Microfluidic-based vascularized microphysiological systems

Somin Lee, Jihoon Ko, Dohyun Park, Seung-Ryeol Lee, Minhwan Chung, Younggyun Lee and Noo Li Jeon

Lab Chip, 2018, 18, 2686
DOI: 10.1039/C8LC00285A

Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies

Halston E. Deal, Ashley C. Brown and Michael A. Daniele

J. Mater. Chem. B, 2020, 8, 7062
DOI: 10.1039/D0TB00544D

Stephanie J. Hachey and Christopher C. W. Hughes

Lab Chip, 2018, 18, 2893
DOI: 10.1039/C8LC00330K

High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip

Muhammad Asad Ullah Khalid, Kyung Hwan Kim, Abdul Rahim Chethikkattuveli Salih, Kinam Hyun, Sung Hyuk Park, Bohye Kang, Afaque Manzoor Soomro, Muhsin Ali, Yesl Jun, Dongeun Huh, Heeyeong Cho and Kyung Hyun Choi

Lab Chip, 2022, 22, 1764
DOI: 10.1039/D1LC01079D

Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges

Jeffrey T. Borenstein, Gerard Cummins, Abhishek Dutta, Eyad Hamad, Michael Pycraft Hughes, Xingyu Jiang, Hyowon (Hugh) Lee, Kin Fong Lei, Xiaowu (Shirley) Tang, Yuanjin Zheng and Jie Chen

Lab Chip, 2023, 23, 4928
DOI: 10.1039/D3LC00296A

Maximizing the impact of microphysiological systems with in vitro–in vivo translation

Murat Cirit and Cynthia L. Stokes

Lab Chip, 2018, 18, 1831
DOI: 10.1039/C8LC00039E

Creating tissue on chip constructs in microtitre plates for drug discovery

N. P. Macdonald, A. Menachery, J. Reboud and J. M. Cooper

RSC Adv., 2018, 8, 9603
DOI: 10.1039/C8RA00849C

Applications of the microphysiology systems database for experimental ADME-Tox and disease models

Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor and Albert Gough

Lab Chip, 2020, 20, 1472
DOI: 10.1039/C9LC01047E

High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows

H. Azizgolshani, J. R. Coppeta, E. M. Vedula, E. E. Marr, B. P. Cain, R. J. Luu, M. P. Lech, S. H. Kann, T. J. Mulhern, V. Tandon, K. Tan, N. J. Haroutunian, P. Keegan, M. Rogers, A. L. Gard, K. B. Baldwin, J. C. de Souza, B. C. Hoefler, S. S. Bale, L. B. Kratchman, A. Zorn, A. Patterson, E. S. Kim, T. A. Petrie, E. L. Wiellette, C. Williams, B. C. Isenberg and J. L. Charest

Lab Chip, 2021, 21, 1454
DOI: 10.1039/D1LC00067E

A photonic biosensor-integrated tissue chip platform for real-time sensing of lung epithelial inflammatory markers

John S. Cognetti, Maya T. Moen, Matthew G. Brewer, Michael R. Bryan, Joshua D. Tice, James L. McGrath and Benjamin L. Miller

Lab Chip, 2023, 23, 239
DOI: 10.1039/D2LC00864E

Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications

Kristin Fabre, Brian Berridge, William R. Proctor, Sherry Ralston, Yvonne Will, Szczepan W. Baran, Gorm Yoder and Terry R. Van Vleet

Lab Chip, 2020, 20, 1049
DOI: 10.1039/C9LC01168D

Design and construction of three-dimensional physiologically-based vascular branching networks for respiratory assist devices

Jose A. Santos, Alla A. Gimbel, Athanasios Peppas, James G. Truslow, Daniel A. Lang, Sivaprasad Sukavaneshvar, Derek Solt, Thomas J. Mulhern, Alex Markoski, Ernest S. Kim, James C.-M. Hsiao, Diana J. Lewis, Daniel I. Harjes, Christopher DiBiasio, Joseph L. Charest and Jeffrey T. Borenstein

Lab Chip, 2021, 21, 4637
DOI: 10.1039/D1LC00287B

Nanofabrication enabled lab-on-a-chip technology for the manipulation and detection of bacteria

Lei Li, Cheng Wang, Yong Nie, Bo Yao and Huan Hu

TrAC Trends in Analytical Chemistry, 2020, 127, 115905
DOI: 10.1016/j.trac.2020.115905

Next-generation experimental and computational strategies for drug-drug interaction prophecy

Aarika Kanukolanu, Lakshmi Vineela Nalla and Siva Nageswara Rao Gajula

Drug Metabolism and Disposition, 2025, 53, 100150
DOI: 10.1016/j.dmd.2025.100150

Reusable Standardized Universal Interface Module (RSUIM) for Generic Organ-on-a-Chip Applications

Qiyue Sun, Jianghua Pei, Qinyu Li, Kai Niu and Xiaolin Wang

Micromachines, 2019, 10, 849
DOI: 10.3390/mi10120849

An integrated microfluidic bubble pocket for long-term perfused three-dimensional intestine-on-a-chip model

Kang Kug (Paul) Lee, Toru Matsu-ura, Andrew E. Rosselot, Taylor R. Broda, James M. Wells and Christian I. Hong

Biomicrofluidics, 2021, 15
DOI: 10.1063/5.0036527

High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro

A. L. Gard, R. J. Luu, C. R. Miller, R. Maloney, B. P. Cain, E. E. Marr, D. M. Burns, R. Gaibler, T. J. Mulhern, C. A. Wong, J. Alladina, J. R. Coppeta, P. Liu, J. P. Wang, H. Azizgolshani, R. Fennell Fezzie, J. L. Balestrini, B. C. Isenberg, B. D. Medoff, R. W. Finberg and J. T. Borenstein

Sci Rep, 2021, 11
DOI: 10.1038/s41598-021-94095-7

In vitro to in vivo extrapolation from 3D hiPSC-derived cardiac microtissues and physiologically based pharmacokinetic modeling to inform next-generation arrhythmia risk assessment

Mark C Daley, Marjory Moreau, Peter Bronk, Jeffrey Fisher, Celinda M Kofron, Ulrike Mende, Patrick McMullen, Bum-Rak Choi and Kareen Coulombe

Toxicological Sciences, 2024, 201, 145
DOI: 10.1093/toxsci/kfae079

Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project

Seiichi Ishida

Front. Toxicol., 2021, 3
DOI: 10.3389/ftox.2021.657765

Recent Advances in Organ‐on‐Chips Integrated with Bioprinting Technologies for Drug Screening

Nima Tabatabaei Rezaei, Hitendra Kumar, Hongqun Liu, Samuel S. Lee, Simon S. Park and Keekyoung Kim

Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202203172

Global expansion of microphysiological systems (MPS) and Japan's initiatives: Innovation in pharmaceutical development and path to regulatory acceptance

Daiju Yamazaki and Seiichi Ishida

Drug Metabolism and Pharmacokinetics, 2025, 60, 101047
DOI: 10.1016/j.dmpk.2024.101047

Recent technological advances in lab-on-a-chip for bone remodeling

Seoyeon Kim, Arun Kumar Rajendran, Sivashanmugam Amirthalingam, Jung Hun Kim, Kyoung-Ha So and Nathaniel S. Hwang

Biosensors and Bioelectronics: X, 2023, 14, 100360
DOI: 10.1016/j.biosx.2023.100360

Microphysiological Systems: Stakeholder Challenges to Adoption in Drug Development

Passley Hargrove-Grimes, Lucie A. Low and Danilo A. Tagle

Cells Tissues Organs, 2022, 211, 269
DOI: 10.1159/000517422

Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation

Roberto Portillo-Lara, Andrew R. Spencer, Brian W. Walker, Ehsan Shirzaei Sani and Nasim Annabi

Biomaterials, 2019, 198, 78
DOI: 10.1016/j.biomaterials.2018.08.010

Pharmaceutical Research Enabled Through Microgravity: Perspectives on the Use of the International Space Station U.S. National Laboratory

Marc A. Giulianotti and Lucie A. Low

Pharm Res, 2020, 37
DOI: 10.1007/s11095-019-2719-z

Design considerations for engineering 3D models to study vascular pathologies in vitro

Suzette T. Lust, Catherine M. Shanahan, Rebecca J. Shipley, Pablo Lamata and Eileen Gentleman

Acta Biomaterialia, 2021, 132, 114
DOI: 10.1016/j.actbio.2021.02.031

Paths to Successful Translation of New Therapies for Severe Traumatic Brain Injury in the Golden Age of Traumatic Brain Injury Research: A Pittsburgh Vision

Patrick M. Kochanek, Travis C. Jackson, Ruchira M. Jha, Robert S.B. Clark, David O. Okonkwo, Hülya Bayır, Samuel M. Poloyac, Amy K. Wagner, Philip E. Empey, Yvette P. Conley, Michael J. Bell, Anthony E. Kline, Corina O. Bondi, Dennis W. Simon, Shaun W. Carlson, Ava M. Puccio, Christopher M. Horvat, Alicia K. Au, Jonathan Elmer, Amery Treble-Barna, Milos D. Ikonomovic, Lori A. Shutter, D. Lansing Taylor, Andrew M. Stern, Steven H. Graham, Valerian E. Kagan, Edwin K. Jackson, Stephen R. Wisniewski and C. Edward Dixon

Journal of Neurotrauma, 2020, 37, 2353
DOI: 10.1089/neu.2018.6203

New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development

Jonathon Parrish, Khoon Lim, Boyang Zhang, Milica Radisic and Tim B.F. Woodfield

Trends in Biotechnology, 2019, 37, 1327
DOI: 10.1016/j.tibtech.2019.04.009

Improving natural product research translation: From source to clinical trial

Barbara C. Sorkin, Adam J. Kuszak, Gregory Bloss, Naomi K. Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N. Brown, Frederic D. Bushman, Steven J. Casper, Floyd H. Chilton, Christopher S. Coffey, Mario G. Ferruzzi, D. Craig Hopp, Mairead Kiely, Daniel Lakens, John B. MacMillan, David O. Meltzer, Marco Pahor, Jeffrey Paul, Kathleen Pritchett‐Corning, Sara K. Quinney, Barbara Rehermann, Kenneth D. R. Setchell, Nisha S. Sipes, Jacqueline M. Stephens, D. Lansing Taylor, Hervé Tiriac, Michael A. Walters, Dan Xi, Giovanna Zappalá and Guido F. Pauli

The FASEB Journal, 2020, 34, 41
DOI: 10.1096/fj.201902143R

The NIH microphysiological systems program: developing in vitro tools for safety and efficacy in drug development

Danilo A Tagle

Current Opinion in Pharmacology, 2019, 48, 146
DOI: 10.1016/j.coph.2019.09.007

A proof-of-concept study poised to remodel the drug development process

Zaher Nahle

Front. Med. Technol., 2022, 4
DOI: 10.3389/fmedt.2022.1053588

Blood-brain-barrier modeling with tissue chips for research applications in space and on Earth

Anne Yau, Aditi Jogdand and Yupeng Chen

Front. Space Technol., 2023, 4
DOI: 10.3389/frspt.2023.1176943

Progress and application of lung-on-a-chip for lung cancer

Lantao Li, Wentao Bo, Guangyan Wang, Xin Juan, Haiyi Xue and Hongwei Zhang

Front. Bioeng. Biotechnol., 2024, 12
DOI: 10.3389/fbioe.2024.1378299

Are we ready to integrate 3D culture systems in acute myeloid leukemia and bone marrow microenvironment research?

Azmeer Sharipol and Benjamin J. Frisch

Front. Hematol., 2024, 3
DOI: 10.3389/frhem.2024.1407698

Human Microphysiological Systems and Organoids as in Vitro Models for Toxicological Studies

George A. Truskey

Front. Public Health, 2018, 6
DOI: 10.3389/fpubh.2018.00185

An Insight on Microfluidic Organ-on-a-Chip Models for PM2.5-Induced Pulmonary Complications

Disha Shah, Bhavarth Dave, Mehul R. Chorawala, Bhupendra G. Prajapati, Sudarshan Singh, Gehan M. Elossaily, Mohd Nazam Ansari and Nemat Ali

ACS Omega, 2024, 9, 13534
DOI: 10.1021/acsomega.3c10271

American Society for Bone and Mineral Research‐Orthopaedic Research Society Joint Task Force Report on Cell‐Based Therapies – Secondary Publication

Regis J. O'Keefe, Rocky S. Tuan, Nancy E. Lane, Hani A. Awad, Frank Barry, Bruce A. Bunnell, Céline Colnot, Matthew T. Drake, Hicham Drissi, Nathaniel A. Dyment, Lisa A. Fortier, Robert E. Guldberg, Rita Kandel, David G. Little, Mary F. Marshall, Jeremy J. Mao, Norimasa Nakamura, Benedikt L. Proffen, Scott A. Rodeo, Vicki Rosen, Stavros Thomopoulos, Edward M. Schwarz and Rosa Serra

Journal Orthopaedic Research, 2020, 38, 485
DOI: 10.1002/jor.24485

High throughput 3D gel-based neural organotypic model for cellular assays using fluorescence biosensors

Srikanya Kundu, Molly E. Boutin, Caroline E. Strong, Ty Voss and Marc Ferrer

Commun Biol, 2022, 5
DOI: 10.1038/s42003-022-04177-z

Microfluidic organ-on-a-chip models of human liver tissue

Ehsanollah Moradi, Sasan Jalili-Firoozinezhad and Mehran Solati-Hashjin

Acta Biomaterialia, 2020, 116, 67
DOI: 10.1016/j.actbio.2020.08.041

Clinical Trial in a Dish

Chi Keung Lam and Joseph C. Wu

ATVB, 2021, 41, 1019
DOI: 10.1161/ATVBAHA.120.314695

Newer insights into the pathobiological and pharmacological basis of the sex disparity in patients with pulmonary arterial hypertension

Tanvirul Hye, Pankaj Dwivedi, Wei Li, Tim Lahm, Eva Nozik-Grayck, Kurt R. Stenmark and Fakhrul Ahsan

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021, 320, L1025
DOI: 10.1152/ajplung.00559.2020

Bioinspired In Vitro Brain Vasculature Model for Nanomedicine Testing Based on Decellularized Spinach Leaves

Aleksandra L. Predeina, Artur Y. Prilepskii, Verónica de Zea Bermudez and Vladimir V. Vinogradov

Nano Lett., 2021, 21, 9853
DOI: 10.1021/acs.nanolett.1c01920

Dissolvable temporary barrier: a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models

Ding Wang, Qinyu Li, Chenyang Zhou, Zhangjie Li, Kangyi Lu, Yijun Liu, Lian Xuan and Xiaolin Wang

Bio-des. Manuf., 2024, 7, 153
DOI: 10.1007/s42242-023-00267-x

Microphysiological Systems for Cancer Immunotherapy Research and Development

Yansong Peng and Esak Lee

Advanced Biology, 2024, 8
DOI: 10.1002/adbi.202300077

Microphysiological Systems: A Pathologist’s Perspective

Radhakrishna Sura, Terry Van Vleet and Brian R. Berridge

Vet Pathol, 2020, 57, 358
DOI: 10.1177/0300985820908794

Making sense of antisense oligonucleotide therapy

Mark Greener

Prescriber, 2020, 31, 15
DOI: 10.1002/psb.1848

Tissue Chips in Space: Modeling Human Diseases in Microgravity

Lucie A. Low and Marc A. Giulianotti

Pharm Res, 2020, 37
DOI: 10.1007/s11095-019-2742-0

Integrative microphysiological tissue systems of cancer metastasis to the liver

Amanda M Clark, Nancy L Allbritton and Alan Wells

Seminars in Cancer Biology, 2021, 71, 157
DOI: 10.1016/j.semcancer.2020.06.010

Advanced bioengineering technologies for preclinical research

Elena Martinez, Jean-Philippe St-Pierre and Fabio Variola

Advances in Physics: X, 2019, 4, 1622451
DOI: 10.1080/23746149.2019.1622451

Multistep Fluidic Control Network toward the Automated Generation of Organ-on-a-Chip

Hsin-Lin Hsieh, Pulak Nath and Jen-Huang Huang

ACS Biomater. Sci. Eng., 2019, 5, 4852
DOI: 10.1021/acsbiomaterials.9b00912

High‐Throughput On‐Chip Human Mesenchymal Stromal Cell Potency Prediction

Rebecca S. Schneider, Alexandra C. Vela, Evelyn Kendall Williams, Karen E. Martin, Wilbur A. Lam and Andrés J. García

Adv Healthcare Materials, 2022, 11
DOI: 10.1002/adhm.202101995

Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro

Benedikt Scheidecker, Stéphane Poulain, Masahiro Sugimoto, Taketomo Kido, Takumi Kawanishi, Atsushi Miyajima, Soo Hyeon Kim, Hiroshi Arakawa, Yukio Kato, Masaki Nishikawa, Mathieu Danoy, Yasuyuki Sakai and Eric Leclerc

Biofabrication, 2024, 16, 025037
DOI: 10.1088/1758-5090/ad30c5

Microfluidic Invasion Chemotaxis Platform for 3D Neurovascular Co-Culture

Emel Sokullu, Zeynel Levent Cücük, Misagh Rezapour Sarabi, Mehmet Tugrul Birtek, Hesam Saghaei Bagheri and Savas Tasoglu

Fluids, 2022, 7, 238
DOI: 10.3390/fluids7070238

Recent advances in microfluidic technologies for organ-on-a-chip

Chang Tian, Qin Tu, Wenming Liu and Jinyi Wang

TrAC Trends in Analytical Chemistry, 2019, 117, 146
DOI: 10.1016/j.trac.2019.06.005

Converging global crises are forcing the rapid adoption of disruptive changes in drug discovery

J. Mark Treherne and Gillian R. Langley

Drug Discovery Today, 2021, 26, 2489
DOI: 10.1016/j.drudis.2021.05.001

The Lattice-Boltzmann Modeling of Microflows in a Cell Culture Microdevice for High-Throughput Drug Screening

Roman G. Szafran and Mikita Davykoza

Applied Sciences, 2021, 11, 9140
DOI: 10.3390/app11199140

American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies

Regis J O'Keefe, Rocky S Tuan, Nancy E Lane, Hani A Awad, Frank Barry, Bruce A Bunnell, Céline Colnot, Matthew T Drake, Hicham Drissi, Nathaniel A Dyment, Lisa A Fortier, Robert E Guldberg, Rita Kandel, David G Little, Mary F Marshall, Jeremy J Mao, Norimasa Nakamura, Benedikt L Proffen, Scott A. Rodeo, Vicki Rosen, Stavros Thomopoulos, Edward M. Schwarz and Rosa Serra

Journal of Bone and Mineral Research, 2020, 35, 3
DOI: 10.1002/jbmr.3839

‘You-on-a-chip’ for precision medicine

Lucie A. Low and Danilo A. Tagle

Expert Review of Precision Medicine and Drug Development, 2018, 3, 137
DOI: 10.1080/23808993.2018.1456333

Tissue chips as headway model and incitement technology

Prerna Suchitan Modi, Abhishek Singh, Awyang Chaturvedi, Shailly Agarwal, Raghav Dutta, Ranu Nayak and Alok Kumar Singh

Synthetic and Systems Biotechnology, 2025, 10, 86
DOI: 10.1016/j.synbio.2024.08.007

Microphysiological Systems: Design, Fabrication, and Applications

Kai Wang, Kun Man, Jiafeng Liu, Yang Liu, Qi Chen, Yong Zhou and Yong Yang

ACS Biomater. Sci. Eng., 2020, 6, 3231
DOI: 10.1021/acsbiomaterials.9b01667

Epigenetic Mechanisms as Emerging Therapeutic Targets and Microfluidic Chips Application in Pulmonary Arterial Hypertension

Linh Ho, Nazir Hossen, Trieu Nguyen, Au Vo and Fakhrul Ahsan

Biomedicines, 2022, 10, 170
DOI: 10.3390/biomedicines10010170

Comparative Analysis of Blood‐Derived Endothelial Cells for Designing Next‐Generation Personalized Organ‐on‐Chips

Tanmay Mathur, James J. Tronolone and Abhishek Jain

JAHA, 2021, 10
DOI: 10.1161/JAHA.121.022795

A Review of State-of-the-Art on Enabling Additive Manufacturing Processes for Precision Medicine

Atheer Awad, Alvaro Goyanes, Abdul W. Basit, Ahmed S. Zidan, Changxue Xu, Wei Li, Roger J. Narayan and Roland K. Chen

Journal of Manufacturing Science and Engineering, 2023, 145
DOI: 10.1115/1.4056199

Progress and Prospects in Translating Nanobiotechnology in Medical Theranostics

Amna Batool, Farid Menaa, Bushra Uzair, Barkat Ali Khan and Bouzid Menaa

CNANO, 2020, 16, 685
DOI: 10.2174/1573413715666191126093258

Liver Microphysiological Systems for Predicting and Evaluating Drug Effects

Alexandre J. S. Ribeiro, Xinning Yang, Vikram Patel, Rajnikanth Madabushi and David G. Strauss

Clin Pharma and Therapeutics, 2019, 106, 139
DOI: 10.1002/cpt.1458

Towards spatially-organized organs-on-chip: Photopatterning cell-laden thiol-ene and methacryloyl hydrogels in a microfluidic device

Jennifer E. Ortiz-Cárdenas, Jonathan M. Zatorski, Abhinav Arneja, Alyssa N. Montalbine, Jennifer M. Munson, Chance John Luckey and Rebecca R. Pompano

Organs-on-a-Chip, 2022, 4, 100018
DOI: 10.1016/j.ooc.2022.100018

Predicting Clinical Outcomes of SARS‐CoV‐2 Drug Efficacy with a High‐Throughput Human Airway Microphysiological System

Landys Lopez Quezada, Felix Mba Medie, Rebeccah J. Luu, Robert B. Gaibler, Elizabeth P. Gabriel, Logan D. Rubio, Thomas J. Mulhern, Elizabeth E. Marr, Jeffrey T. Borenstein, Christine R. Fisher and Ashley L. Gard

Advanced Biology, 2024, 8
DOI: 10.1002/adbi.202300511

Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond

Chun Liu, Angelos Oikonomopoulos, Nazish Sayed and Joseph C. Wu

Development, 2018, 145
DOI: 10.1242/dev.156166

Biofabrication methods for reconstructing extracellular matrix mimetics

Abdellah Aazmi, Duo Zhang, Corrado Mazzaglia, Mengfei Yu, Zhen Wang, Huayong Yang, Yan Yan Shery Huang and Liang Ma

Bioactive Materials, 2024, 31, 475
DOI: 10.1016/j.bioactmat.2023.08.018

Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood–Brain Barrier Alterations

Cristina Elena Staicu, Florin Jipa, Emanuel Axente, Mihai Radu, Beatrice Mihaela Radu and Felix Sima

Biomolecules, 2021, 11, 916
DOI: 10.3390/biom11060916

Microfluidic platform accelerates tissue processing into single cells for molecular analysis and primary culture models

Jeremy A. Lombardo, Marzieh Aliaghaei, Quy H. Nguyen, Kai Kessenbrock and Jered B. Haun

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-23238-1

Bone Marrow Microenvironment-On-Chip for Culture of Functional Hematopoietic Stem Cells

Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto and Benjamin J. Frisch

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.855777

A microphysiological systems approach to design gastrointestinal system

Vidhi Mathur, Mrunmayi Gadre, Amrutha H. K. and Kirthanashri S. Vasanthan

Journal of Biomaterials Science, Polymer Edition, 2025, 1
DOI: 10.1080/09205063.2025.2532567

Microphysiological systems: What it takes for community adoption

Passley Hargrove-Grimes, Lucie A Low and Danilo A Tagle

Exp Biol Med (Maywood), 2021, 246, 1435
DOI: 10.1177/15353702211008872

Investigation of absorption, metabolism and toxicity of ginsenosides compound K based on human organ chips

Dongdong Liu, Siming Jiao, Jinhua Wei, Xuebing Zhang, Yuxin Pei, Zhichao Pei, Jianjun Li and Yuguang Du

International Journal of Pharmaceutics, 2020, 587, 119669
DOI: 10.1016/j.ijpharm.2020.119669

Developing organs‐on‐chips for biomedical applications

Lingyu Sun, Hanxu Chen, Dongyu Xu, Rui Liu and Yuanjin Zhao

Smart Medicine, 2024, 3
DOI: 10.1002/SMMD.20240009

Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment

Daniel T. Doty, Julia Schueler, Vienna L. Mott, Cassie M. Bryan, Nathan F. Moore, John C. Ho and Jeffrey T. Borenstein

IJMS, 2020, 21, 6478
DOI: 10.3390/ijms21186478

Type‐Independent 3D Writing and Nano‐Patterning of Confined Biopolymers

Un Yang, Byunghwa Kang, Moon‐Jung Yong, Dong‐Hwan Yang, Si‐Young Choi, Jung Ho Je and Seung Soo Oh

Advanced Science, 2023, 10
DOI: 10.1002/advs.202207403

In Vitro Disease Models of the Endocrine Pancreas

Marko Milojević, Jan Rožanc, Jernej Vajda, Laura Činč Ćurić, Eva Paradiž, Andraž Stožer, Uroš Maver and Boštjan Vihar

Biomedicines, 2021, 9, 1415
DOI: 10.3390/biomedicines9101415

Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells

Huensuk Kim and Christoph Schaniel

Front. Immunol., 2018, 9
DOI: 10.3389/fimmu.2018.02243

Pathology, proteomics and the pathway to personalised medicine

Ping Jin, Jiang Lan, Kui Wang, Mark S. Baker, Canhua Huang and Edouard C. Nice

Expert Review of Proteomics, 2018, 15, 231
DOI: 10.1080/14789450.2018.1425618

Microfluidic technologies for ex vivo tissue biopsies: A review

F.C. Garcia-Garcia, P.L. Candarlioglu, J.D. Porter, D.E. Davies, E.J. Swindle and H. Morgan

Organs-on-a-Chip, 2022, 4, 100020
DOI: 10.1016/j.ooc.2022.100020

An Easy-to-Use Arrayed Brain–Heart Chip

Xiyao Peng, Lei Wu, Qiushi Li, Yuqing Ge, Tiegang Xu and Jianlong Zhao

Biosensors, 2024, 14, 517
DOI: 10.3390/bios14110517

Applications of 3D Bioprinting Technology in Induced Pluripotent Stem Cells-Based Tissue Engineering

Arvind Kumar Shukla, Ge Gao and Byoung Soo Kim

Micromachines, 2022, 13, 155
DOI: 10.3390/mi13020155

Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip

Andrei Georgescu, Joseph Hai Oved, Jonathan H. Galarraga, Thomas Cantrell, Samira Mehta, Brian M. Dulmovits, Timothy S. Olson, Pouria Fattahi, Anni Wang, Pelin L. Candarlioglu, Asli Muvaffak, Michele M. Kim, Sezin Aday Aydin, Jeongyun Seo, Eric S. Diffenderfer, Anthony Lynch, G. Scott Worthen and Dan Dongeun Huh

Cell Stem Cell, 2024, 31, 1847
DOI: 10.1016/j.stem.2024.11.003

Phenotypic screening in Organ-on-a-Chip systems: a 1537 kinase inhibitor library screen on a 3D angiogenesis assay

Camilla Soragni, Karla Queiroz, Chee Ping Ng, Arthur Stok, Thomas Olivier, Dora Tzagkaraki, Jeroen Heijmans, Johnny Suijker, Sander P. M. de Ruiter, Aleksandra Olczyk, Marleen Bokkers, Frederik Schavemaker, Sebastian J. Trietsch, Henriëtte L. Lanz, Paul Vulto and Jos Joore

Angiogenesis, 2024, 27, 37
DOI: 10.1007/s10456-023-09888-3

Research progress of organoid technology applied to nonhuman primates

SiYuan HE, XiangLin SUN, EnWu LONG, ZhengHao LU and Liang ZHOU

Sci. Sin.-Vitae, 2025, 55, 1676
DOI: 10.1360/SSV-2024-0263

Advances in Engineering Human Tissue Models

Chrysanthi-Maria Moysidou, Chiara Barberio and Róisín Meabh Owens

Front. Bioeng. Biotechnol., 2021, 8
DOI: 10.3389/fbioe.2020.620962

Principles and procedures for assessment of acute toxicity incorporating in silico methods

Craig M. Zwickl, Jessica C. Graham, Robert A. Jolly, Arianna Bassan, Ernst Ahlberg, Alexander Amberg, Lennart T. Anger, Lisa Beilke, Phillip Bellion, Alessandro Brigo, Heather Burleigh-Flayer, Mark T.D. Cronin, Amy A. Devlin, Trevor Fish, Susanne Glowienke, Kamila Gromek, Agnes L. Karmaus, Ray Kemper, Sunil Kulkarni, Elena Lo Piparo, Federica Madia, Matthew Martin, Melisa Masuda-Herrera, Britt L. McAtee, Jordi Mestres, Lawrence Milchak, Chandrika Moudgal, Moiz Mumtaz, Wolfgang Muster, Louise Neilson, Grace Patlewicz, Alexandre Paulino, Alessandra Roncaglioni, Patricia Ruiz, David T. Szabo, Jean-Pierre Valentin, Ioanna Vardakou, David Woolley and Glenn J. Myatt

Computational Toxicology, 2022, 24, 100237
DOI: 10.1016/j.comtox.2022.100237

Real-time monitoring of immediate drug response and adaptation upon repeated treatment in a microfluidic chip system

Anastasiia Zuieva, Suzan Can, Franziska Boelke, Stefanie Reuter, Sebastian Schattscheider, Elfi Töpfer, Anika Westphal, Ralf Mrowka and Stefan Wölfl

Arch Toxicol, 2022, 96, 1483
DOI: 10.1007/s00204-022-03272-8

Integrated Patient Digital and Biomimetic Twins for Precision Medicine: A Perspective

Mark T. Miedel, Mark E. Schurdak, Andrew M. Stern, Alejandro Soto-Gutierrez, Eric von Strobl, Jaideep Behari and D. Lansing Taylor

Semin Liver Dis, 2025
DOI: 10.1055/a-2649-1560

Neuroinflammation-on-a-chip for multiple sclerosis research: a narrative review

Christin Berjaoui, Charbel Kachouh, Safaa Joumaa, Mohammad Hussein Ghayyad, Bisrat Abate Bekele, Rita Ajirenike, Zeina Al Maaz, Sara Awde, Magda Wojtara, Abubakar Nazir and Olivier Uwishema

Annals of Medicine & Surgery, 2024, 86, 4053
DOI: 10.1097/MS9.0000000000002231

On-chip 3D potency assay for prediction of clinical outcomes for cell therapy candidates for osteoarthritis

Rebecca S. Schneider, Elisa B. Nieves, Bhavay Aggarwal, Annie C. Bowles-Welch, Hazel Y. Stevens, Linda E. Kippner, Scott D. Boden, Kenneth Mautner, Hicham Drissi, Krishnendu Roy, Wilbur A. Lam, Saurabh Sinha and Andrés J. García

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-60158-w

Bioethical implications of organ‐on‐a‐chip on modernizing drug development

Rahul G. Thakar and Kathleen N. Fenton

Artificial Organs, 2023, 47, 1553
DOI: 10.1111/aor.14620

Human biomimetic liver microphysiology systems in drug development and precision medicine

Albert Gough, Alejandro Soto-Gutierrez, Lawrence Vernetti, Mo R. Ebrahimkhani, Andrew M. Stern and D. Lansing Taylor

Nat Rev Gastroenterol Hepatol, 2021, 18, 252
DOI: 10.1038/s41575-020-00386-1

A high-throughput, 28-day, microfluidic model of gingival tissue inflammation and recovery

Ashley L. Gard, Rebeccah J. Luu, Ryan Maloney, Madeline H. Cooper, Brian P. Cain, Hesham Azizgolshani, Brett C. Isenberg, Jeffrey T. Borenstein, Jane Ong, Joseph L. Charest and Else M. Vedula

Commun Biol, 2023, 6
DOI: 10.1038/s42003-023-04434-9

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães and Emad Moeendarbary

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202500217

Potential of Drug Efficacy Evaluation in Lung and Kidney Cancer Models Using Organ-on-a-Chip Technology

Seong-Hye Hwang, Sangchul Lee, Jee Yoon Park, Jessie Sungyun Jeon, Young-Jae Cho and Sejoong Kim

Micromachines, 2021, 12, 215
DOI: 10.3390/mi12020215

Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application

Jonathan Cairns, Emilyanne Leonard, Kainat Khan, Conor Parks, Gareth Maglennon, Bairu Zhang, Stanley E. Lazic, Lorna Ewart and Rhiannon David

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1142581

Improved Ocular Tissue Models and Eye-On-A-Chip Technologies Will Facilitate Ophthalmic Drug Development

Charles B. Wright, Steven M. Becker, Lucie A. Low, Danilo A. Tagle and Paul A. Sieving

Journal of Ocular Pharmacology and Therapeutics, 2020, 36, 25
DOI: 10.1089/jop.2018.0139