Facile synthesis and eco-friendly analytical methods for concurrent estimation of selected pharmaceutical drugs in their solutions: application to quality by design, lean six sigma, and stability studies

Nada S. Al-Kadhi, Mahmoud A. Mohamed, Hoda A. Ahmed and Hossam F. Nassar

BMC Chemistry, 2023, 17
DOI: 10.1186/s13065-023-01028-8

Development of a robust and reliable reverse-phase high-performance liquid chromatography (RP-HPLC) method using analytical quality by design principles for the accurate determination of esculin in its bulk form

Sarvesh Patil, Anjana Adhyapak, Priya Shetti and Rohan Gurao

Futur J Pharm Sci, 2023, 9
DOI: 10.1186/s43094-023-00524-x

Recent approaches in green liquid chromatography for pharmaceutical analysis: A comprehensive review on green analytical sustainable chemistry

Sachin D. Patil, Shreya R. Karode, Neha R. Kolate and Tanay M. Korde

Sustainable Chemistry One World, 2025, 6, 100069
DOI: 10.1016/j.scowo.2025.100069

Green RP-HPLC method for the estimation of carfilzomib in bulk, protein nanocarriers and human plasma: Application of chemometrics and Monte-Carlo simulations

Drishti Panjwani, Asha Patel, Deepak Mishra, Shruti Patel, Viral Patel, Mange Ram Yadav and Bhupinder Singh

Journal of Chromatography B, 2024, 1249, 124350
DOI: 10.1016/j.jchromb.2024.124350

Advances in green liquid chromatography for pharmaceutical analysis: A comprehensive review on analytical greenness to sustainable chemistry approaches

Mahmood Ahmed, Abdullah, Eisha Eiman, Khairia Mohammed Al-Ahmary, Fatima Aftab, Aamir Sohail, Hussain Raza and Ijaz Ali

Microchemical Journal, 2024, 205, 111400
DOI: 10.1016/j.microc.2024.111400

A Rapid and Sensitive UHPLC–MS/MS Method for Determination of Chlorogenic Acid and Its Application to Distribution and Neuroprotection in Rat Brain

Chongfei Bai, Xiaogang Zhou, Lu Yu, Anguo Wu, Le Yang, Jianping Chen, Xue Tang, Wenjun Zou, Jianming Wu and Linjie Zhu

Pharmaceuticals, 2023, 16, 178
DOI: 10.3390/ph16020178

Development of an aqueous kinetic spectrophotometric method for the analysis of lacosamide optimized through Taguchi and Box-Behnken design; A comparative green assessment

Abdullah Mannan and Mohammad Kashif

Green Analytical Chemistry, 2025, 12, 100198
DOI: 10.1016/j.greeac.2024.100198

Analytical assessment of a novel RP-HPLC method for the concurrent quantification of selected pharmaceutical drugs levodopa and carbidopa using eight greenness metrics comparing to the lean six sigma approach

Samar M. Mahgoub, M. Ramadan Mahmoud, Ammena Y. Binsaleh, Manal A. Almalki, Mahmoud A. Mohamed and Hossam F. Nassar

Sustainable Chemistry and Pharmacy, 2023, 36, 101291
DOI: 10.1016/j.scp.2023.101291

Advancing Green Chemistry in Antiviral Therapeutics: A Comprehensive Review

Kanderi Archana and Sumithra Mani

CDRR, 2025, 17, 10
DOI: 10.2174/0125899775309331240607105830

Development and Validation of a Stability Indicating RP-HPLC Method for the Estimation of Deferiprone in its Capsule Dosage Form

Bharti S Fegade, Aishwarya S. Mhatre, Vijay K. Munipalli, Hemant P Magar, Pankaj P Thakur, Ashok Kumar and Vaidun Bhaskar

RJPT, 2024, 2725
DOI: 10.52711/0974-360X.2024.00427

Molecularly imprinted micro-extraction of pharmaceuticals in biological samples

Ahmed Isa, Seyda Nur Samanci, Pinar Kocabay, Ahmet Cetinkaya, S. Irem Kaya and Sibel A. Ozkan

Microchemical Journal, 2025, 212, 113530
DOI: 10.1016/j.microc.2025.113530

Green metric tools for analytical methods assessment critical review, case studies and crucify

Leela Prasad Kowtharapu, Naresh Kumar Katari, Siva Krishna Muchakayala and Vishnu Murthy Marisetti

TrAC Trends in Analytical Chemistry, 2023, 166, 117196
DOI: 10.1016/j.trac.2023.117196

Implementation of green analytical principles to develop and validate the HPLC method for the separation and identification of degradation products of Panobinostat, and its characterization by using LC-QTOF-MS/MS and its in-silico toxicity prediction using ADMET software

Vijay Nayak Bhukya and Durga Prasad Beda

Green Analytical Chemistry, 2024, 8, 100090
DOI: 10.1016/j.greeac.2023.100090

AQbD TLC-densitometric method approach along with green fingerprint and whiteness assessment for quantifying two combined antihypertensive agents and their impurities

Hend M. Nagieb, Nada S. Abdelwahab, Maha M. Abdelrahman, Hala E. Zaazaa and Nermine S. Ghoniem

BMC Chemistry, 2024, 18
DOI: 10.1186/s13065-024-01125-2

LIQUID CHROMATOGRAPHY DEPENDENT STABILITY INDICATING METHODOLOGY: DEVELOPMENT AND AUTHENTICATION FOR FORMULATIONS OF CAPSULE TYPE CONTAINING TEGAFUR, GIMERACIL, AND OTERACIL

MAILAMURI HARITHA KUMARI, BALA MURALI KRISHNA KHANDAPU and RUDRARAJU RAMESH RAJU

Int J App Pharm, 2023, 71
DOI: 10.22159/ijap.2023v15i4.47831

A Highly Sensitive Green Analytical UHPLC-MS/MS Method for the Quantification of Trace Level of N-Nitroso Meglumine Impurity in Tafamidis Meglumine Applying the Quality by Design

G. Raghuvaran and Shobha Rani Satla

ajc, 2025, 37, 1949
DOI: 10.14233/ajchem.2025.33582

Application of Plackett–Burman Design for Spectrochemical Determination of the Last-Resort Antibiotic, Tigecycline, in Pure Form and in Pharmaceuticals: Investigation of Thermodynamics and Kinetics

Ahmed S. El-Shafie, Aseel Yousef and Marwa El-Azazy

Pharmaceuticals, 2022, 15, 888
DOI: 10.3390/ph15070888

Integrating green analytical chemistry and analytical quality by design: an innovative approach for RP-UPLC method development of ensifentrine in bulk and inhalation formulations

Mohan Goud Vanga, Sarad Pawar Naik Bukke, Praveen Kumar Kusuma, Bayapa Reddy Narapureddy and Chandrashekar Thalluri

BMC Chemistry, 2025, 19
DOI: 10.1186/s13065-025-01448-8

Screening of variables affecting the selective leaching of valuable metals from waste motherboards’ PCBs

Vahid Rahimi, Emilio Antonio Inzulza-Moraga, Diego Gómez-Díaz, María Sonia Freire and Julia González-Álvarez

Environ Sci Pollut Res, 2024
DOI: 10.1007/s11356-024-32793-1

Development of a gradient method for sulfamethoxazole, trimethoprim, isoniazid, and pyridoxine hydrochloride in rabbit plasma through QbD-driven investigation

Premsagar K M, Bhagyalakshmi C, Piyong Sola, Akramul Ansary, Tridib Kumar Das, T. Yunus Pasha, Koushik Nandan Dutta, Ramesh B and Manish Majumder

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-77062-w

Green chemistry-driven RP-HPLC method for diltiazem and lidocaine hydrochloride in bulk and gel formulations using AQbD

Shivam Kumar, Neha Singh, Sourabh Satapathy, Kuladip Barman, Balak Das Kurmi and Preeti Patel

Accred Qual Assur, 2025
DOI: 10.1007/s00769-025-01661-x

Current green capillary electrophoresis and liquid chromatography methods for analysis of pharmaceutical and biomedical samples (2019–2023) – A review

Timotej Jankech, Ivana Gerhardtova, Ondrej Stefanik, Petra Chalova, Josef Jampilek, Petra Majerova, Andrej Kovac and Juraj Piestansky

Analytica Chimica Acta, 2024, 1323, 342889
DOI: 10.1016/j.aca.2024.342889

QUALITY BY DESIGN APPROACH IN HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS DETERMINATION OF ABIRATERONE ACETATE AND PREDNISOLONE WITH GREENNESS ASSESSMENT

Priya Jagtap, Dr. Reshma Jadhav, Dr. Ashish Jain, Bhavesh Mahajan, Prapti Gawand, Prathamesh Chaudhari and Aishwarya Patil

Prospect. Pharm. Sci., 2025
DOI: 10.56782/pps.369

Development and Validation of a UHPLC–MS/MS Method for the Quantification of a Novel PYGB Inhibitor in Plasma: Application to Pharmacokinetic Studies

Sumei Xu, Shuai Li, Zhiwei Yan, Youde Wang and Liying Zhang

Molecules, 2023, 28, 6995
DOI: 10.3390/molecules28196995

DIFFUSE REFLECTANCE INFRARED FOURIER TRANSFORM SPECTROSCOPIC METHOD FOR ESTIMATION OF NERATINIB IN PHARMACEUTICALS: APPLICATION TO ANALYTICAL QUALITY BY DESIGN AND GREENNESS ASSESSMENT

Sagar S. Panda, Aman Kumar and Ravi K.V.V. Bera

IND. DRU., 2024, 61, 30
DOI: 10.53879/id.61.03.13870

A brief review on application of design of experiment for the analysis of pharmaceuticals using HPLC

Sachin D. Patil and Shailesh S. Chalikwar

Annales Pharmaceutiques Françaises, 2024, 82, 203
DOI: 10.1016/j.pharma.2023.12.011

High‐performance thin layer chromatographic method development and validation for simultaneous estimation of solifenacin succinate and silodosin using quality by design approach and greenness assessment

Sandesh Lodha, Arya Pillai, Gajanan Kalyankar, Praful Dedhiya, Shrikant Joshi, Shailesh Shah and Dinesh Shah

Separation Science Plus, 2024, 7
DOI: 10.1002/sscp.202300178

Combined green analytical principles and quality by design for ultraperformance liquid chromatography analytical method development, the characterization and in-silico toxicity prediction of Ixazomib degradation products using mass spectrometry

Vijay Nayak Bhukya, Durga Prasad Beda, Kumar Shiva Gubbiyappa and Raghuveer Pathuri

Green Analytical Chemistry, 2024, 8, 100105
DOI: 10.1016/j.greeac.2024.100105

Green analytical chemistry metrics for evaluating the greenness of analytical procedures

Lei Yin, Luyao Yu, Yingxia Guo, Chuya Wang, Yuncheng Ge, Xinyue Zheng, Ning Zhang, Jiansong You, Yong Zhang and Meiyun Shi

Journal of Pharmaceutical Analysis, 2024, 14, 101013
DOI: 10.1016/j.jpha.2024.101013

Sustainable HPLC technique for measurement of antidiabetic drugs: Appraisal of green and white metrics, content uniformity, andin vitrodissolution

Asma S. Al-Wasidi, Hoda A. Ahmed, Samar M. Mahgoub, Mahmoud A. Mohamed and Hossam F. Nassar

Reviews in Analytical Chemistry, 2024, 43
DOI: 10.1515/revac-2023-0075

Analytical Quality by Design (AQbD) Principles in Development and Validation of Stability‐Indicating RP‐HPLC Method for Simultaneous Estimation of Diltiazem HCl and Eugenol in Nanoethosomes

Purva Usgaonkar, Anjana Adhyapak and Rahul Koli

Separation Science Plus, 2024, 7
DOI: 10.1002/sscp.202400155

Investigating the stability of a cerebral vasodilator drug using chromatographic methods: Evaluation of methods’ practicality and environmental aspects

Amal M. Al-Mohaimeed, Maha F. El-Tohamy, Mohamed G.H. Ali, Neven M. Habib, Nada S. Abdelwahab, Maha M. Abdelrahman, Hamada M. Mahmoud and Aml A. Emam

Journal of Chromatography B, 2024, 1249, 124371
DOI: 10.1016/j.jchromb.2024.124371

Efficient integration of analytical quality-by-design and tri-hued HPLC-DAD approach for synchronized assessment of gemigliptin and rosuvastatin in their fixed-dose pills: Application to stability study

Sara M. Mohyeldin, Hoda G. Daabees, Wael Talaat and Miranda F. Kamal

Sustainable Chemistry and Pharmacy, 2024, 42, 101777
DOI: 10.1016/j.scp.2024.101777

A quality by design HPLC method for cephalosporin analysis in pharmaceuticals and water samples with environmental impact assessment

Ali Alqahtani, Taha Alqahtani, Adel Al Fatease and Enas H. Tolba

Sci Rep, 2025, 15
DOI: 10.1038/s41598-024-84647-y

Green liquid chromatographic method for simultaneous determination of metformin, linagliptin and rivaroxaban: Tablet manufacturing and application to in-vitro dissolution studies

Irshad Alam, Saeeda Nadir Ali, Amtul Qayoom, Rehana Bibi, Muzna Aqeel and Haji Muhammad

Microchemical Journal, 2023, 193, 109025
DOI: 10.1016/j.microc.2023.109025

Navigating the AQbD Landscape: Enhancing Quality Management in Liquid Chromatography Method Development

Selvakumar Kanthiah, J. Joysa Ruby, Hiriyanna SGB and Valliappan Kannappan

Biomedical Chromatography, 2025, 39
DOI: 10.1002/bmc.70031