Direct alteration of unactivated C–H bonds of organic building blocks.
The metal-free C–H functionalisation is providing environmentally benign, cost-effective, sustainable catalytic systems. Comprehensive developments of various metal-free C–H functionalisation reactions are the focal point of this review.
This review presents a comprehensive overview of the synthesis of cyclopropanes using enantioselective Michael Initiated Ring Closure (MIRC) reactions.
This article highlights recent computational research on heme-based carbene transfer reactions. Mechanistic insights reveal how cofactor components, coordination modes, substrates, and protein environments influence reactivity and selectivity.
Variants of the peroxidase YfeX show enhanced carbene transfer reactivity with a variety of substrates, including primary and secondary amines, olefins and indoles.