Transdermal on-demand drug delivery based on an iontophoretic hollow microneedle array system

Usanee Detamornrat, Marc Parrilla, Juan Domínguez-Robles, Qonita Kurnia Anjani, Eneko Larrañeta, Karolien De Wael and Ryan F. Donnelly

Lab Chip, 2023, 23, 2304
DOI: 10.1039/D3LC00160A

Advances in biomedical systems based on microneedles: design, fabrication, and application

Xinghao Wang, Zifeng Wang, Min Xiao, Zhanhong Li and Zhigang Zhu

Biomater. Sci., 2024, 12, 530
DOI: 10.1039/D3BM01551C

Dissolvable microarray patches of levodopa and carbidopa for Parkinson’s disease management

Qonita Kurnia Anjani, Natalia Moreno-Castellanos, Yaocun Li, Akmal Hidayat Bin Sabri and Ryan F. Donnelly

European Journal of Pharmaceutics and Biopharmaceutics, 2024, 199, 114304
DOI: 10.1016/j.ejpb.2024.114304

A Bilayer Microarray Patch (MAP) for HIV Pre-Exposure Prophylaxis: The Role of MAP Designs and Formulation Composition in Enhancing Long-Acting Drug Delivery

Lalitkumar K. Vora, Ismaiel A. Tekko, Fabiana Volpe Zanutto, Akmal Sabri, Robert K. M. Choy, Jessica Mistilis, Priscilla Kwarteng, Courtney Jarrahian, Helen O. McCarthy and Ryan F. Donnelly

Pharmaceutics, 2024, 16, 142
DOI: 10.3390/pharmaceutics16010142

Double-layer dissolving microneedles for delivery of mesenchymal stem cell Secretome: Formulation, characterisation and skin irritation study

Avelia Devina Calista Nainggolan, Pietradewi Hartrianti, Qonita Kurnia Anjani, Ryan F. Donnelly, Agus Budiawan Naro Putra, Katherine Kho, Arief Kurniawan, Rr. Kirana Andranilla, Shereen Angelina Rattu and Delly Ramadon

European Journal of Pharmaceutics and Biopharmaceutics, 2024, 204, 114495
DOI: 10.1016/j.ejpb.2024.114495

Determination of vat-photopolymerization parameters for microneedles fabrication and characterization of HPMC/PVP K90 dissolving microneedles utilizing 3D-printed mold

Baramee Chanabodeechalermrung, Tanpong Chaiwarit, Suruk Udomsom, Pornchai Rachtanapun, Promporn Piboon and Pensak Jantrawut

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-67243-y

PowderInjector microneedles: smart cavity microneedles as a novel intradermal delivery system for high doses of niacinamide

Abraham M. Abraham, Oluwamayowa Emmanuella Afolabi, Qonita Kurnia Anjani and Ryan F. Donnelly

International Journal of Pharmaceutics, 2025, 683, 125992
DOI: 10.1016/j.ijpharm.2025.125992

Tip loaded cyclodextrin-carvedilol complexes microarray patches

Qonita Kurnia Anjani, Akmal Hidayat Bin Sabri, Khuriah Abdul Hamid, Natalia Moreno-Castellanos, Huanhuan Li and Ryan F. Donnelly

Carbohydrate Polymers, 2023, 320, 121194
DOI: 10.1016/j.carbpol.2023.121194

Microneedle-Mediated Transdermal Delivery of Genetic Materials, Stem Cells, and Secretome: An Update and Progression

Avelia Devina Calista Nainggolan, Qonita Kurnia Anjani, Pietradewi Hartrianti, Ryan F. Donnelly, Arief Kurniawan and Delly Ramadon

Pharmaceutics, 2023, 15, 2767
DOI: 10.3390/pharmaceutics15122767

MAP-box: a novel, low-cost and easy-to-fabricate 3D-printed box for the storage and transportation of dissolving microneedle array patches

Qonita Kurnia Anjani, Álvaro Cárcamo-Martínez, Luki Ahmadi Hari Wardoyo, Natalia Moreno-Castellanos, Akmal Hidayat Bin Sabri, Eneko Larrañeta and Ryan F. Donnelly

Drug Deliv. and Transl. Res., 2024, 14, 208
DOI: 10.1007/s13346-023-01393-w

Polymeric microarray patches for transdermal delivery of amodiaquine and artesunate: A novel strategy against Plasmodium falciparum

Qonita Kurnia Anjani, Fabiana Volpe-Zanuto, Andang Miatmoko, Natalia Moreno-Castellanos, Janaina Tenorio Novais, Xiomara A. Gaitán, Berlian Sarasitha Hariawan, Devy Maulidya Cahyani, Rifda Tarimi Octavia, Ahmad Shahrul Mubarok, Wiwit Ananda Wahyu Setyaningsih, Callum Johnston, Daniel Y. Bargieri and Ryan F. Donnelly

Materials Today Bio, 2025, 35, 102500
DOI: 10.1016/j.mtbio.2025.102500

Fabrication of PVA Coatings Applied to Electrospun PLGA Scaffolds to Prevent Postoperative Adhesions

Arsalan D. Badaraev, Evgenii V. Plotnikov, Vladislav R. Bukal, Gleb E. Dubinenko, Johannes Frueh, Sven Rutkowski and Sergei I. Tverdokhlebov

JFB, 2025, 16, 57
DOI: 10.3390/jfb16020057

Liposome-loaded polymeric microneedles for enhanced skin deposition of rifampicin

Qonita Kurnia Anjani, Anjali K. Pandya, Sara Demartis, Juan Domínguez-Robles, Natalia Moreno-Castellanos, Huanhuan Li, Elisabetta Gavini, Vandana B. Patravale and Ryan F. Donnelly

International Journal of Pharmaceutics, 2023, 646, 123446
DOI: 10.1016/j.ijpharm.2023.123446

Up-to-date Combinational Polymeric Approaches for the Enhancement of Drug Absorption and Membrane Transductivity

Panagiotis Theodosis-Nobelos and Maria Rikkou-Kalourkoti

LDDD, 2024, 21, 659
DOI: 10.2174/1570180820666230119103518

Fabrication and characterisation of poly(sulfonated) and poly(sulfonic acid) dissolving microneedles for delivery of antibiotic and antifungal agents

Akmal Hidayat Bin Sabri, Qonita Kurnia Anjani, Pratik Gurnani, Juan Domínguez-Robles, Natalia Moreno-Castellanos, Li Zhao, Aaron R.J. Hutton and Ryan F. Donnelly

International Journal of Pharmaceutics, 2023, 644, 123292
DOI: 10.1016/j.ijpharm.2023.123292

Fluorescence-Coupled Techniques for Determining Rose Bengal in Dermatological Formulations and Their Application to Ex Vivo Skin Deposition Studies

Qonita Kurnia Anjani, Sara Demartis, Fabiana Volpe-Zanutto, Huanhuan Li, Akmal Hidayat Bin Sabri, Elisabetta Gavini and Ryan F. Donnelly

Pharmaceutics, 2023, 15, 408
DOI: 10.3390/pharmaceutics15020408

Hydrogel-forming microarray patches combined with powder-based reservoir for labetalol hydrochloride transdermal delivery

Qonita Kurnia Anjani, Usanee Detamornrat, Eneko Larrañeta and Ryan F. Donnelly

International Journal of Pharmaceutics, 2025, 669, 125061
DOI: 10.1016/j.ijpharm.2024.125061

Enhancing Intradermal Delivery of Lidocaine by Dissolving Microneedles: Comparison between Hyaluronic Acid and Poly(Vinyl Pyrrolidone) Backbone Polymers

Delly Ramadon, Lissa Florencia Putri Sutrisna, Yahdiana Harahap, Kurnia Sari Setio Putri, Fathin Ulayya, Pietradewi Hartrianti, Qonita Kurnia Anjani and Ryan F. Donnelly

Pharmaceutics, 2023, 15, 289
DOI: 10.3390/pharmaceutics15010289

Separable and Inseparable Silk Fibroin Microneedles for the Transdermal Delivery of Colchicine: Development, Characterization, and Comparisons

Shiji Liao, Guirong Qiu, Yanping Hu, Bohong Guo and Yuqin Qiu

AAPS PharmSciTech, 2023, 25
DOI: 10.1208/s12249-023-02716-3

From Patents to Progress: Unraveling Gout's Journey Through Clinical Trials and Advancements

Vikash Singh Bhadouria, Sushma Verma, Chhaya Agarwal and Deep Shikha Sharma

RRCT, 2025, 20, 96
DOI: 10.2174/0115748871308473240926044126

Solusomes (novel soluplus ® enriched nano-vesicular carriers) for improving the oral bioavailability of Candesartan cilexetil

Mohammed Abdallah, Aysha Sayed Mohamed, Mina Ibrahim Tadros, Mohamed El-Nabarawi and Mai Ahmed Tawfik

Pharmaceutical Development and Technology, 2024, 29, 13
DOI: 10.1080/10837450.2023.2289166

Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management

Rand Ghanma, Yara A. Naser, Qonita Kurnia Anjani, Akmal Hidayat Bin Sabri, Aaron R.J. Hutton, Lalitkumar K. Vora, Achmad Himawan, Natalia Moreno-Castellanos, Brett Greer, Helen O. McCarthy, Alejandro J. Paredes and Ryan F. Donnelly

International Journal of Pharmaceutics, 2024, 660, 124342
DOI: 10.1016/j.ijpharm.2024.124342

Gout therapeutics and drug delivery

Xiuju Peng, Xiaotong Li, Bing Xie, Yaoyao Lai, Alejandro Sosnik, Hamza Boucetta, Zhongjian Chen and Wei He

Journal of Controlled Release, 2023, 362, 728
DOI: 10.1016/j.jconrel.2023.09.011

Primaquine and chloroquine nano-sized solid dispersion-loaded dissolving microarray patches for the improved treatment of malaria caused by Plasmodium vivax

Qonita Kurnia Anjani, Fabiana Volpe-Zanutto, Khuriah Abdul Hamid, Akmal Hidayat Bin Sabri, Natalia Moreno-Castellano, Xiomara A. Gaitán, Juliana Calit, Daniel Y. Bargieri and Ryan F. Donnelly

Journal of Controlled Release, 2023, 361, 385
DOI: 10.1016/j.jconrel.2023.08.009

Formulation and evaluation of ivermectin-loaded dissolving microarray patches for rosacea disease

Qonita Kurnia Anjani, Sara Demartis, Natalia Moreno-Castellanos, Elisabetta Gavini and Ryan F. Donnelly

J. Pharm. Investig., 2024, 54, 683
DOI: 10.1007/s40005-024-00682-x

Design and Evaluation of Chitosan‐Coated Liposomal Microneedle Capsules for Oral Insulin Delivery: A Proof of Concept

Kirthana Gopal, Melbha Starlin Chellathurai, Zarif Mohamed Sofian, Pornanong Aramwit and Syed Mahmood

Macromolecular Bioscience, 2026, 26
DOI: 10.1002/mabi.202500661

Co-Delivery of Loxoprofen and Tofacitinib by Photothermal Microneedles for Rheumatoid Arthritis Treatment

Yi Lu, Ting Xiao, Rongrong Lai, Ziyi Liu, Weixuan Luo, Yixuan Wang, Shijia Fu, Guihong Chai, Jinjing Jia and Yuehong Xu

Pharmaceutics, 2023, 15, 1500
DOI: 10.3390/pharmaceutics15051500

Nanogel, a versatile nanoscopic platform for the simultaneous delivery of acyclovir and lignocaine for the treatment of Herpes simplex virus infection: formulation and characterizations

Adnan Aslam, Barkat A Khan, M Khalid Khan and Muhammad Bilal K Niazi

Nano Ex., 2025, 6, 015010
DOI: 10.1088/2632-959X/adb49a

Fabrication and Characterization of Dissolving Microneedles Containing Oryza sativa L. Extract Complex for Enhancement of Transfollicular Delivery

Tanpong Chaiwarit, Baramee Chanabodeechalermrung, Pensak Jantrawut, Warintorn Ruksiriwanich and Mathukorn Sainakham

Polymers, 2024, 16, 2377
DOI: 10.3390/polym16162377

Dissolving microneedle patches for delivery of amniotic mesenchymal stem cell metabolite products for skin regeneration in UV-aging induced mice

Andang Miatmoko, Berlian Sarasitha Hariawan, Devy Maulidya Cahyani, Qonita Kurnia Anjani, Febri Annuryanti, Rifda Tarimi Octavia, Djoko Legowo, Kusuma Eko Purwantari, Noorma Rosita, Purwati, Ryan F. Donnelly and Dewi Melani Hariyadi

European Journal of Pharmaceutics and Biopharmaceutics, 2024, 204, 114482
DOI: 10.1016/j.ejpb.2024.114482

Microneedle transdermal drug delivery as a candidate for the treatment of gouty arthritis: Material structure, design strategies and prospects

Hong Yi, Haojie Yu, Li Wang, Yu Wang, Chenguang Ouyang and Basem E. Keshta

Acta Biomaterialia, 2024, 187, 20
DOI: 10.1016/j.actbio.2024.08.032

Lyophilised reservoirs in combination with hydrogel-forming microarray patches for transdermal delivery of isoniazid and pyridoxine hydrochloride

Qonita Kurnia Anjani, Aaron R.J. Hutton, Akmal Hidayat Bin Sabri, Febri Annuryanti, Helen O. McCarthy and Ryan F. Donnelly

Biomaterials Advances, 2025, 176, 214343
DOI: 10.1016/j.bioadv.2025.214343

HPMC/PVP K90 Dissolving Microneedles Fabricated from 3D-Printed Master Molds: Impact on Microneedle Morphology, Mechanical Strength, and Topical Dissolving Property

Baramee Chanabodeechalermrung, Tanpong Chaiwarit, Siripat Chaichit, Suruk Udomsom, Phornsawat Baipaywad, Patnarin Worajittiphon and Pensak Jantrawut

Polymers, 2024, 16, 452
DOI: 10.3390/polym16040452

Fabrication and characterization of voriconazole-loaded dissolving microneedle systems: a synergistic approach combining 3D printing and vacuum compression molding

Oliwia Kordyl, Antoni Białek, Jolanta Długaszewska, Dorota Kamińska, Agata Nowak, Dariusz T. Mlynarczyk, Ariadna Nowicka, Michał Gackowski, Joanna Budna-Tukan, Andrzej Miklaszewski, Monika Wojtyłko, Zuzanna Styrna, Valentyn Mohylyuk, Bozena Michniak-Kohn and Tomasz Osmałek

International Journal of Pharmaceutics, 2026, 697, 126858
DOI: 10.1016/j.ijpharm.2026.126858

Safety Evaluation of Repeated Application of Polymeric Microarray Patches in Miniature Pigs

Qonita Kurnia Anjani, Aaron R. J. Hutton, Peter E. McKenna, Eneko Larrañeta and Ryan F. Donnelly

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202501512

Soluplus®-Based Pharmaceutical Formulations: Recent Advances in Drug Delivery and Biomedical Applications

Nerea Guembe-Michel, Paul Nguewa and Gustavo González-Gaitano

IJMS, 2025, 26, 1499
DOI: 10.3390/ijms26041499

Revitalizing Colchicine: Novel Delivery Platforms and Derivatives to Expand Its Therapeutic Potential

Natallia V. Dubashynskaya, Anton N. Bokatyi, Mikhail M. Galagudza and Yury A. Skorik

IJMS, 2025, 26, 7591
DOI: 10.3390/ijms26157591

Microneedles as an Emerging Platform for Transdermal Delivery of Phytochemicals

B.H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Raghu Raj Singh Thakur, Ryan F. Donnelly and Lalitkumar K. Vora

Mol. Pharmaceutics, 2024, 21, 6007
DOI: 10.1021/acs.molpharmaceut.4c00894

Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation

Qonita Kurnia Anjani, Natalia Moreno-Castellanos, Masoud Adhami, Delly Ramadon, Jangga Jangga and Ryan F. Donnelly

Drug Deliv. and Transl. Res., 2025, 15, 355
DOI: 10.1007/s13346-024-01616-8

Parafilm® M and Strat-M® as skin simulants in in vitro permeation of dissolving microarray patches loaded with proteins

Qonita Kurnia Anjani, Avelia Devina Calista Nainggolan, Huanhuan Li, Andang Miatmoko, Eneko Larrañeta and Ryan F. Donnelly

International Journal of Pharmaceutics, 2024, 655, 124071
DOI: 10.1016/j.ijpharm.2024.124071

Novel long-acting treatment for schizophrenia based on paliperidone dissolving and implantable microarray patches

Li Zhao, Linlin Li, Eneko Larrañeta, Alejandro J. Paredes and Ryan F. Donnelly

European Journal of Pharmaceutics and Biopharmaceutics, 2024, 204, 114481
DOI: 10.1016/j.ejpb.2024.114481

Formulation and in vitro, in vivo characterizations of colchicine loaded nanoemulsion for gout management

Muhammad Sohail Majid, Barkat A. Khan, Muhammad Khalid Khan and Muhammad Bilal K. Niazi

Discov Appl Sci, 2026, 8
DOI: 10.1007/s42452-026-08376-9

Combination of Dissolving Microneedles with Nanosuspension and Co-Grinding for Transdermal Delivery of Ketoprofen

Delly Ramadon, Fathin Ulayya, Annisa Sakinah Qur’ani, Iskandarsyah Iskandarsyah, Yahdiana Harahap, Qonita Kurnia Anjani, Vania Aileen, Pietradewi Hartrianti and Ryan F. Donnelly

Pharmaceuticals, 2023, 16, 378
DOI: 10.3390/ph16030378

Rasagiline mesylate-based microneedle patches: A patient-friendly treatment regimen for Parkinson’s disease

Tahir Emre Yalcin, Qonita Kurnia Anjani, Yaocun Li, Eneko Larrañeta, Alejandro J. Paredes and Ryan F. Donnelly

International Journal of Pharmaceutics, 2025, 683, 126019
DOI: 10.1016/j.ijpharm.2025.126019