Synthesis of imidazopyridines via NaIO4/TBHP-promoted (3 + 2) cycloaddition and biological evaluation as anticancer agents

Huiping Luo, Zhengyu Hu, Jihai Shi, Yongxin Lou, Zhonghua Shi, Xin Jin, Jia Chen, Xing Liu and Qiang Huang

RSC Adv., 2025, 15, 15497
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DBU-catalysed cascade nucleophilic addition/cyclization to access 7-nitro (ester) imidazo[1,2-a] pyridin-8-amines

Devendra Nagineni, Abburi Naga Pranathi, Prakash Suman Behera, Manasa Konderpu, Balasubramanian Sridhar and Srinivas Kantevari

Org. Biomol. Chem., 2025, 23, 8920
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2-Chloro-3-cyano-4-nitrobenzyl pyridinium bromide as a potent anti-lung cancer molecule prepared using a single-step solvent-free method

Sadaiyan Govindaraj, Kilivelu Ganesan, Perumal Elumalai, Rajanathadurai Jeevitha, Annadurai Subramani, Mohammed Amanullah and Awad Saeed Al-Samghan

RSC Adv., 2024, 14, 24898
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Kabbe condensation: a comprehensive review of spirochromanone synthesis and medicinal applications

Rashinikumar Samandram, Boopathi Komarasamy, Prasanth Murugan, Prabhakaran Jayaraj, Manohar Vemparala, Abdul Fareed Chaman and Parthiban Anaikutti

RSC Adv., 2026, 16, 13183
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Synthesis of phosphoryl imidazo[1,2-a]pyridines enabled by a molecular I2 catalyzed Gröbcke-Blackburn-Bienaymé reaction

Wen Qin, Lingmeng Xie, Jingru Zou, Xingang Xie and Xing Huo

Tetrahedron, 2025, 185, 134864
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Biological assessment of a novel isoindoline-naphthyridine derivative with anticancer potential in oral squmaous cell carcinoma: In vitro and In silico approach

Jay Bhushan Jawale, Monal Yuwanati, Sambath Baskaran, M. Senthil Murugan and Parthiban Anaikutti

Biochemical and Biophysical Research Communications, 2026, 798, 153236
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Toxicological evaluation of imidazo-based heterocyclic derivatives: In-vitro and in-vivo acute toxicity studies

Sunil Kumar, Ajay Singhal, Pankaj Kumar, Manish Jain, Manpreet Kaur, Ishika Gupta, Deepak B. Salunke and Sandip V. Pawar

Toxicology Reports, 2025, 14, 101872
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Synthetic Strategies of Imidazole Derivatives for Anticancer and Antimicrobial Agents: Comparative Studies

Areej M. Jaber and Mohammed M. Al-Mahadeen

MROC, 2025, 22, 818
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Insights into medicinal attributes of imidazo[1,2‐a]pyridine derivatives as anticancer agents

Ankush Kumar, Vishakha Sharma, Tapan Behl, Subbulakshmi Ganesan, Deepak Nathiya, Monica Gulati, Mohammad Khalid, Gehan M. Elossaily, Sridevi Chigurupati and Monika Sachdeva

Archiv der Pharmazie, 2024, 357
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Green and Sustainable Approaches for the Synthesis of Imidazo[1,2‐a]Pyridines: Advances, Challenges, and Future Perspectives

Deepika Geedkar, Rashmi Sharma, Ashok Kumar and Pratibha Sharma

The Chemical Record, 2026, 26
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Imidazo[1,2‐a]Pyrazine Linked Benzimidazole, Tetrahydropyrimidine, and 1,3,4‐Oxadizoles as Anticancer Agents

Gutti Umamaheswar Rao, Jayaprakash Rao Yerrabelly, Hemasri yerrabelly and Krishna Reddy Valluru

Journal of Heterocyclic Chem, 2026, 63, 60
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Microwave-Assisted Synthesis of Imidazo[1,2-a]Pyridine Derivatives by Three-Component Reaction of Phenyl Glyoxals, 2-Aminopyridines, and Barbituric Acids

Nguyen Thi Chung, Vo Cong Dung and Dau Xuan Duc

LOC, 2026, 23, 116
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Imidazo[1,2-a]pyridines in Medicinal Chemistry: Recent Advances in Synthesis and Biological Activities

Larissa A. P. Ferreira, Lucas Caruso, Nathalia F. Nadur, Daiana P. Franco, Gleyton L. S. Sousa, Renata B. Lacerda and Arthur E. Kümmerle

ACS Omega, 2026, 11, 2348
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Two step synthesis, characterization and anti-bacterial activity of series of dihydroisobenzofuran-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl) pyrazine/pyrimidines

Shabhari Prasad Suggala and Jagadeesh Kumar Ega

Discov. Chem., 2026, 3
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Efficient and Scalable Synthesis of Imidazo[1,2-a]pyridine-8-Carboxamides: a Versatile Methodology

Drashti Shah, Bhargav Bhimani, Ranjitsinh Dabhi, Vidhi Trivedi, Rohit Bhatia, Divy Patel, Kunal Nepali and Ashish Patel

J Pharm Innov, 2026, 21
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Efficient and Environmentally Sustainable Heterogeneous Polystyrene Divinylbenzene-Supported Sulphanilic Acid Catalyst for the Synthesis of Imidazopyridine Derivatives

Sunil B Hiwale

Int J Sci Res Sci & Technol, 2025, 12, 844
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Design, Synthesis, and Anticancer Activity of N‐1 Terminal Segment of α‐(2, 5,7‐Tri‐tert‐butylindol‐3‐yl)alanine‐Incorporated Short Peptides

Rajavenkatesh Krishnamoorthy, Meenakshi Singh, Parthiban Anaikutti, Mahesh Chand Pavar, Esthar Selvaraj, Saravanakumar Rajagopal and Rajendran Babhu Vignesh

ChemistrySelect, 2024, 9
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Isoindolinone Derivatives: Synthesis, In Vitro Anticancer, Antioxidant, and Molecular Docking Studies

Prabhakaran Jayaraj, Rajavenkatesh Krishnamoorthy, Priyanka Adhikari, Meenakshi Singh, Suresh Rajamanickam, Deepika Dhillon, Jayaraman Muthukumaran and Parthiban Anaikutti

ChemistrySelect, 2025, 10
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HFIP-promoted synthesis of imidazo [1,2-a]pyridines containing CF3-substituted tertiary alcohols at room temperature

Juanjuan Gao, Xiaohua Guo, Zhaowen Liu and Yifan Cao

Tetrahedron, 2024, 156, 133943
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Imidazo[1,2‐a]Pyridine Derivatives as Promising Anticancer Agents: Synthesis and Therapeutic Potential

Drashti Shah and Ashish Patel

Archiv der Pharmazie, 2026, 359
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A new chemical mechanism for a one-pot synthesis of imidazo[1,2-a]pyridine scaffold as a pharmaceutical intermediate utilizing a robust UiO-66@Fe2O3 hybrid nanocomposite catalyst

Elahe Kamali Dehkordi, Mohammad Kazemeini and Alireza Mohammadi

Results in Engineering, 2026, 30, 110769
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High-performance NiFe2O4 spinel catalysts: Recyclability and efficiency in multicomponent reactions

Henrique P. Mota, João M. Anghinoni, Emilly C. Silva, Pâmela Macchion, Sabrina S. Ferreira, Jaqueline F. de Souza, Eder J. Lenardão and André R. Fajardo

Journal of Organometallic Chemistry, 2025, 1025, 123478
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Hantzsch reaction: The important key for pyridine/dihydropyridine synthesis

Md Faizan, Rajnish Kumar, Avijit Mazumder, Salahuddin, Neelima Kukreti, Pankaj Kumar Tyagi and Bhupinder Kapoor

Synthetic Communications, 2024, 54, 1221
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Novel 3-aminoimidazole[1,2-α]pyridine/pyrazine analogues: Synthesis and biological evaluation as anticancer agents

Isra’ Al-Qadi, Michel Hanania, Saied M Soliman, Nurul Izzaty Hassan, Wan Nurfadhilah Zaharim, Saki Raheem and Nawaf Al-Maharik

Journal of Molecular Structure, 2025, 1340, 142549
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