An efficient synthesis of a small library of potentially bioactive 3,4-dihydro-1H-[1,4]oxazino[4,3-a]indoles is described through the reaction of ethyl 1H-indole-2-carboxylates and activated glycerol carbonate.
This review summarizes the synthetic advancements for the construction of polycyclic fused indole scaffolds from easily accessible indole-2-carboxamide derivatives as a valuable synthetic precursor.
The review highlights the use of Ugi multicomponent reactions and subsequent transformation strategies to create diverse indole frameworks in enantioselective and diastereoselective manner, underscoring their vital importance in medicinal chemistry.
A sustainable electrochemical approach for site-selective C–H mono and bis-chalcogenation (sulfenylation or selenylation) of indolizine frameworks is described.
An efficient N-heterocyclic carbene (NHC)-catalyzed enantioselective [3 + 3] annulation for the synthesis of 2-aryl-2,3-dihydropyrimido[1,2-a]indol-4(1H)-ones in good yields with high to excellent enantioselectivities has been developed.