Nadhita Chanchaona, Liang Ding, Shiliang Lin, Sulaiman Sarwar, Simone Dimartino, Ashleigh J. Fletcher, Daniel M. Dawson, Kristina Konstas, Matthew R. Hill and Cher Hon Lau

J. Mater. Chem. A, 2023, 11, 9859
DOI: 10.1039/D2TA09253K

Rhodium catalyzed synthesis of difluoromethyl cyclopropanes

Katharina J. Hock, Lucas Mertens and Rene M. Koenigs

Chem. Commun., 2016, 52, 13783
DOI: 10.1039/C6CC07745E

Enzyme immobilization inside the porous wood structure: a natural scaffold for continuous-flow biocatalysis

Christian Goldhahn, Josef A. Taut, Mark Schubert, Ingo Burgert and Munish Chanana

RSC Adv., 2020, 10, 20608
DOI: 10.1039/C9RA10633B

Stereoselective organic reactions promoted by immobilized chiral catalysts in continuous flow systems

Alessandra Puglisi, Maurizio Benaglia and Valerio Chiroli

Green Chem., 2013, 15, 1790
DOI: 10.1039/c3gc40195b

Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously

Michael A. Mercadante and Nicholas E. Leadbeater

Org. Biomol. Chem., 2011, 9, 6575
DOI: 10.1039/c1ob05808h

Efficient and selective oxidation of sulfides in batch and continuous flow using styrene-based polymer immobilised ionic liquid phase supported peroxotungstates

S. Doherty, J. G. Knight, M. A. Carroll, A. R. Clemmet, J. R. Ellison, T. Backhouse, N. Holmes, L. A. Thompson and R. A. Bourne

RSC Adv., 2016, 6, 73118
DOI: 10.1039/C6RA11157B

Residence time distribution, a simple tool to understand the behaviour of polymeric mini-flow reactors

Victor Sans, Naima Karbass, M. Isabel Burguete, Eduardo García-Verdugo and Santiago V. Luis

RSC Adv., 2012, 2, 8721
DOI: 10.1039/c2ra20903a

A continuous flow electrochemical reactor using readily available metal wires and carbon fibers as electrodes: environmentally benign halogenations of alkenes, alkynes, and aromatics

Yinqing Xie, Long Lin and Bo Xu

Green Chem., 2024, 26, 5173
DOI: 10.1039/D4GC01503G

Multicomponent reactions: advanced tools for sustainable organic synthesis

Răzvan C. Cioc, Eelco Ruijter and Romano V. A. Orru

Green Chem., 2014, 16, 2958
DOI: 10.1039/C4GC00013G

3D graphene/nylon rope as a skeleton for noble metal nanocatalysts for highly efficient heterogeneous continuous-flow reactions

Sai Zhang, Xuetao Shen, Zhiping Zheng, Yuanyuan Ma and Yongquan Qu

J. Mater. Chem. A, 2015, 3, 10504
DOI: 10.1039/C5TA00409H

A chiral organocatalytic polymer-based monolithic reactor

Valerio Chiroli, Maurizio Benaglia, Alessandra Puglisi, Riccardo Porta, Ravindra P. Jumde and Alessandro Mandoli

Green Chem., 2014, 16, 2798
DOI: 10.1039/c4gc00031e

Anionic polymerizations in a microreactor

Zhao Jin, Huiyue Wang, Xin Hu, Yihuan Liu, Yujing Hu, Shuangfei Zhao, Ning Zhu, Zheng Fang and Kai Guo

React. Chem. Eng., 2022, 7, 1026
DOI: 10.1039/D1RE00360G

Flash-synthesis of low dispersity PPVviaanionic polymerization in continuous flow reactors and block copolymer synthesis

Kirsten Verstraete, Neomy Zaquen and Tanja Junkers

Polym. Chem., 2020, 11, 7094
DOI: 10.1039/D0PY01245A

End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts

David R. Snead and Timothy F. Jamison

Chem. Sci., 2013, 4, 2822
DOI: 10.1039/c3sc50859e

Metal organic frameworks as solid catalysts for liquid-phase continuous flow reactions

Amarajothi Dhakshinamoorthy, Sergio Navalon, Abdullah M. Asiri and Hermenegildo Garcia

Chem. Commun., 2020, 56, 26
DOI: 10.1039/C9CC07953J

Automated microfluidic platform for studies of carbon dioxide dissolution and solubility in physical solvents

Milad Abolhasani, Mayank Singh, Eugenia Kumacheva and Axel Günther

Lab Chip, 2012, 12, 1611
DOI: 10.1039/c2lc21043f

A microfluidic approach for flexible and efficient operation of a cross-coupling reactive flow

A. Perazzo, G. Tomaiuolo, L. Sicignano, G. Toscano, R. E. Meadows, S. P. Nolan and S. Guido

RSC Adv., 2015, 5, 63786
DOI: 10.1039/C5RA10971J

A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy

Victor Sans, Luzian Porwol, Vincenza Dragone and Leroy Cronin

Chem. Sci., 2015, 6, 1258
DOI: 10.1039/C4SC03075C

Glycosylation with N-acetyl glycosamine donors using catalytic iron(iii) triflate: from microwave batch chemistry to a scalable continuous-flow process

Amandine Xolin, Arnaud Stévenin, Mathieu Pucheault, Stéphanie Norsikian, François-Didier Boyer and Jean-Marie Beau

Org. Chem. Front., 2014, 1, 992
DOI: 10.1039/C4QO00183D

Eu(iii)-doped calcium molybdate nano- and microstructures: microfluidic synthesis and morphology tuning via solvent dielectric constant and viscosity control

Pietro Ostellari, Francesca Tajoli, Ilaria Fortunati, Tommaso Carofiglio, Denis Badocco, Paolo Pastore and Silvia Gross

CrystEngComm, 2024, 26, 6052
DOI: 10.1039/D4CE00549J

Improving photo-controlled living radical polymerization from trithiocarbonates through the use of continuous-flow techniques

Mao Chen and Jeremiah A. Johnson

Chem. Commun., 2015, 51, 6742
DOI: 10.1039/C5CC01562F

Toward Continuous‐Flow Synthesis of Biologically Interesting Pyrazole Derivatives

Amrita Das, Haruro Ishitani and Shū Kobayashi

Adv Synth Catal, 2019, 361, 5127
DOI: 10.1002/adsc.201900954

Self-adaptive flexible valve as passive flow regulator

Qiang Zhang, Xirui Peng, Shayuan Weng, Rundong Zhang, Daining Fang, Ruike Zhao and H. Jerry Qi

Extreme Mechanics Letters, 2020, 39, 100824
DOI: 10.1016/j.eml.2020.100824

Continuous Platinum‐Mediated Hydrogenation of Refametinib Iodo‐nitroaniline Key Intermediate DIM‐NA: The Combined Challenges of Selectivity and Catalyst Deactivation

Todor Baramov, Jorma Hassfeld, Michael Gottfried, Hermann Bauer, Tanja Herrmann, Mourad Ben Said and Stefan Roggan

Eur J Org Chem, 2017, 2017, 3921
DOI: 10.1002/ejoc.201700625

A Photoflow Reactor for the Continuous Photoredox‐Mediated Synthesis of C‐Glycoamino Acids and C‐Glycolipids

R. Stephen Andrews, Jennifer J. Becker and Michel R. Gagné

Angew Chem Int Ed, 2012, 51, 4140
DOI: 10.1002/anie.201200593

Modernized Low Pressure Carbonylation Methods in Batch and Flow Employing Common Acids as a CO Source

Célia Brancour, Takahide Fukuyama, Yu Mukai, Troels Skrydstrup and Ilhyong Ryu

Org. Lett., 2013, 15, 2794
DOI: 10.1021/ol401092a

Continuous Industrial-Scale Centrifugal Partition Chromatography with Automatic Solvent System Handling: Concept and Instrumentation

László Lorántfy, Dóra Rutterschmid, Róbert Örkényi, Dávid Bakonyi, József Faragó, Gergő Dargó and Árpád Könczöl

Org. Process Res. Dev., 2020, 24, 2676
DOI: 10.1021/acs.oprd.0c00338

Induktives Heizen unter Hochfrequenzbedingungen: Anwendung in der kontinuierlichen Synthese des Neuroleptikums Olanzapin (Zyprexa)

Jan Hartwig, Sascha Ceylan, Lukas Kupracz, Ludovic Coutable and Andreas Kirschning

Angewandte Chemie, 2013, 125, 9995
DOI: 10.1002/ange.201302239

Continuous flow catalytic partial hydrogenation of hydrocarbons and alcohols over hybrid Pd/ZrO2/PVA wall reactors

Carmen Moreno-Marrodan, Francesca Liguori, Pierluigi Barbaro and Haruo Sawa

Applied Catalysis A: General, 2018, 558, 34
DOI: 10.1016/j.apcata.2018.03.025

Open‐source flow setup for rapid and efficient [18F]fluoride drying for automation of PET tracer syntheses

Florian Menzel, Jonathan Cotton, Thomas Ziegler, Andreas Maurer and Jochen M. Neumaier

Labelled Comp Radiopharmac, 2024, 67, 40
DOI: 10.1002/jlcr.4080

Microfluidic Precolumn Derivatization of Environmental Phenols with Coumarin-6-Sulfonyl Chloride and HPLC Separation

FakhrEldin O. Suliman, Jihad N. Al-Busaidi, Hiader A.J. Al-Lawati and Salma M.Z. Al-Kindy

J Chromatogr Sci, 2015, 53, 1379
DOI: 10.1093/chromsci/bmv028

Recent Advances in Asymmetric Catalysis in Flow

Dongbo Zhao and Kuiling Ding

ACS Catal., 2013, 3, 928
DOI: 10.1021/cs300830x

Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline

Lukas Kupracz and Andreas Kirschning

Adv Synth Catal, 2013, 355, 3375
DOI: 10.1002/adsc.201300614

Photocatalytic and Electrochemical Borylation and Silylation Reactions

Tony Biremond, Margaux Riomet, Philippe Jubault and Thomas Poisson

The Chemical Record, 2023, 23
DOI: 10.1002/tcr.202300172

The rapid generation of isothiocyanates in flow

Marcus Baumann and Ian R Baxendale

Beilstein J. Org. Chem., 2013, 9, 1613
DOI: 10.3762/bjoc.9.184

Solution styrene polymerization in a millireactor

Luna Fullin, Edoardo Melloni and Ardson dos S. Vianna Jr.

Chemical Engineering and Processing: Process Intensification, 2015, 98, 1
DOI: 10.1016/j.cep.2015.09.017

Self-Organization of Fluids in a Multienzymatic Pump System

Subhabrata Maiti, Oleg E. Shklyaev, Anna C. Balazs and Ayusman Sen

Langmuir, 2019, 35, 3724
DOI: 10.1021/acs.langmuir.8b03607

Microphotochemistry: 4,4'-Dimethoxybenzophenone mediated photodecarboxylation reactions involving phthalimides

Oksana Shvydkiv, Kieran Nolan and Michael Oelgemöller

Beilstein J. Org. Chem., 2011, 7, 1055
DOI: 10.3762/bjoc.7.121

Process Development of Heterogeneous Rh Catalyzed Carbene Transfer Reactions Under Continuous Flow Conditions

Tahani A. C. A. Bayrakdar and Camille Lescot

ChemSusChem, 2023, 16
DOI: 10.1002/cssc.202300596

Process Development of Biocatalytic Regioselective 5′-O-Levulinylation of 2′-Deoxynucleosides

Alejandro Carnero, Yogesh S. Sanghvi, Vicente Gotor, Susana Fernández and Miguel Ferrero

Org. Process Res. Dev., 2015, 19, 701
DOI: 10.1021/acs.oprd.5b00152

Advances in Continuous Flow Production of 5-(Hydroxymethyl)furfural, 2,5-Furandicarboxylic Acid, 2,5-Diformylfuran, and 2,5-Dimethylfuran

Cora Sofía Lecona-Vargas and Marie-Josée Dumont

Ind. Eng. Chem. Res., 2024, 63, 16222
DOI: 10.1021/acs.iecr.4c01673

Continuous Flow, Highly Enantioselective Michael Additions Catalyzed by a PS-Supported Squaramide

Pinar Kasaplar, Carles Rodríguez-Escrich and Miquel A. Pericàs

Org. Lett., 2013, 15, 3498
DOI: 10.1021/ol400974z

Rapid On-Demand Synthesis of Lomustine under Continuous Flow Conditions

Zinia Jaman, Tiago J. P. Sobreira, Ahmed Mufti, Christina R. Ferreira, R. Graham Cooks and David H. Thompson

Org. Process Res. Dev., 2019, 23, 334
DOI: 10.1021/acs.oprd.8b00387

Continuous Selective Hydrogenation of Refametinib Iodo-nitroaniline Key Intermediate DIM-NA over Raney Cobalt Catalyst at kg/day Scale with Online UV–Visible Conversion Control

Mourad Ben Said, Todor Baramov, Tanja Herrmann, Michael Gottfried, Jorma Hassfeld and Stefan Roggan

Org. Process Res. Dev., 2017, 21, 705
DOI: 10.1021/acs.oprd.7b00039

Iterative Syntheses—The Gateway to New Automation Protocols

Jan Hartwig and Andreas Kirschning

Angew Chem Int Ed, 2015, 54, 10412
DOI: 10.1002/anie.201504615

Enhancement of Nucleophilic Aromatic Substitutions by the Synergistic Effects of Microcavitation and Continuous-Flow Chemistry

Chi-Lik Ken Lee, Zhi-Yu Sem, Hendra Hendra, Xiaoqian Liu and Wei Lek Kwan

J Flow Chem, 2013, 3, 114
DOI: 10.1556/JFC-D-13-00015

Evaluation of a flow-photochemistry platform for the synthesis of compact modules

Matthias Nettekoven, Bernd Püllmann, Rainer E. Martin and David Wechsler

Tetrahedron Letters, 2012, 53, 1363
DOI: 10.1016/j.tetlet.2012.01.010

The formation of a hydrothermal carbon coating on graphite microfiber felts for using as structured acid catalyst

Laura Roldán, Iván Santos, Sabino Armenise, José María Fraile and Enrique García-Bordejé

Carbon, 2012, 50, 1363
DOI: 10.1016/j.carbon.2011.11.008

Controlled Transformations of Aryl Halides in a Flow System: Selective Synthesis of Aryl Azides and Aniline Derivatives

Ádám Georgiádes, Sándor B. Ötvös and Ferenc Fülöp

Adv Synth Catal, 2018, 360, 1841
DOI: 10.1002/adsc.201701539

Liver-on-a-Chip‒Magnetic Nanoparticle Bound Synthetic Metalloporphyrin-Catalyzed Biomimetic Oxidation of a Drug in a Magnechip Reactor

Balázs Decsi, Réka Krammer, Kristóf Hegedűs, Ferenc Ender, Benjámin Gyarmati, András Szilágyi, Róbert Tőtős, Gabriel Katona, Csaba Paizs, György T. Balogh, László Poppe and Diána Balogh-Weiser

Micromachines, 2019, 10, 668
DOI: 10.3390/mi10100668

Photocatalytic Synthesis of Allylic Trifluoromethyl Substituted Styrene Derivatives in Batch and Flow

Lukas M. Kreis, Simon Krautwald, Nicole Pfeiffer, Rainer E. Martin and Erick M. Carreira

Org. Lett., 2013, 15, 1634
DOI: 10.1021/ol400410m

Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical

Patrick L. Heider, Stephen C. Born, Soubir Basak, Brahim Benyahia, Richard Lakerveld, Haitao Zhang, Rachael Hogan, Louis Buchbinder, Aaron Wolfe, Salvatore Mascia, James M. B. Evans, Timothy F. Jamison and Klavs F. Jensen

Org. Process Res. Dev., 2014, 18, 402
DOI: 10.1021/op400294z

Highly selective monosubstitution of symmetrical dialkoxysilanes in continuous flow: Kinetics and mechanisms research

Jiadi Zhou, Shangkun Bai, Weilong Zhang, Bingbing Chen, Yuyu Yang, Qilin Xu and Zhiqun Yu

Can J Chem Eng, 2025, 103, 5623
DOI: 10.1002/cjce.25727

A New Enabling Technology for Convenient Laboratory Scale Continuous Flow Processing at Low Temperatures

Duncan L. Browne, Marcus Baumann, Bashir H. Harji, Ian R. Baxendale and Steven V. Ley

Org. Lett., 2011, 13, 3312
DOI: 10.1021/ol2010006

Composite Polymer/Oxide Hollow Fiber Contactors: Versatile and Scalable Flow Reactors for Heterogeneous Catalytic Reactions in Organic Synthesis

Eric G. Moschetta, Solymar Negretti, Kathryn M. Chepiga, Nicholas A. Brunelli, Ying Labreche, Yan Feng, Fateme Rezaei, Ryan P. Lively, William J. Koros, Huw M. L. Davies and Christopher W. Jones

Angew Chem Int Ed, 2015, 54, 6470
DOI: 10.1002/anie.201500841

Multicomponent Approach to Silica‐Grafted Peptide Catalysts: A 3 D Continuous‐Flow Organocatalytic System with On‐line Monitoring of Conversion and Stereoselectivity

Gabriel S. Scatena, Alexander F. de la Torre, Quezia B. Cass, Daniel G. Rivera and Márcio W. Paixão

ChemCatChem, 2014, 6, 3208
DOI: 10.1002/cctc.201402501

Continuous flow cationic polymerizations

Huiyue Wang, Zhao Jin, Xin Hu, Qiao Jin, Songwei Tan, Ali Reza Mahdavian, Ning Zhu and Kai Guo

Chemical Engineering Journal, 2022, 430, 132791
DOI: 10.1016/j.cej.2021.132791

In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes using a Continuous Flow Method

David Cantillo, Mostafa Baghbanzadeh and C. Oliver Kappe

Angewandte Chemie, 2012, 124, 10337
DOI: 10.1002/ange.201205792

Integrated Micro‐Flow Synthesis Based on Photochemical Wolff Rearrangement

Shinichiro Fuse, Yuma Otake and Hiroyuki Nakamura

Eur J Org Chem, 2017, 2017, 6466
DOI: 10.1002/ejoc.201700789

Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry

Volker Hessel, Dana Kralisch, Norbert Kockmann, Timothy Noël and Qi Wang

ChemSusChem, 2013, 6, 746
DOI: 10.1002/cssc.201200766

Design and Application of a Low-Temperature Continuous Flow Chemistry Platform

James A. Newby, D. Wayne Blaylock, Paul M. Witt, Julio C. Pastre, Marija K. Zacharova, Steven V. Ley and Duncan L. Browne

Org. Process Res. Dev., 2014, 18, 1211
DOI: 10.1021/op500213j

Memory of chirality in a room temperature flow electrochemical reactor

Tomas Hardwick, Rossana Cicala, Thomas Wirth and Nisar Ahmed

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-73957-6

Application of Microflow Conditions to Visible Light Photoredox Catalysis

Matthias Neumann and Kirsten Zeitler

Org. Lett., 2012, 14, 2658
DOI: 10.1021/ol3005529

Stereoselective organocatalysis and flow chemistry

Alessandra Puglisi and Sergio Rossi

Physical Sciences Reviews, 2021, 6
DOI: 10.1515/psr-2018-0099

Flow Hydrodediazoniation of Aromatic Heterocycles

Liesa Röder, Alexander J. Nicholls and Ian R. Baxendale

Molecules, 2019, 24, 1996
DOI: 10.3390/molecules24101996

Control of mixing in a continuous-flow microreactor with an integrated bubble

Dmitry Bratsun, Aleksey Mizev, Ramil Siraev and Elena Krasnyakova

J Flow Chem, 2025, 15, 59
DOI: 10.1007/s41981-025-00343-6

Continuous Flow System with a Polymer‐Supported Dirhodium(II) Catalyst: Application to Enantioselective Carbonyl Ylide Cycloaddition Reactions

Koji Takeda, Tadashi Oohara, Naoyuki Shimada, Hisanori Nambu and Shunichi Hashimoto

Chemistry A European J, 2011, 17, 13992
DOI: 10.1002/chem.201102733

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

Ashley R Longstreet, Suzanne M Opalka, Brian S Campbell, B Frank Gupton and D Tyler McQuade

Beilstein J. Org. Chem., 2013, 9, 2570
DOI: 10.3762/bjoc.9.292

Chip‐basierte Freiflusselektrophorese mit integrierter Nanospray‐Massenspektrometrie‐Kopplung

Christian Benz, Michael Boomhoff, Johannes Appun, Christoph Schneider and Detlev Belder

Angewandte Chemie, 2015, 127, 2805
DOI: 10.1002/ange.201409663

The application of a monolithic triphenylphosphine reagent for conducting Appel reactions in flow microreactors

Kimberley A Roper, Heiko Lange, Anastasios Polyzos, Malcolm B Berry, Ian R Baxendale and Steven V Ley

Beilstein J. Org. Chem., 2011, 7, 1648
DOI: 10.3762/bjoc.7.194

Preparation of Mono- and Diisocyanates in Flow from Renewable Carboxylic Acids

Thien An Phung Hai, Laurent J. S. De Backer, Nicholas D. P. Cosford and Michael D. Burkart

Org. Process Res. Dev., 2020, 24, 2342
DOI: 10.1021/acs.oprd.0c00167

Efficient Organic Synthesis based on Micro-flow Photo-reaction, Imidoylation, and Acylation

Shinichiro Fuse and Takashi Takahashi

J. Syn. Org. Chem., Jpn., 2015, 73, 442
DOI: 10.5059/yukigoseikyokaishi.73.442

Important Industrial Procedures Revisited in Flow: Very Efficient Oxidation and N-Alkylation Reactions with High Atom-Economy

Gellért Sipos, Viktor Gyollai, Tamás Sipőcz, György Dormán, László Kocsis, Richard V. Jones and Ferenc Darvas

J Flow Chem, 2013, 3, 51
DOI: 10.1556/JFC-D-12-00025

A Photoflow Reactor for the Continuous Photoredox‐Mediated Synthesis of C‐Glycoamino Acids and C‐Glycolipids

R. Stephen Andrews, Jennifer J. Becker and Michel R. Gagné

Angewandte Chemie, 2012, 124, 4216
DOI: 10.1002/ange.201200593

A layered double hydroxide, a synthetically useful heterogeneous catalyst for azide−alkyne cycloadditions in a continuous-flow reactor

Sándor B. Ötvös, Ádám Georgiádes, Mónika Ádok-Sipiczki, Rebeka Mészáros, István Pálinkó, Pál Sipos and Ferenc Fülöp

Applied Catalysis A: General, 2015, 501, 63
DOI: 10.1016/j.apcata.2015.05.003

Bridging Lab and Industry with Flow Electrochemistry

Nour Tanbouza, Thierry Ollevier and Kevin Lam

iScience, 2020, 23, 101720
DOI: 10.1016/j.isci.2020.101720

A Continuous Hydrogenation Reactor Based on a Powdered Catalyst Enmeshed in an Expanded Poly(tetrafluoroethylene) Matrix

Sean Breen, Purnima Barua, Yuan-Qing Fang, David D. Ford, Ali Hasan, Manish Joshi, Sara Mason, Kevin D. Nagy, Sifat bin Quadery, Grace Russell, Vladimiros Nikolakis, John D. Holcombe, Andrea Adamo and Lorenzo Milani

Org. Process Res. Dev., 2025, 29, 299
DOI: 10.1021/acs.oprd.4c00303

Continuous‐Flow Synthesis of (R)‐Tamsulosin Utilizing Sequential Heterogeneous Catalysis

Yuki Saito, Ken Nishizawa, Benjamin Laroche, Haruro Ishitani and Shū Kobayashi

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202115643

Miniaturized and Automated Synthesis of Biomolecules—Overview and Perspectives

Daniela S. Mattes, Nicole Jung, Laura K. Weber, Stefan Bräse and Frank Breitling

Advanced Materials, 2019, 31
DOI: 10.1002/adma.201806656

Exceptionally Stable and Efficient Solid Supported Hoveyda-Type Catalyst

Krzysztof Skowerski, Jakub Pastva, Stefan J. Czarnocki and Jana Janoscova

Org. Process Res. Dev., 2015, 19, 872
DOI: 10.1021/acs.oprd.5b00132

Direct Asymmetric Aldol Reaction in Continuous Flow Using Gel‐Bound Organocatalysts

Carsten J. Schmiegel, Rene Baier and Dirk Kuckling

Eur J Org Chem, 2021, 2021, 2578
DOI: 10.1002/ejoc.202100268

Continuous Partial Hydrogenation Reactions by Pd@unconventional Bimodal Porous Titania Monolith Catalysts

Noemi Linares, Sarah Hartmann, Anne Galarneau and Pierluigi Barbaro

ACS Catal., 2012, 2, 2194
DOI: 10.1021/cs3005902

Supported Gold Nanoparticles for Alcohols Oxidation in Continuous-Flow Heterogeneous Systems

Barbara Ballarin, Davide Barreca, Elisa Boanini, Maria Cristina Cassani, Paolo Dambruoso, Alessandro Massi, Adriana Mignani, Daniele Nanni, Chiara Parise and Anna Zaghi

ACS Sustainable Chem. Eng., 2017, 5, 4746
DOI: 10.1021/acssuschemeng.7b00133

Oxidation of Alcohols in Continuous Flow with a Solid Phase Hypervalent Iodine Catalyst

Kathrin Bensberg, Athanasios Savvidis, Frederic Ballaschk, Adrián Gómez‐Suárez and Stefan F. Kirsch

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202304011

A chip-integrated highly variable thermal flow rate sensor

Christian Hoera, Mirjam M. Skadell, Simon A. Pfeiffer, Maik Pahl, Zhe Shu, Erik Beckert and Detlev Belder

Sensors and Actuators B: Chemical, 2016, 225, 42
DOI: 10.1016/j.snb.2015.11.009

Biocatalytic Recycling of Polyethylene Terephthalate: From Conventional to Innovative Routes for Transforming Plastic and Textile Waste into Renewable Resources

Damayanti Damayanti, David Septian Sumanto Marpaung, Abdul Rozak Kodarif, Andri Sanjaya, Desi Riana Saputri, Yunita Fahni, Lutfia Rahmiyati, Putri Zulva Silvia, Dewi Qurrota A’yuni, Calaelma Logys Imalia, Dikri Uzlifah Janah and Ho Shing Wu

Resources, 2025, 14, 176
DOI: 10.3390/resources14110176

Performance of NIR-Mediated Antibacterial Continuous Flow Microreactors Prepared by Mussel-Inspired Immobilization of Cs0.33WO3 Photothermal Agents

Young Kwang Kim, Eun Bi Kang, Sung Min Kim, Chan Pil Park, Insik In and Sung Young Park

ACS Appl. Mater. Interfaces, 2017, 9, 3192
DOI: 10.1021/acsami.6b16634

Continuous‐Flow Synthesis of (R)‐Tamsulosin Utilizing Sequential Heterogeneous Catalysis

Yuki Saito, Ken Nishizawa, Benjamin Laroche, Haruro Ishitani and Shū Kobayashi

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202115643

Macrocellular Titanosilicate Monoliths as Highly Efficient Structured Olefin Epoxidation Catalysts

Valentin Smeets, Ludivine van den Biggelaar, Tarek Barakat, Eric M. Gaigneaux and Damien P. Debecker

ChemCatChem, 2019, 11, 1593
DOI: 10.1002/cctc.201900028

Scalable Flow Synthesis of [6,6]‐Phenyl‐C61‐butyric Acid Methyl Ester (PCBM) using a Flow Photoreactor with a Sodium Lamp

Mitsuhiro Ueda, Naoyuki Imai, Shunsuke Yoshida, Hiroshi Yasuda, Takahide Fukuyama and Ilhyong Ryu

Eur J Org Chem, 2017, 2017, 6483
DOI: 10.1002/ejoc.201700745

Optimizing the Heck–Matsuda Reaction in Flow with a Constraint-Adapted Direct Search Algorithm

Daniel Cortés-Borda, Ksenia V. Kutonova, Corentin Jamet, Marina E. Trusova, Françoise Zammattio, Charlotte Truchet, Mireia Rodriguez-Zubiri and François-Xavier Felpin

Org. Process Res. Dev., 2016, 20, 1979
DOI: 10.1021/acs.oprd.6b00310

Unconventional Pd@Sulfonated Silica Monoliths Catalysts for Selective Partial Hydrogenation Reactions under Continuous Flow

Francesca Liguori, Pierluigi Barbaro, Bilel Said, Anne Galarneau, Vladimiro Dal Santo, Elisa Passaglia and Alessandro Feis

ChemCatChem, 2017, 9, 3245
DOI: 10.1002/cctc.201700381

General, Modular Access toward Immobilized Chiral Phosphoric Acid Catalysts and Their Application in Flow Chemistry

Michael Laue, Maximilian Schneider, Markus Gebauer, Winfried Böhlmann, Roger Gläser and Christoph Schneider

ACS Catal., 2024, 14, 5550
DOI: 10.1021/acscatal.4c00985

Bromination of Aromatic Compounds using Bromine in a Microreactor

Qiulin Deng, Ruwei Shen, Rong Ding and Lixiong Zhang

Chem Eng & Technol, 2016, 39, 1445
DOI: 10.1002/ceat.201400723

Synthesis and Utilization of Nitroalkyne Equivalents in Batch and Continuous Flow

Peter D. Morse and Timothy F. Jamison

Angewandte Chemie, 2017, 129, 14187
DOI: 10.1002/ange.201706157

The Microwave‐to‐Flow Paradigm: Translating High‐Temperature Batch Microwave Chemistry to Scalable Continuous‐Flow Processes

Toma N. Glasnov and C. Oliver Kappe

Chemistry A European J, 2011, 17, 11956
DOI: 10.1002/chem.201102065

Microfluidic Hydrogenation Reactions by using a Channel‐Supported Rhodium Catalyst

Tom Haywood and Philip W. Miller

ChemCatChem, 2014, 6, 1199
DOI: 10.1002/cctc.201301109

Applications of Continuous-Flow Photochemistry in Organic Synthesis, Material Science, and Water Treatment

Dario Cambié, Cecilia Bottecchia, Natan J. W. Straathof, Volker Hessel and Timothy Noël

Chem. Rev., 2016, 116, 10276
DOI: 10.1021/acs.chemrev.5b00707

Understanding flow chemistry for the production of active pharmaceutical ingredients

Anand S. Burange, Sameh M. Osman and Rafael Luque

iScience, 2022, 25, 103892
DOI: 10.1016/j.isci.2022.103892

Enantioselective β‐Arylation of Ketones Enabled by Lithiation/Borylation/1,4‐Addition Sequence Under Flow Conditions

Wei Shu and Stephen L. Buchwald

Angew Chem Int Ed, 2012, 51, 5355
DOI: 10.1002/anie.201202221

The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow

Kimberley A Roper, Malcolm B Berry and Steven V Ley

Beilstein J. Org. Chem., 2013, 9, 1781
DOI: 10.3762/bjoc.9.207

Enzymatic reactions for the preparation of homocalycotomine enantiomers

László Schönstein, Enikő Forró and Ferenc Fülöp

Tetrahedron: Asymmetry, 2013, 24, 1059
DOI: 10.1016/j.tetasy.2013.07.025

Controlling mass transfer in a continuous-flow microreactor with a variable wall relief

Dmitry Bratsun and Ramil Siraev

International Communications in Heat and Mass Transfer, 2020, 113, 104522
DOI: 10.1016/j.icheatmasstransfer.2020.104522

Lipase-Catalyzed Monostearin Synthesis under Continuous Flow Conditions

Ivaldo I. Junior, Marcela C. Flores, Felipe K. Sutili, Selma G. F. Leite, Leandro S. de M. Miranda, Ivana C. R. Leal and Rodrigo O. M. A. de Souza

Org. Process Res. Dev., 2012, 16, 1098
DOI: 10.1021/op200132y

Triple-channel microreactor for biphasic gas–liquid reactions: Photosensitized oxygenations

Ram Awatar Maurya, Chan Pil Park and Dong-Pyo Kim

Beilstein J. Org. Chem., 2011, 7, 1158
DOI: 10.3762/bjoc.7.134

Flow carbonylation of sterically hindered ortho-substituted iodoarenes

Carl J Mallia, Gary C Walter and Ian R Baxendale

Beilstein J. Org. Chem., 2016, 12, 1503
DOI: 10.3762/bjoc.12.147

Heuristics, Protocol, and Considerations for Flow Chemistry in Photoredox Catalysis

Eric G. Moschetta, Steven M. Richter and Steven J. Wittenberger

ChemPhotoChem, 2017, 1, 539
DOI: 10.1002/cptc.201700128

Flow synthesis of annulated 5-aryl-substituted pyridines by tandem intramolecular inverse-electron-demand hetero-/retro-Diels–Alder reaction

Rainer E. Martin, Mario Lenz, Thibaut Alzieu, Johannes D. Aebi and Liliane Forzy

Tetrahedron Letters, 2013, 54, 6703
DOI: 10.1016/j.tetlet.2013.09.069

Proof of Concept: Magnetic Fixation of Dendron-Functionalized Iron Oxide Nanoparticles Containing Palladium Nanoparticles for Continuous-Flow Suzuki Coupling Reactions

Thomas H. Rehm, Anca Bogdan, Christian Hofmann, Patrick Löb, Zinaida B. Shifrina, David G. Morgan and Lyudmila M. Bronstein

ACS Appl. Mater. Interfaces, 2015, 7, 27254
DOI: 10.1021/acsami.5b08466

Continuous flow catalysis with a biomimetic copper(II) complex covalently immobilized on graphite felt

Ronan Marion, Gopinathan Muthusamy and Florence Geneste

Journal of Catalysis, 2012, 286, 266
DOI: 10.1016/j.jcat.2011.11.011

Fatty acids residue from palm oil refining process as feedstock for lipase catalyzed monoacylglicerol production under batch and continuous flow conditions

Ivaldo I. Junior, Marcela C. Flores, Felipe K. Sutili, Selma G.F. Leite, Leandro S. de M. e Miranda, Ivana C.R. Leal and Rodrigo O.M.A. de Souza

Journal of Molecular Catalysis B: Enzymatic, 2012, 77, 53
DOI: 10.1016/j.molcatb.2012.01.008

Continuous Recycling of Homogeneous Pd/Cu Catalysts for Cross-Coupling Reactions

Siddharth Sharma, K. C. Basavaraju, Ajay K. Singh and Dong-Pyo Kim

Org. Lett., 2014, 16, 3974
DOI: 10.1021/ol501802w

Composite Polymer/Oxide Hollow Fiber Contactors: Versatile and Scalable Flow Reactors for Heterogeneous Catalytic Reactions in Organic Synthesis

Eric G. Moschetta, Solymar Negretti, Kathryn M. Chepiga, Nicholas A. Brunelli, Ying Labreche, Yan Feng, Fateme Rezaei, Ryan P. Lively, William J. Koros, Huw M. L. Davies and Christopher W. Jones

Angewandte Chemie, 2015, 127, 6570
DOI: 10.1002/ange.201500841

Flow Synthesis in Hot Water: Synthesis of the Atypical Antipsychotic Iloperidone

Jan Hartwig and Andreas Kirschning

Chemistry A European J, 2016, 22, 3044
DOI: 10.1002/chem.201504409

Ruthenium-Based Complexes Bearing Quaternary Ammonium Tags as Versatile Catalysts for Olefin Metathesis: From the Discovery to Practical Applications

Tomasz K. Olszewski, Michał Bieniek and Krzysztof Skowerski

Org. Process Res. Dev., 2020, 24, 125
DOI: 10.1021/acs.oprd.9b00483

Preparation of Biowax Esters in Continuous Flow Conditions

Daniela Caputo, Michele Casiello, Amelita Grazia Laurenza, Francesco Fracassi, Caterina Fusco, Angelo Nacci and Lucia D’Accolti

ACS Omega, 2019, 4, 12286
DOI: 10.1021/acsomega.9b00861

Claisen‐Umlagerung im Rühr‐ und Durchflussbetrieb: Verständnis des Mechanismus und Steuerung der Einflussgrößen

Volker Hessel, Elnaz Shahbazali, Timothy Noël and Sergei Zelentsov

Chemie Ingenieur Technik, 2014, 86, 2160
DOI: 10.1002/cite.201400125

Electrolyte Developments for All‐Solid‐State Lithium Batteries: Classifications, Recent Advances and Synthesis Methods

Cheuk Hei Chan, Hon Ho Wong, Shipeng Liang, Mingzi Sun, Tong Wu, Qiuyang Lu, Lu Lu, Baian Chen and Bolong Huang

Batteries & Supercaps, 2024, 7
DOI: 10.1002/batt.202400432

Continuous‐Flow Dynamic Kinetic Resolution of Racemic Alcohols by Lipase–Oxovanadium Cocatalysis

Koichi Higashio, Satoko Katsuragi, Dhiman Kundu, Niklas Adebar, Carmen Plass, Franziska Kühn, Harald Gröger and Shuji Akai

Eur J Org Chem, 2020, 2020, 1961
DOI: 10.1002/ejoc.202000186

Mixing control in a continuous-flow microreactor using electro-osmotic flow

Ramil Siraev, Pavel Ilyushin, Dmitry Bratsun, Anna Samoilova and Alexander Nepomnyashchy

Math. Model. Nat. Phenom., 2021, 16, 49
DOI: 10.1051/mmnp/2021043

A Modular, Argon-Driven Flow Platform for Natural Product Synthesis and Late-Stage Transformations

Merlin Kleoff, Johannes Schwan, Mathias Christmann and Philipp Heretsch

Org. Lett., 2021, 23, 2370
DOI: 10.1021/acs.orglett.1c00661

Reaction screening in continuous flow reactors

Dara Khairunnisa Binte Mohamed, Xingjian Yu, Jiesheng Li and Jie Wu

Tetrahedron Letters, 2016, 57, 3965
DOI: 10.1016/j.tetlet.2016.07.072

Nanocatalysis in Flow

Roberto Ricciardi, Jurriaan Huskens and Willem Verboom

ChemSusChem, 2015, 8, 2586
DOI: 10.1002/cssc.201500514

Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

Andrew R. Bogdan and Amanda W. Dombrowski

J. Med. Chem., 2019, 62, 6422
DOI: 10.1021/acs.jmedchem.8b01760

Polyacrylonitrile Fiber Supported N-Heterocyclic Carbene Ag(I) As Efficient Catalysts for Three-Component Coupling and Intramolecular 1,3-Dipolar Cycloaddition Reactions under Flow Conditions

Jian Cao, Gang Xu, Pengyu Li, Minli Tao and Wenqin Zhang

ACS Sustainable Chem. Eng., 2017, 5, 3438
DOI: 10.1021/acssuschemeng.7b00103

A Flow Reactor with Inline Analytics: Design and Implementation

Kristina Somerville, Michael Tilley, Guanlong Li, Debasis Mallik and Michael G. Organ

Org. Process Res. Dev., 2014, 18, 1315
DOI: 10.1021/op5002512

Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

Andreas Kirschning and Frank Hahn

Angew Chem Int Ed, 2012, 51, 4012
DOI: 10.1002/anie.201107386

Continuous‐Flow retro‐Diels–Alder Reaction: A Process Window for Designing Heterocyclic Scaffolds

Imane Nekkaa, Márta Palkó, István M. Mándity, Ferenc Miklós and Ferenc Fülöp

Eur J Org Chem, 2018, 2018, 4456
DOI: 10.1002/ejoc.201800682

Matched confinement enables high-stability Pt/SiO2 catalysts for continuous-flow hydrogenation of halogenated nitroarenes

Dongchuang Wan, Heng Huang, Zhenli Xiang, Chunyu Yin, Jiaxin Yu, Shilong Xiong, Chaofan Ma, Yebin Zhou, Wei He, Xiaonian Li and Chunshan Lu

Materials Today Chemistry, 2026, 53, 103476
DOI: 10.1016/j.mtchem.2026.103476

Continuous‐Flow Synthesis of the Anti‐Malaria Drug Artemisinin

François Lévesque and Peter H. Seeberger

Angew Chem Int Ed, 2012, 51, 1706
DOI: 10.1002/anie.201107446

Microcapillary film reactor outperforms single-bore mesocapillary reactors in continuous flow chemical reactions

Kirandeep K. Gill, Rachel Gibson, Kam Ho Chester Yiu, Patrick Hester and Nuno M. Reis

Chemical Engineering Journal, 2021, 408, 127860
DOI: 10.1016/j.cej.2020.127860

Switching Modes of Mixing Due to an Adjustable Gap in a Continuous-Flow Microreactor

Dmitry Bratsun and Ramil Siraev

Actuators, 2019, 9, 2
DOI: 10.3390/act9010002

An integrated microfluidic chip enabling control and spatially resolved monitoring of temperature in micro flow reactors

Christian Hoera, Stefan Ohla, Zhe Shu, Erik Beckert, Stefan Nagl and Detlev Belder

Anal Bioanal Chem, 2015, 407, 387
DOI: 10.1007/s00216-014-8297-3

Heat on – Calibration of IR Spectroscopy at Process Conditions for Continuous Esterification

Johann‐Kilian Schnoor, Lennard D. Schulte and Marcel A. Liauw

Chemie Ingenieur Technik, 2020, 92, 1467
DOI: 10.1002/cite.202000050

Multistep Continuous‐Flow Synthesis in Medicinal Chemistry: Discovery and Preliminary Structure–Activity Relationships of CCR8 Ligands

Trine P. Petersen, Sahar Mirsharghi, Pia C. Rummel, Stefanie Thiele, Mette M. Rosenkilde, Andreas Ritzén and Trond Ulven

Chemistry A European J, 2013, 19, 9343
DOI: 10.1002/chem.201204350

Continuous-Flow Preparation and Use of β-Chloro Enals Using the Vilsmeier Reagent

Laurent Pellegatti and Stephen L. Buchwald

Org. Process Res. Dev., 2012, 16, 1442
DOI: 10.1021/op300168z

Continuous-flow hydration–condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst

Magnus Rueping, Teerawut Bootwicha, Hannah Baars and Erli Sugiono

Beilstein J. Org. Chem., 2011, 7, 1680
DOI: 10.3762/bjoc.7.198

Kontinuierlich produzieren

Tobias Bauer

Nachr Chem, 2012, 60, 633
DOI: 10.1002/nadc.201290229

Partial hydrogenation reactions over Pd-containing hybrid inorganic/polymeric catalytic membranes

Francesca Liguori, Pierluigi Barbaro, Cristiana Giordano and Haruo Sawa

Applied Catalysis A: General, 2013, 459, 81
DOI: 10.1016/j.apcata.2013.03.040

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**

Ashley P. Mattey, Grayson J. Ford, Joan Citoler, Christopher Baldwin, James R. Marshall, Ryan B. Palmer, Matthew Thompson, Nicholas J. Turner, Sebastian C. Cosgrove and Sabine L. Flitsch

Angewandte Chemie, 2021, 133, 18808
DOI: 10.1002/ange.202103805

The Oxygen‐Mediated Synthesis of 1,3‐Butadiynes in Continuous Flow: Using Teflon AF‐2400 to Effect Gas/Liquid Contact

Trine P. Petersen, Anastasios Polyzos , Matthew O'Brien, Trond Ulven, Ian R. Baxendale and Steven V. Ley

ChemSusChem, 2012, 5, 274
DOI: 10.1002/cssc.201100339

Synthesis of a Precursor to Sacubitril Using Enabling Technologies

Shing-Hing Lau, Samuel L. Bourne, Benjamin Martin, Berthold Schenkel, Gerhard Penn and Steven V. Ley

Org. Lett., 2015, 17, 5436
DOI: 10.1021/acs.orglett.5b02806

Strategic Immobilization of Molecular Catalysts onto Carbon Nanotubes via Noncovalent Interaction for Catalytic Organic Transformations

Naoya Kumagai and Masakatsu Shibasaki

Israel Journal of Chemistry, 2017, 57, 270
DOI: 10.1002/ijch.201600126

Flow Chemistry: Towards A More Sustainable Heterocyclic Synthesis

Pedro Brandão, Marta Pineiro and Teresa M. V. D. Pinho e Melo

Eur J Org Chem, 2019, 2019, 7188
DOI: 10.1002/ejoc.201901335

Mineral Grains, Dimples, and Hot Volcanic Organic Streams: Dynamic Geological Backstage of Macromolecular Evolution

Nikolai E. Skoblikow and Andrei A. Zimin

J Mol Evol, 2018, 86, 172
DOI: 10.1007/s00239-018-9839-7

Continuous Synthesis of 4-Cyclopropyl-1,2,5-Oxadiazole-3-Carboxylic Acid

艳梅董

HJMCe, 2023, 11, 133
DOI: 10.12677/HJMCe.2023.113017

Applications of Flow Chemistry in Total Synthesis of Natural Products

Sasadhar Majhi

COC, 2023, 27, 1072
DOI: 10.2174/1385272827666230809094232

Heterogeneous Dipeptide‐Catalyzed α‐Amination of Aldehydes in a Continuous‐Flow Reactor: Effect of Residence Time on Enantioselectivity

Sándor B. Ötvös, Aliz Szloszár, István M. Mándity and Ferenc Fülöp

Adv Synth Catal, 2015, 357, 3671
DOI: 10.1002/adsc.201500375

Photochemistry with laser radiation in condensed phase using miniaturized photoreactors

Elke Bremus-Köbberling, Arnold Gillner, Frank Avemaria, Céline Réthoré and Stefan Bräse

Beilstein J. Org. Chem., 2012, 8, 1213
DOI: 10.3762/bjoc.8.135

Fouling Detection in an Optically Accessible Microstructured Heat Exchanger

Christoph Spiegel, Manfred Kraut, Georg Rabsch, Christof Küsters, Wolfgang Augustin and Stephan Scholl

Chem Eng & Technol, 2019, 42, 2067
DOI: 10.1002/ceat.201900161

First Continuous‐Flow Intramolecular Dehydrative Friedel–Crafts Alkylation of Benzyl Alcohols in 1,1,1,3,3,3‐Hexafluoro‐2‐Propanol Catalyzed by HO‐Substituted Sulfonic Acid‐Functionalized Silica Gel

Kosho Makino, Nanase Koizumi, Makoto Hashimoto, Koji Ichinose, Shunsuke Sueki, Tetsu Tsubogo and Masahiro Anada

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202500861

Flow Dehydration and Hydrogenation of Allylic Alcohols: Application to the Waste‐Free Synthesis of Pristane

Akihiro Furuta, Yuki Hirobe, Takahide Fukuyama, Ilhyong Ryu, Yoshiyuki Manabe and Koichi Fukase

Eur J Org Chem, 2017, 2017, 1365
DOI: 10.1002/ejoc.201700072

Stereoselective Synthesis of ABBV-992 Enabled by a Flow Diazotization and a Partial Reduction of a Pyridone

Patrick B. Brady, Kaid C. Harper, Bryan K. Sorensen, Stephen N. Greszler, Chunqiu Lai, Alan S. Florjancic, Gang Zhao, Bhadra H. Shelat, Gregory E. Storer, Rodger F. Henry and T. Matthew Hansen

Org. Process Res. Dev., 2024, 28, 3152
DOI: 10.1021/acs.oprd.4c00077

Photobiocatalysis in Continuous Flow

Santiago Nahuel Chanquia, Alessia Valotta, Heidrun Gruber-Woelfler and Selin Kara

Front. Catal., 2022, 1
DOI: 10.3389/fctls.2021.816538

Continuous Microflow Bromination of Alkenes Combined with a Circulatory Recycling of a Fluorous Polyether as a Bromine Support

T. Fukuyama, Md. T. Rahman, N. Kamata, M. Tokizane, Y. Fukuda and I. Ryu

J Flow Chem, 2013, 3, 4
DOI: 10.1556/JFC-D-12-00023

The continuous synthesis and application of graphene supported palladium nanoparticles: a highly effective catalyst for Suzuki-Miyaura cross-coupling reactions

Kendra W. Brinkley, Michael Burkholder, Ali R. Siamaki, Katherine Belecki and B. Frank Gupton

Green Processing and Synthesis, 2015, 4, 241
DOI: 10.1515/gps-2015-0021

Chemical reaction engineering, process design and scale-up issues at the frontier of synthesis: Flow chemistry

Ilenia Rossetti and Matteo Compagnoni

Chemical Engineering Journal, 2016, 296, 56
DOI: 10.1016/j.cej.2016.02.119

Catalytic Flow Hydrogenation of Aromatic Nitro Compounds Using Polysilane-Supported Palladium

Masaharu Ueno, Yasuharu Morii, Kiyoko Uramoto, Hidekazu Oyamada, Yuichiro Mori and Shū Kobayashi

J Flow Chem, 2014, 4, 160
DOI: 10.1556/JFC-D-14-00024

Capillary effects of submicron heterogeneities in aqueous solutions of sugars. The additional mechanism of microfluidics

Nikita V. Penkov, Vasily A. Zhmurin, Andrey A. Manokhin, Alexey V. Kobelev and Nadezda A. Penkova

Journal of Molecular Liquids, 2024, 410, 125638
DOI: 10.1016/j.molliq.2024.125638

FOMSy: 3D-printed flexible open-source microfluidic system and flow synthesis of PET-tracer

Florian Menzel, Jonathan Cotton, Thomas Klein, Andreas Maurer, Thomas Ziegler and Jochen M. Neumaier

J Flow Chem, 2023, 13, 247
DOI: 10.1007/s41981-023-00267-z

Continuous Flow Synthesis of Highly Substituted Tetrahydrofurans

Patrick Hoffmeyer and Christoph Schneider

Eur J Org Chem, 2019, 2019, 5326
DOI: 10.1002/ejoc.201900421

Handling Hazards Using Continuous Flow Chemistry: Synthesis of N1-Aryl-[1,2,3]-triazoles from Anilines via Telescoped Three-Step Diazotization, Azidodediazotization, and [3 + 2] Dipolar Cycloaddition Processes

Matthieu Teci, Michael Tilley, Michael A. McGuire and Michael G. Organ

Org. Process Res. Dev., 2016, 20, 1967
DOI: 10.1021/acs.oprd.6b00292

A multipass catalytic reactor insert for continuous hydrogen generation from methylcyclohexane

Deepali Arora, Matt Richards, Yutong Zhu, Ivan Martinez-Botella, Xingdong Wang, Zongli Xie, John Chiefari, Simon Saubern and Christian Hornung

Chemical Engineering and Processing - Process Intensification, 2024, 201, 109822
DOI: 10.1016/j.cep.2024.109822

The Eschenmoser coupling reaction under continuous-flow conditions

Sukhdeep Singh, J Michael Köhler, Andreas Schober and G Alexander Groß

Beilstein J. Org. Chem., 2011, 7, 1164
DOI: 10.3762/bjoc.7.135

Synthesis of Carbohydrates in a Continuous Flow Reactor by Immobilized Phosphatase and Aldolase

Lara Babich, Aloysius F. Hartog, Lieke J. C. van Hemert, Floris P. J. T. Rutjes and Ron Wever

ChemSusChem, 2012, 5, 2348
DOI: 10.1002/cssc.201200468

Quaternary Ammonium-Based Functionalized Polyacrylonitrile Fibers with Polarity Tunable Inner Surface Microenvironment for C–C Bond Forming Reactions under Continuous Flow Conditions

Lu Wang, Gang Xu, Jian Xiao, Minli Tao and Wenqin Zhang

Ind. Eng. Chem. Res., 2019, 58, 12401
DOI: 10.1021/acs.iecr.9b01375

Continuous Thermal Oxidation of Alkenes with Nitrous Oxide in a Packed Bed Reactor

Stephen G. Newman, Kyoungmi Lee, Jianghuai Cai, Lu Yang, William H. Green and Klavs F. Jensen

Ind. Eng. Chem. Res., 2015, 54, 4166
DOI: 10.1021/ie504129e

Fuel cell and electrolyzer using plastic waste directly as fuel

Tetsuya Hori, Kazuyo Kobayashi, Shinya Teranishi, Masahiro Nagao and Takashi Hibino

Waste Management, 2020, 102, 30
DOI: 10.1016/j.wasman.2019.10.019

Generation of ynolates via reductive lithiation using flow microreactors

Satoshi Umezu, Toshiya Yoshiiwa, Manabu Tokeshi and Mitsuru Shindo

Tetrahedron Letters, 2014, 55, 1822
DOI: 10.1016/j.tetlet.2014.01.147

Flow Update for the Carbonylation of 1-Silyl-Substituted Organolithiums under CO Pressure

Takahide Fukuyama, Takenori Totoki and Ilhyong Ryu

Org. Lett., 2014, 16, 5632
DOI: 10.1021/ol5026958

Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

D. Tyler McQuade and Peter H. Seeberger

J. Org. Chem., 2013, 78, 6384
DOI: 10.1021/jo400583m

Cooperative N-heterocyclic carbene Au and amino catalysis for continuous synthesis of secondary propargylamines in a fiber supported hydrophilic microenvironment

Jian Cao, Pengyu Li, Gang Xu, Minli Tao, Ning Ma and Wenqin Zhang

Chemical Engineering Journal, 2018, 349, 456
DOI: 10.1016/j.cej.2018.05.046

Photochemical Transformations Accelerated in Continuous‐Flow Reactors: Basic Concepts and Applications

Yuanhai Su, Natan J. W. Straathof, Volker Hessel and Timothy Noël

Chemistry A European J, 2014, 20, 10562
DOI: 10.1002/chem.201400283

Structure and Reactivity of Supported Hybrid Platinum Nanoparticles for the Flow Hydrogenation of Functionalized Nitroaromatics

Gianvito Vilé, Neyvis Almora-Barrios, Núria López and Javier Pérez-Ramírez

ACS Catal., 2015, 5, 3767
DOI: 10.1021/acscatal.5b00885

A Safe and Efficient Flow Oxidation of Aldehydes with O2

Laurent Vanoye, Asma Aloui, Mertxe Pablos, Régis Philippe, Aurélien Percheron, Alain Favre-Réguillon and Claude de Bellefon

Org. Lett., 2013, 15, 5978
DOI: 10.1021/ol401273k

Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

Marek Trojanowicz

Molecules, 2020, 25, 1434
DOI: 10.3390/molecules25061434

Ruthenium Complex Bearing a Hydroxy Group Functionalised N‐Heterocyclic Carbene Ligand – A Universal Platform for Synthesis of Tagged and Immobilised Catalysts for Olefin Metathesis

Louis Monsigny, Stefan Czarnocki, Michał Sienkiewicz, William Kopcha, René Frankfurter, Carla Vogt, Wladimir Solodenko, Anna Kajetanowicz, Andreas Kirschning and Karol Grela

Eur J Org Chem, 2021, 2021, 6424
DOI: 10.1002/ejoc.202101092

Flash Flow Pyrolysis: Mimicking Flash Vacuum Pyrolysis in a High-Temperature/High-Pressure Liquid-Phase Microreactor Environment

David Cantillo, Hassan Sheibani and C. Oliver Kappe

J. Org. Chem., 2012, 77, 2463
DOI: 10.1021/jo3001645

Sustainability and Techno-Economic Assessment of Batch and Flow Chemistry in Seven Industrial Pharmaceutical Processes

Mert Can Ince, Brahim Benyahia and Gianvito Vilé

ACS Sustainable Chem. Eng., 2025, 13, 2864
DOI: 10.1021/acssuschemeng.4c09289

Efficient and selective chemical transformations under flow conditions: The combination of supported catalysts and supercritical fluids

M Isabel Burguete, Eduardo García-Verdugo and Santiago V Luis

Beilstein J. Org. Chem., 2011, 7, 1347
DOI: 10.3762/bjoc.7.159

Application of Flow Photochemical Bromination in the Synthesis of a 5-Bromomethylpyrimidine Precursor of Rosuvastatin: Improvement of Productivity and Product Purity

Damjan Šterk, Marko Jukič and Zdenko Časar

Org. Process Res. Dev., 2013, 17, 145
DOI: 10.1021/op300248y

Diazo Compounds in Continuous‐Flow Technology

Simon T. R. Müller and Thomas Wirth

ChemSusChem, 2015, 8, 245
DOI: 10.1002/cssc.201402874

Teflon microreactors for organic syntheses

Tomasz Szymborski, Paweł Jankowski and Piotr Garstecki

Sensors and Actuators B: Chemical, 2018, 255, 2274
DOI: 10.1016/j.snb.2017.09.035

Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide

Sándor B. Ötvös, István M. Mándity and Ferenc Fülöp

Journal of Catalysis, 2012, 295, 179
DOI: 10.1016/j.jcat.2012.08.006

Three-Step Continuous Flow Synthesis of the Intermediate 4-Fluoro-2-methoxy-5-nitrophenol of Linzagolix

Tengfei Gong, Fei Ji, Yichen Shi, Yiyang Dong, Yu Xia, Fawen Wu and Xiaoming Zha

Org. Process Res. Dev., 2025, 29, 146
DOI: 10.1021/acs.oprd.4c00405

An Enlightening Reactor

Daniel K. Kim and Vy M. Dong

ACS Cent. Sci., 2017, 3, 526
DOI: 10.1021/acscentsci.7b00218

Synthesis and Utilization of Nitroalkyne Equivalents in Batch and Continuous Flow

Peter D. Morse and Timothy F. Jamison

Angew Chem Int Ed, 2017, 56, 13999
DOI: 10.1002/anie.201706157

A Solvent-Free Base Liberation of a Tertiary Aminoalkyl Halide by Flow Chemistry

Michael J. Pedersen, Tommy Skovby, Michael J. Mealy, Kim Dam-Johansen and Søren Kiil

Org. Process Res. Dev., 2016, 20, 2043
DOI: 10.1021/acs.oprd.6b00223

Kinetic resolution of a precursor for myo-inositol phosphates under continuous flow conditions

Evelin A. Manoel, Karla C. Pais, Marcella C. Flores, Leandro Soter de M. e Miranda, Maria Alice Zarur Coelho, Alessandro B.C. Simas, Denise M.G. Freire and Rodrigo Octavio M.A. de Souza

Journal of Molecular Catalysis B: Enzymatic, 2013, 87, 139
DOI: 10.1016/j.molcatb.2012.11.006

Microreactor-Mediated Organocatalysis: Towards the Development of Sustainable Domino Reactions

Laura Carroccia, Biagia Musio, Leonardo Degennaro, Giuseppe Romanazzi and Renzo Luisi

J Flow Chem, 2013, 3, 29
DOI: 10.1556/JFC-D-13-00003

Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds

Antonella Ilenia Alfano, Sveva Pelliccia, Giacomo Rossino, Orazio Chianese, Vincenzo Summa, Simona Collina and Margherita Brindisi

ACS Med. Chem. Lett., 2023, 14, 672
DOI: 10.1021/acsmedchemlett.3c00072

Green semi-hydrogenation of alkynes by Pd@borate monolith catalysts under continuous flow

Francesca Liguori and Pierluigi Barbaro

Journal of Catalysis, 2014, 311, 212
DOI: 10.1016/j.jcat.2013.11.027

Potential solvents in coupling reactions catalyzed by Cu(II)Fe(III)-layered double hydroxide in a continuous-flow reactor

Rebeka Mészáros, Sándor B. Ötvös, Zoltán Kónya, Ákos Kukovecz, Pál Sipos, Ferenc Fülöp and István Pálinkó

Reac Kinet Mech Cat, 2017, 121, 345
DOI: 10.1007/s11144-016-1133-3

Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439

Shing-Hing Lau, Alicia Galván, Rohan R. Merchant, Claudio Battilocchio, José A. Souto, Malcolm B. Berry and Steven V. Ley

Org. Lett., 2015, 17, 3218
DOI: 10.1021/acs.orglett.5b01307

A flow-system array for the discovery and scale up of inorganic clusters

Craig J. Richmond, Haralampos N. Miras, Andreu Ruiz de la Oliva, Hongying Zang, Victor Sans, Leonid Paramonov, Charalampos Makatsoris, Ross Inglis, Euan K. Brechin, De-Liang Long and Leroy Cronin

Nature Chem, 2012, 4, 1037
DOI: 10.1038/nchem.1489

The applications of organozinc reagents in continuous flow chemistry: Negishi coupling

Roop Varghese Rubert and Rony Rajan Paul

J Flow Chem, 2023, 13, 217
DOI: 10.1007/s41981-022-00253-x

Simple and rapid hydrogenation of p-nitrophenol with aqueous formic acid in catalytic flow reactors

Rahat Javaid, Shin-ichiro Kawasaki, Akira Suzuki and Toshishige M Suzuki

Beilstein J. Org. Chem., 2013, 9, 1156
DOI: 10.3762/bjoc.9.129

Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

Mao Chen and Stephen L. Buchwald

Angew Chem Int Ed, 2013, 52, 11628
DOI: 10.1002/anie.201306094

The Meerwein–Ponndorf–Verley type reaction in a mixture of supercritical isopropanol/CO2 in a continuous flow reactor in the presence of alumina

I.V. Il‘ina, V.P. Sivcev, K.P. Volcho, N.F. Salakhutdinov and V.I. Anikeev

The Journal of Supercritical Fluids, 2012, 61, 115
DOI: 10.1016/j.supflu.2011.10.004

Design and Optimization of the Single-Stage Continuous Mixed Suspension–Mixed Product Removal Crystallization of 2-Chloro-N-(4-methylphenyl)propenamide

Gladys Kate Pascual, Philip Donnellan, Brian Glennon, Barbara Wood and Roderick C. Jones

ACS Omega, 2022, 7, 13676
DOI: 10.1021/acsomega.1c07228

Ionically polymer-immobilized MacMillan catalysts in continuous-flow asymmetric Diels–Alder reaction

Md Azgar Ali, Joh Yamada and Naoki Haraguchi

Chemistry Letters, 2026, 55
DOI: 10.1093/chemle/upag007

Flow Synthesis of 2-Methylpyridines via α-Methylation

Camille Manansala and Geoffrey Tranmer

Molecules, 2015, 20, 15797
DOI: 10.3390/molecules200915797

Application of Digital Methods in Polymer Science and Engineering

Timo Schuett, Patrick Endres, Tobias Standau, Stefan Zechel, Rodrigo Q. Albuquerque, Christian Brütting, Holger Ruckdäschel and Ulrich S. Schubert

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202309844

Macroscopic mixer for disparate property liquid–liquid mixing in aqueous sanitizer preparation

R. M. Ohol and B. Vasuki

Chem. Pap., 2022, 76, 701
DOI: 10.1007/s11696-021-01886-3

Scalable Palladium-Catalyzed C(sp3)–H Carbonylation of Alkylamines in Batch and Continuous Flow

Jacek Zakrzewski, Polina Yaseneva, Connor J. Taylor, Matthew J. Gaunt and Alexei A. Lapkin

Org. Process Res. Dev., 2023, 27, 649
DOI: 10.1021/acs.oprd.2c00378

Highly efficient synthesis and application of aryl diazonium salts via femtosecond laser-tailored 3D flow microfluidic chips

Jing Ren, Miao Wu, Kaiwu Dong, Min Zhang, Ya Cheng and Guoyue Shi

Chinese Chemical Letters, 2023, 34, 107694
DOI: 10.1016/j.cclet.2022.07.037

Iterative Synthesen: das Tor zu neuen Automationsprotokollen

Jan Hartwig and Andreas Kirschning

Angewandte Chemie, 2015, 127, 10554
DOI: 10.1002/ange.201504615

Continuous-Flow Chemistry and Photochemistry for Manufacturing of Active Pharmaceutical Ingredients

Pavlína Horáková and Kamila Kočí

Molecules, 2022, 27, 8536
DOI: 10.3390/molecules27238536

Continuous-flow processes for the catalytic partial hydrogenation reaction of alkynes

Carmen Moreno-Marrodan, Francesca Liguori and Pierluigi Barbaro

Beilstein J. Org. Chem., 2017, 13, 734
DOI: 10.3762/bjoc.13.73

Chemoselective three-phase hydrogenation of an Ombrabulin nitro-stilbene intermediate in a continuous-flow mobile platform

Thomas H. Rehm, Dorothee Reinhard, Hans-Joachim Kost, Christian Hofmann, Ralf Zapf, Patrick Löb, Yosra Laribi, Philippe Perrichon, Charline Berguerand, Lioubov Kiwi-Minsker, Esther Sulman, Gabor Szirbik, Hannes Richert, Jürgen Lang, Michael Gottfried and Stefan Roggan

Chemical Engineering Journal, 2017, 316, 1069
DOI: 10.1016/j.cej.2017.02.022

From Anilines to Aziridines: A Two-Step Synthesis under Continuous-Flow Conditions

Sergio Rossi, Alessandra Puglisi, Daniela Intrieri and Emma Gallo

J Flow Chem, 2016, 6, 234
DOI: 10.1556/1846.2016.00027

Gold nanoparticles stabilized by modified halloysite nanotubes for catalytic applications

Marina Massaro, Carmelo G. Colletti, Bruno Fiore, Valeria La Parola, Giuseppe Lazzara, Susanna Guernelli, Nelsi Zaccheroni and Serena Riela

Applied Organom Chemis, 2019, 33
DOI: 10.1002/aoc.4665

Koch–Haaf reaction of adamantanols in an acid-tolerant hastelloy-made microreactor

Takahide Fukuyama, Yu Mukai and Ilhyong Ryu

Beilstein J. Org. Chem., 2011, 7, 1288
DOI: 10.3762/bjoc.7.149

Micro-Reactor Device For Dbsa-catalyzed Biodiesel Synthesis from Microalgae Chlorella Sp.

Ali A. Jazie, Mustafa Jawad Nuhma, Hassan Abdulkadhim Abbas, Hajar Alias and M.L. Kolhe

E3S Web Conf., 2020, 173, 01005
DOI: 10.1051/e3sconf/202017301005

The Use of Gases in Flow Synthesis

Carl J. Mallia and Ian R. Baxendale

Org. Process Res. Dev., 2016, 20, 327
DOI: 10.1021/acs.oprd.5b00222

Enhancing Zeolite Performance by Catalyst Shaping in a Mesoscale Continuous‐Flow Diels–Alder Process

Sofie Seghers, Jasper Lefevere, Steven Mullens, Anton De Vylder, Joris W. Thybaut and Christian V. Stevens

ChemSusChem, 2018, 11, 1686
DOI: 10.1002/cssc.201800362

Recent advances in photoredox catalytic transformations by using continuous-flow technology

Xin Yuan, Hai-Bin Fan, Jie Liu, Long-Zhou Qin, Jian Wang, Xiu Duan, Jiang-Kai Qiu and Kai Guo

Chinese Journal of Catalysis, 2023, 50, 175
DOI: 10.1016/S1872-2067(23)64447-X

The Claisen Rearrangement – Part 2: Impact Factor Analysis of the Claisen Rearrangement, in Batch and in Flow

Volker Hessel, Elnaz Shahbazali, Timothy Noël and Sergei Zelentsov

ChemBioEng Reviews, 2014, 1, 244
DOI: 10.1002/cben.201400022

High-performance miniature CSTR for biphasic C–C bond-forming reactions

Yiming Mo, Hongkun Lin and Klavs F. Jensen

Chemical Engineering Journal, 2018, 335, 936
DOI: 10.1016/j.cej.2017.10.114

Continuous Flow Spirocyclization Reactions: Towards Efficient Synthesis of Chiral Spiropenicillanates

Américo J. S. Alves, João A. D. Silvestre and Teresa M. V. D. Pinho e Melo

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400689

Синтез 4,4’-метилендианилин (МДА) в микроканале

М.В. Шишанов, Д.В. Яшунин, И.Д. Цветков, Х.Г. Кук and Ю. Чжоу

Chemical Bulletin, 2025, 7, 34
DOI: 10.58224/2619-0575-2024-7-3-34-48

Synthesis and Reactions of Ynolates via a Stop-Flow Method with a Flow Microreactor

Toshiya Yoshiiwa, Satoshi Umezu, Manabu Tokeshi, Yoshinobu Baba and Mitsuru Shindo

J Flow Chem, 2014, 4, 180
DOI: 10.1556/JFC-D-14-00008

In Situ Performance Monitoring of Electrochemical Oxygen and Hydrogen Peroxide Sensors in an Additively Manufactured Modular Microreactor

Moritz Doering, Laura L. Trinkies, Jochen Kieninger, Manfred Kraut, Stefan J. Rupitsch, Roland Dittmeyer, Gerald A. Urban and Andreas Weltin

ACS Omega, 2024, 9, 19700
DOI: 10.1021/acsomega.4c02210

Enzymatic Strategy for the Resolution of New 1‐Hydroxymethyl Tetrahydro‐β‐carboline Derivatives in Batch and Continuous‐Flow Systems

Rita Megyesi, Enikő Forró and Ferenc Fülöp

ChemistryOpen, 2016, 5, 254
DOI: 10.1002/open.201500203

Reactor Selection for Effective Continuous Biocatalytic Production of Pharmaceuticals

Rowan Lindeque and John Woodley

Catalysts, 2019, 9, 262
DOI: 10.3390/catal9030262

Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis

Magnus Rueping, Teerawut Bootwicha and Erli Sugiono

Beilstein J. Org. Chem., 2012, 8, 300
DOI: 10.3762/bjoc.8.32

Mixing Enhancement By Gravity-dependent Convection in a Y-shaped Continuous-flow Microreactor

Dmitry A. Bratsun, Ramil R. Siraev, Len M. Pismen, Elena A. Mosheva, Andrey V. Shmyrov and Alexey I. Mizev

Microgravity Sci. Technol., 2022, 34
DOI: 10.1007/s12217-022-09994-9

Rapid and Safe Continuous‐Flow Simmons‐Smith Cyclopropanation using a Zn/Cu Couple Column

José Luis Nova‐Fernández, Gustavo Pascual‐Coca, Silvia Cabrera and José Alemán

Adv Synth Catal, 2024, 366, 710
DOI: 10.1002/adsc.202300665

ChemInform Abstract: Ten Key Issues in Modern Flow Chemistry.

Jens Wegner, Sascha Ceylan and Andreas Kirschning

ChemInform, 2011, 42
DOI: 10.1002/chin.201135224

Exploring New Parameter Spaces for the Oxidative Homocoupling of Aniline Derivatives: Sustainable Synthesis of Azobenzenes in a Flow System

Ádám Georgiádes, Sándor B. Ötvös and Ferenc Fülöp

ACS Sustainable Chem. Eng., 2015, 3, 3388
DOI: 10.1021/acssuschemeng.5b01096

Copper‐Catalyzed Formation of CO Bonds by Direct α‐CH Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous‐Flow Formats

G. Sathish Kumar, Bartholomäus Pieber, K. Rajender Reddy and C. Oliver Kappe

Chemistry A European J, 2012, 18, 6124
DOI: 10.1002/chem.201200815

Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF

Trine P. Petersen, Anders Foller Larsen, Andreas Ritzén and Trond Ulven

J. Org. Chem., 2013, 78, 4190
DOI: 10.1021/jo400390t

Highly Controlled Gas/Liquid Processes in a Continuous Lab‐Scale Device

J. J. F. van Gool, S. A. M. W. van den Broek, R. M. Ripken, P. J. Nieuwland, K. Koch and F. P. J. T. Rutjes

Chem Eng & Technol, 2013, 36, 1042
DOI: 10.1002/ceat.201200553

An Autonomous Self-Optimizing Flow Reactor for the Synthesis of Natural Product Carpanone

Daniel Cortés-Borda, Eric Wimmer, Boris Gouilleux, Elvina Barré, Nicolas Oger, Lubna Goulamaly, Louis Peault, Benoît Charrier, Charlotte Truchet, Patrick Giraudeau, Mireia Rodriguez-Zubiri, Erwan Le Grognec and François-Xavier Felpin

J. Org. Chem., 2018, 83, 14286
DOI: 10.1021/acs.joc.8b01821

Continuous preparation of carbon-nanotube-supported platinum catalysts in a flow reactor directly heated by electric current

Alicja Schlange, Antonio Rodolfo dos Santos, Ulrich Kunz and Thomas Turek

Beilstein J. Org. Chem., 2011, 7, 1412
DOI: 10.3762/bjoc.7.165

Catalytic Hydrogenation of Aliphatic Nitro Compounds with Polysilane/Bone Charcoal‐Supported Palladium Catalysts under Continuous‐Flow Conditions

Yuki Saito, Haruro Ishitani and Shū Kobayashi

Asian J Org Chem, 2016, 5, 1124
DOI: 10.1002/ajoc.201600279

Simultaneous self-optimisation of yield and purity through successive combination of inline FT-IR spectroscopy and online mass spectrometry in flow reactions

Verena Fath, Philipp Lau, Christoph Greve, Philipp Weller, Norbert Kockmann and Thorsten Röder

J Flow Chem, 2021, 11, 285
DOI: 10.1007/s41981-021-00140-x

Synthesis of Nontoxic Protoflavone Derivatives through Selective Continuous‐Flow Hydrogenation of the Flavonoid B‐Ring

Sándor B. Ötvös, Máté Vágvölgyi, Gábor Girst, Ching‐Ying Kuo, Hui‐Chun Wang, Ferenc Fülöp and Attila Hunyadi

ChemPlusChem, 2018, 83, 72
DOI: 10.1002/cplu.201700463

An Accessible Continuous Flow Procedure for the Enantioselective Desymmetrization of a Key Precursor of Bioactive Myo‐Inositol Derivatives

Evelin A. Manoel, Marcela G. Vasconcelos, Denise M. G. Freire and Alessandro B. C. Simas

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202405535

Efficient lipase-catalysed route for the kinetic resolution of salsolidine and its ß-carboline analogue

Barbara Kovács, Rita Megyesi, Enikő Forró and Ferenc Fülöp

Tetrahedron: Asymmetry, 2017, 28, 1829
DOI: 10.1016/j.tetasy.2017.10.019

Prototyping of Meso- and Microfluidic Devices with Embedded TiO2 Photocatalyst for Photodegradation of an Organic Dye

Druval S. De Sá, Bojan A. Marinkovic, Eric C. Romani, Tommaso Del Rosso, Rodrigo O. M. A. de Souza, Alessandro Massi and Omar Pandoli

J Flow Chem, 2016, 6, 101
DOI: 10.1556/1846.2015.00043

Stereoselective Chemoenzymatic Synthesis of Enantiopure 2-(1H-imidazol-yl)cycloalkanols under Continuous Flow Conditions

Raúl Porcar, Victor Sans, Nicolás Ríos-Lombardía, Vicente Gotor-Fernández, Vicente Gotor, M. Isabel Burguete, Eduardo García-Verdugo and Santiago V. Luis

ACS Catal., 2012, 2, 1976
DOI: 10.1021/cs300282w

Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline

Xacobe C Cambeiro, Rafael Martín-Rapún, Pedro O Miranda, Sonia Sayalero, Esther Alza, Patricia Llanes and Miquel A Pericàs

Beilstein J. Org. Chem., 2011, 7, 1486
DOI: 10.3762/bjoc.7.172

Recent Advances in Microflow Photochemistry

Michael Oelgemöller and Oksana Shvydkiv

Molecules, 2011, 16, 7522
DOI: 10.3390/molecules16097522

Process Intensification Tools in the Small‐Scale Pharmaceutical Manufacturing of Small Molecules

Aleksandar Mitic and Krist V. Gernaey

Chem Eng & Technol, 2015, 38, 1699
DOI: 10.1002/ceat.201400765

Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp3)−H Activation

Jacek Zakrzewski, Adam P. Smalley, Mikhail A. Kabeshov, Matthew J. Gaunt and Alexei A. Lapkin

Angewandte Chemie, 2016, 128, 9024
DOI: 10.1002/ange.201602483

Chemical Wastes in the Peptide Synthesis Process and Ways to Reduce Them

Mahan Haji Abbasi Somehsaraie, Vaezeh Fathi Vavsari, Mohammad Kamangar and Saeed Balalaie

Iran J Pharm Res, 2022, 21
DOI: 10.5812/ijpr-123879

Homogeneous Photocatalytic Reactions with Organometallic and Coordination Compounds—Perspectives for Sustainable Chemistry

Norbert Hoffmann

ChemSusChem, 2012, 5, 352
DOI: 10.1002/cssc.201100286

A Continuous Flow Solution to Achieving Efficient Aerobic Anti‐Markovnikov Wacker Oxidation

S. L. Bourne and S. V. Ley

Adv Synth Catal, 2013, 355, 1905
DOI: 10.1002/adsc.201300278

Reconfiguration of a Continuous Flow Platform for Extended Operation: Application to a Cryogenic Fluorine-Directed ortho-Lithiation Reaction

James A. Newby, D. Wayne Blaylock, Paul M. Witt, Richard M. Turner, Patrick L. Heider, Bashir H. Harji, Duncan L. Browne and Steven V. Ley

Org. Process Res. Dev., 2014, 18, 1221
DOI: 10.1021/op500221s

Basic concept of testing chip for micro flow rate

Shunsuke Kagami, Ryouji Doihara and Noriyuki Furuichi

Measurement: Sensors, 2025, 38, 101584
DOI: 10.1016/j.measen.2024.101584

Synthesis of Urea Derivatives in Two Sequential Continuous-Flow Reactors

Péter Bana, Ágnes Lakó, Nóra Zsuzsa Kiss, Zoltán Béni, Áron Szigetvári, János Kóti, György István Túrós, János Éles and István Greiner

Org. Process Res. Dev., 2017, 21, 611
DOI: 10.1021/acs.oprd.7b00019

Continuous proline catalysis via leaching of solid proline

Suzanne M Opalka, Ashley R Longstreet and D Tyler McQuade

Beilstein J. Org. Chem., 2011, 7, 1671
DOI: 10.3762/bjoc.7.197

Fast functionalization of (7‐aza)indoles using continuous flow processes

Joseph D'Attoma, Grégoire Cozien, Pierre Louis Brun, Yves Robin, Stéphane Bostyn, Frédéric Buron and Sylvain Routier

ChemistrySelect, 2016, 1, 338
DOI: 10.1002/slct.201600012

Cyclization of citronellal in a supercritical solvent in a flow reactor in the presence of Al2O3

V. I. Anikeev, I. V. Il’ina, K. P. Volcho and N. F. Salakhutdinov

Russ. J. Phys. Chem., 2012, 86, 1917
DOI: 10.1134/S0036024412120035

Minimizing E-factor in the continuous-flow synthesis of diazepam and atropine

Anne-Catherine Bédard, Ashley R. Longstreet, Joshua Britton, Yuran Wang, Hideki Moriguchi, Robert W. Hicklin, William H. Green and Timothy F. Jamison

Bioorganic & Medicinal Chemistry, 2017, 25, 6233
DOI: 10.1016/j.bmc.2017.02.002

On-demand synthesis of organozinc halides under continuous flow conditions

Mateo Berton, Lena Huck and Jesús Alcázar

Nat Protoc, 2018, 13, 324
DOI: 10.1038/nprot.2017.141

Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

Mao Chen and Stephen L. Buchwald

Angewandte Chemie, 2013, 125, 11842
DOI: 10.1002/ange.201306094

Synthesis of N-Allyloxycarbonyl 3,5-Dihydroxyphenylglycine via Photochemical Wolff Rearrangement—Nucleophilic Addition Sequence in a Micro-Flow Reactor

Yuto Mifune, Shinichiro Fuse and Hiroshi Tanaka

J Flow Chem, 2014, 4, 173
DOI: 10.1556/JFC-D-14-00015

Synthesis of polyethylene-polyacrylate block copolymers in continuous flow

Stephen Don Sarkar, Huong Dau and Eva Harth

Chem, 2024, 10, 2872
DOI: 10.1016/j.chempr.2024.05.016

Continuous-flow retro-Diels–Alder reaction: an efficient method for the preparation of pyrimidinone derivatives

Imane Nekkaa, Márta Palkó, István M Mándity and Ferenc Fülöp

Beilstein J. Org. Chem., 2018, 14, 318
DOI: 10.3762/bjoc.14.20

Size and shape control of metal nanoparticles in millifluidic reactors

Samuel E. Lohse

Physical Sciences Reviews, 2018, 3
DOI: 10.1515/psr-2017-0120

Hybrid Modeling of an Active Pharmaceutical Ingredient Flow Synthesis in a Ring-Opening Reaction of an Epoxide with a Grignard Reagent

Junu Kim, Yusuke Hayashi, Sara Badr, Kazuya Okamoto, Toshikazu Hakogi, Haruo Furukawa, Satoshi Yoshikawa, Hayao Nakanishi and Hirokazu Sugiyama

Ind. Eng. Chem. Res., 2023, 62, 17824
DOI: 10.1021/acs.iecr.3c02137

Two-Step Flow Synthesis of Biarylmethanes by Reductive Arylation of Tosylhydrazones

Lukas Kupracz and Andreas Kirschning

J Flow Chem, 2013, 3, 11
DOI: 10.1556/JFC-D-12-00021

Safe Hydroformylation of Aliphatic Alkene in a Flow Reactor

Hisashi Masui, Eiki Honda, Sakura Niitsu, Mitsuru Shoji and Takashi Takahashi

IJOC, 2018, 08, 135
DOI: 10.4236/ijoc.2018.81009

Flow‐Based, Cerium Oxide Enhanced, Low‐Level Palladium Sonogashira and Heck Coupling Reactions by Perovskite Catalysts

Claudio Battilocchio, Benjamin N. Bhawal, Rajeev Chorghade, Benjamin J. Deadman, Joel M. Hawkins and Steven V. Ley

Israel Journal of Chemistry, 2014, 54, 371
DOI: 10.1002/ijch.201300049

Synthesis of Nitro-Containing Compounds through Multistep Continuous Flow with Heterogeneous Catalysts

Haruro Ishitani, Yuki Saito, Tetsu Tsubogo and Shu̅ Kobayashi

Org. Lett., 2016, 18, 1346
DOI: 10.1021/acs.orglett.6b00282

Low‐Temperature Solution Crystallization of Nanostructured Oxides and Thin Films

Iñigo Bretos, Stefano Diodati, Ricardo Jiménez, Francesca Tajoli, Jesús Ricote, Giulia Bragaggia, Marina Franca, Maria Lourdes Calzada and Silvia Gross

Chemistry A European J, 2020, 26, 9157
DOI: 10.1002/chem.202000448

Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions

Lena Huck, Antonio de la Hoz, Angel Díaz-Ortiz and Jesus Alcázar

Org. Lett., 2017, 19, 3747
DOI: 10.1021/acs.orglett.7b01590

Design and implementation of a mixer for different physical and chemical properties liquid-liquid mixing and mixing performance evaluation with a UV-Visible spectrophotometer

R.M. Ohol and B. Vasuki

Materials Today: Proceedings, 2022, 57, 1677
DOI: 10.1016/j.matpr.2021.12.318

Stereoselective DielsAlder Reactions Promoted under Continuous‐Flow Conditions by Silica‐Supported Chiral Organocatalysts

Riccardo Porta, Maurizio Benaglia, Valerio Chiroli, Francesca Coccia and Alessandra Puglisi

Israel Journal of Chemistry, 2014, 54, 381
DOI: 10.1002/ijch.201300106

Flow “Fine” Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods

Shū Kobayashi

Chemistry An Asian Journal, 2016, 11, 425
DOI: 10.1002/asia.201500916

Continuous Synthesis and Use of N-Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O

Suzanne M. Opalka, Jin Kyoon Park, Ashley R. Longstreet and D. Tyler McQuade

Org. Lett., 2013, 15, 996
DOI: 10.1021/ol303442m

The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

Marcus Baumann and Ian R Baxendale

Beilstein J. Org. Chem., 2015, 11, 1194
DOI: 10.3762/bjoc.11.134

Microwave and continuous flow technologies in drug discovery

Sara Sadler, Alexander R Moeller and Graham B Jones

Expert Opinion on Drug Discovery, 2012, 7, 1107
DOI: 10.1517/17460441.2012.727393

Flow Chemistry System for Carbohydrate Analysis by Rapid Labeling of Saccharides after Glycan Hydrolysis

Wei-Ting Hung, Yi-Ting Chen, Chung-Hsuan Chen, Yuan Chuan Lee, Jim-Min Fang and Wen-Bin Yang

SLAS Technology, 2020, 25, 356
DOI: 10.1177/2472630320924620

A General Continuous Flow Method for Palladium Catalysed Carbonylation Reactions Using Single and Multiple Tube‐in‐Tube Gas‐Liquid Microreactors

Ulrike Gross, Peter Koos, Matthew O'Brien, Anastasios Polyzos and Steven V. Ley

Eur J Org Chem, 2014, 2014, 6418
DOI: 10.1002/ejoc.201402804

Application of Heterogeneous Polymer-Supported Catalysts to Continuous Flow Systems

Takao Osako, Yoichi M. A. Yamada and Yasuhiro Uozumi

J. Syn. Org. Chem., Jpn., 2016, 74, 621
DOI: 10.5059/yukigoseikyokaishi.74.621

The impact of Novel Process Windows on the Claisen rearrangement

Hiroki Kobayashi, Brian Driessen, Dannie J.G.P. van Osch, Ali Talla, Shinichi Ookawara, Timothy Noël and Volker Hessel

Tetrahedron, 2013, 69, 2885
DOI: 10.1016/j.tet.2013.02.038

Continuous‐Flow Di‐N‐Alkylation of 1H‐Benzimidazole in a Fixed‐Bed Reactor

Tobias Sauk, Laurids Henke, Chunyu Xiao, Dave Hartig and Stephan Scholl

Chem Eng & Technol, 2019, 42, 2215
DOI: 10.1002/ceat.201900114

Synthesis of Tailored Segmented Polyurethanes Utilizing Continuous-Flow Reactors and Real-Time Process Monitoring

Xabier Lopez de Pariza, Tim Erdmann, Pedro L. Arrechea, Leron Perez, Charles Dausse, Nathaniel H. Park, James L. Hedrick and Haritz Sardon

Chem. Mater., 2021, 33, 7986
DOI: 10.1021/acs.chemmater.1c01919

Freeform generative design of complex functional structures

Gerald G. Pereira, David Howard, Paulus Lahur, Michael Breedon, Phil Kilby and Christian H. Hornung

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-62830-5

Enantioselective β‐Arylation of Ketones Enabled by Lithiation/Borylation/1,4‐Addition Sequence Under Flow Conditions

Wei Shu and Stephen L. Buchwald

Angewandte Chemie, 2012, 124, 5451
DOI: 10.1002/ange.201202221

Challenges in transfer of gas-liquid reactions from batch to continuous operation: dimensional analysis and simulations for aerobic oxidation

Jens Friedland and Robert Güttel

J Flow Chem, 2021, 11, 625
DOI: 10.1007/s41981-021-00176-z

Asymmetric α‐Amination of Aldehydes Catalyzed by PS‐Diphenylprolinol Silyl Ethers: Remediation of Catalyst Deactivation for Continuous Flow Operation

Xinyuan Fan, Sonia Sayalero and Miquel A. Pericàs

Adv Synth Catal, 2012, 354, 2971
DOI: 10.1002/adsc.201200887

A Two‐Step Continuous‐Flow Synthesis of N‐(2‐Aminoethyl)acylamides through Ring‐Opening/Hydrogenation of Oxazolines

Bernhard Gutmann, Jean‐Paul Roduit, Dominique Roberge and C. Oliver Kappe

Chemistry A European J, 2011, 17, 13146
DOI: 10.1002/chem.201102772

Enamine Catalysis in Flow with an Immobilized Peptidic Catalyst

Yukihiro Arakawa and Helma Wennemers

ChemSusChem, 2013, 6, 242
DOI: 10.1002/cssc.201200740

Technological Trends in Flow and Microreactor Synthesis: A Review as Viewed from Patent Survey and Scale-up Studies

Tsutomu Matsumoto

J. Syn. Org. Chem., Jpn., 2015, 73, 512
DOI: 10.5059/yukigoseikyokaishi.73.512

Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR Monitoring

Irini Abdiaj, Clemens R. Horn and Jesus Alcazar

J. Org. Chem., 2019, 84, 4748
DOI: 10.1021/acs.joc.8b02358

Synthesis of new heterocyclic resveratrol analogues in milli- and microreactors: intensification of the Wittig reaction

Milena Mlakić, Lucija Rajič, Anabela Ljubić, Vitomir Vušak, Bruno Zelić, Martin Gojun, Ilijana Odak, Ivona Čule, Ivana Šagud, Anita Šalić and Irena Škorić

J Flow Chem, 2022, 12, 429
DOI: 10.1007/s41981-022-00239-9

Continuous-Flow Stereoselective Organocatalyzed Diels–Alder Reactions in a Chiral Catalytic “Homemade” HPLC Column

Valerio Chiroli, Maurizio Benaglia, Franco Cozzi, Alessandra Puglisi, Rita Annunziata and Giuseppe Celentano

Org. Lett., 2013, 15, 3590
DOI: 10.1021/ol401390z

Thermal Behavior of a Catalytic Packed-Bed Milli-reactor Operated under Radio Frequency Heating

Sourav Chatterjee, Thomas K. Houlding, Valentin Yu. Doluda, Vladimir P. Molchanov, Valentina G. Matveeva and Evgeny V. Rebrov

Ind. Eng. Chem. Res., 2017, 56, 13273
DOI: 10.1021/acs.iecr.7b01723

The Hitchhiker’s Guide to Flow Chemistry

Matthew B. Plutschack, Bartholomäus Pieber, Kerry Gilmore and Peter H. Seeberger

Chem. Rev., 2017, 117, 11796
DOI: 10.1021/acs.chemrev.7b00183

Methanolysis of epoxidized soybean oil in continuous flow conditions

Vincenzo Pantone, Amelita Grazia Laurenza, Cosimo Annese, Francesco Fracassi, Caterina Fusco, Angelo Nacci, Antonella Russo and Lucia D’Accolti

Industrial Crops and Products, 2017, 109, 1
DOI: 10.1016/j.indcrop.2017.08.001

Continuous flow photolysis of aryl azides: Preparation of 3H-azepinones

Farhan R Bou-Hamdan, François Lévesque, Alexander G O'Brien and Peter H Seeberger

Beilstein J. Org. Chem., 2011, 7, 1124
DOI: 10.3762/bjoc.7.129

Process Catalyst Mass Efficiency by Using Proline Tetrazole Column‐Flow System

Erika Nakashima and Hisashi Yamamoto

Chemistry A European J, 2018, 24, 1076
DOI: 10.1002/chem.201705982

Kontinuierliche Synthese des Malariawirkstoffs Artemisinin

François Lévesque and Peter H. Seeberger

Angewandte Chemie, 2012, 124, 1738
DOI: 10.1002/ange.201107446

Continuous-Flow Microreactors for Polymer Synthesis: Engineering Principles and Applications

Yuanhai Su, Yang Song and Liang Xiang

Top Curr Chem (Z), 2018, 376
DOI: 10.1007/s41061-018-0224-1

Strategic Application of Residence‐Time Control in Continuous‐Flow Reactors

István M. Mándity, Sándor B. Ötvös and Ferenc Fülöp

ChemistryOpen, 2015, 4, 212
DOI: 10.1002/open.201500018

Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant

Richard Lakerveld, Brahim Benyahia, Patrick Heider, Haitao Zhang, Richard Braatz and Paul Barton

Processes, 2013, 1, 330
DOI: 10.3390/pr1030330

Olefin Metathesis in Continuous Flow Reactor Employing Polar Ruthenium Catalyst and Soluble Metal Scavenger for Instant Purification of Products of Pharmaceutical Interest

Ren Wei Toh, Michał Patrzałek, Tomasz Nienałtowski, Jakub Piątkowski, Anna Kajetanowicz, Jie Wu and Karol Grela

ACS Sustainable Chem. Eng., 2021, 9, 16450
DOI: 10.1021/acssuschemeng.1c06522

Batch versus Flow Photochemistry: A Revealing Comparison of Yield and Productivity

Luke D. Elliott, Jonathan P. Knowles, Paul J. Koovits, Katie G. Maskill, Michael J. Ralph, Guillaume Lejeune, Lee J. Edwards, Richard I. Robinson, Ian R. Clemens, Brian Cox, David D. Pascoe, Guido Koch, Martin Eberle, Malcolm B. Berry and Kevin I. Booker‐Milburn

Chemistry A European J, 2014, 20, 15226
DOI: 10.1002/chem.201404347

Flow synthesis of oxadiazoles coupled with sequential in-line extraction and chromatography

Kian Donnelly and Marcus Baumann

Beilstein J. Org. Chem., 2022, 18, 232
DOI: 10.3762/bjoc.18.27

A Microfluidic System for the Continuous Recycling of Unmodified Homogeneous Palladium Catalysts through Liquid/Liquid Phase Separation

Pengfei Li, Jason S. Moore and Klavs F. Jensen

ChemCatChem, 2013, 5, 1729
DOI: 10.1002/cctc.201300054

Studies on the Continuous-Flow Synthesis of Nonpeptidal bis-Tetrahydrofuran Moiety of Darunavir

Raquel A. C. Leão, Raquel O. de Lopes, Marco A. de M. Bezerra, Mauro N. Muniz, Bruna B. Casanova, Simone C. B. Gnoatto, Grace Gosmann, Laszlo Kocsis, Rodrigo O. M. A. de Souza and Leandro S. M. de Miranda

J Flow Chem, 2015, 5, 216
DOI: 10.1556/1846.2015.00031

Enantioselective Continuous‐Flow Production of 3‐Indolylmethanamines Mediated by an Immobilized Phosphoric Acid Catalyst

Laura Osorio‐Planes, Carles Rodríguez‐Escrich and Miquel A. Pericàs

Chemistry A European J, 2014, 20, 2367
DOI: 10.1002/chem.201303860

Role of Flow Microreactors for Pharmaceutical Production: Screening of Reaction Conditions and Sample Preparation

Yukihito Sumino and Takahide Fukuyama

J. Synth. Org. Chem. Jpn., 2012, 70, 896
DOI: 10.5059/yukigoseikyokaishi.70.896

Flow chemistry vs. flow analysis

Marek Trojanowicz

Talanta, 2016, 146, 621
DOI: 10.1016/j.talanta.2015.07.043

Resource utilization of waste deNOx catalyst for continuous-flow catalysis by supported metal reactors

Qijie Jin, Yuesong Shen, Xiujun Li and Yanwei Zeng

Molecular Catalysis, 2020, 480, 110634
DOI: 10.1016/j.mcat.2019.110634

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries

Guido Gambacorta, James S Sharley and Ian R Baxendale

Beilstein J. Org. Chem., 2021, 17, 1181
DOI: 10.3762/bjoc.17.90

Flowing to purity: Advancing acetylsalicylic acid production from batch to continuous to full-flow

Wen-Ching Chen, Pin-De Lee, Can-Hong Ni, Ya-Hui Chuang, Guan-Yu Lu, Jia-Lin Zhan, Siu Chun Wong and Ya-Yu Chiang

Separation and Purification Technology, 2025, 369, 133107
DOI: 10.1016/j.seppur.2025.133107

Continuous Flow and Microwave‐Assisted Vorbrüggen Glycosylations: Historical Perspective to High‐Throughput Strategies

Atul Manvar and Anamik Shah

Asian J Org Chem, 2014, 3, 1134
DOI: 10.1002/ajoc.201402119

Flow Effects on the Controlled Growth of Nanostructured Networks at Microcapillary Walls for Applications in Continuous Flow Reactions

Gang Wang, Cansheng Yuan, Boyi Fu, Luye He, Elsa Reichmanis, Hongzhi Wang, Qinghong Zhang and Yaogang Li

ACS Appl. Mater. Interfaces, 2015, 7, 21580
DOI: 10.1021/acsami.5b06851

Continuous‐Flow Hydrogenation and Reductive Deuteration of Nitriles: a Simple Access to α,α‐Dideutero Amines

Rebeka Mészáros, Bai‐Jing Peng, Sándor B. Ötvös, Shyh‐Chyun Yang and Ferenc Fülöp

ChemPlusChem, 2019, 84, 1508
DOI: 10.1002/cplu.201900526

A Machine‐Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor‐1

Claudio Battilocchio, Benjamin J. Deadman, Nikzad Nikbin, Matthew O. Kitching, Ian R. Baxendale and Steven V. Ley

Chemistry A European J, 2013, 19, 7917
DOI: 10.1002/chem.201300696

A sustainable approach for the synthesis of bismuth molybdate by continuous flow method using custom design reactor and their photocatalytic application for environmental remediation

Brijesh Kumar Shukla, Shalu Rawat, Hema Bhandari, Jiwan Singh and Seema Garg

Appl Nanosci, 2022, 12, 2497
DOI: 10.1007/s13204-022-02524-4

A High Mobility Reactor Unit for R&D Continuous Flow Transfer Hydrogenations

Rasmus K. Jensen, Nikolaj Thykier, Martin V. Enevoldsen and Anders T. Lindhardt

Org. Process Res. Dev., 2017, 21, 370
DOI: 10.1021/acs.oprd.6b00441

In Situ Generated Iron Oxide Nanocrystals as Efficient and Selective Catalysts for the Reduction of Nitroarenes using a Continuous Flow Method

David Cantillo, Mostafa Baghbanzadeh and C. Oliver Kappe

Angew Chem Int Ed, 2012, 51, 10190
DOI: 10.1002/anie.201205792

Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride

Christiane Schotten, Dorota Plaza, Simone Manzini, Steven P. Nolan, Steven V. Ley, Duncan L. Browne and Alexei Lapkin

ACS Sustainable Chem. Eng., 2015, 3, 1453
DOI: 10.1021/acssuschemeng.5b00397

Fluoroalkyl‐Substituted Diazomethanes and Their Application in a General Synthesis of Pyrazoles and Pyrazolines

Lucas Mertens, Katharina J. Hock and Rene M. Koenigs

Chemistry A European J, 2016, 22, 9542
DOI: 10.1002/chem.201601707

Gas/Liquid‐Phase Micro‐Flow Trifluoromethylation using Fluoroform: Trifluoromethylation of Aldehydes, Ketones, Chalcones, and N‐Sulfinylimines

Kazuki Hirano, Satoshi Gondo, Nagender Punna, Etsuko Tokunaga and Norio Shibata

ChemistryOpen, 2019, 8, 406
DOI: 10.1002/open.201800286

Continuous flow production in the final step of vortioxetine synthesis. Piperazine ring formation on a flow platform with a focus on productivity and scalability

Zoltán Boros, László Nagy-Győr, Katalin Kátai-Fadgyas, Imre Kőhegyi, István Ling, Tamás Nagy, Zoltán Iványi, Márk Oláh, György Ruzsics, Ottó Temesi and Balázs Volk

J Flow Chem, 2019, 9, 101
DOI: 10.1007/s41981-019-00036-x

A Fast‐Initiating Ionically Tagged Ruthenium Complex: A Robust Supported Pre‐catalyst for Batch‐Process and Continuous‐Flow Olefin Metathesis

Etienne Borré, Mathieu Rouen, Isabelle Laurent, Magaly Magrez, Fréderic Caijo, Christophe Crévisy, Wladimir Solodenko, Loic Toupet, René Frankfurter, Carla Vogt, Andreas Kirschning and Marc Mauduit

Chemistry A European J, 2012, 18, 16369
DOI: 10.1002/chem.201201589

Computer‐Aided Living Polymerization Conducted under Continuous‐Flow Conditions†

Zeyu Wang, Yang Zhou and Mao Chen

Chin. J. Chem., 2022, 40, 285
DOI: 10.1002/cjoc.202100544

Solid‐Acid Catalyzed Continuous‐Flow Aminolysis of Epoxides

Ken Nishizawa, Yuki Saito and Shū Kobayashi

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202403094

Utilization of microflow reactors to carry out synthetically useful organic photochemical reactions

Kazuhiko Mizuno, Yasuhiro Nishiyama, Takuya Ogaki, Kimitada Terao, Hiroshi Ikeda and Kiyomi Kakiuchi

Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 2016, 29, 107
DOI: 10.1016/j.jphotochemrev.2016.10.002

Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

James Gardiner, Xuan Nguyen, Charlotte Genet, Mike D. Horne, Christian H. Hornung and John Tsanaktsidis

Org. Process Res. Dev., 2018, 22, 1448
DOI: 10.1021/acs.oprd.8b00153

Visible‐Light Photoredox Catalysis in Flow

Joseph W. Tucker, Yuan Zhang, Timothy F. Jamison and Corey R. J. Stephenson

Angewandte Chemie, 2012, 124, 4220
DOI: 10.1002/ange.201200961

Development of a miniaturized packed bed reactor with ω -transaminase immobilized in LentiKats ®

Marijan Bajić, Igor Plazl, Radek Stloukal and Polona Žnidaršič-Plazl

Process Biochemistry, 2017, 52, 63
DOI: 10.1016/j.procbio.2016.09.021

A continuous flow microreactor as a practical tool for the synthesis of active pharmaceutical ingredients

K. Vijaya Bhaskar, Mohammad Rashed, K. Subrahmanya Bhat, Jechan Lee, Ki-Hyun Kim and Kezia Buruga

Process Safety and Environmental Protection, 2024, 192, 437
DOI: 10.1016/j.psep.2024.09.122

Photoredox-catalyzed [4+2] annulation of cyclobutylanilines with alkenes, alkynes, and diynes in continuous flow

Jiang Wang, Theresa H. Nguyen and Nan Zheng

Sci. China Chem., 2016, 59, 180
DOI: 10.1007/s11426-015-5547-y

Is there a future for enzymatic biodiesel industrial production in microreactors?

Sandra Budžaki, Goran Miljić, Marina Tišma, Smitha Sundaram and Volker Hessel

Applied Energy, 2017, 201, 124
DOI: 10.1016/j.apenergy.2017.05.062

Micro reaction technology for valorization of biomolecules using enzymes and metal catalysts

Ivana Denčić, Timothy Noël, Jan Meuldijk, Mart de Croon and Volker Hessel

Engineering in Life Sciences, 2013, 13, 326
DOI: 10.1002/elsc.201200149

Nanomanufacturing of Tobacco Mosaic Virus-Based Spherical Biomaterials Using a Continuous Flow Method

Michael A. Bruckman, Allen VanMeter and Nicole F. Steinmetz

ACS Biomater. Sci. Eng., 2015, 1, 13
DOI: 10.1021/ab500059s

Microreactor Technology: Identifying Focus Fields and Emerging Trends by Using CiteSpace II

Lin Yang, Yutao Sun and Lijing Zhang

ChemPlusChem, 2023, 88
DOI: 10.1002/cplu.202200349

Visible‐Light Photoredox Catalysis in Flow

Joseph W. Tucker, Yuan Zhang, Timothy F. Jamison and Corey R. J. Stephenson

Angew Chem Int Ed, 2012, 51, 4144
DOI: 10.1002/anie.201200961

High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences

Andrew R. Bogdan, Manwika Charaschanya, Amanda W. Dombrowski, Ying Wang and Stevan W. Djuric

Org. Lett., 2016, 18, 1732
DOI: 10.1021/acs.orglett.6b00378

Photo-induced copper-mediated (meth)acrylate polymerization towards graphene oxide and reduced graphene oxide modification

Svitlana Railian, Joris J. Haven, Lowie Maes, Dries De Sloovere, Vanessa Trouillet, Alexander Welle, Peter Adriaensens, Marlies K. Van Bael, An Hardy, Wim Deferme and Tanja Junkers

European Polymer Journal, 2020, 134, 109810
DOI: 10.1016/j.eurpolymj.2020.109810

Three-Step Chemo Enzymatic Continuous-Flow Cascade Synthesis of 1-Monoacylglycerol

Ivaldo Itabaiana, Ivana C. R. Leal, Leandro S. M. Miranda and Rodrigo O. M. A. de Souza

J Flow Chem, 2013, 3, 122
DOI: 10.1556/JFC-D-13-00019

Safe Generation and Synthetic Utilization of Hydrazoic Acid in a Continuous Flow Reactor

Bernhard Gutmann, David Obermayer, Jean-Paul Roduit, Dominique M. Roberge and C. Oliver Kappe

J Flow Chem, 2012, 2, 8
DOI: 10.1556/jfchem.2012.00021

Highly Functionalized Biaryls via Suzuki–Miyaura Cross‐Coupling Catalyzed by Pd@MOF under Batch and Continuous Flow Regimes

Vlad Pascanu, Peter R. Hansen, Antonio Bermejo Gómez, Carles Ayats, Ana E. Platero‐Prats, Magnus J. Johansson, Miquel À. Pericàs and Belén Martín‐Matute

ChemSusChem, 2015, 8, 123
DOI: 10.1002/cssc.201402858

Multicomponent-Multicatalyst Reactions (MC)2R: Efficient Dibenzazepine Synthesis

Jennifer Tsoung, Jane Panteleev, Matthias Tesch and Mark Lautens

Org. Lett., 2014, 16, 110
DOI: 10.1021/ol4030925

Use of Continuous MSMPR Crystallization with Integrated Nanofiltration Membrane Recycle for Enhanced Yield and Purity in API Crystallization

Steven Ferguson, Franziska Ortner, Justin Quon, Ludmila Peeva, Andrew Livingston, Bernhardt L. Trout and Allan S. Myerson

Crystal Growth & Design, 2014, 14, 617
DOI: 10.1021/cg401491y

Continuous flow (micro-)reactors for heterogeneously catalyzed reactions: Main design and modelling issues

Ilenia Rossetti

Catalysis Today, 2018, 308, 20
DOI: 10.1016/j.cattod.2017.09.040

Novel porous ceramic sheet supported metal reactors for continuous-flow catalysis

Qijie Jin, Bingxu Lu, Youchun Pan, Xingjun Tao, Cindy Himmelhaver, Yuesong Shen, Sasa Gu, Yanwei Zeng and XiuJun Li

Catalysis Today, 2020, 358, 324
DOI: 10.1016/j.cattod.2019.12.006

Continuous-flow enzymatic resolution strategy for the acylation of amino alcohols with a remote stereogenic centre: synthesis of calycotomine enantiomers

László Schönstein, Enikő Forró and Ferenc Fülöp

Tetrahedron: Asymmetry, 2013, 24, 202
DOI: 10.1016/j.tetasy.2013.01.006

Recent developments of automated flow chemistry in pharmaceutical compounds synthesis

Jiashu Wu, Xingxing Yang, Yourong Pan, Tao Zuo, Zuozhou Ning, Chengxi Li and Zhiguo Zhang

J Flow Chem, 2023, 13, 385
DOI: 10.1007/s41981-023-00285-x

Mussel‐Inspired Immobilization of Catalysts for Microchemical Applications

Sung Min Kim, Young Ho Park, Seung Woo Seo, Chan Pil Park, Sung Young Park and Insik In

Adv Materials Inter, 2015, 2
DOI: 10.1002/admi.201500174

Asymmetric Carbon–Carbon Bond Formation under Continuous‐Flow Conditions with Chiral Heterogeneous Catalysts

Tetsu Tsubogo, Takanori Ishiwata and Shū Kobayashi

Angew Chem Int Ed, 2013, 52, 6590
DOI: 10.1002/anie.201210066

Encapsulated Cobalt Oxide on Carbon Nanotube Support as Catalyst for Selective Continuous Hydrogenation of the Showcase Substrate 1‐Iodo‐4‐nitrobenzene

Todor Baramov, Patrick Loos, Jorma Hassfeld, Hannes Alex, Matthias Beller, Tobias Stemmler, Gregor Meier, Michael Gottfried and Stefan Roggan

Adv Synth Catal, 2016, 358, 2903
DOI: 10.1002/adsc.201600461

Going with the flow

Rainer E. Martin

Science, 2016, 352, 44
DOI: 10.1126/science.aaf3065

Double-Diffusive Convection in the Continuous Flow Microreactors

A I Mizev, E A Mosheva and A V Shmyrov

J. Phys.: Conf. Ser., 2021, 1945, 012036
DOI: 10.1088/1742-6596/1945/1/012036

Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant

Mateo Berton, Juliana M. de Souza, Irini Abdiaj, D. Tyler McQuade and David R. Snead

J Flow Chem, 2020, 10, 73
DOI: 10.1007/s41981-019-00060-x

Flow Bioreactors as Complementary Tools for Biocatalytic Process Intensification

Lucia Tamborini, Pedro Fernandes, Francesca Paradisi and Francesco Molinari

Trends in Biotechnology, 2018, 36, 73
DOI: 10.1016/j.tibtech.2017.09.005

Precious metal-based Catalytic Membrane Reactors for continuous flow catalytic hydrodechlorination

Raúl B. del Olmo, Maria Torres, Julia Nieto-Sandoval, Macarena Munoz, Zahara M. de Pedro and Jose A. Casas

Journal of Environmental Chemical Engineering, 2024, 12, 112754
DOI: 10.1016/j.jece.2024.112754

Low‐Temperature Continuous‐Flow Dehydration of Xylose Over Water‐Tolerant Niobia–Titania Heterogeneous Catalysts

Carmen Moreno‐Marrodan, Pierluigi Barbaro, Stefano Caporali and Filippo Bossola

ChemSusChem, 2018, 11, 3649
DOI: 10.1002/cssc.201801414

Continuous‐Flow Synthesis of Biaryls Enabled by Multistep Solid‐Handling in a Lithiation/Borylation/Suzuki–Miyaura Cross‐Coupling Sequence

Wei Shu, Laurent Pellegatti, Matthias A. Oberli and Stephen L. Buchwald

Angewandte Chemie, 2011, 123, 10853
DOI: 10.1002/ange.201105223

Reconfigurable Flow Platform for Automated Reagent Screening and Autonomous Optimization for Bioinspired Lignans Synthesis

Ehu Camille Aka, Eric Wimmer, Elvina Barré, Natarajan Vasudevan, Daniel Cortés-Borda, Tchirioua Ekou, Lynda Ekou, Mireia Rodriguez-Zubiri and François-Xavier Felpin

J. Org. Chem., 2019, 84, 14101
DOI: 10.1021/acs.joc.9b02263

Asymmetrische Kohlenstoff‐Kohlenstoff‐Kupplungen unter kontinuierlichen Durchflussbedingungen mit chiralen Heterogenkatalysatoren

Tetsu Tsubogo, Takanori Ishiwata and Shū Kobayashi

Angewandte Chemie, 2013, 125, 6722
DOI: 10.1002/ange.201210066

Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp3)−H Activation

Jacek Zakrzewski, Adam P. Smalley, Mikhail A. Kabeshov, Matthew J. Gaunt and Alexei A. Lapkin

Angew Chem Int Ed, 2016, 55, 8878
DOI: 10.1002/anie.201602483

EDA photochemistry using continuous flow

Samuel L. Nickels, Ai-Lan Lee and Filipe Vilela

J Flow Chem, 2025, 15, 221
DOI: 10.1007/s41981-025-00362-3

A continuous-flow synthesis of annulated and polysubstituted furans from the reaction of ketones and α-haloketones

Mark York

Tetrahedron Letters, 2011, 52, 6267
DOI: 10.1016/j.tetlet.2011.09.083

Numerical study of a packed-bed microreactor based on Sierpinski fractal principle

Yao Chen and Xueye Chen

J Braz. Soc. Mech. Sci. Eng., 2020, 42
DOI: 10.1007/s40430-020-02285-7

Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions

Lukas Kupracz, Jan Hartwig, Jens Wegner, Sascha Ceylan and Andreas Kirschning

Beilstein J. Org. Chem., 2011, 7, 1441
DOI: 10.3762/bjoc.7.168

Continuous‐Flow Synthesis of Biaryls Enabled by Multistep Solid‐Handling in a Lithiation/Borylation/Suzuki–Miyaura Cross‐Coupling Sequence

Wei Shu, Laurent Pellegatti, Matthias A. Oberli and Stephen L. Buchwald

Angew Chem Int Ed, 2011, 50, 10665
DOI: 10.1002/anie.201105223

Heating under High‐Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa)

Jan Hartwig, Sascha Ceylan, Lukas Kupracz, Ludovic Coutable and Andreas Kirschning

Angew Chem Int Ed, 2013, 52, 9813
DOI: 10.1002/anie.201302239

Novel Technique for Filtration Avoidance in Continuous Crystallization

Nima Yazdanpanah, Steven T. Ferguson, Allan S. Myerson and Bernhardt L. Trout

Crystal Growth & Design, 2016, 16, 285
DOI: 10.1021/acs.cgd.5b01231

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades**

Ashley P. Mattey, Grayson J. Ford, Joan Citoler, Christopher Baldwin, James R. Marshall, Ryan B. Palmer, Matthew Thompson, Nicholas J. Turner, Sebastian C. Cosgrove and Sabine L. Flitsch

Angew Chem Int Ed, 2021, 60, 18660
DOI: 10.1002/anie.202103805

A chip-integrated optical microfluidic pressure sensor

Christian Hoera, Andreas Kiontke, Maik Pahl and Detlev Belder

Sensors and Actuators B: Chemical, 2018, 255, 2407
DOI: 10.1016/j.snb.2017.08.195

Oscillatory Flow Reactors (OFRs) for Continuous Manufacturing and Crystallization

Thomas McGlone, Naomi E. B. Briggs, Catriona A. Clark, Cameron J. Brown, Jan Sefcik and Alastair J. Florence

Org. Process Res. Dev., 2015, 19, 1186
DOI: 10.1021/acs.oprd.5b00225

On‐the‐fly Catalyst Modification: Strategy to Improve Catalytic Processes Selectivity and Understanding

Jacinto Sá and J. Will Medlin

ChemCatChem, 2019, 11, 3355
DOI: 10.1002/cctc.201900770

Application of Metal‐Based Reagents and Catalysts in Microstructured Flow Devices

Tamilselvi Chinnusamy, Salprima Yudha S , Markus Hager, Peter Kreitmeier and Oliver Reiser

ChemSusChem, 2012, 5, 247
DOI: 10.1002/cssc.201100444

Zeolite incorporation in chip-based microreactors

L.A. Truter, V. Ordomsky, J.C. Schouten and T.A. Nijhuis

Microporous and Mesoporous Materials, 2016, 226, 424
DOI: 10.1016/j.micromeso.2016.02.016

Rapid Conversion of Glycerol to Lactic Acid under Alkaline Hydrothermal Conditions, by Using a Continuous Flow Reaction System

Toshinori Shimanouchi, Shouhei Ueno, Kazuki Shidahara and Yukitaka Kimura

Chemistry Letters, 2014, 43, 535
DOI: 10.1246/cl.131160

A Two-Stage Continuous-Flow Synthesis of Spirooxazine Photochromic Dyes

Mark York and Adriana Edenharter

Australian Journal of Chemistry, 2013, 66, 172
DOI: 10.1071/CH12435

A Continuous-Flow Approach to 3,3,3-Trifluoromethylpropenes: Bringing Together Grignard Addition, Peterson Elimination, Inline Extraction, and Solvent Switching

Trevor A. Hamlin, Gillian M. L. Lazarus, Christopher B. Kelly and Nicholas E. Leadbeater

Org. Process Res. Dev., 2014, 18, 1253
DOI: 10.1021/op500190j

Mixer Design and Flow Rate as Critical Variables in Flow Chemistry Affecting the Outcome of a Chemical Reaction: A Review

Ilya V. Myachin and Leonid O. Kononov

Inventions, 2023, 8, 128
DOI: 10.3390/inventions8050128

Flow Chemistry – A Key Enabling Technology for (Multistep) Organic Synthesis

Jens Wegner, Sascha Ceylan and Andreas Kirschning

Adv Synth Catal, 2012, 354, 17
DOI: 10.1002/adsc.201100584

Rapid Optimization of Photoredox Reactions for Continuous-Flow Systems Using Microscale Batch Technology

María González-Esguevillas, David F. Fernández, Juan A. Rincón, Mario Barberis, Oscar de Frutos, Carlos Mateos, Susana García-Cerrada, Javier Agejas and David W. C. MacMillan

ACS Cent. Sci., 2021, 7, 1126
DOI: 10.1021/acscentsci.1c00303

Enantioselective Organocatalysis in Microreactors: Continuous Flow Synthesis of a (S)-Pregabalin Precursor and (S)-Warfarin

Riccardo Porta, Maurizio Benaglia, Francesca Coccia, Sergio Rossi and Alessandra Puglisi

Symmetry, 2015, 7, 1395
DOI: 10.3390/sym7031395

Membrane-Based, Liquid–Liquid Separator with Integrated Pressure Control

Andrea Adamo, Patrick L. Heider, Nopphon Weeranoppanant and Klavs F. Jensen

Ind. Eng. Chem. Res., 2013, 52, 10802
DOI: 10.1021/ie401180t

Highly Efficient Continuous Flow Reactions Using Singlet Oxygen as a “Green” Reagent

François Lévesque and Peter H. Seeberger

Org. Lett., 2011, 13, 5008
DOI: 10.1021/ol2017643

Chip‐Based Free‐Flow Electrophoresis with Integrated Nanospray Mass‐Spectrometry

Christian Benz, Michael Boomhoff, Johannes Appun, Christoph Schneider and Detlev Belder

Angew Chem Int Ed, 2015, 54, 2766
DOI: 10.1002/anie.201409663

Enantioselective Sequential‐Flow Synthesis of Baclofen Precursor via Asymmetric 1,4‐Addition and Chemoselective Hydrogenation on Platinum/Carbon/Calcium Phosphate Composites

Haruro Ishitani, Yuichi Furiya and Shu Kobayashi

Chemistry An Asian Journal, 2020, 15, 1688
DOI: 10.1002/asia.202000065

The Application of an Automated Control Strategy for an Integrated Continuous Pharmaceutical Pilot Plant

Richard Lakerveld, Brahim Benyahia, Patrick L. Heider, Haitao Zhang, Aaron Wolfe, Christopher J. Testa, Sean Ogden, Devin R. Hersey, Salvatore Mascia, James M. B. Evans, Richard D. Braatz and Paul I. Barton

Org. Process Res. Dev., 2015, 19, 1088
DOI: 10.1021/op500104d

Novel Application of Polymer Networks Carrying Tertiary Amines as a Catalyst Inside Microflow Reactors Used for Knoevenagel Reactions

Patrik Berg, Franziska Obst, David Simon, Andreas Richter, Dietmar Appelhans and Dirk Kuckling

Eur J Org Chem, 2020, 2020, 5765
DOI: 10.1002/ejoc.202000978

Palladium-based Catalytic Membrane Reactor for the continuous flow hydrodechlorination of chlorinated micropollutants

Julia Nieto-Sandoval, Esther Gomez-Herrero, Macarena Munoz, Zahara M. de Pedro and Jose A. Casas

Applied Catalysis B: Environmental, 2021, 293, 120235
DOI: 10.1016/j.apcatb.2021.120235

A continuous synthesis method of hydroxymethyl phosphonates using the microfluidic reactor

Zhiguo WANG, Hongxia LIU , Zhigang WANG and Xuefeng YANG

Rev.Roum.Chim., 2024, 68, 577
DOI: 10.33224/rrch.2023.68.10-12.10

Continuous-Flow Synthesis of Deuterium-Labeled Antidiabetic Chalcones: Studies towards the Selective Deuteration of the Alkynone Core

Sándor Ötvös, Chi-Ting Hsieh, Yang-Chang Wu, Jih-Heng Li, Fang-Rong Chang and Ferenc Fülöp

Molecules, 2016, 21, 318
DOI: 10.3390/molecules21030318

The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds

Péter Bana, Róbert Örkényi, Klára Lövei, Ágnes Lakó, György István Túrós, János Éles, Ferenc Faigl and István Greiner

Bioorganic & Medicinal Chemistry, 2017, 25, 6180
DOI: 10.1016/j.bmc.2016.12.046

anti-Selective Catalytic Asymmetric Nitroaldol Reaction of α-Keto Esters: Intriguing Solvent Effect, Flow Reaction, and Synthesis of Active Pharmaceutical Ingredients

Tomoya Karasawa, Raphaël Oriez, Naoya Kumagai and Masakatsu Shibasaki

J. Am. Chem. Soc., 2018, 140, 12290
DOI: 10.1021/jacs.8b08236

Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions

Trevor A Hamlin and Nicholas E Leadbeater

Beilstein J. Org. Chem., 2013, 9, 1843
DOI: 10.3762/bjoc.9.215

Adaptive Micromixer Based on the Solutocapillary Marangoni Effect in a Continuous-Flow Microreactor

Dmitry Bratsun, Konstantin Kostarev, Alexey Mizev, Sebastian Aland, Marcel Mokbel, Karin Schwarzenberger and Kerstin Eckert

Micromachines, 2018, 9, 600
DOI: 10.3390/mi9110600

Enabling low power acoustics for capillary sonoreactors

Francisco J. Navarro-Brull, Andrew R. Teixeira, Gaurav Giri and Roberto Gómez

Ultrasonics Sonochemistry, 2019, 56, 105
DOI: 10.1016/j.ultsonch.2019.03.013

Continuous Flow Synthesis of 2H‐Thiopyrans via thia‐Diels–Alder Reactions of Photochemically Generated Thioaldehydes

Florian Sachse, Konrad Gebauer and Christoph Schneider

Eur J Org Chem, 2021, 2021, 64
DOI: 10.1002/ejoc.202001343

Development of methodologies for reactions involving gases as reagents: microwave heating and conventionally-heated continuous-flow processing as examples

Michael A. Mercadante and Nicholas E. Leadbeater

Green Processing and Synthesis, 2012, 1, 499
DOI: 10.1515/gps-2011-0016

Transformations of acetophenone and its derivatives in supercritical fluid isopropanol/CO2 in a continuous flow reactor in the presence of alumina

V.P. Sivcev, K.P. Volcho, N.F. Salakhutdinov and V.I. Anikeev

The Journal of Supercritical Fluids, 2012, 70, 35
DOI: 10.1016/j.supflu.2012.05.012

Connected nucleophilic substitution-Claisen rearrangement in flow – Analysis for kilo-lab process solutions with orthogonality

Elnaz Shahbazali, Max Spapens, Hiroki Kobayashi, Shinichi Ookawara, Timothy Noël and Volker Hessel

Chemical Engineering Journal, 2015, 281, 144
DOI: 10.1016/j.cej.2015.06.020

Continuous stream processing: a prototype magnetic field induced flow mixer

Peter Koos, Duncan L. Browne and Steven V. Ley

gps, 2012, 1, 11
DOI: 10.1515/greenps-2011-0501

Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism

Bhavesh H. Patel, Claudia Percivalle, Dougal J. Ritson, Colm D. Duffy and John D. Sutherland

Nature Chem, 2015, 7, 301
DOI: 10.1038/nchem.2202

Miniaturization and Combinatorial Approach in Organic Electrochemistry

Koichi Mitsudo, Yuji Kurimoto, Kazuki Yoshioka and Seiji Suga

Chem. Rev., 2018, 118, 5985
DOI: 10.1021/acs.chemrev.7b00532

Induction Heating: An Enabling Technology for the Heat Management in Catalytic Processes

Wei Wang, Giulia Tuci, Cuong Duong-Viet, Yuefeng Liu, Andrea Rossin, Lapo Luconi, Jean-Mario Nhut, Lam Nguyen-Dinh, Cuong Pham-Huu and Giuliano Giambastiani

ACS Catal., 2019, 9, 7921
DOI: 10.1021/acscatal.9b02471

Improved Livingness and Control over Branching in RAFT Polymerization of Acrylates: Could Microflow Synthesis Make the Difference?

Pieter Derboven, Paul H. M. Van Steenberge, Joke Vandenbergh, Marie‐Francoise Reyniers, Tanja Junkers, Dagmar R. D'hooge and Guy B. Marin

Macromol. Rapid Commun., 2015, 36, 2149
DOI: 10.1002/marc.201500357

Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor

Michael A. Mercadante, Christopher B. Kelly, Christopher (Xiang) Lee and Nicholas E. Leadbeater

Org. Process Res. Dev., 2012, 16, 1064
DOI: 10.1021/op300019w

Continuous-Flow Alcohol Protection and Deprotection Reactions Catalyzed by Silica-Supported Sulfonic Acid

Sebastiaan A. van den Berg, Raoul A. M. Frijns, Tom Wennekes and Han Zuilhof

J Flow Chem, 2015, 5, 95
DOI: 10.1556/1846.2015.00006

Process design methodology for organometallic chemistry in continuous flow systems

Sarah M. Hunter, Flavien Susanne, Robert Whitten, Thoralf Hartwig and Mark Schilling

Tetrahedron, 2018, 74, 3176
DOI: 10.1016/j.tet.2018.04.020

Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)C(sp3) cross-coupling

Irini Abdiaj and Jesús Alcázar

Bioorganic & Medicinal Chemistry, 2017, 25, 6190
DOI: 10.1016/j.bmc.2016.12.041

Diastereodifferentiating [2+2] photocycloaddition of chiral cyclohexenone carboxylates with cyclopentene by a microreactor

Kimitada Terao, Yasuhiro Nishiyama, Shin Aida, Hiroki Tanimoto, Tsumoru Morimoto and Kiyomi Kakiuchi

Journal of Photochemistry and Photobiology A: Chemistry, 2012, 242, 13
DOI: 10.1016/j.jphotochem.2012.05.021

Self-Assembled Asymmetric Catalyst Engaged in a Continuous-Flow Platform: AnAnti-Selective Catalytic Asymmetric Nitroaldol Reaction

Kazuki Hashimoto, Naoya Kumagai and Masakatsu Shibasaki

Org. Lett., 2014, 16, 3496
DOI: 10.1021/ol501432h

Nanocellulose sponges as efficient continuous flow reactors

Congcong Zhang, Xueling Feng, Bijia Wang, Zhiping Mao, Hong Xu, Yi Zhong, Linping Zhang, Xiaoyun Chen and Xiaofeng Sui

Carbohydrate Polymers, 2019, 224, 115184
DOI: 10.1016/j.carbpol.2019.115184

Iron-Catalyzed Batch/Continuous Flow C–H Functionalization Module for the Synthesis of Anticancer Peroxides

Moreshwar B. Chaudhari, Suresh Moorthy, Sohan Patil, Girish Singh Bisht, Haneef Mohamed, Sudipta Basu and Boopathy Gnanaprakasam

J. Org. Chem., 2018, 83, 1358
DOI: 10.1021/acs.joc.7b02854

Asymmetric flow catalysis: Mix-and-go solid-phase Nd/Na catalyst for expeditious enantioselective access to a key intermediate of AZD7594

Akihito Nonoyama, Naoya Kumagai and Masakatsu Shibasaki

Tetrahedron, 2017, 73, 1517
DOI: 10.1016/j.tet.2017.01.066

Strong Cation Exchange with Innocence: Synthesis and Characterization of Borate Containing Resins and Macroporous Monoliths

Francesca Liguori, Serena Coiai, Elisa Passaglia and Pierluigi Barbaro

Macromolecules, 2013, 46, 5423
DOI: 10.1021/ma401120v

Two-step Continuous-flow Synthesis of 1,2-dimethyl-3-methylsulfanylbenzene via Diazotization and Methanethiolation

Lixia Li, Qi Zhang, Ce Bian, Wei Wei, Wenxuan Sun, Lu Ji, Hande Wang, Chuan Zhou, Ke Wang, Dangsheng Gong and Dongmao Yan

COC, 2024, 28, 222
DOI: 10.2174/0113852728277310240103111746

End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

Salvatore Mascia, Patrick L. Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I. Barton, Richard D. Braatz, Charles L. Cooney, James M. B. Evans, Timothy F. Jamison, Klavs F. Jensen, Allan S. Myerson and Bernhardt L. Trout

Angewandte Chemie, 2013, 125, 12585
DOI: 10.1002/ange.201305429

An Enantioselective Recyclable Polystyrene‐Supported Threonine‐Derived Organocatalyst for Aldol Reactions

Andrea H. Henseler, Carles Ayats and Miquel A. Pericàs

Adv Synth Catal, 2014, 356, 1795
DOI: 10.1002/adsc.201400033

Gas-Phase Catalytic Transfer Hydrogenation of Methyl Levulinate with Ethanol over ZrO2

Paola Blair Vásquez, Tommaso Tabanelli, Eleonora Monti, Stefania Albonetti, Danilo Bonincontro, Nikolaos Dimitratos and Fabrizio Cavani

ACS Sustainable Chem. Eng., 2019, 7, 8317
DOI: 10.1021/acssuschemeng.8b06744

Development of 3D+G printing for the design of customizable flow reactors

Fedor A. Kucherov, Leonid V. Romashov and Valentine P. Ananikov

Chemical Engineering Journal, 2022, 430, 132670
DOI: 10.1016/j.cej.2021.132670

Pentafluoroethylation of Carbonyl Compounds Using HFC-125 in a Flow Microreactor System

Makoto Ono, Yuji Sumii, Yamato Fujihira, Takumi Kagawa, Hideyuki Mimura and Norio Shibata

J. Org. Chem., 2021, 86, 14044
DOI: 10.1021/acs.joc.1c00728

Finding the sweet spot: the role of nature and nurture in medicinal chemistry

Michael M. Hann and György M. Keserü

Nat Rev Drug Discov, 2012, 11, 355
DOI: 10.1038/nrd3701

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

Riccardo Porta, Maurizio Benaglia and Alessandra Puglisi

Org. Process Res. Dev., 2016, 20, 2
DOI: 10.1021/acs.oprd.5b00325

Preparation of Arene Chromium Tricarbonyl Complexes Using Continuous-Flow Processing: (η6-C6H5CH3)Cr(CO)3 as an Example

Christopher Lee, Elizabeth A. Pedrick and Nicholas E. Leadbeater

J Flow Chem, 2012, 2, 115
DOI: 10.1556/JFC-D-12-00018

Model‐based design of a plant‐wide control strategy for a continuous pharmaceutical plant

Richard Lakerveld, Brahim Benyahia, Richard D. Braatz and Paul I. Barton

AIChE Journal, 2013, 59, 3671
DOI: 10.1002/aic.14107

3D-printed devices for continuous-flow organic chemistry

Vincenza Dragone, Victor Sans, Mali H Rosnes, Philip J Kitson and Leroy Cronin

Beilstein J. Org. Chem., 2013, 9, 951
DOI: 10.3762/bjoc.9.109

Modeling Pore-Scale Two-Phase Flow: How to Avoid Gas-Channeling Phenomena in Micropacked-Bed Reactors via Catalyst Wettability Modification

Francisco J. Navarro-Brull and Roberto Gómez

Ind. Eng. Chem. Res., 2018, 57, 84
DOI: 10.1021/acs.iecr.7b02493

Microemulsion-Based Organogels as an Efficient Support for Lipase-Catalyzed Reactions under Continuous-Flow Conditions

Ivaldo Itabaiana, Karen M. Gonçalves, Maria Zoumpanioti, Ivana C. R. Leal, Leandro S. M. e Miranda, Aristotelis Xenakis and Rodrigo O. M. A. de Souza

Org. Process Res. Dev., 2014, 18, 1372
DOI: 10.1021/op500136c

Organic–inorganic hybrid electro-optic material with Disperse Red 1 chromophore fabricated by flow chemistry

Yoonseok Ko, Minsang Kim, Changho Noh, Mi-Jeong Kim, Keechang Lee, Jongback Kim, Sung Dug Kim and Sang Soo Jee

J Flow Chem, 2022, 12, 79
DOI: 10.1007/s41981-021-00191-0

Using Continuous Processes to Increase Production

Neal G. Anderson

Org. Process Res. Dev., 2012, 16, 852
DOI: 10.1021/op200347k

Benchtop factory for cross-coupling reactions by circulatory catalyst flow using low-viscosity ionic liquid as reaction medium and catalyst support

Takahide Fukuyama and Ilhyong Ryu

Green Processing and Synthesis, 2012, 1, 417
DOI: 10.1515/gps-2011-0008

In situ fabric coloration with indigo synthesised in flow

Michael P. Haaf, Katrina M. Piemonte, D. Tyler McQuade, Lucy Cotton and Richard S. Blackburn

Coloration Technology, 2019, 135, 127
DOI: 10.1111/cote.12383

Aerobic C–H Olefination of Indoles via a Cross-Dehydrogenative Coupling in Continuous Flow

Hannes P. L. Gemoets, Volker Hessel and Timothy Noël

Org. Lett., 2014, 16, 5800
DOI: 10.1021/ol502910e

Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

Tobias Brodmann, Peter Koos, Albrecht Metzger, Paul Knochel and Steven V. Ley

Org. Process Res. Dev., 2012, 16, 1102
DOI: 10.1021/op200275d

Continuous Flow Synthesis under High-Temperature/High-Pressure Conditions Using a Resistively Heated Flow Reactor

Ahmed Adeyemi, Joakim Bergman, Jonas Brånalt, Jonas Sävmarker and Mats Larhed

Org. Process Res. Dev., 2017, 21, 947
DOI: 10.1021/acs.oprd.7b00063

The continuous kilogram-scale process for the synthesis of 2,4,5-trifluorobromobenzene via Gattermann reaction using microreactors

Qiulin Deng, Qin Lei, Ruwei Shen, Chao Chen and Lixiong Zhang

Chemical Engineering Journal, 2017, 313, 1577
DOI: 10.1016/j.cej.2016.11.035

Continuous Synthesis of 4-Cyclopropyl-1,2,5-Oxadiazole-3-Carboxylic Acid

艳梅董

HJMCe, 2023, 11, 133
DOI: 10.12677/HJMCe.2022.113017

A Carbon Nanotube Confinement Strategy to Implement Homogeneous Asymmetric Catalysis in the Solid Phase

Kazuki Hashimoto, Naoya Kumagai and Masakatsu Shibasaki

Chemistry A European J, 2015, 21, 4262
DOI: 10.1002/chem.201406402

Passive Micro Elastofluidic Controller for Constant Flow Rate

Hafiz Muhammad Musharaf, Jun Zhang and Nam‐Trung Nguyen

Adv Materials Technologies, 2026, 11
DOI: 10.1002/admt.202501522

A Solid‐Supported Organocatalyst for Continuous‐Flow Enantioselective Aldol Reactions

Carles Ayats, Andrea H. Henseler and Miquel A. Pericàs

ChemSusChem, 2012, 5, 320
DOI: 10.1002/cssc.201100570

Synthesis of Riboflavines, Quinoxalinones and Benzodiazepines through Chemoselective Flow Based Hydrogenations

Marcus Baumann, Ian Baxendale, Christian Hornung, Steven Ley, Maria Rojo and Kimberley Roper

Molecules, 2014, 19, 9736
DOI: 10.3390/molecules19079736

A continuous flow synthesis and derivatization of 1,2,4-thiadiazoles

Marcus Baumann and Ian R. Baxendale

Bioorganic & Medicinal Chemistry, 2017, 25, 6218
DOI: 10.1016/j.bmc.2017.01.022

Sustainable Practices in Medicinal Chemistry: Current State and Future Directions

Marian C. Bryan, Barry Dillon, Lawrence G. Hamann, Gregory J. Hughes, Michael E. Kopach, Emily A. Peterson, Mehrnaz Pourashraf, Izzat Raheem, Paul Richardson, Daniel Richter and Helen F. Sneddon

J. Med. Chem., 2013, 56, 6007
DOI: 10.1021/jm400250p

Multistep continuous flow synthesis of Erlotinib

Hui Jin, Qin Cai, Peiwen Liu, Yan Chen, Derong Wang, Weiping Zhu, Yufang Xu and Xuhong Qian

Chinese Chemical Letters, 2024, 35, 108721
DOI: 10.1016/j.cclet.2023.108721

Unlocking the Potential Benefits of Flow Chemistry in the Drug-Discovery Process

Paul Richardson

Future Med. Chem., 2014, 6, 845
DOI: 10.4155/fmc.14.49

Continuous-Flow Heck–Matsuda Reaction: Homogeneous versus Heterogeneous Palladium Catalysts

Nicolas Oger, Erwan Le Grognec and François-Xavier Felpin

J. Org. Chem., 2014, 79, 8255
DOI: 10.1021/jo501468z

An Efficient and More Sustainable One-Step Continuous-Flow Multicomponent Synthesis Approach to Chromene Derivatives

Buchi Reddy Vaddula, Swathi Yalla and Michael A. Gonzalez

J Flow Chem, 2015, 5, 172
DOI: 10.1556/1846.2015.00015

A Visible‐Light‐Powered Polymerization Method for the Immobilization of Enantioselective Organocatalysts into Microreactors

Rico Warias, Daniele Ragno, Alessandro Massi and Detlev Belder

Chemistry A European J, 2020, 26, 13152
DOI: 10.1002/chem.202002063

Building a Sulfonamide Library by Eco-Friendly Flow Synthesis

Antimo Gioiello, Emiliano Rosatelli, Michela Teofrasti, Paolo Filipponi and Roberto Pellicciari

ACS Comb. Sci., 2013, 15, 235
DOI: 10.1021/co400012m

Highly Selective Continuous‐Flow Synthesis of Potentially Bioactive Deuterated Chalcone Derivatives

Chi‐Ting Hsieh, Sándor B. Ötvös, Yang‐Chang Wu, István M. Mándity, Fang‐Rong Chang and Ferenc Fülöp

ChemPlusChem, 2015, 80, 859
DOI: 10.1002/cplu.201402426

A Catalytic Reactor for the Organocatalyzed Enantioselective Continuous Flow Alkylation of Aldehydes

Riccardo Porta, Maurizio Benaglia, Alessandra Puglisi, Alessandro Mandoli, Andrea Gualandi and Pier Giorgio Cozzi

ChemSusChem, 2014, 7, 3534
DOI: 10.1002/cssc.201402610

Flow Synthesis of Substituted γ‐Lactones by Consecutive Photocatalytic/Reductive Reactions

Maurizio Fagnoni, Filippo Bonassi, Alessandro Palmieri, Stefano Protti, Davide Ravelli and Roberto Ballini

Adv Synth Catal, 2014, 356, 753
DOI: 10.1002/adsc.201300859

Continuous Flow Conversion of Biomass-Derived Methyl Levulinate into γ-Valerolactone Using Functional Metal Organic Frameworks

Weiyi Ouyang, Deyang Zhao, Yantao Wang, Alina M. Balu, Christophe Len and Rafael Luque

ACS Sustainable Chem. Eng., 2018, 6, 6746
DOI: 10.1021/acssuschemeng.8b00549

End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

Salvatore Mascia, Patrick L. Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I. Barton, Richard D. Braatz, Charles L. Cooney, James M. B. Evans, Timothy F. Jamison, Klavs F. Jensen, Allan S. Myerson and Bernhardt L. Trout

Angew Chem Int Ed, 2013, 52, 12359
DOI: 10.1002/anie.201305429

Investigation of a Lithium–Halogen Exchange Flow Process for the Preparation of Boronates by Using a Cryo‐Flow Reactor

James A. Newby, Lena Huck, D. Wayne Blaylock, Paul M. Witt, Steven V. Ley and Duncan L. Browne

Chemistry A European J, 2014, 20, 263
DOI: 10.1002/chem.201303736

Bismuth(III)-Catalyzed Hydration of Terminal Alkynes: Sustainable Synthesis of Methyl Ketones in Batch and Flow

Sándor B. Ötvös, Zsanett Szécsényi and Ferenc Fülöp

ACS Sustainable Chem. Eng., 2019, 7, 13286
DOI: 10.1021/acssuschemeng.9b02520

Process parameter and kinetic study for the azidation of a zidovudine intermediate with sodium azide in microreactors

Rongkun Jiang, Xiao Xue, Fang Zhao, Weiping Zhu, Minjing Shang, Yuanhai Su, Yufang Xu and Xuhong Qian

Chemical Engineering Journal, 2022, 429, 132207
DOI: 10.1016/j.cej.2021.132207

Electrochemical Synthesis of Sulfonamides in Single‐Pass Flow

Johannes Schneider, Stephan P. Blum and Siegfried R. Waldvogel

ChemElectroChem, 2023, 10
DOI: 10.1002/celc.202300456

Continuous Stripping with Dense Carbon Dioxide

Márton Kőrösi, Petra Kántor, Péter Bana and Edit Székely

ACS Omega, 2023, 8, 46757
DOI: 10.1021/acsomega.3c06087

Vereinigung von chemischer Synthese und Biosynthese: ein neues Kapitel in der Totalsynthese von Naturstoffen und Naturstoffbibliotheken

Andreas Kirschning and Frank Hahn

Angewandte Chemie, 2012, 124, 4086
DOI: 10.1002/ange.201107386

Development of Immobilized SPINOL-Derived Chiral Phosphoric Acids for Catalytic Continuous Flow Processes. Use in the Catalytic Desymmetrization of 3,3-Disubstituted Oxetanes

Junshan Lai, Mauro Fianchini and Miquel A. Pericàs

ACS Catal., 2020, 10, 14971
DOI: 10.1021/acscatal.0c04497

Novel continuous flow synthesis of 6-methoxy-2,3-difluorobenzaldehyde, the key intermediate of linzagolix

Wei Jiang, Jian Huang and Dun Wang

J Flow Chem, 2026, 16, 45
DOI: 10.1007/s41981-026-00373-8

Flow Chemistry Syntheses of Styrenes, Unsymmetrical Stilbenes and Branched Aldehydes

Samuel L. Bourne, Matthew O'Brien, Sivarajan Kasinathan, Peter Koos, Päivi Tolstoy, Dennis X. Hu, Roderick W. Bates, Benjamin Martin, Berthold Schenkel and Steven V. Ley

ChemCatChem, 2013, 5, 159
DOI: 10.1002/cctc.201200778

Rapid Continuous Synthesis of 5′-Deoxyribonucleosides in Flow via Brønsted Acid Catalyzed Glycosylation

Bo Shen and Timothy F. Jamison

Org. Lett., 2012, 14, 3348
DOI: 10.1021/ol301324g

Interrupted Curtius Rearrangements of Quaternary Proline Derivatives: A Flow Route to Acyclic Ketones and Unsaturated Pyrrolidines

Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry

J. Org. Chem., 2021, 86, 14199
DOI: 10.1021/acs.joc.1c01133

The integration of flow reactors into synthetic organic chemistry

Ian R. Baxendale

J of Chemical Tech & Biotech, 2013, 88, 519
DOI: 10.1002/jctb.4012