Cross Reference Logo
Citations to this article as recorded by CrossRef and RSC Journals (125 citations).

Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices
Claudio Parolo, Andrea Idili, Jason Heikenfeld and Kevin W. Plaxco
Lab Chip, 2023, 23, 1339
DOI: 10.1039/D2LC00716A

Real-time cell barrier monitoring by spatial transepithelial electrical resistance measurement on a microelectrode array integrated Transwell
Yimin Shi, Sheng Sun, Hui Liu, Mingda Zhao, Meiyan Qin, Jinlong Liu, Jingfang Hu, Yang Zhao, Mingxiao Li, Lingqian Zhang and Chengjun Huang
Lab Chip, 2025, 25, 253
DOI: 10.1039/D4LC00817K

Steady-state monitoring of oxygen in a high-throughput organ-on-chip platform enables rapid and non-invasive assessment of drug-induced nephrotoxicity
Samuel H. Kann, Erin M. Shaughnessey, Xin Zhang, Joseph L. Charest and Else M. Vedula
Analyst, 2023, 148, 3204
DOI: 10.1039/D3AN00380A

Real-time monitoring of epithelial barrier function by impedance spectroscopy in a microfluidic platform
João Fernandes, Nikita Karra, Joel Bowring, Riccardo Reale, Jonathan James, Cornelia Blume, Theresa J. Pell, Wendy C. Rowan, Donna E. Davies, Emily J. Swindle and Hywel Morgan
Lab Chip, 2022, 22, 2041
DOI: 10.1039/D1LC01046H

From mouth to gut: microfluidic in vitro simulation of human gastro-intestinal digestion and intestinal permeability
Miguel Xavier, Patrícia M. Rodrigues, Mafalda D. Neto, Maria I. Guedes, Victor Calero, Lorenzo Pastrana and Catarina Gonçalves
Analyst, 2023, 148, 3193
DOI: 10.1039/D2AN02088B

Measuring barrier function in organ-on-chips with cleanroom-free integration of multiplexable electrodes
Elsbeth G. B. M. Bossink, Mariia Zakharova, Douwe S. de Bruijn, Mathieu Odijk and Loes I. Segerink
Lab Chip, 2021, 21, 2040
DOI: 10.1039/D0LC01289K

Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems
Alisa Ugodnikov, Henrik Persson and Craig A. Simmons
Lab Chip, 2024, 24, 3199
DOI: 10.1039/D3LC01027A

Organ-on-a-chip with integrated semitransparent organic electrodes for barrier function monitoring
Denise Marrero, Anton Guimera, Laure Maes, Rosa Villa, Mar Alvarez and Xavi Illa
Lab Chip, 2023, 23, 1825
DOI: 10.1039/D2LC01097F

Fish-gut-on-chip: development of a microfluidic bioreactor to study the role of the fish intestinein vitro
Carolin Drieschner, Sarah Könemann, Philippe Renaud and Kristin Schirmer
Lab Chip, 2019, 19, 3268
DOI: 10.1039/C9LC00415G

In situ monitoring of barrier function on-chip via automated, non-invasive luminescence sensing
Bryan G. Schellberg, Abigail N. Koppes and Ryan A. Koppes
Lab Chip, 2025
DOI: 10.1039/D4LC01090F

High throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia
A. Nicolas, F. Schavemaker, K. Kosim, D. Kurek, M. Haarmans, M. Bulst, K. Lee, S. Wegner, T. Hankemeier, J. Joore, K. Domansky, H. L. Lanz, P. Vulto and S. J. Trietsch
Lab Chip, 2021, 21, 1676
DOI: 10.1039/D0LC00770F

A pumpless microfluidic co-culture system to model the effects of shear flow on biological barriers
Marsel Lino, Henrik Persson, Mohammad Paknahad, Alisa Ugodnikov, Morvarid Farhang Ghahremani, Lily E. Takeuchi, Oleg Chebotarev, Caleb Horst and Craig A. Simmons
Lab Chip, 2025, 25, 1489
DOI: 10.1039/D4LC00835A

Spatial trans-epithelial electrical resistance (S-TEER) integrated in organs-on-chips
Noa Renous, Mark D. Kiri, Ronny A. Barnea, Rossana Rauti, Yael Leichtmann-Bardoogo and Ben M. Maoz
Lab Chip, 2022, 22, 71
DOI: 10.1039/D1LC00789K

Innovative electrode and chip designs for transendothelial electrical resistance measurements in organs-on-chips
Muriel A. Holzreuter and Loes I. Segerink
Lab Chip, 2024, 24, 1121
DOI: 10.1039/D3LC00901G

Research on the Asymmetric Phenomenon of Voltage Polarity Based on Dielectric Wetting
Yuxing Ye, Hui Jin, Meng Zhao, Fengying Xu and Zhuo Jiang
Materials, 2024, 17, 2717
DOI: 10.3390/ma17112717

Advancement of Sensor Integrated Organ-on-Chip Devices
Gabriel A. Clarke, Brenna X. Hartse, Amir Ehsan Niaraki Asli, Mehrnoosh Taghavimehr, Niloofar Hashemi, Mehran Abbasi Shirsavar, Reza Montazami, Nima Alimoradi, Vahid Nasirian, Lionel J. Ouedraogo and Nicole N. Hashemi
Sensors, 2021, 21, 1367
DOI: 10.3390/s21041367

Modelling Human Gut‐Microbiome Interactions in a 3D Bioelectronic Platform
Chrysanthi‐Maria Moysidou, Douglas C. van Niekerk, Verena Stoeger, Charalampos Pitsalidis, Lorraine A. Draper, Aimee M. Withers, Katherine Hughes, Reece McCoy, Rachana Acharya, Colin Hill and Róisín M. Owens
Small Science, 2024, 4
DOI: 10.1002/smsc.202300349

Analysis of the Dynamics of the Electric Capacitance of a Cell Monolayer at the Late Stages of Caco-2 cell Differentiation
T.N. Gerasimenko, S.V. Nikulin, V.A. Petrov and D.A. Sakharov
Biiotehnologiâ (Mosk.), 2019, 35, 87
DOI: 10.21519/0234-2758-2019-35-6-87-90

A comprehensive review on organ-on-chips as powerful preclinical models to study tissue barriers
Yagmur Filiz, Alessio Esposito, Carmelo De Maria, Giovanni Vozzi and Ozlem Yesil-Celiktas
Prog. Biomed. Eng., 2024, 6, 042001
DOI: 10.1088/2516-1091/ad776c

Compound Absorption in Polymer Devices Impairs the Translatability of Preclinical Safety Assessments
Aurino M. Kemas, Reza Zandi Shafagh, Nayere Taebnia, Maurice Michel, Lena Preiss, Ute Hofmann and Volker M. Lauschke
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202303561

Monitoring Contractile Cardiomyocytes via Impedance Using Multipurpose Thin Film Ruthenium Oxide Electrodes
Esther Tanumihardja, Douwe S. de Bruijn, Rolf H. Slaats, Wouter Olthuis and Albert van den Berg
Sensors, 2021, 21, 1433
DOI: 10.3390/s21041433

Application of Micro-Engineered Kidney, Liver, and Respiratory System Models to Accelerate Preclinical Drug Testing and Development
Hanieh Gholizadeh, Shaokoon Cheng, Agisilaos Kourmatzis, Hanwen Xing, Daniela Traini, Paul M. Young and Hui Xin Ong
Bioengineering, 2022, 9, 150
DOI: 10.3390/bioengineering9040150

Intestinal Stem Cell-on-Chip to Study Human Host-Microbiota Interaction
Fatina Siwczak, Elise Loffet, Mathilda Kaminska, Hristina Koceva, Maxime M. Mahe and Alexander S. Mosig
Front. Immunol., 2021, 12
DOI: 10.3389/fimmu.2021.798552

Materials for blood brain barrier modeling in vitro
Magali P. Ferro, Sarah C. Heilshorn and Roisin M. Owens
Materials Science and Engineering: R: Reports, 2020, 140, 100522
DOI: 10.1016/j.mser.2019.100522

Electrochemical Sensing Directions for Next-Generation Healthcare: Trends, Challenges, and Frontiers
Juan F. Hernández-Rodríguez, Daniel Rojas and Alberto Escarpa
Anal. Chem., 2021, 93, 167
DOI: 10.1021/acs.analchem.0c04378

Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development
Zening Li, Jianan Hui, Panhui Yang and Hongju Mao
Biosensors, 2022, 12, 370
DOI: 10.3390/bios12060370

Advances in reconstructing intestinal functionalities in vitro: From two/three dimensional-cell culture platforms to human intestine-on-a-chip
Li Wang, Jian Wu, Jun Chen, Wenkun Dou, Qili Zhao, Junlei Han, Jinliang Liu, Weiguang Su, Anqing Li, Pengbo Liu, Zhao An, Chonghai Xu and Yu Sun
Talanta, 2021, 226, 122097
DOI: 10.1016/j.talanta.2021.122097

A Design Method of Organ-on-a-Chip with Highly Accurate Measurement of Trans-Epithelial Electrical Resistance
Takashi Miyazaki, Yoshikazu Hirai, Ken-ichiro Kamei, Toshiyuki Tsuchiya and Osamu Tabata
IEEJ Trans. SM, 2021, 141, 237
DOI: 10.1541/ieejsmas.141.237

Recent Advances in Integrated Organ‐Chip Sensing Toward Robust and User‐Friendly Systems
Bryan G. Schellberg, Ryan A. Koppes and Abigail N. Koppes
J Biomedical Materials Res, 2025, 113
DOI: 10.1002/jbm.a.37876

Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes
Jonathan R. Soucy, Adam J. Bindas, Abigail N. Koppes and Ryan A. Koppes
iScience, 2019, 21, 521
DOI: 10.1016/j.isci.2019.10.052

Standardizing designed and emergent quantitative features in microphysiological systems
Dennis M. Nahon, Renée Moerkens, Hande Aydogmus, Bas Lendemeijer, Adriana Martínez-Silgado, Jeroen M. Stein, Milica Dostanić, Jean-Philippe Frimat, Cristina Gontan, Mees N. S. de Graaf, Michel Hu, Dhanesh G. Kasi, Lena S. Koch, Kieu T. T. Le, Sangho Lim, Heleen H. T. Middelkamp, Joram Mooiweer, Paul Motreuil-Ragot, Eva Niggl, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Nele Revyn, José M. Rivera-Arbelaez, Jelle Slager, Laura M. Windt, Mariia Zakharova, Berend J. van Meer, Valeria V. Orlova, Femke M. S. de Vrij, Sebo Withoff, Massimo Mastrangeli, Andries D. van der Meer and Christine L. Mummery
Nat. Biomed. Eng, 2024, 8, 941
DOI: 10.1038/s41551-024-01236-0

Developing organs‐on‐chips for biomedical applications
Lingyu Sun, Hanxu Chen, Dongyu Xu, Rui Liu and Yuanjin Zhao
Smart Medicine, 2024, 3
DOI: 10.1002/SMMD.20240009

Advancing Intelligent Organ‐on‐a‐Chip Systems with Comprehensive In Situ Bioanalysis
Xiao Li, Hui Zhu, Bingsong Gu, Cong Yao, Yuyang Gu, Wangkai Xu, Jia Zhang, Jiankang He, Xinyu Liu and Dichen Li
Advanced Materials, 2024, 36
DOI: 10.1002/adma.202305268

Highly scalable and standardized organ-on-chip platform with TEER for biological barrier modeling
Hoang-Tuan Nguyen, Siiri-Liisa Rissanen, Mimosa Peltokangas, Tino Laakkonen, Jere Kettunen, Lara Barthod, Ragul Sivakumar, Anniina Palojärvi, Pauliina Junttila, Jussi Talvitie, Michele Bassis, Sarah L. Nickels, Sara Kalvala, Polina Ilina, Päivi Tammela, Sarka Lehtonen, Jens C. Schwamborn, Sebastien Mosser and Prateek Singh
Tissue Barriers, 2024, 12
DOI: 10.1080/21688370.2024.2315702

Bioengineered human gut-on-a-chip for advancing non-clinical pharmaco-toxicology
Yong Cheol Shin, Nam Than, Soo Jin Park and Hyun Jung Kim
Expert Opinion on Drug Metabolism & Toxicology, 2024, 20, 593
DOI: 10.1080/17425255.2024.2365254

Design strategy of electrode patterns based on finite element analysis in microfluidic device for Trans‐Epithelial Electrical Resistance (TEER) measurement
Takashi Miyazaki, Yoshikazu Hirai, Ken‐ichiro Kamei, Toshiyuki Tsuchiya and Osamu Tabata
Elect Comm in Japan, 2021, 104
DOI: 10.1002/ecj.12296

An Individual Patient's “Body” on Chips—How Organismoid Theory Can Translate Into Your Personal Precision Therapy Approach
Uwe Marx, Enrico Accastelli, Rhiannon David, Hendrik Erfurth, Leopold Koenig, Roland Lauster, Anja Patricia Ramme, Petra Reinke, Hans-Dieter Volk, Annika Winter and Eva-Maria Dehne
Front. Med., 2021, 8
DOI: 10.3389/fmed.2021.728866

A novel multi-frequency trans-endothelial electrical resistance (MTEER) sensor array to monitor blood-brain barrier integrity
Maider Badiola-Mateos, Davide Di Giuseppe, Roberto Paoli, Maria Jose Lopez-Martinez, Arianna Mencattini, Josep Samitier and Eugenio Martinelli
Sensors and Actuators B: Chemical, 2021, 334, 129599
DOI: 10.1016/j.snb.2021.129599

On-chip Sensing Technique; Measuring Barrier Function of Cell Layer
Takashi MIYAZAKI and Yoshikazu HIRAI
IEEJ Journal, 2024, 144, 202
DOI: 10.1541/ieejjournal.144.202

Polymeric and biological membranes for organ-on-a-chip devices
Kendra Corral-Nájera, Gaurav Chauhan, Sergio O. Serna-Saldívar, Sergio O. Martínez-Chapa and Mohammad Mahdi Aeinehvand
Microsyst Nanoeng, 2023, 9
DOI: 10.1038/s41378-023-00579-z

A finite volume method with interface capacitance insertion on quad-tree meshes for impedance analysis in microfluidic devices
Milan Rother, Liubov Bakhchova and Vadim Issakov
Heliyon, 2025, 11, e43066
DOI: 10.1016/j.heliyon.2025.e43066

Potential of Printed Electrodes for Electrochemical Impedance Spectroscopy (EIS): Toward Membrane Fouling Detection
Guo Liang Goh, Ming Feng Tay, Jia Min Lee, Jia Shin Ho, Lee Nuang Sim, Wai Yee Yeong and Tzyy Haur Chong
Adv Elect Materials, 2021, 7
DOI: 10.1002/aelm.202100043

Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques
Hui Wang, Xiangyang Li, Pengcheng Shi, Xiaoyan You and Guoping Zhao
Materials Today Bio, 2024, 26, 101079
DOI: 10.1016/j.mtbio.2024.101079

A lung cancer-on-chip platform with integrated biosensors for physiological monitoring and toxicity assessment
Muhammad Asad Ullah Khalid, Young Soo Kim, Muhsin Ali, Byung Gul Lee, Young-Jae Cho and Kyung Hyun Choi
Biochemical Engineering Journal, 2020, 155, 107469
DOI: 10.1016/j.bej.2019.107469

From 3D Back to 2D Monolayer Stomach Organoids-on-a-Chip
Phatcharida Jantaree, Liubov Bakhchova, Ulrike Steinmann and Michael Naumann
Trends in Biotechnology, 2021, 39, 745
DOI: 10.1016/j.tibtech.2020.11.013

Integrating mechanical sensor readouts into organ-on-a-chip platforms
Ingrid Anaya Morales, Christina-Marie Boghdady, Benjamin E. Campbell and Christopher Moraes
Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.1060895

Skin-on-a-chip technologies towards clinical translation and commercialization
Nilufar Ismayilzada, Ceren Tarar, Sajjad Rahmani Dabbagh, Begüm Kübra Tokyay, Sara Asghari Dilmani, Emel Sokullu, Hasan Erbil Abaci and Savas Tasoglu
Biofabrication, 2024, 16, 042001
DOI: 10.1088/1758-5090/ad5f55

An easy-repeat method to build a blood-brain barrier model on a chip with independent TEER detection module
Pan-Hui YANG, Feng-Yi ZHENG, Qiu-Shi LI, Tian TIAN, Guo-Yuan ZHANG, Lei WU and Hong-Ju MAO
Chinese Journal of Analytical Chemistry, 2022, 50, 97
DOI: 10.1016/j.cjac.2021.11.003

Low-Cost Microfabrication Tool Box
Jérôme Charmet, Rui Rodrigues, Ender Yildirim, Pavan Kumar Challa, Benjamin Roberts, Robert Dallmann and Yudan Whulanza
Micromachines, 2020, 11, 135
DOI: 10.3390/mi11020135

Critical Suitability Evaluation of Caco-2 Cells for Gut-on-a-Chip
Xiatong Pan, Jun Chen, Junlei Han, Wenxian Zhang, Weiguang Su, Zhipeng Xu, Xinyu Li, Ming Song, Wei Song, Xi Xie and Li Wang
ACS Appl. Mater. Interfaces, 2024, 16, 51139
DOI: 10.1021/acsami.4c11409

Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine
Fahad Alghannam, Mrwan Alayed, Salman Alfihed, Mahmoud A. Sakr, Dhaifallah Almutairi, Naif Alshamrani and Nojoud Al Fayez
Biosensors, 2025, 15, 76
DOI: 10.3390/bios15020076

Micro‐electrodes for in situ temperature and bio‐impedance measurement
Timothy Ka Wai Leung, Xudong Ji, Boyu Peng, Gary Kwok Ki Chik, Derek Shui Hong Siddhartha Dai, Ge Fang, Tengfei Zhang, Xing Cheng, Ka Wai Kwok, Anderson Chun On Tsang, Gilberto Ka Kit Leung and Paddy Kwok Leung Chan
Nano Select, 2021, 2, 1986
DOI: 10.1002/nano.202100041

A microfluidic tool for real-time impedance monitoring of in vitro renal tubular epithelial cell barrier
Feng Liang, Xiaochen Huang, Boxin Huang, Yong He, Haoyue Luo, Jian Shi, Li Wang, Carole Aimé, Juan Peng and Yong Chen
Sensors and Actuators B: Chemical, 2023, 392, 134077
DOI: 10.1016/j.snb.2023.134077

3D cell culture models and organ‐on‐a‐chip: Meet separation science and mass spectrometry
Ann Lin, Frøydis Sved Skottvoll, Simon Rayner, Stig Pedersen‐Bjergaard, Gareth Sullivan, Stefan Krauss, Steven Ray Wilson and Sean Harrison
Electrophoresis, 2020, 41, 56
DOI: 10.1002/elps.201900170

Rapid Prototyping of Multilayer Microphysiological Systems
Sanjin Hosic, Adam J. Bindas, Marissa L. Puzan, Will Lake, Jonathan R. Soucy, Fanny Zhou, Ryan A. Koppes, David T. Breault, Shashi K. Murthy and Abigail N. Koppes
ACS Biomater. Sci. Eng., 2021, 7, 2949
DOI: 10.1021/acsbiomaterials.0c00190

Systematic characterization of cleanroom-free fabricated macrovalves, demonstrating pumps and mixers for automated fluid handling tuned for organ-on-chip applications
Elsbeth G. B. M. Bossink, Anke R. Vollertsen, Joshua T. Loessberg-Zahl, Andries D. van der Meer, Loes I. Segerink and Mathieu Odijk
Microsyst Nanoeng, 2022, 8
DOI: 10.1038/s41378-022-00378-y

Human Organs‐on‐Chips: A Review of the State‐of‐the‐Art, Current Prospects, and Future Challenges
Payam Zarrintaj, Mohammad Reza Saeb, Florian J. Stadler, Mohsen Khodadadi Yazdi, Mojtaba Nasiri Nezhad, Shabnam Mohebbi, Farzad Seidi, Mohammad Reza Ganjali and Masoud Mozafari
Advanced Biology, 2022, 6
DOI: 10.1002/adbi.202000526

Gut-on-a-chip: Mimicking and monitoring the human intestine
Denise Marrero, Ferran Pujol-Vila, Daniel Vera, Gemma Gabriel, Xavi Illa, Aleix Elizalde-Torrent, Mar Alvarez and Rosa Villa
Biosensors and Bioelectronics, 2021, 181, 113156
DOI: 10.1016/j.bios.2021.113156

Gut-on-Chip microphysiological systems: Latest advances in the integration of sensing strategies and adoption of mature detection mechanisms
Maria Assunta Signore, Chiara De Pascali, Lucia Giampetruzzi, Pietro Aleardo Siciliano and Luca Francioso
Sensing and Bio-Sensing Research, 2021, 33, 100443
DOI: 10.1016/j.sbsr.2021.100443

Advances in modelling the human microbiome–gut–brain axis in vitro
Chrysanthi-Maria Moysidou and Róisín M. Owens
Biochemical Society Transactions, 2021, 49, 187
DOI: 10.1042/BST20200338

Recent Advances in Cell‐Based In Vitro Models to Recreate Human Intestinal Inflammation
Maria Helena Macedo, Mafalda Dias Neto, Lorenzo Pastrana, Catarina Gonçalves and Miguel Xavier
Advanced Science, 2023, 10
DOI: 10.1002/advs.202301391

Novel design of biplanar electrodes in a multiwell plate for transepithelial electrical resistance measurement in 3D cell cultures
Georges Dubourg, Divyasree Prabhakaran, Harry Dawson, Vasa Radonic, Sara Joksović, Jovana Stanojev and Antoni Homs Corbera
Sensors and Actuators A: Physical, 2025, 387, 116413
DOI: 10.1016/j.sna.2025.116413

Microfluidic Organoids-on-a-Chip: Quantum Leap in Cancer Research
Fahriye Duzagac, Gloria Saorin, Lorenzo Memeo, Vincenzo Canzonieri and Flavio Rizzolio
Cancers, 2021, 13, 737
DOI: 10.3390/cancers13040737

Advances in TEER measurements of biological barriers in microphysiological systems
Hojjatollah Nazari, Jesus Shrestha, Vahid Yaghoubi Naei, Sajad Razavi Bazaz, Milad Sabbagh, Jean Paul Thiery and Majid Ebrahimi Warkiani
Biosensors and Bioelectronics, 2023, 234, 115355
DOI: 10.1016/j.bios.2023.115355

Gut-on-a-chip for exploring the transport mechanism of Hg(II)
Li Wang, Junlei Han, Weiguang Su, Anqing Li, Wenxian Zhang, Huimin Li, Huili Hu, Wei Song, Chonghai Xu and Jun Chen
Microsyst Nanoeng, 2023, 9
DOI: 10.1038/s41378-022-00447-2

Integrated Electrochemical and Optical Biosensing in Organs‐on‐Chip
Pratik Tawade and Massimo Mastrangeli
ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202300560

In vitro electrochemical assays for vascular cells and organs
Yoshinobu Utagawa, Kaoru Hiramoto, Yuji Nashimoto, Kosuke Ino and Hitoshi Shiku
Electrochemical Science Adv, 2022, 2
DOI: 10.1002/elsa.202100089

Human organ chips for regenerative pharmacology
Girija Goyal, Chaitra Belgur and Donald E. Ingber
Pharmacology Res & Perspec, 2024, 12
DOI: 10.1002/prp2.1159

Gut‐on‐chip with integrated sensors: Enables in‐situ monitoring and real‐time evaluation of the chip
Yan Li, Zhiyuan Xiang, Zihong Yuan, Huaping Zhang and Aliu Shi
Electroanalysis, 2024, 36
DOI: 10.1002/elan.202400188

The effect of membrane properties on cell growth in an ‘Airway barrier on a chip’
N. Karra, J. Fernandes, J. James, E.J. Swindle and H. Morgan
Organs-on-a-Chip, 2023, 5, 100025
DOI: 10.1016/j.ooc.2022.100025

A microphysiological system for studying barrier health of live tissues in real time
Ryan Way, Hayley Templeton, Daniel Ball, Ming-Hao Cheng, Stuart A. Tobet and Thomas Chen
Commun Eng, 2024, 3
DOI: 10.1038/s44172-024-00285-2

Integration of Extracellular Matrices into Organ‐on‐Chip Systems
Hazal Kutluk, Effie E. Bastounis and Iordania Constantinou
Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202203256

An isogenic hiPSC-derived BBB-on-a-chip
Pedram Motallebnejad, Andrew Thomas, Sarah L. Swisher and Samira M. Azarin
Biomicrofluidics, 2019, 13
DOI: 10.1063/1.5123476

On-chip electrocatalytic NO sensing using ruthenium oxide nanorods
E. Tanumihardja, A. Paradelo Rodríguez, J.T. Loessberg-Zahl, B. Mei, W. Olthuis and A. van den Berg
Sensors and Actuators B: Chemical, 2021, 334, 129631
DOI: 10.1016/j.snb.2021.129631

Gut-on-a-chip for disease models
Changxiu Xian, Jiaxin Zhang, Suqing Zhao and Xiang-Guang Li
J Tissue Eng, 2023, 14
DOI: 10.1177/20417314221149882

Modeling the Human Body on Microfluidic Chips
Sasan Jalili-Firoozinezhad, Cláudia C. Miranda and Joaquim M.S. Cabral
Trends in Biotechnology, 2021, 39, 838
DOI: 10.1016/j.tibtech.2021.01.004

Microfluidic intestine-on-a-chip: Current progress and further perspectives of probiotic-foodborne pathogen interactions
Xinran Xiang, Xinbin Wang, Yuting Shang and Yu Ding
Trends in Food Science & Technology, 2023, 134, 207
DOI: 10.1016/j.tifs.2023.03.006

Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms
Song Ih Ahn, Yoshitaka J. Sei, Hyun-Ji Park, Jinhwan Kim, Yujung Ryu, Jeongmoon J. Choi, Hak-Joon Sung, Tobey J. MacDonald, Allan I. Levey and YongTae Kim
Nat Commun, 2020, 11
DOI: 10.1038/s41467-019-13896-7

Impedance Spectroscopy as a Tool for Monitoring Performance in 3D Models of Epithelial Tissues
Tatiana Gerasimenko, Sergey Nikulin, Galina Zakharova, Andrey Poloznikov, Vladimir Petrov, Ancha Baranova and Alexander Tonevitsky
Front. Bioeng. Biotechnol., 2020, 7
DOI: 10.3389/fbioe.2019.00474

Non-invasive in vitro NAM for the detection of reversible and irreversible eye damage after chemical exposure for GHS classification purposes (ImAi)
Nicola Knetzger, Norman Ertych, Tanja Burgdorf, Joelle Beranek, Michael Oelgeschläger, Jana Wächter, Annika Horchler, Stefanie Gier, Maike Windbergs, Susann Fayyaz, Fabian A. Grimm, Georg Wiora and Christian Lotz
Arch Toxicol, 2025, 99, 1011
DOI: 10.1007/s00204-024-03940-x

Engineered tools to study endocrine dysfunction of pancreas
Charles G. Alver, Juan Dominguez-Bendala and Ashutosh Agarwal
Biophysics Reviews, 2024, 5
DOI: 10.1063/5.0220396

Fast and real-time electrical transistor assay for quantifying SARS-CoV-2 neutralizing antibodies
Francesco Decataldo, Laura Grumiro, Maria Michela Marino, Francesca Faccin, Catia Giovannini, Martina Brandolini, Giorgio Dirani, Francesca Taddei, Davide Lelli, Marta Tessarolo, Maria Calienni, Carla Cacciotto, Antonio Lavazza, Beatrice Fraboni, Alessandra Scagliarini and Vittorio Sambri
Commun Mater, 2022, 3
DOI: 10.1038/s43246-022-00226-6

Organic electronic transmembrane device for hosting and monitoring 3D cell cultures
Charalampos Pitsalidis, Douglas van Niekerk, Chrysanthi-Maria Moysidou, Alexander J. Boys, Aimee Withers, Romane Vallet and Róisín M. Owens
Sci. Adv., 2022, 8
DOI: 10.1126/sciadv.abo4761

Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization
Shan Liu, Shikha Kumari, Hongyi He, Parichita Mishra, Bhisham Narayan Singh, Divakar Singh, Sutong Liu, Pradeep Srivastava and Chenzhong Li
Biosensors and Bioelectronics, 2023, 231, 115285
DOI: 10.1016/j.bios.2023.115285

Gut‐on‐a‐Chip Reveals Enhanced Peristalsis Reduces Nanoplastic‐Induced Inflammation
Junlei Han, Yushen Wang, Jiemeng Ding, Hao Chen, Chaoyang Shi, Xinyu Li, Zhipeng Xu, Jun Chen, Feng Kong and Li Wang
Small, 2025, 21
DOI: 10.1002/smll.202408208

Real-time quantitative monitoring of in vitro nasal drug delivery by a nasal epithelial mucosa-on-a-chip model
Hanieh Gholizadeh, Hui Xin Ong, Peta Bradbury, Agisilaos Kourmatzis, Daniela Traini, Paul Young, Ming Li and Shaokoon Cheng
Expert Opinion on Drug Delivery, 2021, 18, 803
DOI: 10.1080/17425247.2021.1873274

3D In Vitro Blood‐Brain‐Barrier Model for Investigating Barrier Insults
Wei Wei, Fernando Cardes, Andreas Hierlemann and Mario M. Modena
Advanced Science, 2023, 10
DOI: 10.1002/advs.202205752

Tissue-on-a-Chip: Microphysiometry With Human 3D Models on Transwell Inserts
Christian Schmidt, Jan Markus, Helena Kandarova and Joachim Wiest
Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00760

Real-time physiological sensor-based liver-on-chip device for monitoring drug toxicity
Hafiz Muhammad Umer Farooqi, Muhammad Asad Ullah Khalid, Kyung Hwan Kim, Sun Ryung Lee and Kyung Hyun Choi
J. Micromech. Microeng., 2020, 30, 115013
DOI: 10.1088/1361-6439/ababf4

Microfluidics as a Novel Tool for Biological and Toxicological Assays in Drug Discovery Processes: Focus on Microchip Electrophoresis
Giuseppe Caruso, Nicolò Musso, Margherita Grasso, Angelita Costantino, Giuseppe Lazzarino, Fabio Tascedda, Massimo Gulisano, Susan M. Lunte and Filippo Caraci
Micromachines, 2020, 11, 593
DOI: 10.3390/mi11060593

A 3D bioprinted hydrogel gut-on-chip with integrated electrodes for transepithelial electrical resistance (TEER) measurements
Daniel Vera, María García-Díaz, Núria Torras, Óscar Castillo, Xavi Illa, Rosa Villa, Mar Alvarez and Elena Martinez
Biofabrication, 2024, 16, 035008
DOI: 10.1088/1758-5090/ad3aa4

Transcriptome analysis of signaling pathways involved in the formation of intestinal villi in Caco-2 cells
S.V. Nikulin, M.R Raigorodskaya and D.A. Sakharov
Biiotehnologiâ (Mosk.), 2020, 36, 25
DOI: 10.21519/0234-2758-2020-36-1-25-29

Advances in Engineering Human Tissue Models
Chrysanthi-Maria Moysidou, Chiara Barberio and Róisín Meabh Owens
Front. Bioeng. Biotechnol., 2021, 8
DOI: 10.3389/fbioe.2020.620962

Measurement of oxygen consumption rates of human renal proximal tubule cells in an array of organ-on-chip devices to monitor drug-induced metabolic shifts
Samuel H. Kann, Erin M. Shaughnessey, Jonathan R. Coppeta, Hesham Azizgolshani, Brett C. Isenberg, Else M. Vedula, Xin Zhang and Joseph L. Charest
Microsyst Nanoeng, 2022, 8
DOI: 10.1038/s41378-022-00442-7

Biosensors for Studies on Adhesion-Mediated Cellular Responses to Their Microenvironment
Nicolás Andrés Saffioti, Elisabetta Ada Cavalcanti-Adam and Diego Pallarola
Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.597950

Development of dynamic cell and organotypic skin models, for the investigation of a novel visco-elastic burns treatment using molecular and cellular approaches
Robert G. Wallace, Mary-Rose Kenealy, Aidan J. Brady, Laura Twomey, Emer Duffy, Bernard Degryse, David Caballero-Lima, Niall M. Moyna, Marc-Antoine Custaud, Gerardene Meade-Murphy, Aoife Morrin and Ronan P. Murphy
Burns, 2020, 46, 1585
DOI: 10.1016/j.burns.2020.04.036

Human gut epithelium features recapitulated in MINERVA 2.0 millifluidic organ-on-a-chip device
Francesca Donnaloja, Luca Izzo, Marzia Campanile, Simone Perottoni, Lucia Boeri, Francesca Fanizza, Lorenzo Sardelli, Emanuela Jacchetti, Manuela T. Raimondi, Laura Di Rito, Ilaria Craparotta, Marco Bolis, Carmen Giordano and Diego Albani
APL Bioengineering, 2023, 7
DOI: 10.1063/5.0144862

In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential
Stefanie Fuchs, Sofia Johansson, Anders Ø. Tjell, Gabriel Werr, Torsten Mayr and Maria Tenje
ACS Biomater. Sci. Eng., 2021, 7, 2926
DOI: 10.1021/acsbiomaterials.0c01110

Organic Bioelectronics for In Vitro Systems
Charalampos Pitsalidis, Anna-Maria Pappa, Alexander J. Boys, Ying Fu, Chrysanthi-Maria Moysidou, Douglas van Niekerk, Janire Saez, Achilleas Savva, Donata Iandolo and Róisín M. Owens
Chem. Rev., 2022, 122, 4700
DOI: 10.1021/acs.chemrev.1c00539

Human organs-on-chips for disease modelling, drug development and personalized medicine
Donald E. Ingber
Nat Rev Genet, 2022, 23, 467
DOI: 10.1038/s41576-022-00466-9

Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells
Lucas Keuter, Alessa Wolbeck, Matthias Kasimir, Lina Schürmann, Matthias Behrens and Hans‐Ulrich Humpf
Molecular Nutrition Food Res, 2024, 68
DOI: 10.1002/mnfr.202300639

Intestinal organ chips for disease modelling and personalized medicine
Alican Özkan, Nina Teresa LoGrande, Jessica F. Feitor, Girija Goyal and Donald E. Ingber
Nat Rev Gastroenterol Hepatol, 2024, 21, 751
DOI: 10.1038/s41575-024-00968-3

Microfluidic impedance cytometry for single-cell sensing: Review on electrode configurations
Shu Zhu, Xiaozhe Zhang, Zheng Zhou, Yu Han, Nan Xiang and Zhonghua Ni
Talanta, 2021, 233, 122571
DOI: 10.1016/j.talanta.2021.122571

Modernizing gut-brain axis research in nutritional Science: The role of human-centered New Approach Methodologies
Manuela Cassotta, Yasmany Armas Diaz, Zexiu Qi, Bei Yang, Giuseppe Grosso, José L. Quiles, Maurizio Battino, Justyna Godos and Francesca Giampieri
Trends in Food Science & Technology, 2025, 159, 104980
DOI: 10.1016/j.tifs.2025.104980

Transcriptome Analysis of Signaling Pathways in Caco-2 Cells Involved in the Formation of Intestinal Villi
S. V. Nikulin, M. P. Raigorodskaya and D. A. Sakharov
Appl Biochem Microbiol, 2020, 56, 898
DOI: 10.1134/S0003683820090069

3D Bioelectronic Model of the Human Intestine
Chrysanthi‐Maria Moysidou, Charalampos Pitsalidis, Mohammed Al‐Sharabi, Aimee M. Withers, J. Axel Zeitler and Róisín M. Owens
Advanced Biology, 2021, 5
DOI: 10.1002/adbi.202000306

3D‐Printed Bioreactor with Integrated Impedance Spectroscopy for Cell Barrier Monitoring
Georg Linz, Sebastian Bernhard Rauer, Yasmin Kuhn, Simon Wennemaring, Laura Siedler, Smriti Singh and Matthias Wessling
Adv Materials Technologies, 2021, 6
DOI: 10.1002/admt.202100009

Barrier-on-a-Chip with a Modular Architecture and Integrated Sensors for Real-Time Measurement of Biological Barrier Function
Patrícia Zoio, Sara Lopes-Ventura and Abel Oliva
Micromachines, 2021, 12, 816
DOI: 10.3390/mi12070816

Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system
Hafiz Muhammad Umer Farooqi, Bohye Kang, Muhammad Asad Ullah Khalid, Abdul Rahim Chethikkattuveli Salih, Kinam Hyun, Sung Hyuk Park, Dongeun Huh and Kyung Hyun Choi
Nano Convergence, 2021, 8
DOI: 10.1186/s40580-021-00253-y

Advancements in Organ‐on‐a‐Chip Systems: Materials, Characterization, and Applications
Balu Mahendran Gunasekaran, Soorya Srinivasan, Madeshwari Ezhilan, Venkatachalam Rajagopal and Noel Nesakumar
ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202403611

Organ chips with integrated multifunctional sensors enable continuous metabolic monitoring at controlled oxygen levels
Zohreh Izadifar, Berenice Charrez, Micaela Almeida, Stijn Robben, Kanoelani Pilobello, Janet van der Graaf-Mas, Susan L. Marquez, Thomas C. Ferrante, Kostyantyn Shcherbina, Russell Gould, Nina T. LoGrande, Adama M. Sesay and Donald E. Ingber
Biosensors and Bioelectronics, 2024, 265, 116683
DOI: 10.1016/j.bios.2024.116683

Looking Inside of the Intestinal Permeability Regulation by Protein‐Derivatives from Bovine Milk
Fabiola Guzmán‐Mejía, Daniel Efrain Molotla‐Torres, Marycarmen Godínez‐Victoria, Ximena Valdes‐Hilarios, Elizabeth Sánchez‐Miranda, Rigoberto Oros‐Pantoja and Maria Elisa Drago‐Serrano
Molecular Nutrition Food Res, 2024, 68
DOI: 10.1002/mnfr.202400384

Use of Impedance Spectroscopy to Assess the Effect of Laminins on the in vitro Differentiation of Intestinal Cells
S.V. Nikulin, E.N. Knyazev, D.V. Maltseva, D.A. Sakharov and T.N. Gerasimenko
Biiotehnologiâ (Mosk.), 2019, 35, 102
DOI: 10.21519/0234-2758-2019-35-6-102-107

Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems
Erika Ferrari, Cecilia Palma, Simone Vesentini, Paola Occhetta and Marco Rasponi
Biosensors, 2020, 10, 110
DOI: 10.3390/bios10090110

The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 1—Establishing a Nasal In Vitro Model for Drug Delivery Testing Based on a Novel Cell Line
Sebastian Bendas, Eugen Viktor Koch, Kristina Nehlsen, Tobias May, Andreas Dietzel and Stephan Reichl
Pharmaceutics, 2023, 15, 2245
DOI: 10.3390/pharmaceutics15092245

Sensor‐integrated brain‐on‐a‐chip platforms: Improving the predictive validity in neurodegenerative research
Sarah Spitz, Silvia Schobesberger, Konstanze Brandauer and Peter Ertl
Bioengineering & Transla Med, 2024, 9
DOI: 10.1002/btm2.10604

Potential applications of microfluidics based blood brain barrier (BBB)-on-chips for in vitro drug development
Xiaobo Wang, Ya Hou, Xiaopeng Ai, Jiayi Sun, Binjie Xu, Xianli Meng, Yi Zhang and Sanyin Zhang
Biomedicine & Pharmacotherapy, 2020, 132, 110822
DOI: 10.1016/j.biopha.2020.110822

Organ-on-Chip Technology for Aerobic Intestinal Host – Anaerobic Microbiota Research
Elsbeth G.B.M. Bossink, Loes I. Segerink and Mathieu Odijk
Organs-on-a-Chip, 2022, 4, 100013
DOI: 10.1016/j.ooc.2021.100013

A guide to the organ-on-a-chip
Chak Ming Leung, Pim de Haan, Kacey Ronaldson-Bouchard, Ge-Ah Kim, Jihoon Ko, Hoon Suk Rho, Zhu Chen, Pamela Habibovic, Noo Li Jeon, Shuichi Takayama, Michael L. Shuler, Gordana Vunjak-Novakovic, Olivier Frey, Elisabeth Verpoorte and Yi-Chin Toh
Nat Rev Methods Primers, 2022, 2
DOI: 10.1038/s43586-022-00118-6

Online and in situ analysis of organs-on-a-chip
Milou J.C. Santbergen, Meike van der Zande, Hans Bouwmeester and Michel W.F. Nielen
TrAC Trends in Analytical Chemistry, 2019, 115, 138
DOI: 10.1016/j.trac.2019.04.006

Advances in Trans-Epithelial Electrical Resistance (TEER) monitoring integration in an Intestinal Barrier-on-Chip (IBoC) platform with microbubbles-tolerant analytical method
Lucia Giampetruzzi, Laura Blasi, Amilcare Barca, Elisa Sciurti, Tiziano Verri, Flavio Casino, Pietro Siciliano and Luca Francioso
Sensing and Bio-Sensing Research, 2022, 37, 100512
DOI: 10.1016/j.sbsr.2022.100512

Using Biosensors to Study Organoids, Spheroids and Organs-on-a-Chip: A Mechanobiology Perspective
Muhammad Sulaiman Yousafzai and John A. Hammer
Biosensors, 2023, 13, 905
DOI: 10.3390/bios13100905

Improved Tool for Predicting Skin Irritation on Reconstructed Human Epidermis Models Based on Electrochemical Impedance Spectroscopy
Manuel Chacón, Natalia Vázquez, Sergio Alonso-Alonso, Mairobi Persinal-Medina, Sara Llames, Marta Pevida, Ignacio Alcalde, Jesús Merayo-Lloves and Álvaro Meana
Biosensors, 2023, 13, 162
DOI: 10.3390/bios13020162

An Open-Source Add-On EVOM® Device for Real-Time Transepithelial/Endothelial Electrical Resistance Measurements in Multiple Transwell Samples
Bibek Raut, Li-Jiun Chen, Takeshi Hori and Hirokazu Kaji
Micromachines, 2021, 12, 282
DOI: 10.3390/mi12030282

In situ biosensing technologies for an organ-on-a-chip
Jinyoung Kim, Junghoon Kim, Yoonhee Jin and Seung-Woo Cho
Biofabrication, 2023, 15, 042002
DOI: 10.1088/1758-5090/aceaae