Unravelling the prebiotic origins of the simplest α-ketoacids in cometary ices: a computational investigation

Soumya Ranjan Dash, Rinu Pandya, Geetika Singh, Himanshu Sharma, Tamal Das, Hritwik Haldar, Srinivas Hotha and Kumar Vanka

Chem. Commun., 2024, 60, 11283
DOI: 10.1039/D4CC03074E

Viedma deracemization mechanisms in self-assembly processes

Josep M. Ribó, David Hochberg, Thomas Buhse and Jean-Claude Micheau

Phys. Chem. Chem. Phys., 2025, 27, 2516
DOI: 10.1039/D4CP03910F

Stringent selection on kinetics of condensation reactions: early steps in chemical evolution

Pau Capera-Aragones, Kavita Matange, Vahab Rajaei, Yuval Pinter, Anton S Petrov, Loren Dean Williams and Moran Frenkel-Pinter

Phys. Chem. Chem. Phys., 2026, 28, 7292
DOI: 10.1039/D5CP03057A

Natural, modified and conjugated carbohydrates in nucleic acids

Debashis Dhara, Laurence A. Mulard and Marcel Hollenstein

Chem. Soc. Rev., 2025, 54, 2948
DOI: 10.1039/D4CS00799A

The DOPA scaffold: Tracing catechol chemistry from prebiotic earth to cognitive agency

Amal Alachkar

Progress in Biophysics and Molecular Biology, 2025, 198, 71
DOI: 10.1016/j.pbiomolbio.2025.10.004

Can nanozymes achieve more than enzymes?

Shikuan Shao, Cristina-Maria Hirschbiegel, Ethan F. Allan, Samuel V. Somerville, J. Justin Gooding, Vincent M. Rotello and Xiaohu Xia

Nat Rev Mater, 2026, 11, 413
DOI: 10.1038/s41578-026-00898-3

Assembly of Replicating Protocells with Primitive Metabolism

Caner Karabasoglu, Aysenur Saytas, Beril Akgol, Simay Mercimek and O. Duhan Toparlak

Astrobiology, 2026, 26, 227
DOI: 10.1177/15311074261435277

Fundamental Role of N–O Bond-Containing Compounds in Prebiotic Synthesis

Alexey Yu. Sukhorukov

JACS Au, 2025, 5, 2420
DOI: 10.1021/jacsau.5c00334

Nanoclay–Peptide Interfaces Mediate Prebiotic Chemical Evolution in the Origin of Life

Ying Yan, Jianlong Zou, Menghan Yu, Jing Ouyang and Huaming Yang

Nano Lett., 2025, 25, 15714
DOI: 10.1021/acs.nanolett.5c04307

Interactions of Clay Minerals with Biomolecules and Protocells Complex Structures in the Origin of Life: A Review

Ying Yan and Huaming Yang

Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202406210

Infrared spectroscopy of binary nucleobase mixtures: Vibrational fingerprints of intermolecular interactions

Ana L.F. de Barros and Enio Frota da Silveira

Vibrational Spectroscopy, 2026, 143, 103885
DOI: 10.1016/j.vibspec.2026.103885

On the Origin of Information Dynamics in Early Life

Robert A. Gatenby, Jill Gallaher, Hemachander Subramanian, Emma U. Hammarlund and Christopher J. Whelan

Life, 2025, 15, 234
DOI: 10.3390/life15020234

A Magnesium Binding Site And The Anomeric Effect Regulate The Abiotic Redox Chemistry Of Nicotinamide Nucleotides

Lorenzo Sebastianelli, Harpreet Kaur, Ziniu Chen, Ramanarayanan Krishnamurthy and Sheref S. Mansy

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202400411

From Amino Acids to α‐Keto Acids via β‐Elimination and Transamination Initiates a Pathway to Prebiotic Reaction Networks

Louis M.P. Ter‐Ovanessian, Kate L. Ryan, Joshua Shaarda, R. Trent Stubbs, Ramanarayanan Krishnamurthy and Greg Springsteen

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202507248

Modelling the prebiotic origins of regulation and agency in evolving protocell ecologies

Ben Shirt-Ediss, Arián Ferrero-Fernández, Daniele De Martino, Leonardo Bich, Alvaro Moreno and Kepa Ruiz-Mirazo

Phil. Trans. R. Soc. B, 2025, 380
DOI: 10.1098/rstb.2024.0287

From Amino Acids to α‐Keto Acids via β‐Elimination and Transamination Initiates a Pathway to Prebiotic Reaction Networks

Louis M.P. Ter‐Ovanessian, Kate L. Ryan, Joshua Shaarda, R. Trent Stubbs, Ramanarayanan Krishnamurthy and Greg Springsteen

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202507248

Catalyst‐Free Ammonia Formation at the Gas‐Liquid Interface Enables Selective Nitrogen‐Saccharide Association Under Abiotic Conditions

Shanshan Ma, Bo Sui, Hang Yuan, Ajuan Yu, Guobi Chai, Shusheng Zhang, Hongtu Zhang, Shihao Sun and Wuduo Zhao

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202524389

The Origin of Life and Cellular Systems: A Continuum from Prebiotic Chemistry to Biodiversity

Jaime Gómez-Márquez

Life, 2025, 15, 1745
DOI: 10.3390/life15111745

Organocatalyzed bottom-up formation of protocells

Marian Simon Rafael Ebeling, Otto Berninghausen, Khang Hoang Nguyen, Roland Beckmann and Oliver Trapp

Nat Commun, 2026, 17
DOI: 10.1038/s41467-026-69597-5

Carbon‐ and Nitrogen‐Based Complexes as Photocatalysts for Prebiotic and Oxygen Chemistry during Earth Evolution

Yan Wang, Huan Wang, Sibo Wang and Yuanxing Fang

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202413768

Reciprocating thermochemical mediator of pre-biotic polymer decomposition on mineral surfaces

Rowena Ball and John Brindley

J. R. Soc. Interface., 2025, 22
DOI: 10.1098/rsif.2024.0492

A Photo‐Switchable Peptide Fibril Esterase

Mousumi Samanta, Noy Saad, Dinghao Wu, Niek S. A. Crone, Karina Abramov‐Harpaz, Clil Regev, Rivka Cohen‐Luria, Aimee L. Boyle, Yifat Miller, Alexander Kros and Gonen Ashkenasy

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202413810

Organic Reactivity Matters for the Emergence of Life: Kinetic Barriers and Molecular Diversity Are Suggested as Crucial Factors by Emerging Autonomous System Models

Robert Pascal

ChemSystemsChem, 2025, 7
DOI: 10.1002/syst.202400096

Before LUCA: unearthing the chemical roots of metabolism

Pablo Carbonell and Juli Peretó

Phil. Trans. R. Soc. B, 2025, 380
DOI: 10.1098/rstb.2024.0292

Copper‐Catalyzed Direct Amidation of Carboxylic Acids and Anilines via CS2 Activation

Pinyong Zhong, Hao Chen, Xin Huang and Jin‐Biao Liu

Applied Organom Chemis, 2026, 40
DOI: 10.1002/aoc.70580

Prebiotic Gels as the Cradle of Life

Ramona Khanum, Nirmell Satthiyasilan, Navaniswaran Tharumen, Terence P. Kee, Christian Mayer, P. Susthitha Menon, Tony Z. Jia and Kuhan Chandru

ChemSystemsChem, 2026, 8
DOI: 10.1002/syst.202500038

Chemistry of the origins of life: how prebiotic chemistry can be approached by computational quantum methods

Ana Luiza Quilici, Marcelo V. P. De Sousa and Ataualpa A. C. Braga

Front. Astron. Space Sci., 2026, 13
DOI: 10.3389/fspas.2026.1736181

New chemicals fuel the evolution of microbial biodegradation

Lawrence P. Wackett and Jan Roelof van der Meer

Microbiol Mol Biol Rev, 2025, 89
DOI: 10.1128/mmbr.00207-24

Biological Information as Conformally Invariant Topological Data: A Cyclic Cosmology Solution to Initial Condition Fine-Tuning in Prebiotic Chemistry

Javier Burgos-Salcedo

ejtas, 2026, 4, 50
DOI: 10.59324/ejtas.2026.4(2).05

How Droplets Can Accelerate Reactions─Coacervate Protocells as Catalytic Microcompartments

Iris B. A. Smokers, Brent S. Visser, Annemiek D. Slootbeek, Wilhelm T. S. Huck and Evan Spruijt

Acc. Chem. Res., 2024, 57, 1885
DOI: 10.1021/acs.accounts.4c00114

On the Emergence of Autonomous Chemical Systems through Dissipation Kinetics

Addy Pross and Robert Pascal

Life, 2023, 13, 2171
DOI: 10.3390/life13112171

Abiotic CO2 reduction promoted by carbonate and phyllosilicate minerals on the primitive seafloor

Yuan Zhong, Ning Zhang, Daoming Huan, Jingxiang Low, Isabelle Daniel, H. James Cleaves, Chao Zhang, Yamei Li, Yawen Jiang, Xinyu Wang, Christopher R. Glein, Jiawei Li, Yu Bai, Yaping Li, Fang Huang, Liping Qin, Andrew H. Knoll, Jihua Hao, Ran Long and Yujie Xiong

Nat Commun, 2026, 17
DOI: 10.1038/s41467-026-71130-7

Cross‐Catalysis and Weak Interactions: Keys to the Chiral Polarization of the Biosphere

Sergey V. Stovbun, Aleksey A. Skoblin and Dmitry V. Zlenko

Chirality, 2025, 37
DOI: 10.1002/chir.70051

The Pyruvate–Glyoxalate Pathway as a Toxicity Assessment Tool of Xenobiotics: Lessons from Prebiotic Chemistry

François Gagné and Chantale André

JoX, 2025, 15, 198
DOI: 10.3390/jox15060198

Bistable Functions and Signaling Motifs in Systems Chemistry: Taking the Next Step Toward Synthetic Cells

Indrajit Maity, Nathaniel Wagner, Dharm Dev and Gonen Ashkenasy

Acc. Chem. Res., 2025, 58, 428
DOI: 10.1021/acs.accounts.4c00703

A Prebiotic Route to Lactate from Acetaldehyde, Cyanide and Carbon Dioxide

Shriaya Sharma, Yang Yang and Ji‐Woong Lee

Chemistry A European J, 2025, 31
DOI: 10.1002/chem.202403763

An irreversible thermodynamic model of prebiological dissipative molecular structures inside vacuoles at the surface of the Archean Ocean

Jorge A. Montemayor-Aldrete, José Manuel Nieto-Villar, Carlos J. Villagómez and Rafael F. Márquez-Caballé

BioSystems, 2025, 247, 105379
DOI: 10.1016/j.biosystems.2024.105379

Intelligence, from Origins to Human Culture: An Eco-Evolutionary Perspective

Ken Richardson

Human Development, 2025, 1
DOI: 10.1159/000547754

Reactions Driven by Primitive Nonbiological Polyesters

Arunava Poddar, Nirmell Satthiyasilan, Po-Hsiang Wang, Chen Chen, Ruiqin Yi, Kuhan Chandru and Tony Z. Jia

Acc. Chem. Res., 2024, 57, 2048
DOI: 10.1021/acs.accounts.4c00167

Carbon‐ and Nitrogen‐Based Complexes as Photocatalysts for Prebiotic and Oxygen Chemistry during Earth Evolution

Yan Wang, Huan Wang, Sibo Wang and Yuanxing Fang

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202413768

Chemistry of the Joint Origin and Evolution of Life, Death, and Aging

Aleksei G. Golubev

Biochemistry Moscow, 2025, 90, 1188
DOI: 10.1134/S0006297925601674

Catalyst‐Free Ammonia Formation at the Gas‐Liquid Interface Enables Selective Nitrogen‐Saccharide Association Under Abiotic Conditions

Shanshan Ma, Bo Sui, Hang Yuan, Ajuan Yu, Guobi Chai, Shusheng Zhang, Hongtu Zhang, Shihao Sun and Wuduo Zhao

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202524389

Kinetic Resolution as a General Approach to Enantioenrichment in Prebiotic Chemistry

Min Deng, Jinhan Yu and Donna G. Blackmond

Acc. Chem. Res., 2024, 57, 2234
DOI: 10.1021/acs.accounts.4c00135

The borderlands of foldability: lessons from simplified proteins

Koh Seya, Alfie-Louise R. Brownless, Shina C.L. Kamerlin and Liam M. Longo

Trends in Chemistry, 2026, 8, 362
DOI: 10.1016/j.trechm.2026.03.001

A Photo‐Switchable Peptide Fibril Esterase

Mousumi Samanta, Noy Saad, Dinghao Wu, Niek S. A. Crone, Karina Abramov‐Harpaz, Clil Regev, Rivka Cohen‐Luria, Aimee L. Boyle, Yifat Miller, Alexander Kros and Gonen Ashkenasy

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202413810

Multicomponent Synthesis of C(8)‐Substituted Purine Building Blocks of Peptide Nucleic Acids from Prebiotic Compounds

Eleonora Mancin, Eliana Capecchi, Lorenzo Botta and Bruno Mattia Bizzarri

ChemistryOpen, 2024, 13
DOI: 10.1002/open.202400265