SM01617J

Linear and ring polypeptides complexed with oppositely charged surfactants: the cohesion of the complexes as revealed in atomistic simulations

Vladislav S. Petrovskii, Stepan I. Zholudev and Igor I. Potemkin

Soft Matter, 2024, 20, 388
DOI: 10.1039/D3SM01247F

High-throughput microscopy to determine morphology, microrheology, and phase boundaries applied to phase separating coacervates

Yimin Luo, Mengyang Gu, Chelsea E. R. Edwards, Megan T. Valentine and Matthew E. Helgeson

Soft Matter, 2022, 18, 3063
DOI: 10.1039/D1SM01763B

Effect of polyampholyte net charge on complex coacervation between polyampholytes and inorganic polyoxometalate giant anions

Manuela Ferreira, Benxin Jing, Adrian Lorenzana and Yingxi Zhu

Soft Matter, 2020, 16, 10280
DOI: 10.1039/D0SM01565B

Complex coacervate tissue adhesives: effect of polycation chemistry and ionic strength on cytocompatibility

Ayla N. Kwant, Julien S. Es Sayed, Peter Dijkstra, Janette K. Burgess, Dirk-Jan Slebos, Marleen Kamperman and Simon D. Pouwels

J Mater Sci: Mater Med, 2026, 37
DOI: 10.1007/s10856-025-06994-0

In situ generated hemostatic adhesives: From mechanisms of action to recent advances and applications

Luís P.G. Monteiro, João M.M. Rodrigues and João F. Mano

Biomaterials Advances, 2023, 155, 213670
DOI: 10.1016/j.bioadv.2023.213670

Delivery and controlled release abilities of chitosan/carboxymethylcellulose micropolyelectrolyte complexes (PECs) toward niacinamide (vitamin B3)

Danielle Cristine Mota Ferreira, Carolina Serra Rodrigues, Jane Sélia dos Reis Coimbra and Eduardo Basílio de Oliveira

International Journal of Biological Macromolecules, 2024, 283, 137848
DOI: 10.1016/j.ijbiomac.2024.137848

Ion Pairing and the Structure of Gel Coacervates

Scott P. O. Danielsen, Sergey Panyukov and Michael Rubinstein

Macromolecules, 2020, 53, 9420
DOI: 10.1021/acs.macromol.0c01360

Phase Transitions in Chemically Fueled, Multiphase Complex Coacervate Droplets

Carsten Donau, Fabian Späth, Michele Stasi, Alexander M. Bergmann and Job Boekhoven

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202211905

Unusual Nanostructured Morphologies Enabled by Interpolyelectrolyte Complexation of Polyions Bearing Incompatible Nonionic Segments

Biswajit Saha, Yulia D. Gordievskaya, Priyadarsi De and Elena Yu. Kramarenko

Macromolecules, 2020, 53, 10754
DOI: 10.1021/acs.macromol.0c02230

On the stability and layered organization of protein-DNA condensates

Andrew P. Latham and Bin Zhang

Biophysical Journal, 2022, 121, 1727
DOI: 10.1016/j.bpj.2022.03.028

The Structure and Morphology of Single-Component Oligomeric RNA Delivery Vectors Derived from Amphiphilic Charge-Altering Releasable Transporters

Paul Joshua Hurst, Yuan Jia, Summer Ramsay-Burrough, Rebecca L. McClellan, Joshua T. Arens, Samuel R. Khasnavis, Trevor J. Del Castillo, Mahmoud M. AbdElwakil, Michael J. Lueckheide, Vivek M. Prabhu and Robert M. Waymouth

ACS Nano, 2025, 19, 38954
DOI: 10.1021/acsnano.5c07147

Glucose-Driven Droplet Formation in Complexes of a Supramolecular Peptide and Therapeutic Protein

Sihan Yu, Weike Chen, Guoqiang Liu, Belen Flores, Emily L. DeWolf, Bowen Fan, Yuanhui Xiang and Matthew J. Webber

J. Am. Chem. Soc., 2024, 146, 7498
DOI: 10.1021/jacs.3c13139

Chemically reactive and aging macromolecular mixtures. I. Phase diagrams, spinodals, and gelation

Ruoyao Zhang, Sheng Mao and Mikko P. Haataja

The Journal of Chemical Physics, 2024, 160
DOI: 10.1063/5.0196793

Research progress on temperature-controlled release microcapsules

Min Sun, Xuan Zhang, Ni An, Yaxuan Zhao, Yuhuan Chen, Jing Fang and Fang Yang

Macromol. Res., 2025, 33, 1271
DOI: 10.1007/s13233-025-00423-5

Interplay of distinct modes of charge regulation on poly-acid ionization and conformation

Souradeep Ghosh, Aritra Chowdhury, Dylan T. Tomares, Benjamin Schuler, Arindam Kundagrami and Rohit V. Pappu

The Journal of Chemical Physics, 2025, 163
DOI: 10.1063/5.0297651

Small Amphiphile‐Based Coacervation

Xiao Xiao, Liyan Jia, Jianbin Huang, Yiyang Lin and Yan Qiao

Chemistry An Asian Journal, 2022, 17
DOI: 10.1002/asia.202200938

Brittle-to-Ductile Transitions of Polyelectrolyte Complexes: Humidity, Temperature, and Salt

Isaac A. Ramírez Marrero, Nadine Kaiser, Bernhard von Vacano, Rupert Konradi, Alfred J. Crosby and Sarah L. Perry

Macromolecules, 2025, 58, 2925
DOI: 10.1021/acs.macromol.4c02819

Low-frequency elastic plateau in linear viscoelasticity of polyelectrolyte coacervates

Huiling Li, Ying Liu, Abhishek Shetty and Ronald G. Larson

Journal of Rheology, 2022, 66, 1067
DOI: 10.1122/8.0000488

Conjugated Polyelectrolyte‐Based Complex Fluids as Aqueous Exciton Transport Networks

Anna R. Johnston, Eris D. Minckler, Mia C. J. Shockley, Levi N. Matsushima, Sarah L. Perry and Alexander L. Ayzner

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202117759

Super Gas Barrier of a Polyelectrolyte/Clay Coacervate Thin Film

Hsu‐Cheng Chiang, Thomas J. Kolibaba, Bailey Eberle and Jaime C. Grunlan

Macromol. Rapid Commun., 2021, 42
DOI: 10.1002/marc.202000540

Heteroprotein complex coacervation: Focus on experimental strategies to investigate structure formation as a function of intrinsic and external physicochemical parameters for food applications

Jiabao Zheng, Chuan-he Tang and Weizheng Sun

Advances in Colloid and Interface Science, 2020, 284, 102268
DOI: 10.1016/j.cis.2020.102268

Freeze-enabled synthesis of functional materials: fundamental, progress, and applications

Yunfeng Bai and Haifei Zhang

Progress in Materials Science, 2026, 155, 101523
DOI: 10.1016/j.pmatsci.2025.101523

Macromolecular Crowding Effect on Chitosan-Hyaluronic Acid Complexation and the Activity of Encapsulated Catalase

Xiatong Ou, Ziyao Tang, Yanqi Ye, Xiaochao Chen and Yan Huang

Biomacromolecules, 2024, 25, 3840
DOI: 10.1021/acs.biomac.4c00445

Small‐Molecule‐based Supramolecular Plastics Mediated by Liquid‐Liquid Phase Separation**

Jingjing Yu, Dawei Qi, Ermei Mäkilä, Lippo Lassila, Anastassios C. Papageorgiou, Markus Peurla, Jessica M. Rosenholm, Zhao Zhao, Pekka Vallittu, Sirpa Jalkanen, Chunman Jia and Jianwei Li

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202204611

Structure and Dynamics of Hybrid Colloid–Polyelectrolyte Coacervates

Artem M. Rumyantsev, Oleg V. Borisov and Juan J. de Pablo

Macromolecules, 2023, 56, 1713
DOI: 10.1021/acs.macromol.2c02464

Coacervation-triggered hierarchically assembled hydrogels with application as surgical sealant

Zhongwei Guo, Zunghang Wei and Wei Sun

Biofabrication, 2023, 15, 035021
DOI: 10.1088/1758-5090/acdc55

Mixing protocols determine liquid–liquid phase separation dynamics in polyelectrolyte complex coacervation

Zongpei Wu, Zhen-Gang Wang and Shensheng Chen

Nat Commun, 2026, 17
DOI: 10.1038/s41467-026-68296-5

Dynamical control enables the formation of demixed biomolecular condensates

Andrew Z. Lin, Kiersten M. Ruff, Furqan Dar, Ameya Jalihal, Matthew R. King, Jared M. Lalmansingh, Ammon E. Posey, Nadia A. Erkamp, Ian Seim, Amy S. Gladfelter and Rohit V. Pappu

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-43489-4

Structure and properties of bottlebrush polyelectrolyte complexes

Kaden C. Stevens and Matthew V. Tirrell

Journal of Polymer Science, 2024, 62, 3808
DOI: 10.1002/pol.20230540

Analysis of the Binding of Cytokines to Highly Charged Polymer Networks

Uwe Freudenberg, Passant Atallah, Jens‐Uwe Sommer, Carsten Werner and Matthias Ballauff

Macromolecular Bioscience, 2023, 23
DOI: 10.1002/mabi.202200561

Recent progress in polysaccharide microsphere-based hemostatic material for intravascular and extravascular hemostasis: A review

Fan Leng, Jie Liu, Enfu Du, Sai Lei, Cong Xie, Xulin Jiang and Tong-fei Li

International Journal of Biological Macromolecules, 2025, 300, 140280
DOI: 10.1016/j.ijbiomac.2025.140280

Preparation of Poly(acrylate)/Poly(diallyldimethylammonium) Coacervates without Small Counterions and Their Phase Behavior upon Salt Addition towards Poly-Ions Segregation

Marcos Vinícius Aquino Queirós and Watson Loh

Polymers, 2021, 13, 2259
DOI: 10.3390/polym13142259

A Perspective on the Glass Transition and the Dynamics of Polyelectrolyte Multilayers and Complexes

Hongwei Li, Suvesh Manoj Lalwani, Chikaodinaka I. Eneh, Tamunoemi Braide, Piotr Batys, Maria Sammalkorpi and Jodie L. Lutkenhaus

Langmuir, 2023, 39, 14823
DOI: 10.1021/acs.langmuir.3c00974

Polyelectrolyte Complexes and Coacervates Formed by De novo-Designed Peptides and Oligonucleotide

Tian-Hao Ren and De-Hai Liang

Chin J Polym Sci, 2024, 42, 1333
DOI: 10.1007/s10118-024-3096-6

Molecular insights into the interaction between a disordered protein and a folded RNA

Rishav Mitra, Emery T. Usher, Selin Dedeoğlu, Matthew J. Crotteau, Olivia A. Fraser, Neela H. Yennawar, Varun V. Gadkari, Brandon T. Ruotolo, Alex S. Holehouse, Loïc Salmon, Scott A. Showalter and James C. A. Bardwell

Proc. Natl. Acad. Sci. U.S.A., 2024, 121
DOI: 10.1073/pnas.2409139121

Preparation and characterization of microcapsule acids via interfacial polymerization based on mini-emulsion templates

Jingyi Zhu, Yuzhi Tang, Jie Zhou, Zhaozhong Yang, Jiayu He and Jin Zhang

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2026, 736, 139611
DOI: 10.1016/j.colsurfa.2026.139611

From vesicles to materials: bioinspired strategies for fabricating hierarchically structured soft matter

Esther Amstad and Matthew J. Harrington

Phil. Trans. R. Soc. A., 2021, 379
DOI: 10.1098/rsta.2020.0338

Polylysine‐Based Complex Coacervates as pH‐Responsive Carriers for Doxorubicin Hydrochloride

Pilar A. Haro–Gutiérrez, Jonathan M. Barba–Godínez, Zaira Y. García–Carvajal and Ernesto Tinajero–Díaz

Polymers for Advanced Techs, 2025, 36
DOI: 10.1002/pat.70292

Linear viscoelasticity and time-temperature-salt and other superpositions in polyelectrolyte coacervates

Ronald G. Larson, Ying Liu and Huiling Li

Journal of Rheology, 2021, 65, 77
DOI: 10.1122/8.0000156

Self-Assembling Polypeptides in Complex Coacervation

Arvind Sathyavageeswaran, Júlia Bonesso Sabadini and Sarah L. Perry

Acc. Chem. Res., 2024, 57, 386
DOI: 10.1021/acs.accounts.3c00689

Optimization of Polyelectrolyte Coacervate Membranes via Aqueous Phase Separation

Shao-Hsiang Joe Hung, Meng-Chen Chiang and Jessica D. Schiffman

ACS Appl. Mater. Interfaces, 2025, 17, 1361
DOI: 10.1021/acsami.4c18989

Mixed Ion–Electron-Conducting Polymer Complexes as High-Rate Battery Binders

Gordon Pace, Alexandra Zele, Phong Nguyen, Raphaële J. Clément and Rachel A. Segalman

Chem. Mater., 2023, 35, 8101
DOI: 10.1021/acs.chemmater.3c01587

Dynamic Coupling in Unentangled Liquid Coacervates Formed by Oppositely Charged Polyelectrolytes

Christian Aponte-Rivera and Michael Rubinstein

Macromolecules, 2021, 54, 1783
DOI: 10.1021/acs.macromol.0c01393

Spray-drying of casein/pectin bioconjugate microcapsules containing grape (Vitis labrusca) by-product extract

Jéssica Bassetto Carra, Ricardo Luís Nascimento de Matos, Ana Paula Novelli, Renê Oliveira do Couto, Fabio Yamashita, Marcos Alessandro dos Santos Ribeiro, Eduardo César Meurer, Waldiceu Aparecido Verri, Rubia Casagrande, Sandra Regina Georgetti, Nilton Syogo Arakawa and Marcela Maria Baracat

Food Chemistry, 2022, 368, 130817
DOI: 10.1016/j.foodchem.2021.130817

Bridging Field Theory and Ion Pairing in the Modeling of Polyelectrolytes and Complex Coacervation

Charles E. Sing and Jian Qin

Macromolecules, 2023, 56, 5941
DOI: 10.1021/acs.macromol.3c01020

Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy

Pengchao Zhao, Xianfeng Xia, Xiayi Xu, Kevin Kai Chung Leung, Aliza Rai, Yingrui Deng, Boguang Yang, Huasheng Lai, Xin Peng, Peng Shi, Honglu Zhang, Philip Wai Yan Chiu and Liming Bian

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-27463-6

Saloplastics based on protein-peptides complexes immobilizing organic molecules in gastrointestinal drug delivery for ulcerative colitis treatment

Liang Guo, Ge-Ge Zheng, Rong-Yi Li, Cheng-yu Fu, Jie Chen, Yue-Cheng Meng, Yang Pan and Po Hu

International Journal of Biological Macromolecules, 2024, 281, 136077
DOI: 10.1016/j.ijbiomac.2024.136077

Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions

Mina Farag, Wade M. Borcherds, Anne Bremer, Tanja Mittag and Rohit V. Pappu

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-41274-x

How can we interpret the relationship between liquid-liquid phase separation and amyotrophic lateral sclerosis?

Kohsuke Kanekura and Masahiko Kuroda

Laboratory Investigation, 2022, 102, 912
DOI: 10.1038/s41374-022-00791-x

Lower Critical Solution Temperature-Driven Self-Coacervation of Nonionic Polyester Underwater Adhesives

Amal Narayanan, Joshua R. Menefee, Qianhui Liu, Ali Dhinojwala and Abraham Joy

ACS Nano, 2020, 14, 8359
DOI: 10.1021/acsnano.0c02396

Structure and Dynamics of Hybrid Colloid–Polyelectrolyte Coacervates: Insights from Molecular Simulations

Boyuan Yu, Heyi Liang, Paul F. Nealey, Matthew V. Tirrell, Artem M. Rumyantsev and Juan J. de Pablo

Macromolecules, 2023, 56, 7256
DOI: 10.1021/acs.macromol.3c01079

Poly(glutamic acid)-Based Viscosity Reducers for Concentrated Formulations of a Monoclonal IgG Antibody

Annamaria Lapenna, Camille Dagallier, Sylvain Huille and Christophe Tribet

Mol. Pharmaceutics, 2024, 21, 982
DOI: 10.1021/acs.molpharmaceut.3c01159

Valence-induced jumps in coacervate properties

Mo Yang, Zachary A. Digby, Yuhui Chen and Joseph B. Schlenoff

Sci. Adv., 2022, 8
DOI: 10.1126/sciadv.abm4783

Complex Coacervate Materials as Artificial Cells

Alexander B. Cook, Sebastian Novosedlik and Jan C. M. van Hest

Acc. Mater. Res., 2023, 4, 287
DOI: 10.1021/accountsmr.2c00239

Liquid–liquid crystalline phase separation in biomolecular solutions

Tommaso P. Fraccia and Giuliano Zanchetta

Current Opinion in Colloid & Interface Science, 2021, 56, 101500
DOI: 10.1016/j.cocis.2021.101500

The European Polysaccharide Network of Excellence (EPNOE) research roadmap 2040: Advanced strategies for exploiting the vast potential of polysaccharides as renewable bioresources

Martin Gericke, Adérito J.R. Amaral, Tatiana Budtova, Pieter De Wever, Thomas Groth, Thomas Heinze, Herman Höfte, Anton Huber, Olli Ikkala, Janusz Kapuśniak, Rupert Kargl, João F. Mano, Már Másson, Pietro Matricardi, Bruno Medronho, Magnus Norgren, Tiina Nypelö, Laura Nyström, Anna Roig, Michael Sauer, Henk A. Schols, John van der Linden, Tanja M. Wrodnigg, Chunlin Xu, Gleb E. Yakubov, Karin Stana Kleinschek and Pedro Fardim

Carbohydrate Polymers, 2024, 326, 121633
DOI: 10.1016/j.carbpol.2023.121633

Effects of different carbohydrates as drying aids on the properties of fish oil powders

Wenjie Zhang, Lijia Chen, Qiqi Bian, Zhengquan Wang, Xichang Wang and Jian Zhong

npj Sci Food, 2026
DOI: 10.1038/s41538-026-00857-w

Coacervate-Based Delivery Systems: Bridging Fundamentals and Applications

Mohammad Souri, Wonjun Yim, Moumita Halder, Zhicheng Jin and Jesse V. Jokerst

ACS Appl. Mater. Interfaces, 2025, 17, 41513
DOI: 10.1021/acsami.5c09726

Gelation and Phase Separation in Oppositely Charged Polyelectrolyte Solutions: The Formation of Quadrupoles

Jiyu Chen, Erqiang Chen and Shuang Yang

Macromolecules, 2025, 58, 11418
DOI: 10.1021/acs.macromol.5c01198

Supramolecular Ionic Polymerization: Cellulose-Based Supramolecular Plastics with Broadly Tunable Mechanical Properties

Zhenghong Chen, Yang Hong, Hiroyuki Inuzuka, Kiichi Mizukami and Takuzo Aida

J. Am. Chem. Soc., 2025, 147, 44507
DOI: 10.1021/jacs.5c16680

Covalently Cross-Linked Polyelectrolyte Complex Nanoparticles with Enhanced Stability against Dissociation at High Ionic Strength

Xiongyu Chen, Zhenhe Zhang, Hongxi Zhong, Manazir Ahmed, Golnaz Heydari, Raymond Park, Ethan Keller, Shuchi Liao, Taehyung Park, Mohsen Ahmadian, Linda M. Abriola, Kurt D. Pennell and Keith P. Johnston

Langmuir, 2025, 41, 91
DOI: 10.1021/acs.langmuir.4c02921

Polymer-Rich Dense Phase Can Concentrate Metastable Silica Precursors and Regulate Their Mineralization

Hang Zhai, Yuke Fan, Wenjun Zhang, Neta Varsano and Assaf Gal

ACS Biomater. Sci. Eng., 2023, 9, 601
DOI: 10.1021/acsbiomaterials.2c01249

Sequestration of Small Ions and Weak Acids and Bases by a Polyelectrolyte Complex Studied by Simulation and Experiment

Roman Staňo, Jéré J. van Lente, Saskia Lindhoud and Peter Košovan

Macromolecules, 2024, 57, 1383
DOI: 10.1021/acs.macromol.3c01209

Heat Shielding from Polyelectrolyte/Clay Coacervate Thin Film

Danixa Rodriguez-Melendez, Ethan T. Iverson, Miguel O. Convento, Dallin L. Smith, Natalie A. Vest, Victor Balcorta-Munoz, Matt Pharr and Jaime C. Grunlan

ACS Appl. Eng. Mater., 2025, 3, 894
DOI: 10.1021/acsaenm.5c00023

Sequence Sensitivity in Membrane Remodeling by Polyampholyte Condensates

Sayantan Mondal and Qiang Cui

J. Phys. Chem. B, 2024, 128, 2087
DOI: 10.1021/acs.jpcb.3c08149

Fundamentals and Design Rules of Polyelectrolyte Complex Materials: A Comprehensive Review

Isaac A. Ramírez Marrero and Sarah L. Perry

Chem. Rev., 2026
DOI: 10.1021/acs.chemrev.5c00971

Sequence-encoded intermolecular base pairing modulates fluidity in DNA and RNA condensates

Sumit Majumder, Sebastian Coupe, Nikta Fakhri and Ankur Jain

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-59456-0

RNA-peptide interactions tune the ribozyme activity within coacervate microdroplet dispersions

Basusree Ghosh, Patrick M. McCall, Kristian Kyle Le Vay, Archishman Ghosh, Lars Hubatsch, David T. Gonzales, Jan Brugués, Hannes Mutschler and T-Y. Dora Tang

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-63656-z

A Jacobian-free pseudo-arclength continuation method for phase transitions in inhomogeneous thermodynamic systems

Samuel Varner, Christopher Balzer and Zhen-Gang Wang

The Journal of Chemical Physics, 2024, 161
DOI: 10.1063/5.0220849

Reentrant Condensation of Polyelectrolytes Induced by Diluted Multivalent Salts: The Role of Electrostatic Gluonic Effects

Huaisong Yong

Biomacromolecules, 2024, 25, 7361
DOI: 10.1021/acs.biomac.4c01037

Simulation study on the co-polymerization of vinyl acetate between ethylene

Xiuqin Dong, Jiaqi Li, Jie Cheng and Yingzhe Yu

Chemical Engineering Science, 2022, 264, 118170
DOI: 10.1016/j.ces.2022.118170

The spatiotemporal studies of the salt-hardening effect of the coacervates of nano-ions for aqueous super-ionic electrolytes with enhanced electrochemical stability

Binghui Xue, Yuan Liu, Weigang Sun, Yuling Liang and Panchao Yin

Journal of Colloid and Interface Science, 2025, 696, 137898
DOI: 10.1016/j.jcis.2025.137898

Biomolecular Condensates are Characterized by Interphase Electric Potentials

Ammon E. Posey, Anne Bremer, Nadia A. Erkamp, Avnika Pant, Tuomas P. J. Knowles, Yifan Dai, Tanja Mittag and Rohit V. Pappu

J. Am. Chem. Soc., 2024, 146, 28268
DOI: 10.1021/jacs.4c08946

Electrostatically Cross-Linked Reversible Gels—Effects of pH and Ionic Strength

Roman Staňo, Peter Košovan, Andrea Tagliabue and Christian Holm

Macromolecules, 2021, 54, 4769
DOI: 10.1021/acs.macromol.1c00470

Moderated ionic bonding for water-free recyclable polyelectrolyte complex materials

Sophie G. M. van Lange, Diane W. te Brake, Giuseppe Portale, Anbazhagan Palanisamy, Joris Sprakel and Jasper van der Gucht

Sci. Adv., 2024, 10
DOI: 10.1126/sciadv.adi3606

Mathematical modeling of microscale biology: Ion pairing, spatially varying permittivity, and Born energy in glycosaminoglycan brushes

William J. Ceely, Marina Chugunova, Ali Nadim and James D. Sterling

Phys. Rev. E, 2023, 107
DOI: 10.1103/PhysRevE.107.024416

Effect of Polymer Gel Elasticity on Complex Coacervate Phase Behavior

Kathryn G. Wilcox, Kai R. Yamagami, Brittany K. Roopnarine, Adam Linscott and Svetlana Morozova

ACS Polym. Au, 2024, 4, 109
DOI: 10.1021/acspolymersau.3c00027

Influence of Nonstoichiometry on the Viscoelastic Properties of a Polyelectrolyte Complex

Yuhui Chen, Mo Yang, Samir Abou Shaheen and Joseph B. Schlenoff

Macromolecules, 2021, 54, 7890
DOI: 10.1021/acs.macromol.1c01154

Multiphasic Coacervates Assembled by Hydrogen Bonding and Hydrophobic Interactions

Xinhao Liu, Abdol Hadi Mokarizadeh, Amal Narayanan, Prathamesh Mane, Avanti Pandit, Yen-Ming Tseng, Mesfin Tsige and Abraham Joy

J. Am. Chem. Soc., 2023, 145, 23109
DOI: 10.1021/jacs.3c06675

Population-based heteropolymer design to mimic protein mixtures

Zhiyuan Ruan, Shuni Li, Alexandra Grigoropoulos, Hossein Amiri, Shayna L. Hilburg, Haotian Chen, Ivan Jayapurna, Tao Jiang, Zhaoyi Gu, Alfredo Alexander-Katz, Carlos Bustamante, Haiyan Huang and Ting Xu

Nature, 2023, 615, 251
DOI: 10.1038/s41586-022-05675-0

On the nature of screening in Voorn–Overbeek type theories

Sunita Kumari, Shikha Dwivedi and Rudolf Podgornik

The Journal of Chemical Physics, 2022, 156
DOI: 10.1063/5.0091721

The Role of Counterion Size in Defining Star‐Shaped Polyelectrolytes Thermodynamics, Conformations, and Ion Dynamics

Andrea Tagliabue and Massimo Mella

Journal of Polymer Science, 2025, 63, 3005
DOI: 10.1002/pol.20241201

Gel-to-Coacervate Transition in Peptide/HA Complexes for MMP-9-Activated Penetration into Tumor Spheroids

Shi Yang, Xiuli Xu, Meixin Wang, Qingming Ma, Chuanliang Feng, Jianwei Wang, Yage Zhang and Yang Song

ACS Appl. Mater. Interfaces, 2025, 17, 18108
DOI: 10.1021/acsami.4c23089

Regulating Nucleic Acid Catalysis Using Active Droplets

Anna‐Lena Holtmannspötter, Corbin Machatzke, Christian Begemann, Elia Salibi, Carsten Donau, Fabian Späth, Job Boekhoven and Hannes Mutschler

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202412534

Photoswitchable Transport Systems: Mobility With Light

Cassidy M. Tobin, Kseniia M. Karnaukh, Hui Nie and Javier Read de Alaniz

Adv Funct Materials, 2026, 36
DOI: 10.1002/adfm.202521901

Condensation Goes Viral: A Polymer Physics Perspective

Jhullian J. Alston and Andrea Soranno

Journal of Molecular Biology, 2023, 435, 167988
DOI: 10.1016/j.jmb.2023.167988

Exploring the effect of experimental conditions on the synthesis and stability of alginate–gelatin coacervates

Marcos Blanco‐López, Alejandro Marcos‐García, Álvaro González‐Garcinuño, Antonio Tabernero and Eva M. Martín del Valle

Polymers for Advanced Techs, 2024, 35
DOI: 10.1002/pat.6554

Recent progress in microencapsulation technology and its applications in petroleum industry

Jingyi Zhu, Jiayu He, Jie Zhou, Zhaozhong Yang, Xiaogang Li, Ying Li and Zhenjiang You

Journal of Molecular Liquids, 2024, 407, 125162
DOI: 10.1016/j.molliq.2024.125162

Influence of dipolar solvent fluctuations on polyelectrolyte thermodynamics and complex coacervation

Michael Beckinghausen and Andrew J. Spakowitz

The Journal of Chemical Physics, 2025, 163
DOI: 10.1063/5.0289614

Ambient Environment Adaptive Elastomer Constructed by Microphase Separation and Segment Complexation of Triblock Copolymers

Weijie Wang, Caihong Zhang, Hao Huang, Bing Xue and Shuguang Yang

ACS Appl. Mater. Interfaces, 2023, 15, 22426
DOI: 10.1021/acsami.3c02931

Designer Condensates: A Toolkit for the Biomolecular Architect

Renee L. Hastings and Steven Boeynaems

Journal of Molecular Biology, 2021, 433, 166837
DOI: 10.1016/j.jmb.2021.166837

Crosslinking, salt-induced aging, and secondary structure formation in Peptide-containing coacervates inspired by spider silk

Armin Amirsadeghi, Raffaella Parlato, Anna Kenbeek, Ana Rita Gaspar, Marta Oggioni, Alessia Lasorsa, Adrivit Mukherjee, Malak Jaber, Małgorzata K. Włodarczyk-Biegun, Patrick C. A. van der Wel, Marleen Kamperman and Guillermo Monreal Santiago

Commun Chem, 2025, 8
DOI: 10.1038/s42004-025-01634-8

Efficient Synthesis of Stable Polyelectrolyte Complex Nanoparticles by Electrostatic Assembly Directed Polymerization

Peng Ding, Lusha Chen, Cheng Wei, Wenjuan Zhou, Chendan Li, Jiahua Wang, Mingwei Wang, Xuhong Guo, Martien A. Cohen Stuart and Junyou Wang

Macromol. Rapid Commun., 2021, 42
DOI: 10.1002/marc.202000635

Developments in describing equilibrium phase transitions of multivalent associative macromolecules

Xiangze Zeng and Rohit V. Pappu

Current Opinion in Structural Biology, 2023, 79, 102540
DOI: 10.1016/j.sbi.2023.102540

The Effects of Chirality and Salt Addition on Phase Separation and Complexation Morphology in Mixtures of Polypeptides and Polypeptoids

Kimiasadat Mirlohi, Anuja Thapa, Donghui Zhang and Whitney C. Blocher McTigue

Biomacromolecules, 2025, 26, 7646
DOI: 10.1021/acs.biomac.5c01165

Nanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis

Xiaobao Chen, Li Liu, Weidan Wang, Yuan Yuan and Wei Wang

Pharmaceutics, 2025, 17, 76
DOI: 10.3390/pharmaceutics17010076

Conjugated Polyelectrolyte‐Based Complex Fluids as Aqueous Exciton Transport Networks

Anna R. Johnston, Eris D. Minckler, Mia C. J. Shockley, Levi N. Matsushima, Sarah L. Perry and Alexander L. Ayzner

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202117759

Polyethylene-Glycol-Conjugated Peptide Coacervates with Tunable Size for Intracellular mRNA Delivery

Yue Sun, Xi Wu, Kimberle Shen, Ke Guo, Daryl Shern Lim, Wei Leong Chew, Jing Yu and Ali Miserez

ACS Nano, 2025, 19, 24724
DOI: 10.1021/acsnano.4c16908

Nanostructured Multiphase Condensation of Complex Coacervates in Polymerization-Induced Electrostatic Self-Assembly

Chao Li, Ye Wang, Xiyu Wang, Zhanwei Gao, Lei Ma, Xinhua Lu and Yuanli Cai

ACS Macro Lett., 2021, 10, 780
DOI: 10.1021/acsmacrolett.1c00308

Looping-in complexation and ion partitioning in nonstoichiometric polyelectrolyte mixtures

Sean Friedowitz, Junzhe Lou, Kayla Patricia Barker, Karis Will, Yan Xia and Jian Qin

Sci. Adv., 2021, 7
DOI: 10.1126/sciadv.abg8654

Bioinspired Printable Tough Adhesives with In Situ Benignly Triggered Mechanical Enhancements

Zhenwei Ma, Ran Huo, Alexander Nottegar, Christopher Chung‐Tze‐Cheong, Qiman Gao, Xiaoyi Lan, Zu‐hua Gao and Jianyu Li

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202403290

Exploration of Phase Behavior in Asymmetric Semiflexible Polyelectrolyte Mixtures Using Polymer Field Theory

Michael Beckinghausen and Andrew J. Spakowitz

Macromolecules, 2024, 57, 2505
DOI: 10.1021/acs.macromol.3c02197

Highly moisture resistant super gas barrier polyelectrolyte complex thin film

Hsu‐Cheng Chiang, Ethan T. Iverson, Kendra Schmieg, Daniel L. Stevens and Jaime C. Grunlan

J of Applied Polymer Sci, 2023, 140
DOI: 10.1002/app.53473

Theory of Condensate Size Control by Molecular Charge Asymmetry

Chengjie Luo, Nathaniel Hess, Dilimulati Aierken, Yicheng Qiang, Jerelle A. Joseph and David Zwicker

ACS Macro Lett., 2025, 14, 1484
DOI: 10.1021/acsmacrolett.5c00342

Effect of pH and protein to polysaccharide ratio on coacervation of sesame protein isolate-Tragacanth gum: Structure-rheology function

Azade Ghorbani, Ali Rafe, Mohammad Ali Hesarinejad and Jose M. Lorenzo

International Journal of Biological Macromolecules, 2025, 311, 143911
DOI: 10.1016/j.ijbiomac.2025.143911

Coacervate Phase Evolution and Membrane Formation in Natural Seawater

Chongrui Zhang, Huawen Peng, J. Herbert Waite and Qiang Zhao

J. Am. Chem. Soc., 2024, 146, 2219
DOI: 10.1021/jacs.3c12539

Chemical structures of encapsulants and their mechanisms of protection for spray-dried probiotics: a review

Hannah Xu En Lim, Shao Rong Choo and Wean Sin Cheow

Applied Food Research, 2026, 6, 101580
DOI: 10.1016/j.afres.2025.101580

Application of Nanoparticles in the Diagnosis of Gastrointestinal Diseases: A Complete Future Perspective

Ning-ning Yue, Hao-ming Xu, Jing Xu, Min-zheng Zhu, Yuan Zhang, Cheng-Mei Tian, Yu-qiang Nie, Jun Yao, Yu-jie Liang, De-feng Li and Li-sheng Wang

IJN, 2023, Volume 18, 4143
DOI: 10.2147/IJN.S413141

Advances in the Structural Design of Polyelectrolyte Complex Micelles

Alexander E. Marras, Jeffrey M. Ting, Kaden C. Stevens and Matthew V. Tirrell

J. Phys. Chem. B, 2021, 125, 7076
DOI: 10.1021/acs.jpcb.1c01258

Aqueous Processing of Stoichiometric and Nonstoichiometric Materials from Complex Coacervates

Shao-Hsiang Joe Hung and Jessica D. Schiffman

Acc. Mater. Res., 2025, 6, 1410
DOI: 10.1021/accountsmr.5c00173

Protected Poly(3-sulfopropyl methacrylate) Copolymers: Synthesis, Stability, and Orthogonal Deprotection

Anton H. Hofman, Matteo Pedone and Marleen Kamperman

ACS Polym. Au, 2022, 2, 169
DOI: 10.1021/acspolymersau.1c00044

Sodium chloride-programmed phase transition of β-conglycinin/lysozyme electrostatic complexes from amorphous precipitates to complex coacervates

Jiabao Zheng, Qing Gao, Ge Ge, Jihong Wu, Chuan-he Tang, Mouming Zhao and Weizheng Sun

Food Hydrocolloids, 2022, 124, 107247
DOI: 10.1016/j.foodhyd.2021.107247

Perspective on the Processing and Functionalities of Solid-State Polyelectrolyte Complexes

Xufei Liu, Huawen Peng and Qiang Zhao

Macromolecules, 2025, 58, 1755
DOI: 10.1021/acs.macromol.4c02394

Bioinspired coacervate-based bioinks for construction of multiscale tissue engineering scaffolds

Zhongwei Guo, Shiqiang Zhang, Yilin Guo, Jingjing Xia, Xiao Wu, Hao Hu, Rongcheng Hu, Fangli Huang, Qiulei Gao, Chun Liu, Jingjiang Qiu and Wei Sun

Nano Res., 2024, 17, 8209
DOI: 10.1007/s12274-024-6844-6

Chemical specificity in polyzwitterion-polyelectrolyte coacervates: polycations vs polyanions

Jong K. Keum, Panagiotis Christakopoulos, Zening Liu, Tianyu Li, Jihua Chen, Alexis Williams, Dale K. Hensley, Kunlun Hong, Yangyang Wang, Rigoberto Advincula and Rajeev Kumar

European Polymer Journal, 2024, 215, 113177
DOI: 10.1016/j.eurpolymj.2024.113177

Nano and microencapsulation of bacteriocins for food applications: A review

Noushin Eghbal, Christophe Viton and Adem Gharsallaoui

Food Bioscience, 2022, 50, 102173
DOI: 10.1016/j.fbio.2022.102173

Deciphering the Role of π-Interactions in Polyelectrolyte Complexes Using Rationally Designed Peptides

Sara Tabandeh, Cristina Elisabeth Lemus and Lorraine Leon

Polymers, 2021, 13, 2074
DOI: 10.3390/polym13132074

Learning nature’s assembly language with polymers

Oliver Xie, Alexander E. Cohen, Martin Z. Bazant and Bradley D. Olsen

Proc. Natl. Acad. Sci. U.S.A., 2026, 123
DOI: 10.1073/pnas.2519094123

Regulierung von Nukleinsäurekatalyse mit aktiven Koazervaten

Anna‐Lena Holtmannspötter, Corbin Machatzke, Christian Begemann, Elia Salibi, Carsten Donau, Fabian Späth, Job Boekhoven and Hannes Mutschler

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202412534

Coacervation between Two Positively Charged Poly(ionic liquid)s

Chongrui Zhang, Yinmin Cai and Qiang Zhao

Macromol. Rapid Commun., 2022, 43
DOI: 10.1002/marc.202200191

Catechol-Amine-Decorated Epoxy Resin as an Underwater Adhesive: A Coacervate Concept Using a Liquid Marble Strategy

Monisha Baby, Soumyamol Panthaplackal Bhaskaran and Satheesh Chandran Maniyeri

ACS Omega, 2023, 8, 7289
DOI: 10.1021/acsomega.2c04163

Droplet Microfluidics for the Label‐Free Extraction of Complete Phase Diagrams and Kinetics of Liquid–Liquid Phase Separation in Finite Volumes

Alessia Villois, Umberto Capasso Palmiero, Prerit Mathur, Gaia Perone, Timo Schneider, Lunna Li, Matteo Salvalaglio, Andrew deMello, Stavros Stavrakis and Paolo Arosio

Small, 2022, 18
DOI: 10.1002/smll.202202606

Structural regulation of carboxymethyl starch/whey protein isolated coacervate microcapsules for colon-targeted delivery of oleoylethanolamine and promotion of satiety hormones secretion

Haize Su, Yingying Li, Zhibing Zhang and Xiaoxi Li

Food Hydrocolloids, 2025, 169, 111601
DOI: 10.1016/j.foodhyd.2025.111601

Multicompartment Synthetic Vesicles for Artificial Cell Applications

Jooyong Shin and Yeongseon Jang

ACS Appl. Eng. Mater., 2024, 2, 2758
DOI: 10.1021/acsaenm.3c00812

Phase Separation of Oppositely Charged Polymers Regulates Bioinspired Silicification

Hang Zhai, Tatyana Bendikov and Assaf Gal

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202115930

Lysozyme/tripolyphosphate complex coacervates: Properties, curcumin encapsulation and antibacterial activity

Maximiliano L. Agazzi, M. Fernanda Paletti Rovey, Eugenia Apuzzo, Santiago E. Herrera, Mariana B. Spesia, M.de las Mercedes Oliva and Omar Azzaroni

Food Hydrocolloids, 2023, 145, 109134
DOI: 10.1016/j.foodhyd.2023.109134

Interactions between Hyaluronic Acid and Chitosan by Isothermal Titration Calorimetry: The Effect of Ionic Strength, pH, and Polymer Molecular Weight

Fatma Akcay Ogur, Sezin Mamasoglu, Sarah L. Perry, Fatma Ahu Akin and A. Basak Kayitmazer

J. Phys. Chem. B, 2024, 128, 9022
DOI: 10.1021/acs.jpcb.4c03930

Bioinspired Processing: Complex Coacervates as Versatile Inks for 3D Bioprinting

Mohammad Khoonkari, Julien Es Sayed, Marta Oggioni, Armin Amirsadeghi, Peter Dijkstra, Daniele Parisi, Frank Kruyt, Patrick van Rijn, Małgorzata Katarzyna Włodarczyk‐Biegun and Marleen Kamperman

Advanced Materials, 2023, 35
DOI: 10.1002/adma.202210769

Phase Separation of Polyelectrolytes: The Effect of Charge Regulation

Bin Zheng, Yael Avni, David Andelman and Rudolf Podgornik

J. Phys. Chem. B, 2021, 125, 7863
DOI: 10.1021/acs.jpcb.1c01986

Viscoelastic and flow behaviour of β-lactoglobulin/lactoferrin coacervates: Influence of temperature and ionic strength

Rima Hachfi Soussi, Ghazi Ben Messaoud, Florence Rousseau, Pascaline Hamon, Marie-Hélène Famelart and Saïd Bouhallab

International Journal of Biological Macromolecules, 2025, 292, 139121
DOI: 10.1016/j.ijbiomac.2024.139121

Thermoresponsive Complex Coacervates as Advanced Carriers for Cell‐Laden Liquid‐Core Capsules for Biomedical Applications

Luís P. G. Monteiro, Mariana Carreira, Julien Es Sayed, Marleen Kamperman, João M. M. Rodrigues and João Mano

Small, 2026
DOI: 10.1002/smll.202513642

Amyloid-polysaccharide interfacial coacervates as therapeutic materials

Mohammad Peydayesh, Sabrina Kistler, Jiangtao Zhou, Viviane Lutz-Bueno, Francesca Damiani Victorelli, Andréia Bagliotti Meneguin, Larissa Spósito, Tais Maria Bauab, Marlus Chorilli and Raffaele Mezzenga

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-37629-z

Nucleotide-Specific RNA Conformations and Dynamics as Precursors to Ribonucleoprotein Condensates

Tong Wang, Qingyue Hu, Scout Fronhofer and Lois Pollack

J. Am. Chem. Soc., 2025, 147, 36146
DOI: 10.1021/jacs.5c05892

Enhancing Polyelectrolyte Strength of Biopolymers for Fully Recyclable and Biodegradable Plastics

Pamela C. Cai, Vanessa Vaz and Matthew V. Tirrell

ACS Appl. Mater. Interfaces, 2025, 17, 41112
DOI: 10.1021/acsami.5c08313

Effect of Solvent Composition on Non-DLVO Forces and Oriented Attachment of Zinc Oxide Nanoparticles

Lili Liu, Sakshi Yadav Schmid, Zhaojie Feng, Dongsheng Li, Timothy C. Droubay, Peter J. Pauzauskie, Gregory K. Schenter, James J. De Yoreo, Jaehun Chun and Elias Nakouzi

ACS Nano, 2024, 18, 16743
DOI: 10.1021/acsnano.4c01797

Reversible Sequence-Dependent DNA Coacervation with an Azobenzene Intercalator

Yunzhe Li, Julie Pham, Mathieu Morel, Damien Baigl and Sergii Rudiuk

Langmuir, 2025, 41, 33320
DOI: 10.1021/acs.langmuir.5c04489

A Close Look at Molecular Self-Assembly with the Transmission Electron Microscope

Aoon Rizvi, Justin T. Mulvey, Brooke P. Carpenter, Rain Talosig and Joseph P. Patterson

Chem. Rev., 2021, 121, 14232
DOI: 10.1021/acs.chemrev.1c00189

Phase Behavior and Electrochemical Properties of Highly Asymmetric Redox Coacervates

Lucy L. Coria-Oriundo, Gabriel Debais, Eugenia Apuzzo, Santiago E. Herrera, Marcelo Ceolín, Omar Azzaroni, Fernando Battaglini and Mario Tagliazucchi

J. Phys. Chem. B, 2023, 127, 7636
DOI: 10.1021/acs.jpcb.3c03680

Photophysical and Viscoelastic Properties of Ionically Complexed Conjugated Polyelectrolyte for Printed Soft Electronics

Hiba Wakidi, Intanon Lapkriengkri, Alexandra Zele, Sang Do, Suangsiri Arunlimsawat, Andrew Rhode, Emmanuel Lanuza, Gala Rodriguez, Vinich Promarak, Tung Nguyen‐Dang, Angela A. Pitenis, Christopher M. Bates, Michael L. Chabinyc and Thuc‐Quyen Nguyen

Adv Funct Materials, 2026, 36
DOI: 10.1002/adfm.202504946

Folded domain charge properties influence the conformational behavior of disordered tails

Ishan Taneja and Alex S. Holehouse

Current Research in Structural Biology, 2021, 3, 216
DOI: 10.1016/j.crstbi.2021.08.002

Emerging bioadhesives: from traditional bioactive and bioinert to a new biomimetic protein-based approach

Nisal Wanasingha, Naba K. Dutta and Namita Roy Choudhury

Advances in Colloid and Interface Science, 2021, 296, 102521
DOI: 10.1016/j.cis.2021.102521

A generalized grand-reaction method for modeling the exchange of weak (polyprotic) acids between a solution and a weak polyelectrolyte phase

David Beyer and Christian Holm

The Journal of Chemical Physics, 2023, 159
DOI: 10.1063/5.0155973

Complex Coacervation-Based Formulation Strategy for 3D Bioprinting Application

Chen Yang, Seo Hyung Moon and Yun Jung Yang

Korean J. Chem. Eng., 2026, 43, 297
DOI: 10.1007/s11814-025-00587-x

Charge Regulation Triggers Condensation of Short Oligopeptides to Polyelectrolytes

Sebastian P. Pineda, Roman Staňo, Anastasiia Murmiliuk, Pablo M. Blanco, Patricia Montes, Zdeněk Tošner, Ondřej Groborz, Jiří Pánek, Martin Hrubý, Miroslav Štěpánek and Peter Košovan

JACS Au, 2024, 4, 1775
DOI: 10.1021/jacsau.3c00668

Improving the functional properties of canola protein isolate through electrostatic coacervation with soluble fraction of Tragacanth gum

Adel Moghadam, Azade Ghorbani-HasanSaraei, Ali Rafe, Fatemeh Fazeli and Seyed-Ahmad Shahidi

International Journal of Biological Macromolecules, 2025, 330, 148103
DOI: 10.1016/j.ijbiomac.2025.148103

Interplay of Polymer Structure, Solvent Ordering, and Charge Fluctuations in Polyelectrolyte Solution Thermodynamics

Michael Beckinghausen and Andrew J. Spakowitz

Macromolecules, 2023, 56, 136
DOI: 10.1021/acs.macromol.2c01826

Self-Assembly of Star-Polyelectrolytes in Various Solution Conditions

Jun-Jie Zhang and Bin Li

Macromolecules, 2024, 57, 396
DOI: 10.1021/acs.macromol.3c01580

Recent advances in polysaccharides based biomaterials for drug delivery and tissue engineering applications

Ankur Sood, Aastha Gupta and Garima Agrawal

Carbohydrate Polymer Technologies and Applications, 2021, 2, 100067
DOI: 10.1016/j.carpta.2021.100067

A conceptual framework for understanding phase separation and addressing open questions and challenges

Tanja Mittag and Rohit V. Pappu

Molecular Cell, 2022, 82, 2201
DOI: 10.1016/j.molcel.2022.05.018

Functional enzyme–polymer complexes

Curt Waltmann, Carolyn E. Mills, Jeremy Wang, Baofu Qiao, John M. Torkelson, Danielle Tullman-Ercek and Monica Olvera de la Cruz

Proc. Natl. Acad. Sci. U.S.A., 2022, 119
DOI: 10.1073/pnas.2119509119

Lignin-based microcapsule for pesticide delivery: A review

Lingsong Meng, Kefeng Liu, Guihua Yang and Jiachuan Chen

International Journal of Biological Macromolecules, 2025, 331, 148393
DOI: 10.1016/j.ijbiomac.2025.148393

Molecular Mass Dependence of Interfacial Tension in Complex Coacervation

Debra J. Audus, Samim Ali, Artem M. Rumyantsev, Yuanchi Ma, Juan J. de Pablo and Vivek M. Prabhu

Phys. Rev. Lett., 2021, 126
DOI: 10.1103/PhysRevLett.126.237801

An Overview of Coacervates: The Special Disperse State of Amphiphilic and Polymeric Materials in Solution

Satya Priya Moulik, Animesh Kumar Rakshit, Animesh Pan and Bappaditya Naskar

Colloids and Interfaces, 2022, 6, 45
DOI: 10.3390/colloids6030045

Peptide-Based Complex Coacervates Stabilized by Cation−π Interactions for Cell Engineering

Yue Sun, Xi Wu, Jianguo Li, Chandra Shekhar Verma, Jing Yu and Ali Miserez

J. Am. Chem. Soc., 2025, 147, 4284
DOI: 10.1021/jacs.4c14469

Electrospinning Fibers from Oligomeric Complex Coacervates: No Chain Entanglements Needed

Xiangxi Meng, Yifeng Du, Yalin Liu, E. Bryan Coughlin, Sarah L. Perry and Jessica D. Schiffman

Macromolecules, 2021, 54, 5033
DOI: 10.1021/acs.macromol.1c00397

Effect of Cation−π Interactions on the Phase Behavior and Viscoelastic Properties of Polyelectrolyte Complexes

Conner H. Chee, Aijie Han, Gileanna Ortiz, Lexi R. Knight and Jennifer E. Laaser

Macromolecules, 2025, 58, 5177
DOI: 10.1021/acs.macromol.4c02626

Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms

Khatcher O. Margossian, Marcel U. Brown, Todd Emrick and Murugappan Muthukumar

Nat Commun, 2022, 13
DOI: 10.1038/s41467-022-29851-y

The effect of ion pairs on coacervate-driven self-assembly of block polyelectrolytes

Jiadi Jiang, Er-Qiang Chen and Shuang Yang

The Journal of Chemical Physics, 2021, 154
DOI: 10.1063/5.0044845

Wet-adhesive and antibacterial PAH-TPP coacervates with self-mineralizing capability for cranial flap fixation

Weicheng Chen, Jiaxu Shi, Dachuan Liu, Kai Lu, Jianlong Fu, Jingxi Xu, Huan Wang, Zhiliang Guo, Li Dong, Di Li, Xin Li, Miodrag J. Lukic, Wei Xia, Song Chen and Bin Li

Bioactive Materials, 2025, 52, 1
DOI: 10.1016/j.bioactmat.2025.05.024

Towards Decoding the Sequence-Based Grammar Governing the Functions of Intrinsically Disordered Protein Regions

Shasha Chong and Mustafa Mir

Journal of Molecular Biology, 2021, 433, 166724
DOI: 10.1016/j.jmb.2020.11.023

Self-assembling peptides-based nano-cargos for targeted chemotherapy and immunotherapy of tumors: recent developments, challenges, and future perspectives

Xue-Jun Wang, Jian Cheng, Le-Yi Zhang and Jun-Gang Zhang

Drug Delivery, 2022, 29, 1184
DOI: 10.1080/10717544.2022.2058647

One-Step Immunoassay for Biomarker Quantification in Complex Mixtures Based on Phase-Separated Antifouling Coacervates

Philippe S. Lenzen, Tobias Hoch, Itzel Condado-Morales, Raphaël P. B. Jacquat, Roberto Frigerio, Jonathan Garlipp, Francesca Torrini, Alessandro Gori, Umberto Capasso Palmiero, Onur Boyman and Paolo Arosio

Anal. Chem., 2025, 97, 4906
DOI: 10.1021/acs.analchem.4c04661

Coexistence of two coacervate phases of polyglycine in water suggested by polymer reference interaction site model theory

Tsuyoshi Yamaguchi, Song-Ho Chong and Norio Yoshida

The Journal of Chemical Physics, 2023, 159
DOI: 10.1063/5.0185157

Biomimetic Remineralization of Artificial Caries Lesions with a Calcium Coacervate, Its Components and Self-Assembling Peptide P11-4 In Vitro

Basel Kharbot, Haitham Askar, Dominik Gruber and Sebastian Paris

Bioengineering, 2024, 11, 465
DOI: 10.3390/bioengineering11050465

Hydrogen-Bonding-Driven Multifunctional Polymer Hydrogel Networks Based on Tannic Acid

Yongfeng Gao, Xuwen Peng, Qiuqiu Wu, Diling Yang, Wenda Wang, Qiongyao Peng, Tao Wang, Jianmei Wang, Jifang Liu, Hao Zhang and Hongbo Zeng

ACS Appl. Polym. Mater., 2022, 4, 1836
DOI: 10.1021/acsapm.1c01724

Composition and Charge Compensation in Chitosan/Gum Arabic Complex Coacervates in Dependence on pH and Salt Concentration

Philipp Schröder, Stefan Cord-Landwehr, Monika Schönhoff and Cornelia Cramer

Biomacromolecules, 2023, 24, 1194
DOI: 10.1021/acs.biomac.2c01255

Spray-drying microencapsulation of fixed oils: An innovative and sustainable technology to enhance oxidative stability, functionality and application in food systems

Kutloano Mangope, Tafadzwa Kaseke and Olaniyi A. Fawole

Applied Food Research, 2025, 5, 101200
DOI: 10.1016/j.afres.2025.101200

Stable Polyelectrolyte Complexes Releasing Active Agents

Arjaree Jobdeedamrong and Daniel Crespy

Macromol. Rapid Commun., 2026, 47
DOI: 10.1002/marc.202500437

Coacervates Forming Coexisting Phases on a Mineral Surface

Jiaxin Chen, Qingwen Bai, Yanzhang Li, Zhijun Liu, Yan Li and Dehai Liang

Langmuir, 2023, 39, 5814
DOI: 10.1021/acs.langmuir.3c00101

Alkyl polyglucoside-based supramolecular solvent formation in liquid-phase microextraction

Christina Vakh, Svetlana Kasper, Yanina Kovalchuk, Evgenia Safonova and Andrey Bulatov

Analytica Chimica Acta, 2022, 1228, 340304
DOI: 10.1016/j.aca.2022.340304

Substantial Confinement of Crystal Growth of Organic Crystalline Materials in Metal–Organic Membrane Microshells

Dongyoung Jeon, Bokgi Seo, Jongryeol Yang, Woo Sun Shim, Nae-Gyu Kang, Daehwan Park and Jin Woong Kim

Langmuir, 2024, 40, 8225
DOI: 10.1021/acs.langmuir.4c00415

4D Bioprinting via Molecular Network Contraction for Membranous Tissue Fabrication

Shannon T. McLoughlin, Abigail R. McKenna and John P. Fisher

Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202300642

Supramolecular polymers form tactoids through liquid–liquid phase separation

Hailin Fu, Jingyi Huang, Joost J. B. van der Tol, Lu Su, Yuyang Wang, Swayandipta Dey, Peter Zijlstra, George Fytas, Ghislaine Vantomme, Patricia Y. W. Dankers and E. W. Meijer

Nature, 2024, 626, 1011
DOI: 10.1038/s41586-024-07034-7

Phase equilibrium of three-component liquid systems composed of water, alcohol, and sodium chloride studied by the reference interaction-site model integral equation theory

Tsuyoshi Yamaguchi, Song-Ho Chong and Norio Yoshida

The Journal of Chemical Physics, 2023, 158
DOI: 10.1063/5.0142256

Interfacial Structure of Positively Charged Polypeptide Condensates

Yajing Wang, Pengfei Zhang and Zhen-Gang Wang

Biomacromolecules, 2026
DOI: 10.1021/acs.biomac.5c02726

Biomolecule-Based Coacervation: Mechanisms, Applications, and Future Perspectives in Biomedical and Biotechnological Fields

Dong Hyun Kim, Mi-Ran Ki, Da Yeon Chung and Seung Pil Pack

Biomolecules, 2025, 15, 861
DOI: 10.3390/biom15060861

Complex coacervates as artificial membraneless organelles and protocells

Nan-Nan Deng

Biomicrofluidics, 2020, 14
DOI: 10.1063/5.0023678

Linear Viscoelasticity and Time–Alcohol Superposition of Chitosan/Hyaluronic Acid Complex Coacervates

Juanfeng Sun, Jessica D. Schiffman and Sarah L. Perry

ACS Appl. Polym. Mater., 2022, 4, 1617
DOI: 10.1021/acsapm.1c01411

Exploring the Impact of Zwitterions in Discrete Charge Arrangements of Stimuli-Responsive Polyelectrolyte Complexes

Derrick E. Hastings and Harald D. H. Stöver

ACS Appl. Polym. Mater., 2022, 4, 5035
DOI: 10.1021/acsapm.2c00580

Complexation between Oppositely Charged Polyelectrolytes in Dilute Solution: Effects of Charge Asymmetry

Shensheng Chen, Pengfei Zhang and Zhen-Gang Wang

Macromolecules, 2022, 55, 3898
DOI: 10.1021/acs.macromol.2c00339

Diffusive dynamics and electrochemical regulation of weak polyelectrolytes across liquid interfaces

Giulia L Celora, Ralf Blossey, Andreas Münch and Barbara Wagner

Phys. Rev. Research, 2025, 7
DOI: 10.1103/xgbm-69cf

Chemically reactive and aging macromolecular mixtures. II. Phase separation and coarsening

Ruoyao Zhang, Sheng Mao and Mikko P. Haataja

The Journal of Chemical Physics, 2024, 161
DOI: 10.1063/5.0196794

Trends in Sequence-Defined Polyelectrolyte Systems: A Perspective

Qiu-Hui Chang, Ruo-Chao Wang, Le-Ying Qing and Jian Jiang

Chin J Polym Sci, 2025, 43, 1
DOI: 10.1007/s10118-024-3221-6

Predicting the growth and dynamics of ATP-based protocells through modeling

Nazila Yaghini

Phys. Scr., 2025, 100, 105003
DOI: 10.1088/1402-4896/ae08fa

Encapsulation and delivery systems of cinnamon essential oil for food preservation applications

Wanli Zhang, Parya Ezati, Ajahar Khan, Elham Assadpour, Jong-Whan Rhim and Seid Mahdi Jafari

Advances in Colloid and Interface Science, 2023, 318, 102965
DOI: 10.1016/j.cis.2023.102965

Comb Polyelectrolytes Stabilize Complex Coacervate Microdroplet Dispersions

Shang Gao and Samanvaya Srivastava

ACS Macro Lett., 2022, 11, 902
DOI: 10.1021/acsmacrolett.2c00327

High‐Yield Separation of Extracellular Vesicles Using Programmable Zwitterionic Coacervates

Carolina Paganini, Umberto Capasso Palmiero, Sabrina Picciotto, Alessandro Molinelli, Ilaria Porello, Giorgia Adamo, Mauro Manno, Antonella Bongiovanni and Paolo Arosio

Small, 2023, 19
DOI: 10.1002/smll.202204736

Sticky Polyelectrolyte Shield for Enhancing Biological Half-Life of Growth Factors

Young Kim, Sungmi Jeon, Byulhana Kim, Yu Jin Jeong, Tae Hee Kim, Subin Jeong, Iljin Kim, Joomin Oh, Youngmee Jung, Kangwon Lee, Young Bin Choy, Sang Wha Kim and Justin J. Chung

ACS Appl. Mater. Interfaces, 2025, 17, 445
DOI: 10.1021/acsami.4c16261

Effect of Polypeptide Complex Coacervate Microenvironment on Protonation of a Guest Molecule

Saehyun Choi, Ashley R. Knoerdel, Charles E. Sing and Christine D. Keating

J. Phys. Chem. B, 2023, 127, 5978
DOI: 10.1021/acs.jpcb.3c02098

Interfacial tension in polyelectrolyte systems exhibiting associative liquid–liquid phase separation

Vivek M. Prabhu

Current Opinion in Colloid & Interface Science, 2021, 53, 101422
DOI: 10.1016/j.cocis.2021.101422

Co-encapsulation of saffron petal and Stachys schtschegleevii extracts via complex coacervation and graphene oxide-assisted spray drying for co-delivery and stability enhancement

Hamid Rajabi and Seyed Mohammad Ali Razavi

LWT, 2025, 223, 117705
DOI: 10.1016/j.lwt.2025.117705

Amphiphilic Polyelectrolyte Complexes for Fouling-Resistant and Easily Tunable Membranes

Luca Mazzaferro, Teresa M. Grasseschi, Bricker D. Like, Matthew J. Panzer and Ayse Asatekin

ACS Appl. Mater. Interfaces, 2024, 16, 37952
DOI: 10.1021/acsami.4c05723

Complex dynamics of multicomponent biological coacervates

Jenna K.A. Tom and Ashok A. Deniz

Current Opinion in Colloid & Interface Science, 2021, 56, 101488
DOI: 10.1016/j.cocis.2021.101488

Ultrastructure of Critical-Gel-like Polyzwitterion–Polyoxometalate Complex Coacervates: Effects of Temperature, Salt Concentration, and Shear

Benxin Jing, Manuela Ferreira, Kehua Lin, Ruipeng Li, Benjamin M. Yavitt, Jie Qiu, Masafumi Fukuto and Yingxi Zhu

Macromolecules, 2020, 53, 10972
DOI: 10.1021/acs.macromol.0c01618

Superstrong Water-Based Supramolecular Adhesives Derived from Poly(vinyl alcohol)/Poly(acrylic acid) Complexes

Xiang Li, Zilin Wang, Wen Li and Junqi Sun

ACS Materials Lett., 2021, 3, 875
DOI: 10.1021/acsmaterialslett.1c00167

Electrospinnable, Neutral Coacervates for Facile Preparation of Solid Phenolic Bioadhesives

Jun-Sung Kim, Honggu Hwang, Daiheon Lee and Haeshin Lee

ACS Appl. Mater. Interfaces, 2021, 13, 37989
DOI: 10.1021/acsami.1c04925

Chitosan Hydrogels Prepared on the Basis of Polyelectrolyte Complexes (A Review)

Yury Shchipunov

Russ J Gen Chem, 2026, 96
DOI: 10.1134/S1070363225607823

Salt-Dependent Phase Re-entry of Weak Polyelectrolyte Complexes: from Associative to Segregative Liquid–Liquid Phase Separation

Huiling Li, Ying Liu, Fujie Lan, Mohsen Ghasemi and Ronald G. Larson

Macromolecules, 2023, 56, 7909
DOI: 10.1021/acs.macromol.3c01468

Physics of droplet regulation in biological cells

David Zwicker, Oliver W Paulin and Cathelijne ter Burg

Rep. Prog. Phys., 2025, 88, 116601
DOI: 10.1088/1361-6633/ae12a7

Coacervation-Induced Remodeling of Nanovesicles

Sayantan Mondal and Qiang Cui

J. Phys. Chem. Lett., 2023, 14, 4532
DOI: 10.1021/acs.jpclett.3c00705

Microstructure and Viscoelasticity of Oppositely Charged Ionomer Blend Melts

Chia-Chi Tsai, Jie Xu, Cassie Duclos and Shuyi Xie

Macromolecules, 2025, 58, 1608
DOI: 10.1021/acs.macromol.4c02781

Fabrication and characterization of novel β-sitosterol-loaded O/W Pickering emulsions stabilized by edible insects protein/chitosan complex coacervates: Retention and stability evaluation

Patryk Pokorski, Barbara Strojny - Cieślak, Ewa Domian, Michał Załęcki, Anna Grygier, Michał Pruchniewski, Anna Zakrzewska, Havva Aktaş, Marek Aljewicz, Dominik Kmiecik, Jorge A. Custodio - Mendoza, Piotr Boruszewski and Marcin A. Kurek

Carbohydrate Polymers, 2025, 366, 123892
DOI: 10.1016/j.carbpol.2025.123892

Coacervates: Recent developments as nanostructure delivery platforms for therapeutic biomolecules

Eunmi Ban and Aeri Kim

International Journal of Pharmaceutics, 2022, 624, 122058
DOI: 10.1016/j.ijpharm.2022.122058

A molecularly informed field-theoretic study of the complexation of polycation PDADMA with mixed micelles of sodium dodecyl sulfate and ethoxylated surfactants

My Nguyen, Kevin Shen, Nicholas Sherck, Stephan Köhler, Rohini Gupta, Kris T. Delaney, M. Scott Shell and Glenn H. Fredrickson

Eur. Phys. J. E, 2023, 46
DOI: 10.1140/epje/s10189-023-00332-4

Charge Regulation Effects in Weak Polyelectrolyte Complexation

David Beyer, Christian Holm and Zhen-Gang Wang

J. Phys. Chem. Lett., 2025, 16, 8245
DOI: 10.1021/acs.jpclett.5c01877

Origin of the ionic-strength dependent reentrant behavior in the liquid-liquid phase separation of uncharged intrinsically disordered proteins

Sayantan Mondal and Eugene Shakhnovich

Commun Chem, 2026
DOI: 10.1038/s42004-026-02011-9

Precision Doping of Polyelectrolyte Complexes: Insight on the Role of Ions

Mo Yang, Zachary A. Digby and Joseph B. Schlenoff

Macromolecules, 2020, 53, 5465
DOI: 10.1021/acs.macromol.0c00965

Hybrid Field Theory and Particle Simulation Model of Polyelectrolyte–Surfactant Coacervation

Jason J. Madinya and Charles E. Sing

Macromolecules, 2022, 55, 2358
DOI: 10.1021/acs.macromol.2c00187

Controlling Polymer Material Structure during Reaction-Induced Phase Transitions

Robert J. Hickey

Acc. Mater. Res., 2023, 4, 798
DOI: 10.1021/accountsmr.3c00071

Chemical Communication in Artificial Cells: Basic Concepts, Design and Challenges

Hedi Karoui, Pankaj Singh Patwal, B. V. V. S. Pavan Kumar and Nicolas Martin

Front. Mol. Biosci., 2022, 9
DOI: 10.3389/fmolb.2022.880525

Water-Immiscible Coacervate as a Liquid Magnetic Robot for Intravascular Navigation

Pengchao Zhao, Fuyang Qu, Hao Fu, Jianyang Zhao, Jiaxin Guo, Jiankun Xu, Yi-Ping Ho, Michael K. Chan and Liming Bian

J. Am. Chem. Soc., 2023, 145, 3312
DOI: 10.1021/jacs.2c13287

Molecular Weight-Driven Partitioning of Polyelectrolytes During Complexation

Kayla P. Barker, Jacob Horne, Junzhe Lou, Yan Xia and Jian Qin

Macromolecules, 2025, 58, 6249
DOI: 10.1021/acs.macromol.5c00421

Biphasic Coacervation Controlled by Kinetics as Studied by De Novo-Designed Peptides

Tianhao Ren and Dehai Liang

Langmuir, 2025, 41, 1756
DOI: 10.1021/acs.langmuir.4c04114

Phase Behavior Determines Morphology of Amylose Crystallized From Aqueous Solutions

Gregory R. Ziegler and John A. Creek

Cereal Chem, 2025, 102, 386
DOI: 10.1002/cche.10867

Microencapsulation Techniques for Probiotic Formulations: Current Scenario and Future Perspective

Tawseefa Jan, Rajeshwari Negi, Arbina Hilal, Simranjeet Kaur, Divjot Kour, Sofia Sharief Khan, Sheikh Shreaz, Praneet Chauhan, Neelam Yadav, Sarvesh Rustagi, Ashutosh Kumar Rai, Sangram Singh, Ajar Nath Yadav, Naseer Ahmed and Irfan Ahmad

Journal of Food Quality, 2025, 2025
DOI: 10.1155/jfq/6738124

Small‐Molecule‐based Supramolecular Plastics Mediated by Liquid‐Liquid Phase Separation**

Jingjing Yu, Dawei Qi, Ermei Mäkilä, Lippo Lassila, Anastassios C. Papageorgiou, Markus Peurla, Jessica M. Rosenholm, Zhao Zhao, Pekka Vallittu, Sirpa Jalkanen, Chunman Jia and Jianwei Li

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202204611

Active coacervate droplets as a model for membraneless organelles and protocells

Carsten Donau, Fabian Späth, Marilyne Sosson, Brigitte A. K. Kriebisch, Fabian Schnitter, Marta Tena-Solsona, Hyun-Seo Kang, Elia Salibi, Michael Sattler, Hannes Mutschler and Job Boekhoven

Nat Commun, 2020, 11
DOI: 10.1038/s41467-020-18815-9

Understanding the Encapsulation Behavior of Nile Red within Nonionic Block Copolymer Coacervates and Self-Assembled Particles

Nehal S. Idris, Muna Naseer, Justin T. Mulvey, Aoon Rizvi, Ngoc Anh Thy Nguyen and Joseph P. Patterson

Macromolecules, 2026, 59, 1307
DOI: 10.1021/acs.macromol.5c02845

Injectable and Wet-Adhesive Coacervate with Enhanced Photothermal Properties for Localized Tumor Treatment

Zuoao Shi, Beilei Gong, Yingda Wan, Junjie Fu, Yanan Zhang, Xin Wang, Guoqing Yan, Yan Meng, Rupei Tang and Xuefeng Yang

ACS Appl. Polym. Mater., 2025, 7, 9180
DOI: 10.1021/acsapm.5c01461

Encapsulation behavior of curcumin in heteroprotein complex coacervates and precipitates fabricated from β-conglycinin and lysozyme

Jiabao Zheng, Qing Gao, Ge Ge, Weizheng Sun, Paul Van der Meeren and Mouming Zhao

Food Hydrocolloids, 2022, 133, 107964
DOI: 10.1016/j.foodhyd.2022.107964

Structure and Relaxation Dynamics for Complex Coacervate Hydrogels Formed by ABA Triblock Copolymers

Jung-Min Kim, Tae-Young Heo and Soo-Hyung Choi

Macromolecules, 2020, 53, 9234
DOI: 10.1021/acs.macromol.0c01600

A non-spherical nanoparticles system for the delivery of peptides using polymer grafted nanocellulose

YeeYee Khine, Yimeng Li, Wei Ge and Martina H. Stenzel

Colloid Polym Sci, 2025, 303, 1753
DOI: 10.1007/s00396-024-05265-8

Unleashing the power of silk-based proteins as biomaterials for cutting-edge drug delivery: a comprehensive review

Vishal Kumar Parida, Kavita, Rashmi Arora and Teenu Sharma

Journal of Biomaterials Science, Polymer Edition, 2025, 36, 247
DOI: 10.1080/09205063.2024.2397215

The pH role in casein-carboxymethylcellulose nano/microparticles formation

Davi Siqueira da Silva de Souza, Vinícius Augusto Peixoto Tartare, Brenda da Silva Bega, Giovana Cristina Zambuzi, Tatiana Santana Ribeiro, Caue Ribeiro, Osvaldo de Freitas and Kelly Roberta Francisco

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 682, 132953
DOI: 10.1016/j.colsurfa.2023.132953

Phase behavior and interaction mechanism of complex coacervation between nisin and carboxylic curdlan

Ming-Yu Jin, Yun-Bo Yu, Zheng-Cai Liu, Le-Yi Pan, Tong-Xin Liang, Long-Qing Li, Yahui Yu, Lin Li and Jing-Kun Yan

Journal of Molecular Liquids, 2025, 424, 126978
DOI: 10.1016/j.molliq.2025.126978

Phase-separated hydrogels for advanced biomedical engineering: From material design to applications

Junpeng Mu, Sha Li, Zherui Zhang, Ze Li, Sicheng Li, Zongan Li, Haohui Li, Lili Yu, Huajian Ren, Jianan Ren, Xiuwen Wu and Jinjian Huang

Materials Today Bio, 2026, 38, 103096
DOI: 10.1016/j.mtbio.2026.103096

Complex Coacervate-Based Materials for Biomedicine: Recent Advancements and Future Prospects

Partha Sarathi Roy

Ind. Eng. Chem. Res., 2024, 63, 5414
DOI: 10.1021/acs.iecr.3c03830

Unifying the Dynamics of Viscoelastic Liquids across the Complex Coacervation Phase Diagram: Time–Polyelectrolyte–Salt Superposition

Jialin She, Axel Bourdette Kaya, Jérôme Combet, Matthew Tirrell, Francisco J. Cedano-Serrano, Fouzia Boulmedais and Mehdi Vahdati

Macromolecules, 2026, 59, 1383
DOI: 10.1021/acs.macromol.5c02702

Influence of Solvent Dielectric Constant on the Complex Coacervation Phase Behavior of Polymerized Ionic Liquids

Jowon Shin, Heewoon Shin, Sang-Ho Lee, Jong Dae Jang and Hyeong Jun Kim

ACS Macro Lett., 2024, 13, 1678
DOI: 10.1021/acsmacrolett.4c00663

Recent advances in coacervation and underlying noncovalent molecular interaction mechanisms

Qiongyao Peng, Tao Wang, Diling Yang, Xuwen Peng, Hao Zhang and Hongbo Zeng

Progress in Polymer Science, 2024, 153, 101827
DOI: 10.1016/j.progpolymsci.2024.101827

Electrostatic Correlations and Temperature-Dependent Dielectric Constant Can Model LCST in Polyelectrolyte Complex Coacervation

Andrew S. Ylitalo, Christopher Balzer, Pengfei Zhang and Zhen-Gang Wang

Macromolecules, 2021, 54, 11326
DOI: 10.1021/acs.macromol.1c02000

Coacervate Droplets for Synthetic Cells

Zi Lin, Thomas Beneyton, Jean‐Christophe Baret and Nicolas Martin

Small Methods, 2023, 7
DOI: 10.1002/smtd.202300496

Miscibility and phase behavior in bulk and micellar systems of surfactant-polymer coacervate mixtures

Jussara Alves Penido and Watson Loh

Journal of Colloid and Interface Science, 2025, 695, 137826
DOI: 10.1016/j.jcis.2025.137826

Charge distribution of the coating brush drives interchromosome attraction

Valerio Sorichetti, Paul Robin, Ivan Palaia, Alberto Hernandez-Armendariz, Sara Cuylen-Haering and Anđela Šarić

PRX Life, 2025, 3
DOI: 10.1103/41fd-r847

Solid-to-gel phase transition of chitosan-κ-carrageenan complex coacervates: Phase behavior, multiscale structure, and rheology

Meng Xu, Haoqi Zhang, Jiabao Zheng and Weizheng Sun

Food Hydrocolloids, 2026, 173, 112171
DOI: 10.1016/j.foodhyd.2025.112171

Aqueous Formulation of Concentrated Semiconductive Fluid Using Polyelectrolyte Coacervation

My Linh Le, Dakota Rawlings, Scott P. O. Danielsen, Rhiannon M. Kennard, Michael L. Chabinyc and Rachel A. Segalman

ACS Macro Lett., 2021, 10, 1008
DOI: 10.1021/acsmacrolett.1c00354

How Advanced are Self-Assembled Nanomaterials for Targeted Drug Delivery? A Comprehensive Review of the Literature

Hamdi Nsairat, Zainab Lafi, Belal Al-Najjar, Ali Al-Samydai, Fadi Saqallah, Mohamed El-Tanani, Ghaleb Oriquat, Bailasan Sa’bi, Abed Alqader Ibrahim, Anthony Dellinger and Walhan Alshaer

IJN, 2025, Volume 20, 2133
DOI: 10.2147/IJN.S490444

Tuning coacervate properties via protein partner selection: A structural and dynamic comparison of gelatin- and ovalbumin-based coacervates

Mohamed Rjili and Adel Aschi

International Journal of Biological Macromolecules, 2026, 364, 152133
DOI: 10.1016/j.ijbiomac.2026.152133

The Critical Transition from Soluble Complexes to Colloidal Aggregates of Polyelectrolyte Complexes at Non‐Stoichiometric Charge Ratios

Jun Gao, Qiang‐wei Zhan, Ziyao Tang and Yan Huang

Macromol. Rapid Commun., 2022, 43
DOI: 10.1002/marc.202100880

Biodegradable Polymer-Based Microspheres for Depot Injection-Industry Perception

Anand Kyatanwar, Mangal Nagarsenker and Bala Prabhakar

RADDF, 2023, 17, 13
DOI: 10.2174/2667387817666230119103126

Dynamic Ion Gels from the Complex Coacervation of Oppositely Charged Poly(ionic liquid)s

Malak Alaa Eddine, Daniil R. Nosov, Luiz Fernando Lepre, Anatoli Serghei, Daniel F. Schmidt, Damien Montarnal, Alexander S. Shaplov and Eric Drockenmuller

ACS Macro Lett., 2024, 13, 921
DOI: 10.1021/acsmacrolett.4c00253

Ion Solvation-Driven Liquid–Liquid Phase Separation in Divalent Electrolytes with Miscible Organic Solvents

Ying Chen, Jaegeon Ryu, J. David Bazak, Dan Thien Nguyen, Kee Sung Han, Zheng Li, Jian Zhi Hu, Karl T Mueller and Vijayakumar Murugesan

J. Phys. Chem. C, 2023, 127, 15443
DOI: 10.1021/acs.jpcc.3c01701

The rheology of saltwater taffy

San To Chan, Simon J. Haward, Eliot Fried and Gareth H. McKinley

Physics of Fluids, 2023, 35
DOI: 10.1063/5.0163715

Biomolecular condensates—Prerequisites for anhydrobiosis?

Charles A. Elder, Hannah M. Skaggs, Lynnette M. A. Dirk, David F. Grimm, Clinton J. Belott, Willem F. Wolkers, Harriëtte Oldenhof, Vladimir N. Uversky, A. Bruce Downie and Michael A. Menze

Protein Science, 2025, 34
DOI: 10.1002/pro.70192

Analysis of Partitioning of Salt through Doping of Polyelectrolyte Complex Coacervates

Mohsen Ghasemi, Sean Friedowitz and Ronald G. Larson

Macromolecules, 2020, 53, 6928
DOI: 10.1021/acs.macromol.0c00797

Engineering Mechanical Strong Biomaterials Inspired by Structural Building Blocks in Nature

Jiahe Li, Chao Ma, Hongjie Zhang and Kai Liu

Chem. Res. Chin. Univ., 2023, 39, 92
DOI: 10.1007/s40242-023-2357-1

Interfacing Complex Coacervates with Natural Cells

He Meng, Yanglimin Ji and Yan Qiao

ChemSystemsChem, 2025, 7
DOI: 10.1002/syst.202400071

Surfactants application in sample preparation techniques: Insights, trends, and perspectives

Christina Vakh and Stanislawa Koronkiewicz

TrAC Trends in Analytical Chemistry, 2023, 165, 117143
DOI: 10.1016/j.trac.2023.117143

Sequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions

Jonas Wessén, Nancy De La Cruz, Heankel Lyons, Hue Sun Chan and Benjamin R. Sabari

Commun Chem, 2025, 8
DOI: 10.1038/s42004-025-01687-9

Assembly of model postsynaptic densities involves interactions auxiliary to stoichiometric binding

Yi-Hsuan Lin, Haowei Wu, Bowen Jia, Mingjie Zhang and Hue Sun Chan

Biophysical Journal, 2022, 121, 157
DOI: 10.1016/j.bpj.2021.10.008

The counterion-mediated controllable coacervation of nano-ions with polyelectrolytes

Binghui Xue, Yuyan Lai, Yuan Liu, Mu Li, Xinpei Li and Panchao Yin

Journal of Colloid and Interface Science, 2023, 641, 853
DOI: 10.1016/j.jcis.2023.03.105

Determining the Molecular Weight of Polyelectrolytes Using the Rouse Scaling Theory for Salt-Free Semidilute Unentangled Solutions

Aijie Han, Veera Venkata Shravan Uppala, Daniele Parisi, Christy George, Benjamin J. Dixon, Camila Denise Ayala, Xiuli Li, Louis A. Madsen and Ralph H. Colby

Macromolecules, 2022, 55, 7148
DOI: 10.1021/acs.macromol.2c01007

Molecular determinants for the layering and coarsening of biological condensates

Andrew P. Latham and Bin Zhang

Aggregate, 2022, 3
DOI: 10.1002/agt2.306

Decoding nucleic acid contributions to phase separation and ordering in biomolecular condensates

Daniele Asnicar, Simone Codispoti, Carlo Morasso, Alberta Ferrarini and Giuliano Zanchetta

Nucleic Acids Research, 2026, 54
DOI: 10.1093/nar/gkag253

Adhesive Coacervates Driven by Hydrogen‐Bonding Interaction

Qiongyao Peng, Jingsi Chen, Zicheng Zeng, Tao Wang, Li Xiang, Xuwen Peng, Jifang Liu and Hongbo Zeng

Small, 2020, 16
DOI: 10.1002/smll.202004132

Tuning Protein Uptake through Charge and Hydrophobicity in Peptide-Based Complex Coacervates

Arvind Sathyavageeswaran, Mayayi Izzo, Júlia Bonesso Sabadini, Umme Habeeba, Jacob Belden and Sarah L. Perry

Biomacromolecules, 2026, 27, 2795
DOI: 10.1021/acs.biomac.5c02639

Enhanced Concentration Fluctuations in Model Polyelectrolyte Coacervate Mixtures along a Salt Isopleth Phase Diagram

Yuanchi Ma, Samim Ali and Vivek M. Prabhu

Macromolecules, 2021, 54, 11338
DOI: 10.1021/acs.macromol.1c02001

Assembly of Replicating Protocells with Primitive Metabolism

Caner Karabasoglu, Aysenur Saytas, Beril Akgol, Simay Mercimek and O. Duhan Toparlak

Astrobiology, 2026, 26, 227
DOI: 10.1177/15311074261435277

Intrinsic Doping and Electrostatic Complexation of Sulfonated Poly(3,4-ethylenedioxythiophenes) (PEDOTs)

Hyunki Yeo, Anush Singhal, Alexandra Zele, Rachel A. Segalman and Michael L. Chabinyc

ACS Macro Lett., 2025, 14, 1431
DOI: 10.1021/acsmacrolett.5c00508

Bioinspired silica-shell coacervates: enhanced stability and functional versatility

Yitong Wang, Yixin Yun, Janar Tursen, Yuang Tang, Hongke Zhang, Xiaoqi Song, Xiaona Yu, Lujia Han, Wanbin Zhu and Hongliang Wang

Adv Compos Hybrid Mater, 2026, 9
DOI: 10.1007/s42114-025-01576-8

How to Predict the Order of Phase Separation of Polyelectrolyte Complexes and Their Miscibility

Marcos Vinícius Aquino Queirós and Watson Loh

J. Phys. Chem. B, 2022, 126, 5362
DOI: 10.1021/acs.jpcb.2c03454

Fabrication and characterization of fish gelatin/soluble soybean polysaccharide edible blend films through complex coacervation

Yiwei Wang, Jie Liu, Yidan Ding, Xuejing Zheng, Yongchao Jiang and Keyong Tang

Food Hydrocolloids, 2024, 155, 110226
DOI: 10.1016/j.foodhyd.2024.110226

Macromolecular Condensates as Tunable Scaffolds for Bio‐Inspired Silica Hybrids

Protap Biswas, Lior Aram, Nitzan Livni, Roman Kamyshinsky, Nadav Elad, Michal Leskes and Assaf Gal

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202522966

Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids

Ernesto E. Ambroggio, Guadalupe S. Costa Navarro, Luis Benito Pérez Socas, Luis A. Bagatolli and Andrea V. Gamarnik

Journal of Biological Chemistry, 2021, 297, 101059
DOI: 10.1016/j.jbc.2021.101059

Role of Charge Sequence in Polyampholyte Aggregation

Nam-Kyung Lee, Seowon Kim, Youngkyun Jung and Albert Johner

Macromolecules, 2024, 57, 7474
DOI: 10.1021/acs.macromol.4c00595

Ionic Strength-Dependent Structure of Complex Coacervate Core Micelles

Tae-Young Heo and Soo-Hyung Choi

J. Phys. Chem. B, 2024, 128, 1256
DOI: 10.1021/acs.jpcb.3c06004

A mini-review on bio-inspired polymer self-assembly: single-component and interactive polymer systems

Xiangxi Meng

Emerging Topics in Life Sciences, 2022, 6, 593
DOI: 10.1042/ETLS20220057

Transfer Matrix Model of pH Effects in Polymeric Complex Coacervation

Ashley R. Knoerdel, Whitney C. Blocher McTigue and Charles E. Sing

J. Phys. Chem. B, 2021, 125, 8965
DOI: 10.1021/acs.jpcb.1c03065

Polymer, Water, and Salt Partitioning in Complex Coacervates Characterized by Femtosecond Stimulated Raman Microscopy

Francisco van Riel Neto, Carolin Borbeck, Torben Henning Saatkamp, Maxine Kenny, Stephan Schmidt and Peter Gilch

Chemistry Methods, 2025, 5
DOI: 10.1002/cmtd.202500005

Effect of Charged Block Length Asymmetry on Complex Coacervate Core Hydrogels

Moon-Chul Ryu, Tae-Young Heo and Soo-Hyung Choi

Macromolecules, 2026, 59, 1201
DOI: 10.1021/acs.macromol.5c02739

Dilute but Dense – Reversible Crosslinking Enables Water‐Rich (Bio)polymer Condensates

Xinxiang Chen, Jude Ann Vishnu, Pol Besenius, Julian König and Friederike Schmid

Advanced Science, 2026, 13
DOI: 10.1002/advs.202519636

Recent advances in extracellular matrix-inspired nanocarriers

Sanjna Rao and Kristi L. Kiick

Expert Opinion on Drug Delivery, 2025, 22, 1325
DOI: 10.1080/17425247.2025.2519809

Synthesis and Complexation Behavior of Well-Defined Polyester-Based Polyelectrolytes with Varying Charge Densities and Hydrophobicities

Julian Engelhardt, Louis C.P.M. de Smet, Evelien Maaskant and Jasper van der Gucht

Macromolecules, 2025, 58, 12825
DOI: 10.1021/acs.macromol.5c01795

Highly efficient encapsulation of anthocyanins by complex coacervates prepared from pectin and chickpea proteins

Milica Perovic, Jovana Vukobratovic and Mirjana Antov

Acta per tech, 2025, 267
DOI: 10.2298/APT250430019P

Electrostatically Driven Topological Freezing of Polymer Diffusion at Intermediate Confinements

Di Jia and Murugappan Muthukumar

Phys. Rev. Lett., 2021, 126
DOI: 10.1103/PhysRevLett.126.057802

A review on effective encapsulation and release strategy of umami peptides

Baoshan Sun, Bingying Zhang, Lingling Sun, Yawen Zhou, Guiju Zhang, Fan Zhang, Yang Xiao, Bo Xu and Baocai Xu

International Journal of Food Engineering, 2023, 19, 361
DOI: 10.1515/ijfe-2023-0117

Protonation-Induced Liquid–Liquid Phase Separation and Solid-Like Structural Transformation in Amine-Functional Polyelectrolytes

Shivalika Sharma, Rajat Mukherjee, Mehak Jain, Arindam Chowdhury and Kamendra P. Sharma

Macromolecules, 2025, 58, 12072
DOI: 10.1021/acs.macromol.5c01505

Biological Condensate Growth: Examining the Impact of Solute Crowder on Size Expansion

Shangqiang Xie, Congran Yue, Sheng Ye and Zhenlu Li

Biomacromolecules, 2025, 26, 323
DOI: 10.1021/acs.biomac.4c01152

Investigating coacervates as drug carriers using molecular dynamics

Yang Liu, Rongrong Zou, Yiwei Wang, Minghao Wang, Fan Fan, Yeqiang Zhou, Huixu Xie and Mingming Ding

Precision Medicine and Engineering, 2024, 1, 100012
DOI: 10.1016/j.preme.2024.100012

Associative Phase Separation in Single-Step Polyelectrolyte Complex Coatings

Martijn H. P. de Heer Kloots, Hanne M. van der Kooij, Christof van Sluijs, Gerald A. Metselaar, Anthonie Stuiver, Wiebe M. de Vos and Jasper van der Gucht

Langmuir, 2026, 42, 4365
DOI: 10.1021/acs.langmuir.5c04491

Charge Density Mismatch Drives Demixing in Multicomponent Polyelectrolyte Complexes

Aman Agrawal, Yan N. Fang, Syed Rizvi, Nur Fariesha Noor Azman, Matthew V. Tirrell, Alamgir Karim and Angelika E. Neitzel

Macromolecules, 2025, 58, 7776
DOI: 10.1021/acs.macromol.5c00912

Counterion-controlled phase equilibria in a charge-regulated polymer solution

Giulia L. Celora, Ralf Blossey, Andreas Münch and Barbara Wagner

The Journal of Chemical Physics, 2023, 159
DOI: 10.1063/5.0169610

A Two‐Step Intermolecular Interaction Of Molecular Macroions With Multivalent Counterions

Kexing Xiao, Yifan Zhou, Xiaohan Xu, Jennifer E. S. Szymanowski, Yuqing Yang, Bahareh Afsari, Peter C. Burns and Tianbo Liu

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202402359

Time–Ionic Strength Superposition: A Unified Description of Chain Relaxation Dynamics in Polyelectrolyte Complexes

Vaqar M. S. Syed and Samanvaya Srivastava

ACS Macro Lett., 2020, 9, 1067
DOI: 10.1021/acsmacrolett.0c00252

Recent advances in essential oil complex coacervation by efficient physical field technology: A review of enhancing efficient and quality attributes

Lihui Zhang, Min Zhang, Ronghua Ju, Arun S. Mujumdar and Dewei Deng

Critical Reviews in Food Science and Nutrition, 2024, 64, 3384
DOI: 10.1080/10408398.2022.2132207

Tuning the mechanics of gelatin, chitosan, and hyaluronic acid-based biopolyelectrolyte complex hydrogel through the Hofmeister effect

Zheyu Xu, Yue Xia, Yuandong Rao, Xiatong Ou, Jiaqi Huang, Xin Lan, Xiaochao Chen and Yan Huang

European Polymer Journal, 2026, 114783
DOI: 10.1016/j.eurpolymj.2026.114783

Effect of Dynamically Arrested Domains on the Phase Behavior, Linear Viscoelasticity and Microstructure of Hyaluronic Acid – Chitosan Complex Coacervates

Julien Es Sayed, Clément Caïto, Abinaya Arunachalam, Armin Amirsadeghi, Larissa van Westerveld, Denise Maret, Roshan Akdar Mohamed Yunus, Eleonora Calicchia, Olivia Dittberner, Giuseppe Portale, Daniele Parisi and Marleen Kamperman

Macromolecules, 2023, 56, 5891
DOI: 10.1021/acs.macromol.3c00269

Mechanically tunable, antibacterial and bioactive mussel adhesive protein/hyaluronic acid coacervates as bioadhesives

Yang Zhao, Jia Kang, Yuting Cui, Shengli Ji, Rui Nian, Wenfa Yu and Yue Sun

International Journal of Biological Macromolecules, 2023, 247, 125773
DOI: 10.1016/j.ijbiomac.2023.125773

Solid–Liquid–Solution Phases in Poly(diallyldimethylammonium)/Poly(acrylic acid) Polyelectrolyte Complexes at Varying Temperatures

Chikaodinaka I. Eneh, Kevin Nixon, Suvesh Manoj Lalwani, Maria Sammalkorpi, Piotr Batys and Jodie L. Lutkenhaus

Macromolecules, 2024, 57, 2363
DOI: 10.1021/acs.macromol.4c00258

Membranization of Coacervates into Artificial Phagocytes with Predation toward Bacteria

Chunyu Zhao, Junbo Li, Shengliang Wang, Zhijun Xu, Xiaoliang Wang, Xiaoman Liu, Lei Wang and Xin Huang

ACS Nano, 2021, 15, 10048
DOI: 10.1021/acsnano.1c01694

Trehalose-based coacervates for local bioactive protein delivery to the central nervous system

Laboni F. Hassan, Riya Sen and Timothy M. O'Shea

Biomaterials, 2024, 309, 122594
DOI: 10.1016/j.biomaterials.2024.122594

Complex coacervation of low methoxy pectin with three types of gelatins for the encapsulation of fish oil

Wenjie Zhang, Lijia Chen, Qiqi Bian, Huan Gong, Li Li, Zhengquan Wang, Xichang Wang and Jian Zhong

Food Chemistry, 2024, 460, 140567
DOI: 10.1016/j.foodchem.2024.140567

Effects of catechol grafting on chitosan-based coacervation and adhesion

Runkang Gu, Jiangtao Guo, Shiting Zhang, Jin Zhou, Junyou Wang, Martien A. Cohen Stuart and Mingwei Wang

International Journal of Biological Macromolecules, 2024, 267, 131662
DOI: 10.1016/j.ijbiomac.2024.131662

Microphase separation and aggregate self-assembly in brushes of oppositely charged polyelectrolytes triggered by ion pairing

Gabriel Debais and Mario Tagliazucchi

The Journal of Chemical Physics, 2020, 153
DOI: 10.1063/5.0020779

Associative Phase Separation of Aqueous π-Conjugated Polyelectrolytes Couples Photophysical and Mechanical Properties

Anna R. Johnston, Sarah L. Perry and Alexander L. Ayzner

Chem. Mater., 2021, 33, 1116
DOI: 10.1021/acs.chemmater.0c02424

Spontaneous interactions between α-lactalbumin and native or heat-denatured lactoferrin

Skelte G. Anema

International Dairy Journal, 2025, 167, 106266
DOI: 10.1016/j.idairyj.2025.106266

Stabilization of Miscible Aqueous Phases via Diffusion‐Controlled Multifunctional Nanoparticle‐Ligand Complexation

Seyyed Alireza Hashemi, Mahyar Panahi‐Sarmad, Ahmadreza Ghaffarkhah, Vahid Rad, Masoud Soroush, Thomas P. Russell, Orlando J. Rojas and Mohammad Arjmand

Adv Funct Materials, 2026
DOI: 10.1002/adfm.202524954

Counterion-release versus dielectric entropy: insights from the Gouy-Chapman model for a uniformly charged plate

Sachin Raj Pandey, Matthias Ballauff and Roland R. Netz

Colloid Polym Sci, 2026, 304, 715
DOI: 10.1007/s00396-025-05424-5

Liquid–Liquid Phase Separation of Peptide/Oligonucleotide Complexes in Crowded Macromolecular Media

Qingwen Bai, Qiufen Zhang, Hairong Jing, Jiaxin Chen and Dehai Liang

J. Phys. Chem. B, 2021, 125, 49
DOI: 10.1021/acs.jpcb.0c09225

Polyelectrolyte Complex Coacervation across a Broad Range of Charge Densities

Angelika E. Neitzel, Yan N. Fang, Boyuan Yu, Artem M. Rumyantsev, Juan J. de Pablo and Matthew V. Tirrell

Macromolecules, 2021, 54, 6878
DOI: 10.1021/acs.macromol.1c00703

Hybrid Polyethylene Glycol/Sodium Metaphosphate Composites Prepared via Coacervation

Bruno Poletto Rodrigues, Guilherme Nunes Braga Maurício de Macedo, Yang Xia, Andrea Balducci and Lothar Wondraczek

Nanomaterials, 2022, 12, 528
DOI: 10.3390/nano12030528

Developing Design Rules for Polyelectrolyte Complex Materials: Role of Polyelectrolyte Length, Charged Group, and Backbone

Isaac A. Ramírez Marrero, Ria Ghosh, Louisa M. Coughlin, Wen-Wei Wong, Emily Ng, Elijah Kellner, Madyson Redder, Nadine Kaiser, Bernhard von Vacano, Rupert Konradi, E. Bryan Coughlin and Sarah L. Perry

Macromolecules, 2026, 59, 5017
DOI: 10.1021/acs.macromol.6c00009

Reversible protein complexes as a promising avenue for the development of high concentration formulations of biologics

Naoual Dahmana, Pierre-Louis Destruel, Samantha Facchetti, Vanessa Braun, Vanessa Lebouc, Zana Marin, Sulabh Patel and Gregoire Schwach

International Journal of Pharmaceutics, 2023, 648, 123616
DOI: 10.1016/j.ijpharm.2023.123616

Influence of Deliverable Form of Dietary Vitamin D3 on the Immune Response in Late-Lactating Dairy Goats

Adela Mora-Gutierrez, Maryuri T. Núñez de González, Selamawit Woldesenbet, Rahmat Attaie and Yoonsung Jung

Dairy, 2024, 5, 308
DOI: 10.3390/dairy5020025

Understanding How Coacervates Drive Reversible Small Molecule Reactions to Promote Molecular Complexity

Michael I. Jacobs, Edward R. Jira and Charles M. Schroeder

Langmuir, 2021, 37, 14323
DOI: 10.1021/acs.langmuir.1c02231

Validity and Breakdown of Superposition Principles in the Viscoelasticity of Chitosan–Gum Arabic Complex Coacervates

Philipp Schröder, Monika Schönhoff and Cornelia Cramer

Macromolecules, 2023, 56, 4966
DOI: 10.1021/acs.macromol.3c00447

Complex Coacervation of Polymerized Ionic Liquids in Non-aqueous Solvents

Minjung Lee, Sarah L. Perry and Ryan C. Hayward

ACS Polym. Au, 2021, 1, 100
DOI: 10.1021/acspolymersau.1c00017

Surface-Induced Coacervation Facilitates Localized Precipitation of Mineral Precursors from Dilute Solutions

Leilah Krounbi, Konrad Hedderick, Zohar Eyal, Lior Aram, Eyal Shimoni, Lara A. Estroff and Assaf Gal

Chem. Mater., 2021, 33, 3534
DOI: 10.1021/acs.chemmater.0c04668

Injectable bottlebrush triblock copolymer hydrogel crosslinked with ferric ions

Yoshiyuki Nakagawa, Yuichiro Oki, Xiao Da, Arvind K. Singh Chandel, Seiichi Ohta and Taichi Ito

Polymer, 2022, 240, 124519
DOI: 10.1016/j.polymer.2022.124519

Macromolecular Condensates as Tunable Scaffolds for Bio‐Inspired Silica Hybrids

Protap Biswas, Lior Aram, Nitzan Livni, Roman Kamyshinsky, Nadav Elad, Michal Leskes and Assaf Gal

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202522966

Localized assembly in biological activity: Origin of life and future of nanoarchitectonics

Jingwen Song, Kohsaku Kawakami and Katsuhiko Ariga

Advances in Colloid and Interface Science, 2025, 339, 103420
DOI: 10.1016/j.cis.2025.103420

Advances in aqueous two-phase microfluidic technology

Jing Ma, Lei Li, Xiaokang Deng, Si Meng, Yafeng Yu, Cheng Qi, Zhou Liu, Tiantian Kong and Ho Cheung Shum

Chin. Sci. Bull., 2025, 70, 1799
DOI: 10.1360/TB-2024-0937

Block-copolymer-based coacervates enabling constant and sustained release of siRNA-containing polyion complex micelles

Ziwei Ma, Hiroshi Kamizawa, Rento Ota, Bing Jhang Li, Fadlina Aulia, Teruki Nii, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura

Polym J, 2026, 58, 439
DOI: 10.1038/s41428-025-01124-7

Theory of capillary-induced self-coacervation in zwitterionic polymer solutions

Nikolai N. Kalikin, Petr E. Brandyshev and Yury A. Budkov

The Journal of Chemical Physics, 2026, 164
DOI: 10.1063/5.0331572

Diffusive Trends in Concentrated Oppositely-Charged Polyelectrolyte Solutions and Onset of Glassy Dynamics

Harrison Landfield and Muzhou Wang

ACS Macro Lett., 2024, 13, 1164
DOI: 10.1021/acsmacrolett.4c00378

Electrostatic Complexation of Conjugated and Bottlebrush Polyelectrolytes Forms Printable, Conductive Inks

Intanon Lapkriengkri, Alexandra Zele, Hyunki Yeo, Anush Singhal, Rachel A. Segalman, Christopher M. Bates and Michael L. Chabinyc

ACS Appl. Mater. Interfaces, 2026, 18, 4111
DOI: 10.1021/acsami.5c20375

Cytochrome c prompts the recruitment of its nuclear partners SET/TAF-Iβ and NPM1 into biomolecular condensates

Miguel Á. Casado-Combreras, Adrián Velázquez-Campoy, Marlène Martinho, Valérie Belle, Miguel A. De la Rosa and Irene Díaz-Moreno

iScience, 2024, 27, 110435
DOI: 10.1016/j.isci.2024.110435

Salt Resistance as a Measure of the Strength of Polyelectrolyte Complexation

Zachary A. Digby, Mo Yang, Sandrine Lteif and Joseph B. Schlenoff

Macromolecules, 2022, 55, 978
DOI: 10.1021/acs.macromol.1c02151

Biomolecular phase separation through theoretical and computational microscope

Rajeev Kumar, Da‐Hyun Koo, Yu‐Gon Eom and Jeong‐Mo Choi

Bulletin Korean Chem Soc, 2024, 45, 420
DOI: 10.1002/bkcs.12840

Coacervate Formation in Dilute Aqueous Solutions of Inorganic Molecular Clusters with Simple Divalent Countercations

Kexing Xiao, Yuqing Yang, Xiaohan Xu, Jennifer E. S. Szymanowski, Yifan Zhou, Ginger E. Sigmon, Peter C. Burns and Tianbo Liu

Inorg. Chem., 2024, 63, 15331
DOI: 10.1021/acs.inorgchem.4c02103

Tunable Electric Double-Layer Capacitor Performance through Engineered Charge Patterns in Polyelectrolytes

Yan Sui, Tingting Yin, Zixiao Yang, Yichun Zhao, Xiaoyu Kong, Dongluo Wu, Jiajia Zhou, Xiupeng Chen and Xian Kong

Macromolecules, 2025, 58, 6883
DOI: 10.1021/acs.macromol.5c00595

Fortification of dark chocolate with co-encapsulated saffron extract and caffeine

Samineh Sedaghati, Hamid Rajabi and Jahan Ahmadi

Applied Food Research, 2025, 5, 101358
DOI: 10.1016/j.afres.2025.101358

Physics-based computational and theoretical approaches to intrinsically disordered proteins

Joan-Emma Shea, Robert B Best and Jeetain Mittal

Current Opinion in Structural Biology, 2021, 67, 219
DOI: 10.1016/j.sbi.2020.12.012

Assessing the Structure and Equilibrium Conditions of Complex Coacervate Core Micelles by Varying Their Shell Composition and Medium Ionic Strength

Júlia Bonesso Sabadini, Cristiano Luis Pinto Oliveira and Watson Loh

Langmuir, 2024, 40, 2015
DOI: 10.1021/acs.langmuir.3c01606

Studying the effect of electromagnetic field (EMF) and presence of salt on electrostatic interactions between β-lactoglobulin (β-lg) and gum Arabic

Hossein Shahbazi, Mohammad Hadian and Mahtab Heyrani

Journal of Dispersion Science and Technology, 2024, 45, 1455
DOI: 10.1080/01932691.2023.2219310

Driving Forces in the Formation of Biocondensates of Highly Charged Proteins: A Thermodynamic Analysis of the Binary Complex Formation

Matthias Ballauff

Biomolecules, 2024, 14, 1421
DOI: 10.3390/biom14111421

Effect of Ionic Strength and Anion Identity on Rare‐Earth Element Chelation by Poly(acrylic acid)

Connor M. B. Gallagher and Michael D. Schulz

Macro Chemistry & Physics, 2023, 224
DOI: 10.1002/macp.202300235

Interfacial Tensions of Polyelectrolyte Multiphase Coacervation

Jie Wang, Xu Chen, Er-Qiang Chen and Shuang Yang

Macromolecules, 2024, 57, 9698
DOI: 10.1021/acs.macromol.4c02017

Ionic Compatibilization of Polymers

Glenn H. Fredrickson, Shuyi Xie, Jerrick Edmund, My Linh Le, Dan Sun, Douglas J. Grzetic, Daniel L. Vigil, Kris T. Delaney, Michael L. Chabinyc and Rachel A. Segalman

ACS Polym. Au, 2022, 2, 299
DOI: 10.1021/acspolymersau.2c00026

Temperature-Responsive Peptide–Nucleotide Coacervates

Tiemei Lu, Karina K. Nakashima and Evan Spruijt

J. Phys. Chem. B, 2021, 125, 3080
DOI: 10.1021/acs.jpcb.0c10839

Impact of a Lightly Branched Star Polyelectrolyte Architecture on Polyelectrolyte Complexes

Kaden C. Stevens and Matthew V. Tirrell

ACS Macro Lett., 2024, 13, 688
DOI: 10.1021/acsmacrolett.4c00167

Interfacial Structure and Tension of Polyelectrolyte Complex Coacervates

Pengfei Zhang and Zhen-Gang Wang

Macromolecules, 2021, 54, 10994
DOI: 10.1021/acs.macromol.1c01809

Alginate supramolecular for encapsulation of plant biocontrol bacteria: A review

Roohallah Saberi Riseh, Fariba Fathi, Masoumeh Vatankhah and John F. Kennedy

Carbohydrate Polymers, 2025, 358, 123511
DOI: 10.1016/j.carbpol.2025.123511

The Structure of Polyelectrolyte Complex Coacervates and Multilayers

Andrey V. Subbotin and Alexander N. Semenov

Macromolecules, 2021, 54, 1314
DOI: 10.1021/acs.macromol.0c02470

Liquid-liquid and liquid-solid separation in self-assembled chitosan-alginate and chitosan-pectin complexes

Abraham García-Jiménez, Angélica Román-Guerrero, César Pérez-Alonso and Benoit Fouconnier

International Journal of Biological Macromolecules, 2022, 223, 1368
DOI: 10.1016/j.ijbiomac.2022.11.091

Network-forming phase separation of oppositely charged polyelectrolytes forming coacervates in a solvent

Jiaxing Yuan and Hajime Tanaka

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-56583-6

Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein

Marie-Eve Beaulieu, Francisco Castillo and Laura Soucek

Cells, 2020, 9, 1038
DOI: 10.3390/cells9041038

Investigating the Effects of Charge Arrangement in Stimuli-Responsive Polyelectrolytes

Derrick E. Hastings, José C. Bozelli, Richard M. Epand and Harald D. H. Stöver

Macromolecules, 2021, 54, 11427
DOI: 10.1021/acs.macromol.1c01882

Structure–Property Relationships of Granular Hybrid Hydrogels Formed through Polyelectrolyte Complexation

Julien Es Sayed, Adrivit Mukherjee, Siham El Aani, Nayan Vengallur, Marcus Koch, Andrea Giuntoli and Marleen Kamperman

Macromolecules, 2024, 57, 3190
DOI: 10.1021/acs.macromol.3c02335

Treacle’s ability to form liquid-like phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair

Artem K Velichko, Nadezhda V Petrova, Dmitry A Deriglazov, Anastasia P Kovina, Artem V Luzhin, Eugene P Kazakov, Igor I Kireev, Sergey Razin and Omar L Kantidze

eLife, 2025, 13
DOI: 10.7554/eLife.96722.3

Micron-sized DNA–gelatin coacervates generated by ionic complexation in the presence of a nonionic polysaccharide

S. Vílchez, J. Miras, S. Farfan, R. Tur-Guasch, N. de Oliveira, A. Pérez-Calm, S. Grijalvo, C. Rodríguez-Abreu and J. Esquena

Journal of Colloid and Interface Science, 2026, 711, 140031
DOI: 10.1016/j.jcis.2026.140031

Chemically Fueled, Active Droplets Prevent the Aging of Peptides into Amyloid-Like Fibers

Monika Wenisch, Michele Stasi, Simone M. Poprawa, Brigitte A. K. Kriebisch and Job Boekhoven

J. Am. Chem. Soc., 2025
DOI: 10.1021/jacs.5c12831

Effect of calcium-coacervate infiltration of artificial enamel caries lesions in de- and remineralizing conditions

Basel Kharbot, Neziha Bulgun, Helmut Cölfen and Sebastian Paris

Journal of Dentistry, 2024, 142, 104838
DOI: 10.1016/j.jdent.2024.104838

Biomolecular condensates form spatially inhomogeneous network fluids

Furqan Dar, Samuel R. Cohen, Diana M. Mitrea, Aaron H. Phillips, Gergely Nagy, Wellington C. Leite, Christopher B. Stanley, Jeong-Mo Choi, Richard W. Kriwacki and Rohit V. Pappu

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-47602-z

Insights into the Mechanism of Protein Loading by Chain-Length Asymmetric Complex Coacervates

Eugenia Apuzzo, Marilina Cathcarth, Agustín S. Picco, Catalina von Bilderling, Omar Azzaroni, Maximiliano L. Agazzi and Santiago E. Herrera

Biomacromolecules, 2025, 26, 1171
DOI: 10.1021/acs.biomac.4c01516

Nanocellulose-based nanogels for sustained drug delivery: Preparation, characterization and in vitro evaluation

Tesfaye Gabriel, Anteneh Belete, Gerd Hause, Reinhard H.H. Neubert and Tsige Gebre-Mariam

Journal of Drug Delivery Science and Technology, 2022, 75, 103665
DOI: 10.1016/j.jddst.2022.103665

Sticky Science: Using Complex Coacervate Adhesives for Biomedical Applications

Ayla N. Kwant, Julien S. Es Sayed, Marleen Kamperman, Janette K. Burgess, Dirk‐Jan Slebos and Simon D. Pouwels

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202402340

Polyelectrolyte complexation of two oppositely charged symmetric polymers: A minimal theory

Soumik Mitra and Arindam Kundagrami

The Journal of Chemical Physics, 2023, 158
DOI: 10.1063/5.0128904

Differential Effects of Sequence-Local versus Nonlocal Charge Patterns on Phase Separation and Conformational Dimensions of Polyampholytes as Model Intrinsically Disordered Proteins

Tanmoy Pal, Jonas Wessén, Suman Das and Hue Sun Chan

J. Phys. Chem. Lett., 2024, 15, 8248
DOI: 10.1021/acs.jpclett.4c01973

Programmable Zwitterionic Droplets as Biomolecular Sorters and Model of Membraneless Organelles

Umberto Capasso Palmiero, Carolina Paganini, Marie R. G. Kopp, Miriam Linsenmeier, Andreas M. Küffner and Paolo Arosio

Advanced Materials, 2022, 34
DOI: 10.1002/adma.202104837

Phase Separation of Oppositely Charged Polymers Regulates Bioinspired Silicification

Hang Zhai, Tatyana Bendikov and Assaf Gal

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202115930

Coacervates as models of membraneless organelles

N. Amy Yewdall, Alain A.M. André, Tiemei Lu and Evan Spruijt

Current Opinion in Colloid & Interface Science, 2021, 52, 101416
DOI: 10.1016/j.cocis.2020.101416

Coacervation of biopolymers on muscovite surface

Jiaxin Chen, Zhijun Liu, Yanzhang Li, Qingwen Bai, Yan Li and Dehai Liang

Front. Soft. Matter, 2022, 2
DOI: 10.3389/frsfm.2022.1054658

Coacervate-Based Materials: Fabrication, Structure, and Applications

Chong Wang and Luoran Shang

Chem. Mater., 2025, 37, 4944
DOI: 10.1021/acs.chemmater.5c01267

Poly(siloxane)-Derived Ionosilicone Elastomers Reveal the Role of Interfacial Polymer Dynamics in Ionic Double-Layer Rectification

Owen A. Lee, Matthew K. McBride, Yitian Li and Ryan C. Hayward

ACS Macro Lett., 2025, 14, 727
DOI: 10.1021/acsmacrolett.5c00207

A Coarse-Grained Molecular Dynamics Study of Strongly Charged Polyelectrolyte Coacervates: Interfacial, Structural, and Dynamical Properties

Heyi Liang and Juan J. de Pablo

Macromolecules, 2022, 55, 4146
DOI: 10.1021/acs.macromol.2c00246

Coacervate‐Derived Assembly of Poly(ethylene glycol) Nanoparticles for Combinational Tumor Therapy

Hanru Liu, Dandan Ren, Huimin Geng, Yuan Tian, Mengqi Li, Ning Wang, Shiling Yuan, Jingcheng Hao and Jiwei Cui

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202403865

Self-Assembly of Miktoarm Star Polyelectrolytes in Solutions with Various Ionic Strengths

Bin Li and Yong-Lei Wang

ACS Omega, 2022, 7, 20791
DOI: 10.1021/acsomega.2c01317

Distinct Cation–Anion Interactions in the UCST and LCST Behavior of Polyelectrolyte Complex Aqueous Solutions

Zhangxin Ye, Shengtong Sun and Peiyi Wu

ACS Macro Lett., 2020, 9, 974
DOI: 10.1021/acsmacrolett.0c00303

Inorganic Polyphosphate: Coacervate Formation and Functional Significance in Nanomedical Applications

Heinz C Schröder, Meik Neufurth, Huan Zhou, Shunfeng Wang, Xiaohong Wang and Werner E G Müller

IJN, 2022, Volume 17, 5825
DOI: 10.2147/IJN.S389819

Self-assembly of architected macromolecules: Bridging a gap between experiments and simulations

Ji Woong Yu, Changsu Yoo, Suchan Cho, Myungeun Seo and YongJoo Kim

Chemical Physics Reviews, 2025, 6
DOI: 10.1063/5.0236427

Unraveling anomalous dispersion, and hydrophobic aggregation of zein nanoparticles

Priyanka Kaushik, Kamla Rawat and H.B. Bohidar

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 676, 132123
DOI: 10.1016/j.colsurfa.2023.132123

Hybrid Silica Cage-Type Nanostructures Made from Triply Hydrophilic Block Copolymers Single Micelles

Anu Vashishtha, Anthony Phimphachanh, Thomas Gaillard, Julien Schmitt, Corine Gerardin, Gaulthier Rydzek and Tangi Aubert

ACS Nano, 2024, 18, 29008
DOI: 10.1021/acsnano.4c09887

Visualizing Formation and Dynamics of a Three-Dimensional Sponge-like Network of a Coacervate in Real Time

Ryou Kubota, Taro Hiroi, Yuriki Ikuta, Yuchong Liu and Itaru Hamachi

J. Am. Chem. Soc., 2023, 145, 18316
DOI: 10.1021/jacs.3c03793

Rheological evidence for asymmetric phase separation mechanisms in soy glycinin's reentrant coacervation

Lang Qin, Jian Guo, Zhili Wan, Weixiang Sun and Xiaoquan Yang

Food Hydrocolloids, 2026, 172, 111976
DOI: 10.1016/j.foodhyd.2025.111976

Heteroprotein complex between soy protein isolate and lysozyme: Protein conformation, lysozyme activity, and structural characterization

Jiabao Zheng, Chuan-he Tang, Jihong Wu, Ge Ge, Mouming Zhao and Weizheng Sun

Food Chemistry, 2023, 411, 135509
DOI: 10.1016/j.foodchem.2023.135509

Surface-Immobilized Interpolyelectrolyte Complexes Formed by Polyelectrolyte Brushes

Artem M. Rumyantsev, Ekaterina B. Zhulina and Oleg V. Borisov

ACS Macro Lett., 2023, 12, 1727
DOI: 10.1021/acsmacrolett.3c00548

Structure–Thermodynamic Relationship of a Polysaccharide Gel (Alginate) as a Function of Water Content and Counterion Type (Na vs Ca)

Avery A. Agles and Ian C. Bourg

J. Phys. Chem. B, 2023, 127, 1828
DOI: 10.1021/acs.jpcb.2c07129

Incorporating Spherical and Rod-Shaped Gold Nanoparticles into Polymeric Coacervates

Eduardo Pontes Garcia, Julia Bonesso Sabadini, Paulo Ricardo de Abreu Furtado Garcia and Watson Loh

ACS Appl. Polym. Mater., 2026, 8, 5733
DOI: 10.1021/acsapm.6c00218

Molecular Dynamics Simulations of Ion-Containing Polymers Using Generic Coarse-Grained Models

Kuan-Hsuan Shen, Mengdi Fan and Lisa M. Hall

Macromolecules, 2021, 54, 2031
DOI: 10.1021/acs.macromol.0c02557

Biofunctional chitosan–biopolymer composites for biomedical applications

Yabin Guo, Dongling Qiao, Siming Zhao, Peng Liu, Fengwei Xie and Binjia Zhang

Materials Science and Engineering: R: Reports, 2024, 159, 100775
DOI: 10.1016/j.mser.2024.100775

Ionic-Group Dependence of Polyelectrolyte Coacervate Phase Behavior

Sojeong Kim, Minhwan Lee, Won Bo Lee and Soo-Hyung Choi

Macromolecules, 2021, 54, 7572
DOI: 10.1021/acs.macromol.1c00216

Standalone 2-D Nanosheets and the Consequent Hydrogel and Coacervate Phases Formed by 2.5 nm Spherical U60 Molecular Clusters in Dilute Aqueous Solution

Yuqing Yang, Yifan Zhou, Jiahui Chen, Tsuyoshi Kohlgruber, Travis Smith, Bowen Zheng, Jennifer E. S. Szymanowski, Peter C. Burns and Tianbo Liu

J. Phys. Chem. B, 2021, 125, 12392
DOI: 10.1021/acs.jpcb.1c08019

Liquid-liquid phase separation-driven coacervate-derived hydrogels and their biological applications

Jiao Zhang, Qian Hu, Qi Xie, Jingwen Liu, Wenke Lu, Xuewu Song, Liyun Xing, Li Kong, Conglian Yang and Zhiping Zhang

Journal of Controlled Release, 2026, 394, 114856
DOI: 10.1016/j.jconrel.2026.114856

Selectivity of Complex Coacervation in Multiprotein Mixtures

So Yeon Ahn and Allie C. Obermeyer

JACS Au, 2024, 4, 3800
DOI: 10.1021/jacsau.4c00399

Enhanced nutraceutical potential of cannabidiol derived from industrial hemp using plant based complex coacervates

Anto Pradeep Raja Charles, Yang Lan, Jae-Bom Ohm, Bingcan Chen and Jiajia Rao

Industrial Crops and Products, 2025, 223, 120130
DOI: 10.1016/j.indcrop.2024.120130

Molecular Exchange Kinetics in Complex Coacervate Core Micelles: Role of Associative Interaction

Tae-Young Heo, Sojeong Kim, Liwen Chen, Anna Sokolova, Sangwoo Lee and Soo-Hyung Choi

ACS Macro Lett., 2021, 10, 1138
DOI: 10.1021/acsmacrolett.1c00482

An explicit solvent model of coacervate structure and thermodynamics

Kayley Alonso, Atanu Baksi, Isabel Knight, Nga Nguyen, Mohsen Farshad, Samanvaya Srivastava and Jonathan K. Whitmer

The Journal of Chemical Physics, 2026, 164
DOI: 10.1063/5.0305035

An RNA-centric view of transcription and genome organization

Jonathan E. Henninger and Richard A. Young

Molecular Cell, 2024, 84, 3627
DOI: 10.1016/j.molcel.2024.08.021

Bio‐inspired adhesive hydrogel for biomedicine—principles and design strategies

Wenzhao Li, Xinyuan Yang, Puxiang Lai and Luoran Shang

Smart Medicine, 2022, 1
DOI: 10.1002/SMMD.20220024

Modulation of biomolecular phase behavior by metal ions

Katarzyna Sołtys, Aneta Tarczewska and Dominika Bystranowska

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023, 1870, 119567
DOI: 10.1016/j.bbamcr.2023.119567

Ascorbic acid encapsulation by complex coacervation of kappa carrageenan and calcium caseinate pretreated by high‐power ultrasound

M. Pérez‐Cortés, H. Ruiz‐Espinosa, M. Rojas‐López and G. G. Amador‐Espejo

J Food Process Engineering, 2024, 47
DOI: 10.1111/jfpe.14497

Peptide Design and Self-assembly into Targeted Nanostructure and Functional Materials

Nairiti J. Sinha, Matthew G. Langenstein, Darrin J. Pochan, Christopher J. Kloxin and Jeffery G. Saven

Chem. Rev., 2021, 121, 13915
DOI: 10.1021/acs.chemrev.1c00712

Spatiotemporal Formation and Growth Kinetics of Polyelectrolyte Complex Micelles with Millisecond Resolution

Hao Wu, Jeffrey M. Ting, Boyuan Yu, Nicholas E. Jackson, Siqi Meng, Juan J. de Pablo and Matthew V. Tirrell

ACS Macro Lett., 2020, 9, 1674
DOI: 10.1021/acsmacrolett.0c00543

Solutes unmask differences in clustering versus phase separation of FET proteins

Mrityunjoy Kar, Laura T. Vogel, Gaurav Chauhan, Suren Felekyan, Hannes Ausserwöger, Timothy J. Welsh, Furqan Dar, Anjana R. Kamath, Tuomas P. J. Knowles, Anthony A. Hyman, Claus A. M. Seidel and Rohit V. Pappu

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-48775-3

Phase Transitions in Chemically Fueled, Multiphase Complex Coacervate Droplets

Carsten Donau, Fabian Späth, Michele Stasi, Alexander M. Bergmann and Job Boekhoven

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202211905

Phase Transitions of Associative Biomacromolecules

Rohit V. Pappu, Samuel R. Cohen, Furqan Dar, Mina Farag and Mrityunjoy Kar

Chem. Rev., 2023, 123, 8945
DOI: 10.1021/acs.chemrev.2c00814

Chemically realistic coarse-grained models for polyelectrolyte solutions

Supreet Kaur and Arun Yethiraj

The Journal of Chemical Physics, 2022, 156
DOI: 10.1063/5.0080388

Balance of Macrophage Activation by a Complex Coacervate-Based Adhesive Drug Carrier Facilitates Diabetic Wound Healing

Ching-Shuen Wang, Shen-Dean Luo, Shihai Jia, Wilfred Wu, Shwu-Fen Chang, Sheng-Wei Feng, Chieh-Hsiang Yang, Jiann-Her Lin and Yinshen Wee

Antioxidants, 2022, 11, 2351
DOI: 10.3390/antiox11122351

Supernatant Phase in Polyelectrolyte Complex Coacervation: Cluster Formation, Binodal, and Nucleation

Pengfei Zhang and Zhen-Gang Wang

Macromolecules, 2022, 55, 3910
DOI: 10.1021/acs.macromol.2c00340

Extreme dependence of dynamics on concentration in highly crowded polyelectrolyte solutions

Harrison Landfield, Nicholas Kalamaris and Muzhou Wang

Sci. Adv., 2024, 10
DOI: 10.1126/sciadv.ado4976

Nano-Sized Fucoidan Interpolyelectrolyte Complexes: Recent Advances in Design and Prospects for Biomedical Applications

Natallia V. Dubashynskaya, Ekaterina R. Gasilova and Yury A. Skorik

IJMS, 2023, 24, 2615
DOI: 10.3390/ijms24032615

Static and transient vacuolation in protein-based coacervates induced by charged amino acids

Zhenhua Li, Qing Liu, Han Ding, Zhuojun Meng, Qi-Hong Zhao, Nan-Nan Deng and Lifei Zheng

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-61340-w

Glycan-Presenting Coacervates Derived from Charged Poly(active esters): Preparation, Phase Behavior, and Lectin Capture

Michele Denise Illmann, Lea Schäfl, Felicitas Drees, Laura Hartmann and Stephan Schmidt

Biomacromolecules, 2023, 24, 2532
DOI: 10.1021/acs.biomac.3c00046

Emergent microenvironments of nucleoli

Matthew R. King, Kiersten M. Ruff and Rohit V. Pappu

Nucleus, 2024, 15
DOI: 10.1080/19491034.2024.2319957

Polyelectrolyte Complex Coacervates: Structural Insights, Rheological Perspectives, and Industrial Applications

Gwangmin Jo, Byungwook Youn, Doojin Lee and Yeongun Ko

Fibers Polym, 2025, 26, 2263
DOI: 10.1007/s12221-025-00975-4

Interface Engineering in Multiphase Systems toward Synthetic Cells and Organelles: From Soft Matter Fundamentals to Biomedical Applications

Zhou Liu, Wen Zhou, Cheng Qi and Tiantian Kong

Advanced Materials, 2020, 32
DOI: 10.1002/adma.202002932

Theoretical Basis for Classifying Hyperuniform States of Two-Component Systems

Hiroshi Frusawa

Axioms, 2025, 14, 39
DOI: 10.3390/axioms14010039

Recent Advances in Complex Coacervation Design from Macromolecular Assemblies and Emerging Applications

Lili Zhou, Huihui Shi, Zibiao Li and Chaobin He

Macromol. Rapid Commun., 2020, 41
DOI: 10.1002/marc.202000149

Microphase Separation in Neutral Homopolymer Blends Induced by Salt-Doping

Xian Kong and Jian Qin

Macromolecules, 2023, 56, 254
DOI: 10.1021/acs.macromol.2c02198

Core-shell-corona macromolecular architectures via electrostatic co-assembly

Ivan A Babin, Larisa Viktorovna Sigolaeva and Dmitry Vladimirovich Pergushov

Mendeleev Communications, 2025, 35, 410
DOI: 10.71267/mencom.7640

Polyampholyte physics: Liquid–liquid phase separation and biological condensates

Jelena Dinic, Amanda B. Marciel and Matthew V. Tirrell

Current Opinion in Colloid & Interface Science, 2021, 54, 101457
DOI: 10.1016/j.cocis.2021.101457

Charge symmetry broken complex coacervation

Arghya Majee, Markus Bier, Ralf Blossey and Rudolf Podgornik

Phys. Rev. Research, 2020, 2
DOI: 10.1103/PhysRevResearch.2.043417

The role of hydrophobicity in supramolecular polymer/surfactant catalysts: An understandable model for enzymatic catalysis

Paulo F.A. Costa, Rafael de Abreu, Andressa B. Fontana, Haidi D. Fiedler, Anthony J. Kirby, Frank H. Quina, Faruk Nome and Adriana P. Gerola

Journal of Colloid and Interface Science, 2021, 588, 456
DOI: 10.1016/j.jcis.2020.12.081

Site-Specific Polymerization-Induced Electrostatic Self-Assembly: Synthesis of Highly Charged Salt-Tolerant Polyion Complex Nanoreactors

Jie Cai, Xiyu Wang, Yuanyuan Liu, Caihui Luo, Xinhua Lu and Yuanli Cai

Macromolecules, 2023, 56, 10153
DOI: 10.1021/acs.macromol.3c01849

Spatiotemporal Control of Melanin Synthesis in Liquid Droplets

Tlalit Massarano, Avigail Baruch Leshem, Michal Weitman and Ayala Lampel

ACS Appl. Mater. Interfaces, 2022, 14, 20520
DOI: 10.1021/acsami.1c21006

Crossover from Rouse to Reptation Dynamics in Salt-Free Polyelectrolyte Complex Coacervates

Boyuan Yu, Phillip M. Rauscher, Nicholas E. Jackson, Artem M. Rumyantsev and Juan J. de Pablo

ACS Macro Lett., 2020, 9, 1318
DOI: 10.1021/acsmacrolett.0c00522

Complex Coacervates of Linear Polymers and Polymer-Grafted Nanoparticles

Mingjun Zhou, Nickolas Holmlund, Sarah L. Perry and Maria M. Santore

Macromolecules, 2026, 59, 1679
DOI: 10.1021/acs.macromol.5c02924

Structure and stoichiometry of CTAB–DNA complexes

S. Madhukar, A. V. Radhakrishnan, A. K. Majhi and V. A. Raghunathan

The Journal of Chemical Physics, 2020, 153
DOI: 10.1063/5.0033193

Phase Behavior of Ion-Containing Polymers in Polar Solvents: Predictions from a Liquid-State Theory with Local Short-Range Interactions

Yanwei Wang, Qiyuan Qiu, Arailym Yedilbayeva, Diana Kairula and Liang Dai

Polymers, 2022, 14, 4421
DOI: 10.3390/polym14204421

Decoupling the Effects of Charge Density and Hydrophobicity on the Phase Behavior and Viscoelasticity of Complex Coacervates

Isaac A. Ramírez Marrero, Luke Boudreau, Weiguo Hu, Rainer Gutzler, Nadine Kaiser, Bernhard von Vacano, Rupert Konradi and Sarah L. Perry

Macromolecules, 2024, 57, 4680
DOI: 10.1021/acs.macromol.4c00247

Coacervate Droplets as Biomimetic Models for Designing Cell‐Like Microreactors

Tsvetomir Ivanov, Thao. P. Doan‐Nguyen, Mohammed Amin Belahouane, Zhen Dai, Shoupeng Cao, Katharina Landfester and Lucas Caire da Silva

Macromol. Rapid Commun., 2024, 45
DOI: 10.1002/marc.202400626

Layer-by-layer concurrent encapsulation of probiotics and bioactive compounds with supplementation in intermediary layers: An establishing instrument for microbiome recharge, core safety, and targeted delivery

Muhammad Safiullah Virk, Muhammad Abdulrehman Virk, Mehak Gul, Muhammad Awais, Qiufang Liang, Tabussam Tufail, Mingming Zhong, Yufan Sun, Abdul Qayum, Ekram Abd El-Salam, John-Nelson Ekumah, Abdur Rehman, Arif Rashid and Xiaofeng Ren

Food Hydrocolloids, 2025, 161, 110873
DOI: 10.1016/j.foodhyd.2024.110873

Temporal Control Over Complex, Simple, and Multiphase Coacervates Using Ureolysis and Ammonium Carbonate Decomposition

Shana Shirin Valapra, Malak Jaber, Tsvetomir Ivanov, Lucas Caire da Silva and Guillermo Monreal Santiago

ChemSystemsChem, 2026, 8
DOI: 10.1002/syst.202500081

Material properties of biomolecular condensates emerge from nanoscale dynamics

Nicola Galvanetto, Miloš T. Ivanović, Simone A. Del Grosso, Aritra Chowdhury, Andrea Sottini, Daniel Nettels, Robert B. Best and Benjamin Schuler

Proc. Natl. Acad. Sci. U.S.A., 2025, 122
DOI: 10.1073/pnas.2424135122

Molecular determinants of protein-based coacervates

Rachel A. Kapelner, Vivian Yeong and Allie C. Obermeyer

Current Opinion in Colloid & Interface Science, 2021, 52, 101407
DOI: 10.1016/j.cocis.2020.101407

Dendritic Membranized Coacervate Microdroplets: A Robust Platform for Synthetic-Living Cell Consortia

Celia Jimenez-Lopez, Lucas Garcia-Abuin and Eduardo Fernandez-Megia

J. Am. Chem. Soc., 2025, 147, 29457
DOI: 10.1021/jacs.5c09772

Effect of mixing order on structure and formation of polyelectrolyte complexes

Amir Kashkooli, Mangesh Bhendale, Júlia Bonesso Sabadini, Aman Agrawal, Gül H. Zerze and Alamgir Karim

Journal of Colloid and Interface Science, 2026, 716, 140298
DOI: 10.1016/j.jcis.2026.140298

Processing Polyelectrolyte Complexes with Deep Eutectic Solvents

YuLing Chen and Kenneth R. Shull

ACS Macro Lett., 2021, 10, 1243
DOI: 10.1021/acsmacrolett.1c00494

Single-stranded nucleic acid binding and coacervation by linker histone H1

Rachel Leicher, Adewola Osunsade, Gabriella N. L. Chua, Sarah C. Faulkner, Andrew P. Latham, John W. Watters, Tuan Nguyen, Emily C. Beckwitt, Sophia Christodoulou-Rubalcava, Paul G. Young, Bin Zhang, Yael David and Shixin Liu

Nat Struct Mol Biol, 2022, 29, 463
DOI: 10.1038/s41594-022-00760-4

Effect of Copolymer Chemistry on the Humidity- and Temperature-Dependent Mechanical Properties and Structure of Polyelectrolyte Complexes

Isaac A. Ramírez Marrero, Emily Ng, Nadine Kaiser, Bernhard von Vacano, Rupert Konradi, Alfred J. Crosby and Sarah L. Perry

Macromolecules, 2026
DOI: 10.1021/acs.macromol.6c00278

The Kinetic Pathways for the Formation of Complex Coacervate Micelles of Antimicrobial Peptides and Block Copolymers

Thomas D. Vogelaar, Henrik Torjusen, Theyencheri Narayanan and Reidar Lund

Macromolecules, 2025, 58, 158
DOI: 10.1021/acs.macromol.4c02077

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations

Mina Farag, Samuel R. Cohen, Wade M. Borcherds, Anne Bremer, Tanja Mittag and Rohit V. Pappu

Nat Commun, 2022, 13
DOI: 10.1038/s41467-022-35370-7

A pH-Dependent Phase Separation Drives Polyamine-Mediated Silicification from Undersaturated Solutions

Protap Biswas, Nitzan Livni, Debojit Paul, Lior Aram, Razi Safadi, Neta Varsano, Nadav Elad, Roman Kamyshinsky, Michal Leskes and Assaf Gal

ACS Nano, 2024, 18, 33998
DOI: 10.1021/acsnano.4c08707

Subcompartmentalization of polyampholyte species in organelle-like condensates is promoted by charge-pattern mismatch and strong excluded-volume interaction

Tanmoy Pal, Jonas Wessén, Suman Das and Hue Sun Chan

Phys. Rev. E, 2021, 103
DOI: 10.1103/PhysRevE.103.042406

Molecular thermodynamics of complex coacervate systems. Part I: Modeling of polyelectrolyte solutions using pePC-SAFT

Moreno Ascani, Gabriele Sadowski and Christoph Held

Fluid Phase Equilibria, 2025, 591, 114304
DOI: 10.1016/j.fluid.2024.114304

Adsorption of Charge Sequence-Specific Polydisperse Polyelectrolytes

Vaidyanathan Sethuraman, David Zheng, David C. Morse and Kevin D. Dorfman

Macromolecules, 2022, 55, 3030
DOI: 10.1021/acs.macromol.1c02623

Stimuli-Induced Nonequilibrium Phase Transitions in Polyelectrolyte–Surfactant Complex Coacervates

Chloé Seyrig, Gertrude Kignelman, Wim Thielemans, Patrick Le Griel, Nathan Cowieson, Javier Perez and Niki Baccile

Langmuir, 2020, 36, 8839
DOI: 10.1021/acs.langmuir.0c01177

Influence of micellar size on the structure of surfactant-DNA complexes

A. V. Radhakrishnan, S. Madhukar, A. Chowdhury and V. A. Raghunathan

Phys. Rev. E, 2022, 105
DOI: 10.1103/PhysRevE.105.064504

3D-Printable Granular Hydrogel Composed of Hyaluronic Acid-Chitosan Hybrid Polyelectrolyte Complex Microgels

Armin Amirsadeghi, Shahriar Mahdavi, Paula Jager, Marleen Kamperman and Julien Es Sayed

Biomacromolecules, 2025, 26, 3641
DOI: 10.1021/acs.biomac.5c00228

Phase Separation and Gelation in Solutions and Blends of Heteroassociative Polymers

Scott P. O. Danielsen, Alexander N. Semenov and Michael Rubinstein

Macromolecules, 2023, 56, 5661
DOI: 10.1021/acs.macromol.3c00854

Compartmentation of multiple metabolic enzymes and their preparation in vitro and in cellulo

Sayoko Ito-Harashima and Natsuko Miura

Biochimica et Biophysica Acta (BBA) - General Subjects, 2025, 1869, 130787
DOI: 10.1016/j.bbagen.2025.130787

Tuning of Cationic Polymer Functionality in Complex Coacervate Artificial Cells for Optimized Enzyme Activity

Alexander B Cook, Bruno Delgado Gonzalez and Jan C M van Hest

Biomacromolecules, 2024, 25, 425
DOI: 10.1021/acs.biomac.3c01063

Molecular Design of Chemically Fueled Peptide–Polyelectrolyte Coacervate-Based Assemblies

Fabian Späth, Carsten Donau, Alexander M. Bergmann, Moritz Kränzlein, Christopher V. Synatschke, Bernhard Rieger and Job Boekhoven

J. Am. Chem. Soc., 2021, 143, 4782
DOI: 10.1021/jacs.1c01148

Polyamide Epichlorohydrin‐Sodium Benzenesulfonate Form Curable Coacervate via Synergistic Supramolecular Interactions

Jiancong Yuan, Xiaoye He, Yongjie Yuan, Hailiang Zhang and Qiang Zhao

Journal of Polymer Science, 2026, 64, 1663
DOI: 10.1002/pol.20250243

Recent developments in the encapsulation of lavender essential oil

Sara Hedayati, Mohammad Tarahi, Aida Iraji and Mohammad Hashem Hashempur

Advances in Colloid and Interface Science, 2024, 331, 103229
DOI: 10.1016/j.cis.2024.103229

Dynamic equilibrium of β-conglycinin/lysozyme heteroprotein complex coacervates

Jiabao Zheng, Qing Gao, Ge Ge, Jihong Wu, Chuan-he Tang, Mouming Zhao and Weizheng Sun

Food Hydrocolloids, 2022, 124, 107339
DOI: 10.1016/j.foodhyd.2021.107339

Electrostatically Stabilized Microstructures: From Clusters to Necklaces to Bulk Microphases

Artem M. Rumyantsev and Albert Johner

ACS Macro Lett., 2025, 14, 472
DOI: 10.1021/acsmacrolett.4c00834

Role of Charge Patterning and Hydrophobicity in Peptide-Based Complex Coacervates

Arvind Sathyavageeswaran, Pankaj Kumar Pandey, Nickolas Holmlund, Priyanka Kaushik, Shannon McIntosh, Raneem Mokdad and Sarah L. Perry

Biomacromolecules, 2025, 26, 6574
DOI: 10.1021/acs.biomac.5c00773

100th Anniversary of Macromolecular Science Viewpoint: Attractive Soft Matter: Association Kinetics, Dynamics, and Pathway Complexity in Electrostatically Coassembled Micelles

Christian C. M. Sproncken, J. Rodrigo Magana and Ilja K. Voets

ACS Macro Lett., 2021, 10, 167
DOI: 10.1021/acsmacrolett.0c00787

Effect of Solvent Quality on the Phase Behavior of Polyelectrolyte Complexes

Lu Li, Artem M. Rumyantsev, Samanvaya Srivastava, Siqi Meng, Juan J. de Pablo and Matthew V. Tirrell

Macromolecules, 2021, 54, 105
DOI: 10.1021/acs.macromol.0c01000

Investigating the electrostatic complexation of BCNO nanoparticles with a stimuli-responsive double hydrophilic graft copolymer

Yun-Chen Chien, You-Teng Hsu, Chen-Wei Chiang, Pei Yuin Keng and Tzu-Wei Wang

Giant, 2023, 14, 100162
DOI: 10.1016/j.giant.2023.100162

Interplay between autocatalysis and liquid-liquid phase separation produces hierarchical microcompartments

Anton I. Hanopolskyi, Tatiana A. Mikhnevich, Arpita Paikar, Boaz Nutkovich, Iddo Pinkas, Tali Dadosh, Barbara S. Smith, Nikita Orekhov, Ekaterina V. Skorb and Sergey N. Semenov

Chem, 2023, 9, 3666
DOI: 10.1016/j.chempr.2023.08.029

Molecular determinants of phase separation for Drosophila DNA replication licensing factors

Matthew W Parker, Jonchee A Kao, Alvin Huang, James M Berger and Michael R Botchan

eLife, 2021, 10
DOI: 10.7554/eLife.70535

Two Sides of the Same Coin: A Unified Theoretical Treatment of Polyelectrolyte Complexation in Solution and Layer-by-Layer Films

Gabriel Debais and Mario Tagliazucchi

Macromolecules, 2022, 55, 5263
DOI: 10.1021/acs.macromol.2c00250

Encapsulation and sedimentation of nanomaterials through complex coacervation

Pablo González-Monje, Alex Ayala García, Daniel Ruiz-Molina and Claudio Roscini

Journal of Colloid and Interface Science, 2021, 589, 500
DOI: 10.1016/j.jcis.2020.12.067

Liquid-liquid phase separation (LLPS) in synthetic biosystems

Wei Kang, Xiao Ma, Chunxue Liu, Suwan Wang, Yuecheng Zhou, Chuang Xue, Yuci Xu and Bo Li

Materials Science and Engineering: R: Reports, 2024, 157, 100762
DOI: 10.1016/j.mser.2023.100762

Polyelectrolyte–Carbon Dot Complex Coacervation

Pankaj Kumar Pandey, Arvind Sathyavageeswaran, Nickolas Holmlund and Sarah L. Perry

ACS Macro Lett., 2025, 14, 43
DOI: 10.1021/acsmacrolett.4c00745

Applicability of the Generalized Stokes–Einstein Equation of Mode-Coupling Theory to Near-Critical Polyelectrolyte Complex Solutions

Yuanchi Ma, Steven D. Hudson, Paul F. Salipante, Jack F. Douglas and Vivek M. Prabhu

ACS Macro Lett., 2023, 12, 288
DOI: 10.1021/acsmacrolett.2c00647

Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase

Anna C. Papageorgiou, Michaela Pospisilova, Jakub Cibulka, Raghib Ashraf, Christopher A. Waudby, Pavel Kadeřávek, Volha Maroz, Karel Kubicek, Zbynek Prokop, Lumir Krejci and Konstantinos Tripsianes

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-42503-z

Unifying Weak and Strong Charge Correlations within the Random Phase Approximation: Polyampholytes of Various Sequences

Artem M. Rumyantsev, Albert Johner, Matthew V. Tirrell and Juan J. de Pablo

Macromolecules, 2022, 55, 6260
DOI: 10.1021/acs.macromol.2c00569

Effect of Charged Block Length Mismatch on Double Diblock Polyelectrolyte Complex Micelle Cores

Kaden C. Stevens, Alexander E. Marras, Trinity R. Campagna, Jeffrey M. Ting and Matthew V. Tirrell

Macromolecules, 2023, 56, 5557
DOI: 10.1021/acs.macromol.3c00555

Construction of Membraneless and Multicompartmentalized Coacervate Protocells Controlling a Cell Metabolism-like Cascade Reaction

Giovanni B. Perin, Silvia Moreno, Yang Zhou, Markus Günther, Susanne Boye, Brigitte Voit, Maria I. Felisberti and Dietmar Appelhans

Biomacromolecules, 2023, 24, 5807
DOI: 10.1021/acs.biomac.3c00828

Design Rules for the Sequestration of Viruses into Polypeptide Complex Coacervates

Pratik U. Joshi, Claire Decker, Xianci Zeng, Arvind Sathyavageeswaran, Sarah L. Perry and Caryn L. Heldt

Biomacromolecules, 2024, 25, 741
DOI: 10.1021/acs.biomac.3c00938

Polymeric coacervate coating for flame retardant paper

Bethany Palen, Matthew G. Rabaey, Danixa Rodriguez-Melendez, Ethan T. Iverson, Thomas J. Kolibaba and Jaime C. Grunlan

Cellulose, 2022, 29, 4589
DOI: 10.1007/s10570-022-04594-7

Active microrheology of protein condensates using colloidal probe-AFM

Xiufeng Li, Jasper van der Gucht, Philipp Erni and Renko de Vries

Journal of Colloid and Interface Science, 2023, 632, 357
DOI: 10.1016/j.jcis.2022.11.071

Thermosensitive Nanostructured Coacervates Developed by Mixing ABA‐ and AB‐Block Copolymers and Their Unique Sustained Release of Nano‐Micelles in a Regulated Manner

Takumi Egashira, Hiroshi Kamizawa, Yujiro Hamada, Wataru Fushimoto, Hiroshi Y. Yoshikawa, Yuji Higaki, Atsushi Takahara, Takeshi Mori, Yoshiki Katayama and Akihiro Kishimura

Small, 2025
DOI: 10.1002/smll.202505876

Preparation and solution properties of helical sulfonium-based polypeptides and their polyelectrolyte complexes

Fei Xu, Ruizhong Xue, Fangping Yang, Hao Liu, Xu Zhang, Shifang Luan and Haoyu Tang

European Polymer Journal, 2021, 149, 110390
DOI: 10.1016/j.eurpolymj.2021.110390

Biophysical Properties of Self-Assembled Immune Signals Impact Signal Processing and the Nature of Regulatory Immune Function

Eugene Froimchuk, Robert S. Oakes, Senta M. Kapnick, Alexis A. Yanes and Christopher M. Jewell

Nano Lett., 2021, 21, 3762
DOI: 10.1021/acs.nanolett.0c05118

Hydrogen Bond-Regulated Rapid Prototyping and Performance Optimization of Polyvinyl Alcohol–Tannic Acid Hydrogels

Xiangyu Zou and Jun Huang

Gels, 2025, 11, 602
DOI: 10.3390/gels11080602

Tuning the underwater adhesiveness of antibacterial polysaccharides complex coacervates

Perrine Galland, Muhammad Haseeb Iqbal, Damien Favier, Mélanie Legros, Pierre Schaaf, Fouzia Boulmedais and Mehdi Vahdati

Journal of Colloid and Interface Science, 2024, 661, 196
DOI: 10.1016/j.jcis.2024.01.193

Selective Adsorption of Confined Polymers: Self-Consistent Field Theory Studies

Changhang Huang, Rudolf Podgornik and Xingkun Man

Macromolecules, 2021, 54, 9602
DOI: 10.1021/acs.macromol.1c01785

Fatty Acid Vesicles and Coacervates as Model Prebiotic Protocells

Nicolas Martin and Jean‐Paul Douliez

ChemSystemsChem, 2021, 3
DOI: 10.1002/syst.202100024

Hydrogen-bonding polymer complexation: Coacervation interfered with gelation

Caihong Zhang, Weijie Wang, Pengfei Zhang and Shuguang Yang

Giant, 2023, 14, 100166
DOI: 10.1016/j.giant.2023.100166

Microencapsulation of Essential Oils Using Faba Bean Protein and Chia Seed Polysaccharides via Complex Coacervation Method

Alicja Napiórkowska, Arkadiusz Szpicer, Elżbieta Górska-Horczyczak and Marcin Andrzej Kurek

Molecules, 2024, 29, 2019
DOI: 10.3390/molecules29092019

Fluctuations, structure, and size inside coacervates

Murugappan Muthukumar

Eur. Phys. J. E, 2023, 46
DOI: 10.1140/epje/s10189-023-00335-1

Supramolecular fibrillation in coacervates and other confined systems towards biomimetic function

Adrian Sanchez-Fernandez, Ignacio Insua and Javier Montenegro

Commun Chem, 2024, 7
DOI: 10.1038/s42004-024-01308-x

Polyelectrolytes: From Seminal Works to the Influence of the Charge Sequence

Nam-Kyung Lee, Min-Kyung Chae, Youngkyun Jung, Albert Johner and Jean-Francois Joanny

Polymers, 2023, 15, 4593
DOI: 10.3390/polym15234593

Recent progress in liquid embolic agents

Giho Ko, Jin Woo Choi, Nohyun Lee, Dokyoon Kim, Taeghwan Hyeon and Hyo-Cheol Kim

Biomaterials, 2022, 287, 121634
DOI: 10.1016/j.biomaterials.2022.121634

Mixing Order Asymmetry in Nanoparticle-Polymer Complexation and Precipitation Revealed by Isothermal Titration Calorimetry

Letícia Vitorazi and Jean-François Berret

J. Phys. Chem. B, 2024, 128, 7859
DOI: 10.1021/acs.jpcb.4c02484

Rational Design of Zwitterionic Polymers with Tunable Phase Separation Propensity

Timo N. Schneider, Suiying Ye, Nicola Carrara, Umberto Capasso Palmiero, Matteo Salvalaglio and Paolo Arosio

Macromolecules, 2025, 58, 11192
DOI: 10.1021/acs.macromol.5c01394

A compositional view comparing modern biological condensates and primitive phase‐separated compartments

Selene M. C. Cannelli, Ritvik Gupta, Tan Nguyen, Arunava Poddar, Srishti Sharma, Prachiti V. Vithole and Tony Z. Jia

Peptide Science, 2023, 115
DOI: 10.1002/pep2.24331

Solid-Phase Molecular Self-Assembly Leading to Scale-Span Molecular Materials

Jiachen Guo, Huaiyu Song, Letian Yuan, Jianbin Huang and Yun Yan

Nano Lett., 2026, 26, 1975
DOI: 10.1021/acs.nanolett.5c05448

A minimalist design approach to simple coacervates from low-molecular-weight components

Ryou Kubota

Polym J, 2025, 57, 815
DOI: 10.1038/s41428-025-01037-5

Molecular Dynamics Simulations of Polyelectrolyte Complexes

Tania Rajpersaud, Sara Tabandeh, Lorraine Leon and Sharon M. Loverde

Biomacromolecules, 2024, 25, 1468
DOI: 10.1021/acs.biomac.3c01032

Highly Asymmetric Lamellar Structure in Blends of Polystyrene-b-Poly(acrylic acid) Block Copolymers and Poly(4-vinylpyridine) Homopolymers Facilitated by Polyelectrolyte Complexation

Shi-Peng Ding, Kun Qian, Ze Ye, Ding-Li Xia and Jun-Ting Xu

Macromolecules, 2024, 57, 9802
DOI: 10.1021/acs.macromol.4c01435

Spatiotemporal organization of coacervate microdroplets

Xuejing Wang, Pengfei Zhang and Liangfei Tian

Current Opinion in Colloid & Interface Science, 2021, 52, 101420
DOI: 10.1016/j.cocis.2021.101420

Form Equals Function: Influence of Coacervate Architecture on Drug Delivery Applications

Chaeyoung Lim and Whitney C. Blocher McTigue

ACS Biomater. Sci. Eng., 2024, 10, 6766
DOI: 10.1021/acsbiomaterials.4c01105

Charge Density and Hydrophobicity-Dominated Regimes in the Phase Behavior of Complex Coacervates

Jun Huang and Jennifer E. Laaser

ACS Macro Lett., 2021, 10, 1029
DOI: 10.1021/acsmacrolett.1c00382

Soft underwater adhesives based on weak molecular interactions

Mehdi Vahdati, Dominique Hourdet and Costantino Creton

Progress in Polymer Science, 2023, 139, 101649
DOI: 10.1016/j.progpolymsci.2023.101649

Designing polymeric interactions toward smart particles

Ana S Prata, Raul F Nascimento and Carlos RF Grosso

Current Opinion in Food Science, 2022, 46, 100867
DOI: 10.1016/j.cofs.2022.100867

Molecular thermodynamics of complex coacervate systems. Part II: Measuring and modeling of the phase envelope using pePC-SAFT

Moreno Ascani, Wojciech P. Lipínski, Iris B.A. Smokers, Piramsuya Neethirajah, Max Vogel, Evan Spruijt, Gabriele Sadowski and Christoph Held

Fluid Phase Equilibria, 2025, 591, 114305
DOI: 10.1016/j.fluid.2024.114305

Cosolvent Control of Lower and Upper Critical Solution Behavior in Polyelectrolyte Complexes

Yuanchi Ma and Vivek M. Prabhu

ACS Macro Lett., 2025, 14, 962
DOI: 10.1021/acsmacrolett.5c00315

Exploring the effects of excipients on complex coacervation

Xianci Zeng, Pratik U. Joshi, Alexander Lawton, Lynn Manchester, Caryn L. Heldt and Sarah L. Perry

Journal of Colloid and Interface Science, 2025, 695, 137808
DOI: 10.1016/j.jcis.2025.137808

Influence of divalent ions on composition and viscoelasticity of polyelectrolyte complexes

Divya Iyer, Vaqar M. S. Syed and Samanvaya Srivastava

Journal of Polymer Science, 2021, 59, 2895
DOI: 10.1002/pol.20210668

Scaling Field-Theoretic Simulation for Multicomponent Mixtures with Neural Operators

Emmit K. Pert, Clay H. Batton, Xiang Li, Steven Dunne and Grant M. Rotskoff

J. Chem. Theory Comput., 2025, 21, 4167
DOI: 10.1021/acs.jctc.5c00102

Dynamic Covalent Boronate Chemistry for In Situ Formation, Interfacial Stabilization, and Cytomimetic Optimization of Coacervates

Bruno Delgado Gonzalez, Lucas Garcia-Abuin, Celia Jimenez-Lopez and Eduardo Fernandez-Megia

J. Am. Chem. Soc., 2026, 148, 9346
DOI: 10.1021/jacs.5c17688

Engineering Protein–Polyelectrolyte Interactions for Cellular Applications

Rachel S. Fisher, Jane Liao, So Yeon Ahn, Nisha Modi, Aaron K. Kidane and Allie C. Obermeyer

Annual Review of Chemical and Biomolecular Engineering, 2025, 16, 119
DOI: 10.1146/annurev-chembioeng-100722-105929

Targeted RNA condensation in living cells via genetically encodable triplet repeat tags

Zhaolin Xue, Kewei Ren, Rigumula Wu, Zhining Sun, Ru Zheng, Qian Tian, Ahsan Ausaf Ali, Lan Mi and Mingxu You

Nucleic Acids Research, 2023, 51, 8337
DOI: 10.1093/nar/gkad621

Heterogeneous Charged Complexes of Random Copolymers for the Segregation of Organic Molecules

Jeremy Wang, Curt Waltmann, Han Umana-Kossio, Monica Olvera de la Cruz and John M. Torkelson

ACS Cent. Sci., 2021, 7, 882
DOI: 10.1021/acscentsci.1c00119

Exploring the frontier of nanoencapsulation: smart delivery systems for targeted and controlled release

Lokesh Thirumurugan, Raja Kalimuthu, Gomathi Velu, Senthilkumar Murugaiyan, Navin Kumar Thirumurugan and Ajay Govindaraj

Adv. Nat. Sci: Nanosci. Nanotechnol., 2026, 17, 023002
DOI: 10.1088/2043-6262/ae5dd2

Programmable Coacervates Based on Minimalist Sticker–Spacer Frameworks: Chemical Design, Functions, and Emerging Applications

Nadeem Essa and Manzar Abbas

ACS Appl. Mater. Interfaces, 2026, 18, 23969
DOI: 10.1021/acsami.6c03853

Timed Formation and Aging of Complex Coacervates Using a Volatile Salt

Lunan Yan, Weiwei Zheng, Enola Muller, Philippe Carl, Thomas M. Hermans and Guillermo Monreal Santiago

Macromolecules, 2025, 58, 3635
DOI: 10.1021/acs.macromol.4c02728

New insights into protein–polysaccharide complex coacervation: Dynamics, molecular parameters, and applications

Jiabao Zheng, Paul Van der Meeren and Weizheng Sun

Aggregate, 2024, 5
DOI: 10.1002/agt2.449

Driving force and pathway in polyelectrolyte complex coacervation

Shensheng Chen and Zhen-Gang Wang

Proc. Natl. Acad. Sci. U.S.A., 2022, 119
DOI: 10.1073/pnas.2209975119

Excitonically Coupled Simple Coacervates via Liquid/Liquid Phase Separation

Anna R. Johnston, Gregory M. Pitch, Eris D. Minckler, Ivette G. Mora, Vitor H. Balasco Serrão, Eric A. Dailing and Alexander L. Ayzner

J. Phys. Chem. Lett., 2022, 13, 10275
DOI: 10.1021/acs.jpclett.2c02466

Structural Polymorphism of Single pDNA Condensates Elicited by Cationic Block Polyelectrolytes

Kensuke Osada

Polymers, 2020, 12, 1603
DOI: 10.3390/polym12071603

Bioinspired Sandcastle Worm-Derived Peptide-Based Hybrid Hydrogel for Promoting the Formation of Liver Spheroids

Yu-Hsu Chen, Yuan-Hao Ku, Kuo-Cheng Wang, Hung-Chi Chiang, Yu-Pao Hsu, Ming-Te Cheng, Ching-Shuen Wang and Yinshen Wee

Gels, 2022, 8, 149
DOI: 10.3390/gels8030149

Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient

Matthew R. King, Kiersten M. Ruff, Andrew Z. Lin, Avnika Pant, Mina Farag, Jared M. Lalmansingh, Tingting Wu, Martin J. Fossat, Wei Ouyang, Matthew D. Lew, Emma Lundberg, Michael D. Vahey and Rohit V. Pappu

Cell, 2024, 187, 1889
DOI: 10.1016/j.cell.2024.02.029

Cooperation and Competition of Base Pairing and Electrostatic Interactions in Mixtures of DNA Nanostars and Polylysine

Gabrielle R. Abraham, Tianhao Li, Anna Nguyen, William M. Jacobs and Omar A. Saleh

J. Am. Chem. Soc., 2025
DOI: 10.1021/jacs.5c12436

Analytical Formulation and Field-Theoretic Simulation of Sequence-Specific Phase Separation of Protein-Like Heteropolymers with Short- and Long-Spatial-Range Interactions

Jonas Wessén, Suman Das, Tanmoy Pal and Hue Sun Chan

J. Phys. Chem. B, 2022, 126, 9222
DOI: 10.1021/acs.jpcb.2c06181

Bioactive Compounds and the Performance of Proteins as Wall Materials for Their Encapsulation

Therys Senna de Castro Oliveira, Jhonathan Valente Ferreira Gusmão, Thaís Caroline Buttow Rigolon, Daiana Wischral, Pedro Henrique Campelo, Evandro Martins and Paulo Cesar Stringheta

Micro, 2025, 5, 36
DOI: 10.3390/micro5030036

Liquid Crystal Peptide/DNA Coacervates in the Context of Prebiotic Molecular Evolution

Tony Z. Jia and Tommaso P. Fraccia

Crystals, 2020, 10, 964
DOI: 10.3390/cryst10110964

Competition between β-Sheet and Coacervate Domains Yields Diverse Morphologies in Mixtures of Oppositely Charged Homochiral Polypeptides

Nairiti J. Sinha, Keila Cristina Cunha, Robert Murphy, Craig J. Hawker, Joan-Emma Shea and Matthew E. Helgeson

Biomacromolecules, 2023, 24, 3580
DOI: 10.1021/acs.biomac.3c00361