Piezoelectric Materials for Anti-infective Bioapplication

Abstract

Bacterial infection severely limits the effectiveness of biomaterial for tissue repair, posing a major challenge to modern medicine. Despite advances in novel antibiotics and applications for the treatment, challenges remain in clinical practice. To address this issue, biomaterials are engineered to achieve desirable anti-infective performance and compatibility via adjusting surface physicochemical properties. Recently, numerous studies based on piezoelectric materials have been performed in anti-infective and regenerative therapy, but a comprehensive review is still lacking. This article provides a brief overview of the different types of piezoelectric materials and their characteristics. Building on this understanding, it highlights the antibacterial mechanisms including orchestrating electric field and optimizing piezoelectric catalysis, which promote infective tissue regeneration, as well as discusses the anti-infective bioapplication of piezoelectric materials. Furthermore, the exploration concludes with perspectives into the challenges and future research directions of piezoelectric biomaterials.