Harnessing biological insights to accelerate drug discovery against ESKAPE pathogens

Tashi Palmo, Vishwani Jamwal, Diksha Kumari and Kuljit Singh

RSC Med. Chem., 2026
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6-Aryl- and 6,7-diaryl-1,3-dimethyl-1H-perimidin-2(3H)-ones: synthesis, conformational stability, crystal structure and optical properties

Andrey L. Dyatlov, Ekaterina A. Filatova, Alexander F. Pozharskii, Sergey S. Marchenko, Oleg P. Demidov, Anatoly V. Chernyshev, Anatoly V. Metelitsa, Sergei S. Brig, Michael G. Medvedev, Danis R. Bekmansurov, Pavel G. Morozov and Anna V. Gulevskaya

Org. Biomol. Chem., 2025, 23, 948
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Synthesis, conformational stability and molecular structure of 4-aryl- and 4,5-diaryl-1,8-bis(dimethylamino)naphthalenes

Ekaterina A. Filatova, Eugeny A. Ermolenko, Alexander F. Pozharskii, Valery A. Ozeryanskii, Oleg P. Demidov, Anatoly V. Chernyshev, Anatoly V. Metelitsa and Anna V. Gulevskaya

Org. Biomol. Chem., 2023, 21, 3388
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Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity

Natalia Skrzypczak, Adam Buczkowski, Wiktor Bohusz, Ewelina Nowak, Klaudia Tokarska, Aleksandra Leśniewska, Attaa Mohammed Alzebari, Piotr Ruszkowski, Maria Gdaniec, Franz Bartl and Piotr Przybylski

European Journal of Medicinal Chemistry, 2023, 256, 115450
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Geldanamycin, a Naturally Occurring Inhibitor of Hsp90 and a Lead Compound for Medicinal Chemistry

Russell R. A. Kitson, Dominika Kitsonová, David Siegel, David Ross and Christopher J. Moody

J. Med. Chem., 2024, 67, 17946
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Therapeutic Potential of Heat Shock Protein 90 Inhibitors, Geldanamycin, and Analog Compounds in Precision Cancer Therapy

Atta Mohammed Alzebari, Amjad Mahmood Qadir, Mahmood Sherzad Rafaat and Abbas Salihi

Bio. Med. Tar. Jour., 2023, 1, 2
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Iron‐catalyzed intermolecular and intramolecular cyclization reactions of N‐heterocycles

Jyoti Kaushik, Sonika Jain, Dharma Kishore and Jaya Dwivedi

Journal of Heterocyclic Chem, 2024, 61, 875
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Flavin-Dependent Monooxygenase Kmy13 Mediates Formation of the Carbocyclic ansa System during Kendomycin B Biosynthesis

Jiang Chen, Hongjie Zhu, Ming Peng, Shanwen Zhang, Qinglian Li, Yu-Cheng Gu and Jianhua Ju

J. Am. Chem. Soc., 2024
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Natural occurrence, bioactivity, and biosynthesis of triene-ansamycins

Xingchi Yang, Wei Wu, Hongji Li, Mengxue Zhang, Zhiyong Chu, Xiaobo Wang and Peng Sun

European Journal of Medicinal Chemistry, 2022, 244, 114815
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Therapy resistance: Modulating evolutionarily conserved heat shock protein machinery in cancer

Ilona Skrabalak, Alicja Rajtak, Beata Malachowska, Natalia Skrzypczak, Karin A. Skalina, Chandan Guha, Jan Kotarski and Karolina Okla

Cancer Letters, 2025, 616, 217571
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Genomic and Metabolic Profiling of the Endophytic Streptomyces hygroscopicus OsiSh-2 for Protective Bacterial Chemistry

Jun Wu, Haiming Xu, Xiaotong Yang, Yonghua Zhu, Mohamed Ali Farag and Zhiwei Qin

J. Agric. Food Chem., 2025, 73, 31373
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Cascade Transformation of the Ansamycin Benzoquinone Core into Benzoxazole Influencing Anticancer Activity and Selectivity

Natalia Skrzypczak, Krystian Pyta, Wiktor Bohusz, Aleksandra Leśniewska, Maria Gdaniec, Piotr Ruszkowski, Wojciech Schilf, Franz Bartl and Piotr Przybylski

J. Org. Chem., 2023, 88, 9469
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Recent Insights on Synthetic Methods and Pharmacological Potential in Relation with Structure of Benzothiazoles

Ranjeet Kumar Yadav, Rajnish Kumar, Himanshu Singh, Avijit Mazumdar, Salahuddin, Bharti Chauhan and Mohd. Mustaqeem Abdullah

MC, 2023, 19, 325
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Effects of Low and High Doses of Deoxynivalenol on Growth Performance, Blood Biochemistry, Histology, Metabolites, and Microbial Community in Adult Rats

Jinyoung Jeong, Junsik Kim, Boram Lee, Cheolju Park and Minseok Kim

Biology, 2025, 14, 429
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Total Synthesis of (+)-Ansatrienol K

Gang Sheng, Zhong Wan, Hui Li, Yuan Zhao, Jun Ma, Peng Zhao, Hong-Dong Hao, Li Ren and Jin-Ming Gao

J. Org. Chem., 2025, 90, 6605
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Iron-catalyzed synthesis of N-heterocycles via intermolecular and intramolecular cyclization reactions: A review

Maria Sohail, Muhammad Bilal, Tahir Maqbool, Nasir Rasool, Muhammad Ammar, Sajid Mahmood, Ayesha Malik, Muhammad Zubair and Ghulam Abbas Ashraf

Arabian Journal of Chemistry, 2022, 15, 104095
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α-Glucosidase Inhibitors from Two Mangrove-Derived Actinomycetes

Xuejun Lu, Manlai Zhang, Yixian Qiu, Xiuxiu Liu, Cancan Wang, Jianwei Chen, Huawei Zhang, Bin Wei, Yanlei Yu, Youmin Ying, Kui Hong and Hong Wang

Molecules, 2023, 28, 3822
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Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems

Jiaxin Yao, Pengfei Zou, Yanan Cui, Liangzhu Quan, Chunsheng Gao, Zhiping Li, Wei Gong and Meiyan Yang

Pharmaceutics, 2023, 15, 1188
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Genome Mining Reveals Rifamycin Biosynthesis in a Taklamakan Desert Actinomycete

Xinrong Luo, Zhanwen Liu, Xiaoxia Luo, Zhanfeng Xia, Chuanxing Wan, Haoxin Wang and Lili Zhang

Microorganisms, 2025, 13, 1068
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Evaluation of prokaryotic and eukaryotic microbial communities on microplastic‐associated biofilms in marine and freshwater environments

Şuheda Reisoglu, Ceren Cati, Meral Yurtsever and Sevcan Aydin

Engineering in Life Sciences, 2024, 24
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Functionalization of Chlorotonils: Dehalogenil as Promising Lead Compound for In Vivo Application

Walter Hofer, Felix Deschner, Gwenaëlle Jézéquel, Laìs Pessanha de Carvalho, Noran Abdel‐Wadood, Linda Pätzold, Steffen Bernecker, Bernd Morgenstern, Andreas M. Kany, Miriam Große, Marc Stadler, Markus Bischoff, Anna K. H. Hirsch, Jana Held, Jennifer Herrmann and Rolf Müller

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Undescribed ansatrienin analogs from Streptomyces flaveolus including two N-acetylcysteine conjugates

Xiaofan Zhu, Xiaomei Wu, Hongji Li, Mengxue Zhang, Dunning Yu, Zijun Wang, Qianfei Huang, Zhiyong Chu and Peng Sun

Phytochemistry, 2025, 239, 114598
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Recent progress toward developing axial chirality bioactive compounds

Zheyi Wang, Liying Meng, Xinxin Liu, Lingzi Zhang, Zongjiang Yu and Guanzhao Wu

European Journal of Medicinal Chemistry, 2022, 243, 114700
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New Hygrocins K–U and Streptophenylpropanamide A and Bioactive Compounds from the Marine-Associated Streptomyces sp. ZZ1956

Wenwen Yi, Asif Wares Newaz, Kuo Yong, Mingzhu Ma, Xiao-Yuan Lian and Zhizhen Zhang

Antibiotics, 2022, 11, 1455
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Funktionalisierung von Chlorotonilen: Dehalogenil als vielversprechende Leitverbindung für die in vivo‐Anwendung

Walter Hofer, Felix Deschner, Gwenaëlle Jézéquel, Laìs Pessanha de Carvalho, Noran Abdel‐Wadood, Linda Pätzold, Steffen Bernecker, Bernd Morgenstern, Andreas M. Kany, Miriam Große, Marc Stadler, Markus Bischoff, Anna K. H. Hirsch, Jana Held, Jennifer Herrmann and Rolf Müller

Angewandte Chemie, 2024, 136
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New insights into the anticancer therapeutic potential of maytansine and its derivatives

Sameen Zafar, Muhammad Armaghan, Khushbukhat Khan, Nazia Hassan, Javad Sharifi-Rad, Solomon Habtemariam, Marek Kieliszek, Monica Butnariu, Iulia-Cristina Bagiu, Radu Vasile Bagiu and William C. Cho

Biomedicine & Pharmacotherapy, 2023, 165, 115039
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Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma

Meng-Jiao Li, Rui Zhang, Almutamad Sheikho, Jiang-jiang Tang, Yu-qi Gao, Wei-wei Huang and Jin-ming Gao

International Journal of Biological Macromolecules, 2025, 328, 147547
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Review on anticancer activity of flavonoid derivatives: Recent developments and future perspectives

Mani Rajasekar, Palanisamy Bhuvanesh, Pramod Varada and Masilamani Selvam

Results in Chemistry, 2023, 6, 101059
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Design and synthesis of cyclotriphosphazene derivatives bearing hydroxyflavone groups: Antioxidant properties and cytotoxic effects in breast cancer cells

İbrahim Kitmür, Elif Şenkuytu, Seda Mesci, Tuba Yıldırım and Gönül Yenilmez Çiftçi

Journal of Molecular Structure, 2026, 1350, 143993
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Trienomycin A-simplified analogs: Synthesis and anti-neuroinflammatory activity

Yu-Qing Luo, Zhao-Yuan Bian, Dan-Dan Xu, Jiang-Jiang Tang and Jin-Ming Gao

Bioorganic & Medicinal Chemistry Letters, 2023, 80, 129122
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