New nitazoxanide derivatives: design, synthesis, biological evaluation, and molecular docking studies as antibacterial and antimycobacterial agents

Mahmoud Saleh, Yaser A. Mostafa, Jyothi Kumari, Momen M. Thabet, Dharmarajan Sriram, Mahmoud Kandeel and Hajjaj H. M. Abdu-Allah

RSC Med. Chem., 2023, 14, 2714
DOI: 10.1039/D3MD00449J

Different Inductive Effects of Praziquantel Racemate and its Enantiomers on the Enzyme CYP3A4 Mediated by Pregnane X Receptor and its Variants

Ran Meng, Xueli Zhang, Haina Wang, Danlu Zhang and Xin Zhao

CDM, 2021, 22, 232
DOI: 10.2174/1389200221999210104204057

Single-Dose Drug Development Candidate for Schistosomiasis

Derek A. Leas, Jennifer Keiser, Susan A. Charman, David M. Shackleford, Jeremy O. Jones, Michael Campbell, Gong Chen, Kasiram Katneni, Rahul Patil, Meiyu Hu, Thao Pham, Cécile Häberli, Thomas T. Schulze, Andrew J. Neville, Xiaofang Wang, Yuxiang Dong, Paul H. Davis and Jonathan L. Vennerstrom

ACS Infect. Dis., 2024, 10, 3963
DOI: 10.1021/acsinfecdis.4c00677

Antischistosomal activity of imidazolidine-2,4-dione derivatives

Anna Jaromin, Anna Czopek, Thainá R. Teixeira, Agnieszka Zagórska, Josué de Moraes and Audrey Odom John

Antimicrob Agents Chemother, 2026, 70
DOI: 10.1128/aac.01748-25

Medicinal Chemistry Progression of Sapanisertib, the Anticancer and Dual Plasmodium Phosphatidylinositol 4-Kinase Beta and cGMP-Dependent Protein Kinase Inhibitor, for Malaria

Samuel Gachuhi, Stephanie Kamunya, Stephen Fienberg, Lynn Wambua, Nicolaas Salomane, Godfrey Mayoka, Dale Taylor, Dina Coertzen, Mariette van der Watt, Janette Reader, Lyn-Marié Birkholtz, Sergio Wittlin, Liezl Krugmann, Lauren B. Coulson and Kelly Chibale

J. Med. Chem., 2025, 68, 10757
DOI: 10.1021/acs.jmedchem.4c02799

Discovery and biological evaluation of novel N -aryl- N ′-methylbenzodrazides against Schistosoma japonicum in vitro and in vivo

Lvyin Zheng, Yumei Zhong, Yinyin Li, Peiyi Chen, Nina Cheng, Xiaofeng Hua, Lu Ouyang, Nianhua Luo, Jiayi Shen, Yongdong Li, Wei Guo and William H. Witola

Microbiol Spectr, 2026, 14
DOI: 10.1128/spectrum.01932-25

Structure-Based Design of Potential Anti-schistosomiasis Agent Targeting SmHDAC8: An In Silico Approach Utilizing QSAR, MD Simulation and ADMET Prediction

Saudatu Chinade Ja’afaru, Adamu Uzairu, Muhammed Sani Sallau, George Iloegbulam Ndukwe, Muhammad Tukur Ibrahim and Ammar Usman Danazumi

Chemistry Africa, 2024, 7, 725
DOI: 10.1007/s42250-023-00777-2

Robenidine derivatives as potential antischistosomal drug candidates

Christian N. Lotz, Alina Krollenbrock, Lea Imhof, Michael Riscoe and Jennifer Keiser

International Journal for Parasitology: Drugs and Drug Resistance, 2024, 25, 100546
DOI: 10.1016/j.ijpddr.2024.100546

Design, Synthesis and Evaluation of Praziquantel Analogues and New Molecular Hybrids as Potential Antimalarial and Anti-Schistosomal Agents

Freddy Mugisho Kasago, Cécile Häberli, Jennifer Keiser and Wayiza Masamba

Molecules, 2023, 28, 5184
DOI: 10.3390/molecules28135184

Analysis of the Physicochemical Properties of Anti-Schistosomal Compounds to Identify Next-Generation Leads

Diego González Cabrera, Jennifer Keiser and Thomas Spangenberg

ACS Med. Chem. Lett., 2024, 15, 626
DOI: 10.1021/acsmedchemlett.4c00026

Antischistosomal properties of aurone derivatives against juvenile and adult worms of Schistosoma mansoni

Vinicius R.D. Pereira, Lígia S. da Silveira, Ana C. Mengarda, Ismael J. Alves Júnior, Ohana Oliveira Zuza da Silva, Fábio Balbino Miguel, Marcos P. Silva, Ayla das C. Almeida, Daniel da Silva Torres, Priscila de F. Pinto, Elaine S. Coimbra, Josué de Moraes, Mara R.C. Couri and Ademar A. da Silva Filho

Acta Tropica, 2021, 213, 105741
DOI: 10.1016/j.actatropica.2020.105741

Structure–Activity Relationship of Antischistosomal Aryl Hydantoin (AR102)

Derek A. Leas, Cécile Häberli, Karen L. White, David M. Shackleford, Jeremy O. Jones, Michael Campbell, Jianbo Wu, Deepender Kaushik, Yuxiang Dong, Alexander I. Wallick, Susan A. Charman, Jennifer Keiser, Paul H. Davis and Jonathan L. Vennerstrom

J. Med. Chem., 2025, 68, 21725
DOI: 10.1021/acs.jmedchem.5c02056

Inactivation of Schistosoma Using Low-Temperature Plasma

Silvie Hejzlarová, Marta Chanová, Josef Khun, Jaroslav Julák and Vladimír Scholtz

Microorganisms, 2020, 9, 32
DOI: 10.3390/microorganisms9010032

In Vitro , In Vivo , and Absorption, Distribution, Metabolism, and Excretion Evaluation of SF 5 -Containing N,N’ -Diarylureas as Antischistosomal Agents

Alexandra Probst, Eugènia Pujol, Cécile Häberli, Jennifer Keiser and Santiago Vázquez

Antimicrob Agents Chemother, 2021, 65
DOI: 10.1128/AAC.00615-21

Lyotropic liquid crystal and self-emulsifying drug delivery systems nanoparticles as artesunic acid and praziquantel carriers: An innovative approach for formulation of anti-malaria and schistosomicidal drugs

Sheila Correa, Tiago Mendes, Thais Alves, Juliana Souza, Kessi Crescencio, Silmara Allegretti and Marco Chaud

Journal of Drug Delivery Science and Technology, 2024, 101, 106296
DOI: 10.1016/j.jddst.2024.106296

The discovery of a novel series of compounds with single-dose efficacy against juvenile and adult Schistosoma species

J. Mark F. Gardner, Nuha R. Mansour, Andrew S. Bell, Helena Helmby, Quentin Bickle and Robert M. Greenberg

PLoS Negl Trop Dis, 2021, 15, e0009490
DOI: 10.1371/journal.pntd.0009490