Surface functionalization strategies of extracellular vesicles

Sagar Rayamajhi and Santosh Aryal

J. Mater. Chem. B, 2020, 8, 4552
DOI: 10.1039/D0TB00744G

Reversible conjugation of biomembrane vesicles with magnetic nanoparticles using a self-assembled nanogel interface: single particle analysis using imaging flow cytometry

Ryosuke Mizuta, Yoshihiro Sasaki, Kiyofumi Katagiri, Shin-ichi Sawada and Kazunari Akiyoshi

Nanoscale Adv., 2022, 4, 1999
DOI: 10.1039/D1NA00834J

A comprehensive review of challenges and advances in exosome-based drug delivery systems

Sushesh Srivatsa Palakurthi, Brijesh Shah, Sumedha Kapre, Nitin Charbe, Susan Immanuel, Sindhura Pasham, Maharshi Thalla, Ankit Jain and Srinath Palakurthi

Nanoscale Adv., 2024, 6, 5803
DOI: 10.1039/D4NA00501E

Exosomes encapsulated in hydrogels for effective central nervous system drug delivery

Ziba Zakeri, Morteza Heiderzadeh, Azra Kocaarslan, Ecem Metin, Seyed Nasir Hosseini Karimi, Sepideh Saghati, Atay Vural, Göktuğ Akyoldaş, Kemal Baysal, Yusuf Yağcı, Yasemin Gürsoy-Özdemir, Savaş Taşoğlu, Reza Rahbarghazi and Emel Sokullu

Biomater. Sci., 2024, 12, 2561
DOI: 10.1039/D3BM01055D

Recent advances in nanogels for drug delivery and biomedical applications

Arti Vashist, Gabriela Perez Alvarez, Vianessa Andion Camargo, Andrea D. Raymond, Adriana Yndart Arias, Nagesh Kolishetti, Atul Vashist, Pandiaraj Manickam, Saurabh Aggarwal and Madhavan Nair

Biomater. Sci., 2024, 12, 6006
DOI: 10.1039/D4BM00224E

Self-assembled natural small molecule diterpene acids with favorable anticancer activity and biosafety for synergistically enhanced antitumor chemotherapy

Jianjun Cheng, Shiyao Fu, Zhao Qin, Ying Han and Xin Yang

J. Mater. Chem. B, 2021, 9, 2674
DOI: 10.1039/D0TB02995E

Photo-triggered cargo release from liposome chlorin e6-bearing pullulan hybrid nanoparticles via membrane permeabilization

Riku Kawasaki, Reo Ohdake, Takuro Eto, Keita Yamana, Toshimi Nakaya, Takenori Ishida, Akio Kuroda and Atsushi Ikeda

RSC Adv., 2021, 11, 36564
DOI: 10.1039/D1RA07807K

Milk Exosomes: Perspective Agents for Anticancer Drug Delivery

Sergey Sedykh, Anna Kuleshova and Georgy Nevinsky

IJMS, 2020, 21, 6646
DOI: 10.3390/ijms21186646

Engineering exosome polymer hybrids by atom transfer radical polymerization

Sushil Lathwal, Saigopalakrishna S. Yerneni, Susanne Boye, Upenyu L. Muza, Shuntaro Takahashi, Naoki Sugimoto, Albena Lederer, Subha R. Das, Phil G. Campbell and Krzysztof Matyjaszewski

Proc. Natl. Acad. Sci. U.S.A., 2021, 118
DOI: 10.1073/pnas.2020241118

Exosomes; multifaceted nanoplatform for targeting brain cancers

Narges Mardi, Fatemeh Salahpour-Anarjan, Mahdieh Nemati, Nasim Shahsavari Baher, Reza Rahbarghazi and Amir Zarebkohan

Cancer Letters, 2023, 557, 216077
DOI: 10.1016/j.canlet.2023.216077

Nanogels as target drug delivery systems in cancer therapy: A review of the last decade

Anthony A. Attama, Petra O. Nnamani, Ozioma B. Onokala, Agatha A. Ugwu and Adaeze L. Onugwu

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.874510

Cationic Nanogel Coated Norovirus VLP Nasal Vaccine Induces Neutralizing Mucosal IgA and Serum IgG Antibodies

Yoshikazu Yuki, Shiho Kurokawa, Tomoyuki Yamanoue, Tomoya Tsuchihashi, Shigeyuki Tamiya, Shin-ichi Sawada, Yohei Uchida, Kotomi Sugiura, Rika Nakahashi-Ouchida, Naomi Sakon, Daisuke Tokuhara, Kazunari Akiyoshi, Shintaro Sato and Hiroshi Kiyono

Mol. Pharmaceutics, 2026, 23, 2682
DOI: 10.1021/acs.molpharmaceut.5c01806

Cellular Uptake of Engineered Extracellular Vesicles: Biomechanisms, Engineered Strategies, and Disease Treatment

Qingpeng Xie, Yujia Hao, Na Li, Haoyue Song, Xiaohang Chen, Zilan Zhou, Jia Wang, Yuan Zhang, Huifei Li, Pengcheng Han and Xing Wang

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202302280

Stem Cell-Derived Extracellular Vesicles for Cancer Therapy and Tissue Engineering Applications

Chung-Sung Lee, Min Lee, Kun Na and Hee Sook Hwang

Mol. Pharmaceutics, 2023, 20, 5278
DOI: 10.1021/acs.molpharmaceut.3c00376

Engineered Nanobody-Bearing Extracellular Vesicles Enable Precision Trop2 Knockdown in Resistant Breast Cancer

Jassy Mary S. Lazarte, Mounika Aare, Sandeep Chary Padakanti, Arvind Bagde, Aakash Nathani, Zachary Meeks, Li Sun, Yan Li and Mandip Singh

Pharmaceutics, 2025, 17, 1318
DOI: 10.3390/pharmaceutics17101318

Behaviour of a magnetic nanogel in a shear flow

Ivan S. Novikau, Ekaterina V. Novak, Elena S. Pyanzina and Sofia S. Kantorovich

Journal of Molecular Liquids, 2022, 346, 118056
DOI: 10.1016/j.molliq.2021.118056

Fungal exopolysaccharides: Properties, sources, modifications, and biomedical applications

Masoud Hamidi, Oseweuba Valentine Okoro, Peiman Brouki Milan, Mohammad Reza Khalili, Hadi Samadian, Lei Nie and Amin Shavandi

Carbohydrate Polymers, 2022, 284, 119152
DOI: 10.1016/j.carbpol.2022.119152

Cancer Nanomedicines in an Evolving Oncology Landscape

Peng Guo, Jing Huang and Marsha A. Moses

Trends in Pharmacological Sciences, 2020, 41, 730
DOI: 10.1016/j.tips.2020.08.001

Fusogenic Hybrid Extracellular Vesicles with PD-1 Membrane Proteins for the Cytosolic Delivery of Cargos

Raga Ishikawa, Shosuke Yoshida, Shin-ichi Sawada, Yoshihiro Sasaki and Kazunari Akiyoshi

Cancers, 2022, 14, 2635
DOI: 10.3390/cancers14112635

Using the Intranasal Route to Administer Drugs to Treat Neurological and Psychiatric Illnesses: Rationale, Successes, and Future Needs

Andrew Lofts, Fahed Abu-Hijleh, Nicolette Rigg, Ram K. Mishra and Todd Hoare

CNS Drugs, 2022, 36, 739
DOI: 10.1007/s40263-022-00930-4

Exosomes: Recent Advances and Challenges as Targeted Therapeutic Delivery Vesicles

Sourabh Jadhav, Ankaj Kumar and Arvind Gulbake

Crit Rev Ther Drug Carrier Syst, 2023, 40, 101
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022044495

Site- and Structure-Specific Glycosylation Signatures of Bovine, Caprine, Porcine, and Human Milk-Derived Extracellular Vesicles

Xiuyuan Wang, Hanjie Li, Zibo Wang, Jingru Chen, Wenyan Chen, Xiaoman Zhou, Lina Zhang, Shiqian Xu, Xiao-Dong Gao and Ganglong Yang

J. Agric. Food Chem., 2023, 71, 20826
DOI: 10.1021/acs.jafc.3c06439

Next-generation probiotics and engineered BEVs for precision therapeutics in osteoporosis

Jiecheng Wei, Wenshuo Ding, Kaiyi Song, Yongkang Zhang, Qi Luo and Chan Qi

Front. Nutr., 2025, 12
DOI: 10.3389/fnut.2025.1581971

Perilla-Leaf-Derived Extracellular Vesicles Selectively Inhibit Breast Cancer Cell Proliferation and Invasion

Do Kyung Kim, Su Jin Kang and Won Jong Rhee

IJMS, 2023, 24, 15633
DOI: 10.3390/ijms242115633

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

Jagannath Mondal, Shameer Pillarisetti, Vijayabhaskarreddy Junnuthula, Monochura Saha, Seung Rim Hwang, In-kyu Park and Yong-kyu Lee

Journal of Controlled Release, 2023, 353, 1127
DOI: 10.1016/j.jconrel.2022.12.027

Prospective applications of extracellular vesicle-based therapies in regenerative medicine: implications for the use of dental stem cell-derived extracellular vesicles

Wenhao Wang, Zinan Xu, Minyi Liu, Mingxiang Cai and Xiangning Liu

Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1278124

Surface Glycan Profiling of Extracellular Vesicles by Lectin Microarray and Glycoengineering for Control of Cellular Interactions

Asako Shimoda and Kazunari Akiyoshi

Pharm Res, 2023, 40, 795
DOI: 10.1007/s11095-023-03511-2

Extracellular Vesicles and Biomaterial Design: New Therapies for Cardiac Repair

Chloé Pezzana, Florence Agnely, Amélie Bochot, Juergen Siepmann and Philippe Menasché

Trends in Molecular Medicine, 2021, 27, 231
DOI: 10.1016/j.molmed.2020.10.006

Immunocyte Derived Exosomes: Insight into the Potential Chemo-immunotherapeutic Nanocarrier Targeting the Tumor Microenvironment

Moumita Basak, Dharmendra Kumar Chaudhary, Ryou-u Takahashi, Yuki Yamamoto, Swasti Tiwari, Hidetoshi Tahara and Anupama Mittal

ACS Biomater. Sci. Eng., 2023, 9, 20
DOI: 10.1021/acsbiomaterials.2c00893

Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles

Lixue Wang, Guosheng Wang, Wenjun Mao, Yundi Chen, Md. Mofizur Rahman, Chuandong Zhu, Peter M. Prisinzano, Bo Kong, Jing Wang, Luke P. Lee and Yuan Wan

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-39181-2

Kinetics of internal transformations in thermodynamically unstable ferrofluids

A. Yu. Zubarev and L. Yu. Iskakova

Eur. Phys. J. Spec. Top., 2023, 232, 1315
DOI: 10.1140/epjs/s11734-022-00757-6

Extracellular vesicle hybrid engineering for DDS and medical application

Ryosuke Mizuta and Kazunari Akiyoshi

DDS, 2021, 36, 90
DOI: 10.2745/dds.36.90

Development and single‐particle analysis of hybrid extracellular vesicles fused with liposomes using viral fusogenic proteins

Raga Ishikawa, Shosuke Yoshida, Shin‐ichi Sawada, Yoshihiro Sasaki and Kazunari Akiyoshi

FEBS Open Bio, 2022, 12, 1178
DOI: 10.1002/2211-5463.13406

Role of exosomes in tumour growth, chemoresistance and immunity: state-of-the-art

Seyedeh Maryam Hosseinikhah, Fatemeh Gheybi, Seyedeh Alia Moosavian, Mohammad-Ali Shahbazi, Mahmoud Reza Jaafari, Mika Sillanpää, Prashant Kesharwani, Seyedeh Hoda Alavizadeh and Amirhossein Sahebkar

Journal of Drug Targeting, 2023, 31, 32
DOI: 10.1080/1061186X.2022.2114000

Self-assembled Abietic acid encapsulated nanoparticles to improve the stability of Proanthocyanin B2

Ying Han, Xuening Yang, Shiyao Fu, Xiaoting Wang, Hua Zhang, Xiaojie Wei, Bin Li and Xin Yang

Food Chemistry, 2024, 458, 140287
DOI: 10.1016/j.foodchem.2024.140287

Engineered extracellular vesicles for bone therapy

Yingying Jiang, Jiadong Li, Xu Xue, Zhifeng Yin, Ke Xu and Jiacan Su

Nano Today, 2022, 44, 101487
DOI: 10.1016/j.nantod.2022.101487

Harnessing the full potential of extracellular vesicles as drug carriers

Natalie Jasiewicz, Corinne Drabenstott and Juliane Nguyen

Current Opinion in Colloid & Interface Science, 2021, 51, 101412
DOI: 10.1016/j.cocis.2020.101412

Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma

Sasmita Samal, Pratigyan Dash and Mamoni Dash

IJN, 2021, Volume 16, 3509
DOI: 10.2147/IJN.S307843

Advances in Exosome-Based Drug Delivery and Tumor Targeting: From Tissue Distribution to Intracellular Fate

Juntang Shao, Jennica Zaro and Yuxian Shen

IJN, 2020, Volume 15, 9355
DOI: 10.2147/IJN.S281890

DNA Nanomaterial‐Empowered Surface Engineering of Extracellular Vesicles

Xuxiang Yao, Dongdong He, Pengyao Wei, Zitong Niu, Hao Chen, Lin Li, Pan Fu, Yiting Wang, Saiyun Lou, Sihua Qian, Jianping Zheng, Guokun Zuo and Kaizhe Wang

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202306852

Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy

Jianjun Cheng, Haitian Zhao, Bin Li, Hua Zhang, Qianyu Zhao, Shiyao Fu, Ying Han, Weihong Lu, Jiahua Shi and Xin Yang

Acta Pharmaceutica Sinica B, 2023, 13, 879
DOI: 10.1016/j.apsb.2022.06.008

Photo-responsive Self-Reducible Polymers: Overcoming the Spatiotemporal Barriers for Hypersensitivity

Chuang Weng, Haodong Chen, Taoran Xu, Zifen Li, Xinfu Liu, Mingming Ding, Qin Zhang, Hong Tan and Qiang Fu

ACS Materials Lett., 2020, 2, 602
DOI: 10.1021/acsmaterialslett.0c00070

Field application of star polymer-delivered chitosan to amplify plant defense against potato late blight

Xiaodan Wang, Kangkai Zheng, Wenyu Cheng, Jie Li, Xiangxiu Liang, Jie Shen, Daolong Dou, Meizhen Yin and Shuo Yan

Chemical Engineering Journal, 2021, 417, 129327
DOI: 10.1016/j.cej.2021.129327

Engineered bacterial extracellular vesicles for osteoporosis therapy

Han Liu, Mengmeng Li, Tao Zhang, Xinru Liu, Hao Zhang, Zhen Geng and Jiacan Su

Chemical Engineering Journal, 2022, 450, 138309
DOI: 10.1016/j.cej.2022.138309

Biomacromolecule-mediated pulmonary delivery of siRNA and anti-sense oligos: challenges and possible solutions

Yaseen Hussain, Jing-Hao Cui, Haroon Khan, Pooyan Makvandi and Waqas Alam

Expert Rev. Mol. Med., 2021, 23
DOI: 10.1017/erm.2021.25

Marginative Delivery-Mediated Extracellular Leakiness and T Cell Infiltration in Lung Metastasis by a Biomimetic Nanoraspberry

Wei-Ting Shen, Ru-Siou Hsu, Jen-Hung Fang, Pei-Fen Hu, Chi-Shiun Chiang and Shang-Hsiu Hu

Nano Lett., 2021, 21, 1375
DOI: 10.1021/acs.nanolett.0c04122

Engineering strategies of biomaterial-assisted exosomes for skin wound repair: Latest advances and challenges

Yang Xu, Le Ma, Yang Wang and Chunmeng Shi

Chinese Chemical Letters, 2025, 36, 109766
DOI: 10.1016/j.cclet.2024.109766

Designer Exosomes: A New Platform for Biotechnology Therapeutics

Davod Jafari, Samira Shajari, Rasool Jafari, Narges Mardi, Hosna Gomari, Fatemeh Ganji, Mehdi Forouzandeh Moghadam and Ali Samadikuchaksaraei

BioDrugs, 2020, 34, 567
DOI: 10.1007/s40259-020-00434-x

Extracellular Vesicle (EV) biohybrid systems for cancer therapy: Recent advances and future perspectives

Yi-Hsuan Ou, Jeremy Liang, Bertrand Czarny, Matthias G. Wacker, Victor Yu, Jiong-Wei Wang and Giorgia Pastorin

Seminars in Cancer Biology, 2021, 74, 45
DOI: 10.1016/j.semcancer.2021.02.006

Progress of Endogenous and Exogenous Nanoparticles for Cancer Therapy and Diagnostics

Hideaki Fujita, Seiichi Ohta, Noriko Nakamura, Masaharu Somiya and Masanobu Horie

Genes, 2023, 14, 259
DOI: 10.3390/genes14020259

Boron Agent Delivery Platforms Based on Natural Products for Boron Neutron Capture Therapy

Riku Kawasaki, Yamato Miura, Nanami Kono, Seiya Fujita, Keita Yamana and Atsushi Ikeda

ChemMedChem, 2024, 19
DOI: 10.1002/cmdc.202400323

Biofunctional Peptide-Modified Extracellular Vesicles Enable Effective Intracellular Delivery via the Induction of Macropinocytosis

Ikuhiko Nakase

Processes, 2021, 9, 224
DOI: 10.3390/pr9020224

Fabrication and use of silicon hollow-needle arrays to achieve tissue nanotransfection in mouse tissue in vivo

Yi Xuan, Subhadip Ghatak, Andrew Clark, Zhigang Li, Savita Khanna, Dongmin Pak, Mangilal Agarwal, Sashwati Roy, Peter Duda and Chandan K. Sen

Nat Protoc, 2021, 16, 5707
DOI: 10.1038/s41596-021-00631-0

Methods and strategies of bioengineered cell exosomes for the treatment of osteoarthritis

Chengjun Zhang, Jinming Liu, Shijie Chen, Dacheng Zhao, Changshun Chen, Bin Geng and Yayi Xia

Joint Bone Spine, 2026, 93, 106030
DOI: 10.1016/j.jbspin.2025.106030

Overview of the “biophysics in nano-space” session at the 57th annual meeting of the biophysical society of Japan

Hisashi Tadakuma and Daiju Kitagawa

Biophys Rev, 2020, 12, 283
DOI: 10.1007/s12551-020-00646-z

Extracellular Vesicle-Based Hybrid Systems for Advanced Drug Delivery

Diego A. Rodríguez and Pieter Vader

Pharmaceutics, 2022, 14, 267
DOI: 10.3390/pharmaceutics14020267

Starch Nanoparticle/Carboxymethyl Chitosan Nanoassemblies for Intranasal Delivery of Antipsychotic Drugs to the Brain

Matthew A. Campea, Andrew Lofts, Erica Winterhelt, Nahieli Preciado Rivera, Cameron Macdonald, Kevin Gulo, Anna Basatskaya, Ram K. Mishra and Todd Hoare

ACS Appl. Nano Mater., 2025, 8, 10409
DOI: 10.1021/acsanm.5c01088

Advanced rational design of polymeric nanoparticles for the controlled delivery of biologics

J. Jesus Rodriguez-Cruz, Fabiola A. Chapa-Villarreal, Ishaan Duggal and Nicholas A. Peppas

Journal of Controlled Release, 2025, 384, 113940
DOI: 10.1016/j.jconrel.2025.113940

Extracellular Vesicles-Based Drug Delivery Systems: A New Challenge and the Exemplum of Malignant Pleural Mesothelioma

Stefano Burgio, Leila Noori, Antonella Marino Gammazza, Claudia Campanella, Mariantonia Logozzi, Stefano Fais, Fabio Bucchieri, Francesco Cappello and Celeste Caruso Bavisotto

IJMS, 2020, 21, 5432
DOI: 10.3390/ijms21155432

Extracellular vesicle-embedded materials

Yingchang Ma, Steve Brocchini and Gareth R. Williams

Journal of Controlled Release, 2023, 361, 280
DOI: 10.1016/j.jconrel.2023.07.059

Sequential Release of Small Extracellular Vesicles from Bilayered Thiolated Alginate/Polyethylene Glycol Diacrylate Hydrogels for Scarless Wound Healing

Yifan Shen, Guanzhe Xu, Huanxuan Huang, Kaiyang Wang, Hui Wang, Meidong Lang, Hong Gao and Shichang Zhao

ACS Nano, 2021, 15, 6352
DOI: 10.1021/acsnano.0c07714

Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances

Endong Zhang, Philana Phan and Zongmin Zhao

Acta Pharmaceutica Sinica B, 2023, 13, 1789
DOI: 10.1016/j.apsb.2022.08.020

Exploring the role of polymers to overcome ongoing challenges in the field of extracellular vesicles

Laurianne Simon, Vincent Lapinte and Marie Morille

J of Extracellular Vesicle, 2023, 12
DOI: 10.1002/jev2.12386

Amphiphilic biodegradable co-networks of Poly(butylene succinate)-Poly(ethylene glycol) chains for nano-gelation via Click chemistry and its potential dispersant for multi-walled carbon nanotubes

Thanit Kertsomboon and Suwabun Chirachanchai

Polymer Degradation and Stability, 2020, 179, 109266
DOI: 10.1016/j.polymdegradstab.2020.109266

Preparation of engineered extracellular vesicles with full-length functional PD-1 membrane proteins by baculovirus expression system

Raga Ishikawa, Shosuke Yoshida, Shin-ichi Sawada, Yoshihiro Sasaki and Kazunari Akiyoshi

Biochemical and Biophysical Research Communications, 2020, 526, 967
DOI: 10.1016/j.bbrc.2020.03.187

Liposomes or Extracellular Vesicles: A Comprehensive Comparison of Both Lipid Bilayer Vesicles for Pulmonary Drug Delivery

Ali Al-Jipouri, Samah Hamed Almurisi, Khater Al-Japairai, Latifah Munirah Bakar and Abd Almonem Doolaanea

Polymers, 2023, 15, 318
DOI: 10.3390/polym15020318

Exosomes in the Pathogenesis, Progression, and Treatment of Osteoarthritis

Yishu Fan, Zhong Li and Yuchen He

Bioengineering, 2022, 9, 99
DOI: 10.3390/bioengineering9030099

Recent progresses of exosome–liposome fusions in drug delivery

Lulu Zheng, Bo Hu, Deyao Zhao, Wenjing Liu, Qing Liu, Yuanyu Huang and Shaobo Ruan

Chinese Chemical Letters, 2024, 35, 108647
DOI: 10.1016/j.cclet.2023.108647

Milk exosomes as delivery agents for therapy of cancer diseases

S. E. Sedykh, A. M. Timofeeva, A. E. Kuleshova and G. A. Nevinskiy

Advances in Molecular Oncology, 2022, 9, 23
DOI: 10.17650/2313-805X-2022-9-2-23-31

Simple Osthole/Nanocarrier Pesticide Efficiently Controls Both Pests and Diseases Fulfilling the Need of Green Production of Strawberry

Shuo Yan, Qian Hu, Qinhong Jiang, Hongtao Chen, Jie Wei, Meizhen Yin, Xiangge Du and Jie Shen

ACS Appl. Mater. Interfaces, 2021, 13, 36350
DOI: 10.1021/acsami.1c09887

Stem cell exosomes in the pathophysiology of cardiovascular diseases

Andrei S. Rudoy and Alexander V. Moskalev

Bulletin of the Russian Military Medical Academy, 2024, 26, 113
DOI: 10.17816/brmma595914