TANDEM: biomicrofluidic systems with transverse and normal diffusional environments for multidirectional signaling

Michael D. Mohan and Edmond W. K. Young

Lab Chip, 2021, 21, 4081
DOI: 10.1039/D1LC00279A

Recent innovations in cost-effective polymer and paper hybrid microfluidic devices

Wan Zhou, Maowei Dou, Sanjay S. Timilsina, Feng Xu and XiuJun Li

Lab Chip, 2021, 21, 2658
DOI: 10.1039/D1LC00414J

A hybrid fluorescent nanofiber membrane integrated with microfluidic chips towards lung-on-a-chip applications

Perizat Kanabekova, Bereke Dauletkanov, Zhibek Bekezhankyzy, Sultanali Toktarkan, Alma Martin, Tri T. Pham, Konstantinos Kostas and Gulsim Kulsharova

Lab Chip, 2024, 24, 224
DOI: 10.1039/D3LC00751K

Engineering organs-on-a-chip via multi-channel microfluidics

Ji Qiu, Jia Yang, Lihao Liu, Jiameng Wen, Jiachen Yang, Wenwan Shi, Xiaoxiang Gao, Jing Sun, Ling Bai, Xiaojiang Liu and Zhongze Gu

Lab Chip, 2026, 26, 1739
DOI: 10.1039/D5LC00598A

Microfluidic lumen-based systems for advancing tubular organ modeling

María Virumbrales-Muñoz, José M. Ayuso, Max M. Gong, Mouhita Humayun, Megan K. Livingston, Karina M. Lugo-Cintrón, Patrick McMinn, Yasmín R. Álvarez-García and David J. Beebe

Chem. Soc. Rev., 2020, 49, 6402
DOI: 10.1039/D0CS00705F

Magnetic microboats for floating, stiffness tunable, air–liquid interface epithelial cultures

Arvind Chandrasekaran, Sonya Kouthouridis, Wontae Lee, Nicholas Lin, Zhenwei Ma, Mark J. Turner, John W. Hanrahan and Christopher Moraes

Lab Chip, 2019, 19, 2786
DOI: 10.1039/C9LC00267G

Real-time monitoring of epithelial barrier function by impedance spectroscopy in a microfluidic platform

João Fernandes, Nikita Karra, Joel Bowring, Riccardo Reale, Jonathan James, Cornelia Blume, Theresa J. Pell, Wendy C. Rowan, Donna E. Davies, Emily J. Swindle and Hywel Morgan

Lab Chip, 2022, 22, 2041
DOI: 10.1039/D1LC01046H

Parathyroid-on-a-chip simulating parathyroid hormone secretion in response to calcium concentration

Sunghan Lee, Hyo-Il Jung, Jaehun Lee, Youngwon Kim, Jaewoo Chung, Han Su Kim, Jiseok Lim, Ki Chang Nam, Yun-Sung Lim, Han Seok Choi and Bong Seop Kwak

Lab Chip, 2024, 24, 3243
DOI: 10.1039/D4LC00249K

Engineered basement membranes: fromin vivoconsiderations to cell-based assays

Guillaume Perry, Wenjin Xiao, Gavin I. Welsh, Adam W. Perriman and Rachel Lennon

Integr. Biol., 2018, 10, 680
DOI: 10.1039/C8IB00138C

Advances of dual-organ and multi-organ systems for gut, lung, skin and liver models in absorption and metabolism studies

Konstanze Brandauer, Sophie Schweinitzer, Alexandra Lorenz, Judith Krauß, Silvia Schobesberger, Martin Frauenlob and Peter Ertl

Lab Chip, 2025, 25, 1384
DOI: 10.1039/D4LC01011F

Bidirectional airflow in lung airway-on-a-chip with matrix-derived membrane elicits epithelial glycocalyx formation

Siwan Park, Jeremy Newton, Tesnime Hidjir and Edmond W. K. Young

Lab Chip, 2023, 23, 3671
DOI: 10.1039/D3LC00259D

A 96-well format microvascularized human lung-on-a-chip platform for microphysiological modeling of fibrotic diseases

Joscelyn C. Mejías, Michael R. Nelson, Olivia Liseth and Krishnendu Roy

Lab Chip, 2020, 20, 3601
DOI: 10.1039/D0LC00644K

Lymphangion-chip: a microphysiological system which supports co-culture and bidirectional signaling of lymphatic endothelial and muscle cells

Amirali Selahi, Teshan Fernando, Sanjukta Chakraborty, Mariappan Muthuchamy, David C. Zawieja and Abhishek Jain

Lab Chip, 2022, 22, 121
DOI: 10.1039/D1LC00720C

Lung-on-chip microdevices to foster pulmonary drug discovery

Yashi Sisodia, Komal Shah, Adil Ali Sayyed, Meenakshi Jain, Syed Ansar Ali, Piyush Gondaliya, Kiran Kalia and Rakesh Kumar Tekade

Biomater. Sci., 2023, 11, 777
DOI: 10.1039/D2BM00951J

Chitosan–polydopamine hydrogel complex: a novel green adhesion agent for reversibly bonding thermoplastic microdevice and its application for cell-friendly microfluidic 3D cell culture

Kieu The Loan Trinh, Nguyen Xuan Thanh Le and Nae Yoon Lee

Lab Chip, 2020, 20, 3524
DOI: 10.1039/D0LC00621A

Advanced in vitro lung-on-chip platforms for inhalation assays: From prospect to pipeline

Arbel Artzy-Schnirman, Nina Hobi, Nicole Schneider-Daum, Olivier T. Guenat, Claus-Michael Lehr and Josué Sznitman

European Journal of Pharmaceutics and Biopharmaceutics, 2019, 144, 11
DOI: 10.1016/j.ejpb.2019.09.006

A Facile and Scalable Hydrogel Patterning Method for Microfluidic 3D Cell Culture and Spheroid-in-Gel Culture Array

Chengxun Su, Yon Jin Chuah, Hong Boon Ong, Hui Min Tay, Rinkoo Dalan and Han Wei Hou

Biosensors, 2021, 11, 509
DOI: 10.3390/bios11120509

Experimental study of fabricating a four-layers Cantor fractal microfluidic chip by CO2 laser system

Zeyang Wu, Xueye Chen, Zhongli Wu, Qijian Zhang and Qi Gao

Microsyst Technol, 2019, 25, 1251
DOI: 10.1007/s00542-018-4060-6

Comprehending the Membrane Properties for Emulation in Organs‐on‐a‐Chip

Tanmayee Makarand Sathe and Dhananjay Shrikrishna Bodas

Advanced NanoBiomed Research, 2026, 6
DOI: 10.1002/anbr.202500078

Microphysiological Systems for Studying Cellular Crosstalk During the Neutrophil Response to Infection

Isaac M. Richardson, Christopher J. Calo and Laurel E. Hind

Front. Immunol., 2021, 12
DOI: 10.3389/fimmu.2021.661537

Tunable In Situ Synthesis of Ultrathin Extracellular Matrix‐Derived Membranes in Organ‐on‐a‐Chip Devices

Jeremy D. Newton, Yuetong Song, Siwan Park, Kayshani R. Kanagarajah, Amy P. Wong and Edmond W. K. Young

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202401158

Toxicological evaluation of airborne particulate matter. Are cell culture technologies ready to replace animal testing?

Sara Silvani, Marina Figliuzzi and Andrea Remuzzi

J of Applied Toxicology, 2019, 39, 1484
DOI: 10.1002/jat.3804

Host and Pathogen Communication in the Respiratory Tract: Mechanisms and Models of a Complex Signaling Microenvironment

Samuel B. Berry, Amanda J. Haack, Ashleigh B. Theberge, Susanna Brighenti and Mattias Svensson

Front. Med., 2020, 7
DOI: 10.3389/fmed.2020.00537

An Insight on Microfluidic Organ-on-a-Chip Models for PM2.5-Induced Pulmonary Complications

Disha Shah, Bhavarth Dave, Mehul R. Chorawala, Bhupendra G. Prajapati, Sudarshan Singh, Gehan M. Elossaily, Mohd Nazam Ansari and Nemat Ali

ACS Omega, 2024, 9, 13534
DOI: 10.1021/acsomega.3c10271

Advances in lung-on-a-chip platforms for nanotherapeutic evaluation and screening

Kimia Abedi, Jacqueline L. Pavelick, Claudia C. dos Santos and Edmond W.K. Young

Advanced Drug Delivery Reviews, 2026, 234, 115873
DOI: 10.1016/j.addr.2026.115873

Understanding and manipulating morphogenetic processes to generate in vitro models of airways

Katharina Raasch, Pauline Henrot, Alice Hadchouel-Duvergé, Maeva Zysman and Isabelle Dupin

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2025, 329, L234
DOI: 10.1152/ajplung.00015.2025

Respiratory microphysiological system in respiratory research: recent advances and future prospects

Jiaxiang Yin, Zirong Bi, Tiankai Dai, Xiaoyue Zhu, Tao Xu and Huisheng Liu

Respir Res, 2025, 26
DOI: 10.1186/s12931-025-03327-1

Engineering Shelf-Stable Coating for Microfluidic Organ-on-a-Chip Using Bioinspired Catecholamine Polymers

Sultan Khetani, Kar Wey Yong, Vinayaraj Ozhukil Kollath, Erin Eastick, Milad Azarmanesh, Kunal Karan, Arindom Sen and Amir Sanati-Nezhad

ACS Appl. Mater. Interfaces, 2020, 12, 6910
DOI: 10.1021/acsami.9b20826

A rapidly prototyped lung-on-a-chip model using 3D-printed molds

Jesus Shrestha, Maliheh Ghadiri, Melane Shanmugavel, Sajad Razavi Bazaz, Steven Vasilescu, Lin Ding and Majid Ebrahimi Warkiani

Organs-on-a-Chip, 2019, 1, 100001
DOI: 10.1016/j.ooc.2020.100001

Alveolus Lung-on-a-Chip Platform: A Proposal

Noelia Campillo, Vinicius Rosa Oliveira and Renata Kelly da Palma

Chemosensors, 2021, 9, 248
DOI: 10.3390/chemosensors9090248

Capturing the Onset of Bacterial Pulmonary Infection in Acini‐On‐Chips

Arbel Artzy‐Schnirman, Hikaia Zidan, Shani Elias‐Kirma, Lee Ben‐Porat, Janna Tenenbaum‐Katan, Patrick Carius, Ramy Fishler, Nicole Schneider‐Daum, Claus‐Michael Lehr and Josué Sznitman

Adv. Biosys., 2019, 3
DOI: 10.1002/adbi.201900026

Progress and application of lung-on-a-chip for lung cancer

Lantao Li, Wentao Bo, Guangyan Wang, Xin Juan, Haiyi Xue and Hongwei Zhang

Front. Bioeng. Biotechnol., 2024, 12
DOI: 10.3389/fbioe.2024.1378299

Tunable Stiffness of Matrix-Derived Membranes Enables Independent and Coupled Analysis of Pressure and Strain Effects in Barrier Tissue-On-Chip Models

Jeremy D. Newton, Samantha Hossain, Kimia Abedi, Yuetong Song, Jacqueline Pavelick, Claudia C. dos Santos, Amy Wong and Edmond W. K. Young

ACS Appl. Mater. Interfaces, 2025, 17, 67543
DOI: 10.1021/acsami.5c15966

Advances of microfluidic lung chips for assessing atmospheric pollutants exposure

Hui Wang, Fangchao Yin, Zhongyu Li, Wentao Su and Dong Li

Environment International, 2023, 172, 107801
DOI: 10.1016/j.envint.2023.107801

Determination of Benzopyrene-Induced Lung Inflammatory and Cytotoxic Injury in a Chemical Gradient-Integrated Microfluidic Bronchial Epithelium System

Fen Zhang, Chang Tian, Wenming Liu, Kan Wang, Yuanqing Wei, Huaisheng Wang, Jinyi Wang and Songqin Liu

ACS Sens., 2018, 3, 2716
DOI: 10.1021/acssensors.8b01370

Organ-on-a-Chip Applications in Microfluidic Platforms

Ling An, Yi Liu and Yaling Liu

Micromachines, 2025, 16, 201
DOI: 10.3390/mi16020201

An open microfluidic coculture model of fibroblasts and eosinophils to investigate mechanisms of airway inflammation

Yuting Zeng, Xiaojing Su, Meg G. Takezawa, Paul S. Fichtinger, Ulri N. Lee, Jeffery W. Pippin, Stuart J. Shankland, Fang Yun Lim, Loren C. Denlinger, Nizar N. Jarjour, Sameer K. Mathur, Nathan Sandbo, Erwin Berthier, Stephane Esnault, Ksenija Bernau and Ashleigh B. Theberge

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.993872

Where We Stand: Lung Organotypic Living Systems That Emulate Human-Relevant Host–Environment/Pathogen Interactions

Rocio J. Jimenez-Valdes, Uryan I. Can, Brian F. Niemeyer and Kambez H. Benam

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00989

Mechanical Strain-Enabled Reconstitution of Dynamic Environment in Organ-on-a-Chip Platforms: A Review

Qianbin Zhao, Tim Cole, Yuxin Zhang and Shi-Yang Tang

Micromachines, 2021, 12, 765
DOI: 10.3390/mi12070765

Advances in Hydrogels in Organoids and Organs‐on‐a‐Chip

Haitao Liu, Yaqing Wang, Kangli Cui, Yaqiong Guo, Xu Zhang and Jianhua Qin

Advanced Materials, 2019, 31
DOI: 10.1002/adma.201902042

Simulation and modeling of physiological processes of vital organs in organ-on-a-chip biosystem

Sadegh Seidi, Aziz Eftekhari, Ameer Khusro, Reza Shiri Heris, Muhammad Umar Khayam Sahibzada and Márió Gajdács

Journal of King Saud University - Science, 2022, 34, 101710
DOI: 10.1016/j.jksus.2021.101710

Computational Modelling and Big Data Analysis of Flow and Drug Transport in Microfluidic Systems: A Spheroid-on-a-Chip Study

Sina Kheiri, Eugenia Kumacheva and Edmond W.K. Young

Front. Bioeng. Biotechnol., 2021, 9
DOI: 10.3389/fbioe.2021.781566

Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems

Scott B. Campbell, Qinghua Wu, Joshua Yazbeck, Chuan Liu, Sargol Okhovatian and Milica Radisic

ACS Biomater. Sci. Eng., 2021, 7, 2880
DOI: 10.1021/acsbiomaterials.0c00640

A Modular Microscale Granuloma Model for Immune-Microenvironment Signaling Studies in vitro

Samuel B. Berry, Maia S. Gower, Xiaojing Su, Chetan Seshadri and Ashleigh B. Theberge

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00931

Personalized Medicine for the Critically Ill Patient: A Narrative Review

Alexandra Elena Lazar and Leonard Azamfirei

Processes, 2022, 10, 1200
DOI: 10.3390/pr10061200

Mechanical Properties of Soft Biological Membranes for Organ-on-a-Chip Assessed by Bulge Test and AFM

Pauline Zamprogno, Giuditta Thoma, Veronika Cencen, Dario Ferrari, Barbara Putz, Johann Michler, Georg E. Fantner and Olivier T. Guenat

ACS Biomater. Sci. Eng., 2021, 7, 2990
DOI: 10.1021/acsbiomaterials.0c00515

An immune-competent lung-on-a-chip for modelling the human severe influenza infection response

Rachel Ringquist, Eshant Bhatia, Paramita Chatterjee, Drishti Maniar, Zhou Fang, Page Franz, Liana Kramer, Delta Ghoshal, Neha Sonthi, Emma Downey, Joshua Canlas, Abigail Ochal, Savi Agarwal, Valeria Cuéllar, Grace Harrigan, Ahmet F. Coskun, Ankur Singh and Krishnendu Roy

Nat. Biomed. Eng, 2025
DOI: 10.1038/s41551-025-01491-9

Organs-on-chips technologies – A guide from disease models to opportunities for drug development

Anna Grazia Monteduro, Silvia Rizzato, Giusi Caragnano, Adriana Trapani, Gianluigi Giannelli and Giuseppe Maruccio

Biosensors and Bioelectronics, 2023, 231, 115271
DOI: 10.1016/j.bios.2023.115271

Development of microfluidic platform that enables ‘on-chip’ imaging of cells exposed to shear stress and cyclic stretch

Whitney E. Sinclair, Ashtamurthy S. Pawate, Ty’Nya A. Larry, Jeremy M. Schieferstein, Joseph J. Whittenberg, Deborah E. Leckband and Paul J. A. Kenis

Microfluid Nanofluid, 2023, 27
DOI: 10.1007/s10404-022-02619-y

Construction, Features and Regulatory Aspects of Organ-chip for Drug Delivery Applications: Advances and Prospective

Babita Gupta, Rishabha Malviya, Saurabh Srivastava, Irfan Ahmad, Safia Obaidur Rab and Prerna Uniyal

CPD, 2024, 30, 1952
DOI: 10.2174/0113816128305296240523112043

Recent Advances in Microfluidic-Based Microphysiological Systems

Sung-Min Kang

BioChip J, 2022, 16, 13
DOI: 10.1007/s13206-021-00043-y

Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization

Shan Liu, Shikha Kumari, Hongyi He, Parichita Mishra, Bhisham Narayan Singh, Divakar Singh, Sutong Liu, Pradeep Srivastava and Chenzhong Li

Biosensors and Bioelectronics, 2023, 231, 115285
DOI: 10.1016/j.bios.2023.115285

Integration of immune cells in organs-on-chips: a tutorial

Lisette Van Os, Britta Engelhardt and Olivier T. Guenat

Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1191104

Advanced lung organoids and lung-on-a-chip for cancer research and drug evaluation: a review

Leqing Zhu, Jianhua Zhang, Quanwei Guo, Jun Kuang, Dongfang Li, Mengxi Wu, Yijun Mo, Tao Zhang, Xinghua Gao and Jianfeng Tan

Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1299033

Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applications: A Review

Mariana Ferreira, Violeta Carvalho, João Ribeiro, Rui A. Lima, Senhorinha Teixeira and Diana Pinho

Micromachines, 2024, 15, 873
DOI: 10.3390/mi15070873

Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips

Veronika Sedláková, Michaela Kloučková, Zuzana Garlíková, Kateřina Vašíčková, Josef Jaroš, Mário Kandra, Hana Kotasová and Aleš Hampl

Drug Discovery Today, 2019, 24, 971
DOI: 10.1016/j.drudis.2019.03.006

Interfacial engineering for biomolecule immobilisation in microfluidic devices

Deepu Ashok, Jasneil Singh, Henry Robert Howard, Sophie Cottam, Anna Waterhouse and Marcela M.M. Bilek

Biomaterials, 2025, 316, 123014
DOI: 10.1016/j.biomaterials.2024.123014

Advances in Organ-on-a-Chip Materials and Devices

Bishal Kumar Nahak, Anshuman Mishra, Subham Preetam and Ashutosh Tiwari

ACS Appl. Bio Mater., 2022, 5, 3576
DOI: 10.1021/acsabm.2c00041

3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment

Aida Rodriguez-Garcia, Jacqueline Oliva-Ramirez, Claudia Bautista-Flores and Samira Hosseini

Advances in Polymer Technology, 2020, 2020, 1
DOI: 10.1155/2020/6187048

A bronchiole-on-a-chip and a stretching system for studying human disease model of asthma attack

Chun-Hui Sun, Kang-Yun Lee, Yao-Fei Chan, Shu-Chuan Ho, Chien-Ying Liu, Sheng-Ming Wu, Weilun Sun, Yi-Ting Ke and Cheng-Hsien Liu

Sensors and Actuators B: Chemical, 2024, 416, 136031
DOI: 10.1016/j.snb.2024.136031

Emerging Development of Microfluidics-Based Approaches to Improve Studies of Muscle Cell Migration

Ziba Roveimiab, Francis Lin and Judy E. Anderson

Tissue Engineering Part B: Reviews, 2019, 25, 30
DOI: 10.1089/ten.teb.2018.0181

Novel three-dimensional biochip pulmonary sarcoidosis model

Tess M. Calcagno, Chongxu Zhang, Runxia Tian, Babak Ebrahimi, Mehdi Mirsaeidi and Mária A. Deli

PLoS ONE, 2021, 16, e0245805
DOI: 10.1371/journal.pone.0245805

Advances in In Vitro Blood-Air Barrier Models and the Use of Nanoparticles in COVID-19 Research

Neval Sevinc Ozdemir, Dmitry Belyaev, Manuel Nieto Castro, Sascha Balakin, Joerg Opitz, Hevi Wihadmadyatami, Rahmi Anggraeni, Deniz Yucel, Halime Kenar, Natalia Beshchasna, Ika Dewi Ana and Vasif Hasirci

Tissue Engineering Part B: Reviews, 2024, 30, 82
DOI: 10.1089/ten.teb.2023.0117

3D Bioprinting for Engineered Tissue Constructs and Patient‐Specific Models: Current Progress and Prospects in Clinical Applications

Sang Jin Lee, Wonwoo Jeong and Anthony Atala

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202408032

E‐FLOAT: Extractable Floating Liquid Gel‐Based Organ‐on‐a‐Chip for Airway Tissue Modeling under Airflow

Siwan Park and Edmond W. K. Young

Adv Materials Technologies, 2021, 6
DOI: 10.1002/admt.202100828

Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development

Paula G. Miller, Chen‐Yu Chen, Ying I. Wang, Emily Gao and Michael L. Shuler

Biotech & Bioengineering, 2020, 117, 486
DOI: 10.1002/bit.27188

Biomimetic human lung-on-a-chip for modeling disease investigation

Kaiyan Li, Xingyuan Yang, Chang Xue, Lijuan Zhao, Yuan Zhang and Xinghua Gao

Biomicrofluidics, 2019, 13
DOI: 10.1063/1.5100070

Organ-on-a-chip platforms for evaluation of environmental nanoparticle toxicity

Rick Xing Ze Lu and Milica Radisic

Bioactive Materials, 2021, 6, 2801
DOI: 10.1016/j.bioactmat.2021.01.021

Simple-Flow: A 3D-Printed Multiwell Flow Plate to Coculture Primary Human Lung Cells at the Air–Liquid Interface

Cinta Iriondo, Sem Koornneef, Kari-Pekka Skarp, Marjon Buscop-van Kempen, Anne Boerema-de Munck and Robbert J. Rottier

ACS Biomater. Sci. Eng., 2025, 11, 451
DOI: 10.1021/acsbiomaterials.4c01322

Organs-on-a-Chip Module: A Review from the Development and Applications Perspective

Juan Eduardo Sosa-Hernández, Angel M. Villalba-Rodríguez, Kenya D. Romero-Castillo, Mauricio A. Aguilar-Aguila-Isaías, Isaac E. García-Reyes, Arturo Hernández-Antonio, Ishtiaq Ahmed, Ashutosh Sharma, Roberto Parra-Saldívar and Hafiz M. N. Iqbal

Micromachines, 2018, 9, 536
DOI: 10.3390/mi9100536

Microfluidic models of physiological or pathological flow shear stress for cell biology, disease modeling and drug development

Huaying Chen, Zhihang Yu, Siwei Bai, Huaxiu Lu, Dong Xu, Chang Chen, Di Liu and Yonggang Zhu

TrAC Trends in Analytical Chemistry, 2019, 117, 186
DOI: 10.1016/j.trac.2019.06.023

In Vitro Strategies to Vascularize 3D Physiologically Relevant Models

Alessandra Dellaquila, Chau Le Bao, Didier Letourneur and Teresa Simon‐Yarza

Advanced Science, 2021, 8
DOI: 10.1002/advs.202100798

Aspiration-mediated hydrogel micropatterning using rail-based open microfluidic devices for high-throughput 3D cell culture

Dohyun Park, Jungseub Lee, Younggyun Lee, Kyungmin Son, Jin Woo Choi, William J. Jeang, Hyeri Choi, Yunchan Hwang, Ho-Young Kim and Noo Li Jeon

Sci Rep, 2021, 11
DOI: 10.1038/s41598-021-99387-6

Microfluidic lung cancer models: Bridging clinical treatment strategies and tumor microenvironment recapitulation

Zhiyun Yu, Arsalan A. Khan, Wara Naeem, Jeffrey A. Borgia, Michael J. Liptay, Christopher W. Seder and Jian Zhou

APL Bioengineering, 2025, 9
DOI: 10.1063/5.0282002

On the path to predicting immune responses in the lung: Modeling the pulmonary innate immune system at the air-liquid interface (ALI)

Jodi Graf, Michael Trautmann-Rodriguez, Simone Sabnis, April M. Kloxin and Catherine A. Fromen

European Journal of Pharmaceutical Sciences, 2023, 191, 106596
DOI: 10.1016/j.ejps.2023.106596

Microfluidic-Chip-Integrated Biosensors for Lung Disease Models

Shuang Ding, Haijun Zhang and Xuemei Wang

Biosensors, 2021, 11, 456
DOI: 10.3390/bios11110456

Lung-on-a-chip: From design principles to disease applications

Yan Qiu and Guoqing Hu

Biomicrofluidics, 2025, 19
DOI: 10.1063/5.0257908

Engineering biomimetic lung-on-a-chip systems: Recapitulating air-liquid interface, dynamic breathing, and alveolar microenvironments for disease modeling

Juan Zhang, Jing Zhou, Yue Wang, Yi Yang, Tao Yue and Cheng Chang

Medicine in Novel Technology and Devices, 2026, 29, 100415
DOI: 10.1016/j.medntd.2025.100415

In vitro biomimetic models for respiratory diseases: progress in lung organoids and lung-on-a-chip

Xiaochun Zhang, Haolin Liu, Haofeng Cheng, Yuhui Cui, Junli Wang, Qianru Yao, Ping Wang, Yuan Hu and Yu Wang

Stem Cell Res Ther, 2025, 16
DOI: 10.1186/s13287-025-04500-5

Combinations of Drugs for Pulmonary Inhalation: A Review of Novel Technologies and Toxicological Evaluation Using Cellular Models

Sarah Zellnitz-Neugebauer and Eleonore Fröhlich

Sci, 2026, 8, 89
DOI: 10.3390/sci8040089

Lung-on-a-chip: the future of respiratory disease models and pharmacological studies

Jesus Shrestha, Sajad Razavi Bazaz, Hamidreza Aboulkheyr Es, Dania Yaghobian Azari, Benjamin Thierry, Majid Ebrahimi Warkiani and Maliheh Ghadiri

Critical Reviews in Biotechnology, 2020, 40, 213
DOI: 10.1080/07388551.2019.1710458

Innovative three-dimensional models for understanding mechanisms underlying lung diseases: powerful tools for translational research

Mehmet Nizamoglu, Mugdha M. Joglekar, Catarina R. Almeida, Anna-Karin Larsson Callerfelt, Isabelle Dupin, Olivier T. Guenat, Pauline Henrot, Lisette van Os, Jorge Otero, Linda Elowsson, Ramon Farre and Janette K. Burgess

Eur Respir Rev, 2023, 32, 230042
DOI: 10.1183/16000617.0042-2023

Recent Advances in Integrated Organ‐Chip Sensing Toward Robust and User‐Friendly Systems

Bryan G. Schellberg, Ryan A. Koppes and Abigail N. Koppes

J Biomedical Materials Res, 2025, 113
DOI: 10.1002/jbm.a.37876

Microfluidics and organ-on-a-chip technologies: A systematic review of the methods used to mimic bone marrow

Gabriel Santos Rosalem, Libardo Andrés Gonzáles Torres, Estevam Barbosa de Las Casas, Fernando Augusto Siqueira Mathias, Jeronimo Conceição Ruiz, Maria Gabriela Reis Carvalho and Alessandro Polini

PLoS ONE, 2020, 15, e0243840
DOI: 10.1371/journal.pone.0243840

A Decade of Organs-on-a-Chip Emulating Human Physiology at the Microscale: A Critical Status Report on Progress in Toxicology and Pharmacology

Mario Rothbauer, Barbara E.M. Bachmann, Christoph Eilenberger, Sebastian R.A. Kratz, Sarah Spitz, Gregor Höll and Peter Ertl

Micromachines, 2021, 12, 470
DOI: 10.3390/mi12050470

Human microphysiological models of airway and alveolar epithelia

Dave Anuj Lagowala, Seoyoung Kwon, Venkataramana K. Sidhaye and Deok-Ho Kim

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021, 321, L1072
DOI: 10.1152/ajplung.00103.2021

Regulating Cell Orientation Using a Femtosecond Laser-Induced Macro Stripe Design on Metallic Culture Surfaces with Laser-Treated and Mirrored Areas

Chikahiro IMASHIRO, Atsushi EZURA, Takahiro G. YAMADA, Yoshikatsu AKIYAMA and Jun KOMOTORI

ABE, 2025, 14, 126
DOI: 10.14326/abe.14.126

Shape optimization of an innovative hepatic sinusoids-based micromixer

Mahmoud A. Shouman, Ahmed H. El-Shazly, Marwa F. Elkady, Mohamed S. Salem, Mohamed R. Elmarghany and Mohamed Nabil Sabry

Chemical Engineering and Processing - Process Intensification, 2019, 146, 107684
DOI: 10.1016/j.cep.2019.107684

Breakthroughs and Applications of Organ-on-a-Chip Technology

Mufeeda C. Koyilot, Priyadarshini Natarajan, Clayton R. Hunt, Sonish Sivarajkumar, Romy Roy, Shreeram Joglekar, Shruti Pandita, Carl W. Tong, Shamsudheen Marakkar, Lakshminarayanan Subramanian, Shalini S. Yadav, Anoop V. Cherian, Tej K. Pandita, Khader Shameer and Kamlesh K. Yadav

Cells, 2022, 11, 1828
DOI: 10.3390/cells11111828

Revealing immune cell secretion crosstalk in pulmonary pathogenesis: A microfluidic lung-on-a-chip approach

Jiawang Wu, Yi Fu, Xiaolan Wang, Ting Liu, Xinting Zhang, Chongchang Qu, Qianyue Zhang, Shuanglan Xu, Jiao Yang and Xiqian Xing

International Journal of Pharmaceutics, 2025, 685, 126203
DOI: 10.1016/j.ijpharm.2025.126203

UV-triggered polymerization of polycatecholamines enables the production of organ-on-chips inside a biosafety cabinet

Sultan Khetani, Kar Wey Yong, Kevin Guan, Anupriya Singh, Arindam Phani, Vinayaraj Ozhukil Kollath, Seonghwan Kim, Kunal Karan, Arindom Sen and Amir Sanati-Nezhad

Applied Materials Today, 2020, 20, 100721
DOI: 10.1016/j.apmt.2020.100721

Airway-On-A-Chip: Designs and Applications for Lung Repair and Disease

Tanya J. Bennet, Avineet Randhawa, Jessica Hua and Karen C. Cheung

Cells, 2021, 10, 1602
DOI: 10.3390/cells10071602

A novel organ-chip system emulates three-dimensional architecture of the human epithelia and the mechanical forces acting on it

Antonio Varone, Justin Ke Nguyen, Lian Leng, Riccardo Barrile, Josiah Sliz, Carolina Lucchesi, Norman Wen, Achille Gravanis, Geraldine A. Hamilton, Katia Karalis and Christopher D. Hinojosa

Biomaterials, 2021, 275, 120957
DOI: 10.1016/j.biomaterials.2021.120957

Collagen Tubular Airway‐on‐Chip for Extended Epithelial Culture and Investigation of Ventilation Dynamics

Wuyang Gao, Kayshani R. Kanagarajah, Emma Graham, Kayla Soon, Teodor Veres, Theo J. Moraes, Christine E. Bear, Ruud A. Veldhuizen, Amy P. Wong and Axel Günther

Small, 2024, 20
DOI: 10.1002/smll.202309270

A comprehensive review on bioink based microfluidic devices

Kajal P. Chamate, Bhuvaneshwari D. Patil, Nikita V. Bhosale, Nutan V. Desai, Prasad V. Kadam, Avirup Chakraborty and Ravindra V. Badhe

Bioprinting, 2024, 44, e00371
DOI: 10.1016/j.bprint.2024.e00371

The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review

Kena Song, Guoqiang Li, Xiangyang Zu, Zhe Du, Liyu Liu and Zhigang Hu

Micromachines, 2020, 11, 297
DOI: 10.3390/mi11030297

Smart biomaterials in healthcare: Breakthroughs in tissue engineering, immunomodulation, patient-specific therapies, and biosensor applications

Ansheed Raheem, Kalpana Mandal, Swarup Biswas, Amir Ahari, Alireza Hassani Najafabadi, Neda Farhadi, Fatemeh Zehtabi, Ankit Gangrade, Marvin Mecwan, Surjendu Maity, Saurabh Sharma, Joseph Nathanael Arputharaj, Pearlin Amaan Khan, Anjaneyulu Udduttula, Negar Hosseinzadeh Kouchehbaghi, Danial Khorsandi, Rajesh Vasita, Reihaneh Haghniaz, Rondinelli Donizetti Herculano, Johnson V. John, Hyeok Kim, Mehmet Remzi Dokmeci, Ketul C. Popat, Yangzhi Zhu and Geetha Manivasagam

Applied Physics Reviews, 2025, 12
DOI: 10.1063/5.0238817

Advances in Smoking Related In Vitro Inhalation Toxicology: A Perspective Case of Challenges and Opportunities from Progresses in Lung-on-Chip Technologies

Ajay Vikram Singh, Romi Singh Maharjan, Charlotte Kromer, Peter Laux, Andreas Luch, Tanusri Vats, Vaisali Chandrasekar, Sarada Prasad Dakua and Byung-Wook Park

Chem. Res. Toxicol., 2021, 34, 1984
DOI: 10.1021/acs.chemrestox.1c00219

Hydrogel-integrated Microfluidic Systems for Advanced Stem Cell Engineering

Soohwan An, Seung Yeop Han and Seung-Woo Cho

BioChip J, 2019, 13, 306
DOI: 10.1007/s13206-019-3402-5

Role of Biomaterials in the Development of Epithelial Support in 3D In Vitro Airway Epithelium Development: A Systematic Review

Ab Karim Nashihah, Fairuz Izan Muhammad Firdaus, Mh. Busra Fauzi, Nadhratun Naiim Mobarak and Yogeswaran Lokanathan

IJMS, 2023, 24, 14935
DOI: 10.3390/ijms241914935

Organ-on-a-Chip: Opportunities for Assessing the Toxicity of Particulate Matter

Jia-Wei Yang, Yu-Chih Shen, Ko-Chih Lin, Sheng-Jen Cheng, Shiue-Luen Chen, Chong-You Chen, Priyank V. Kumar, Shien-Fong Lin, Huai-En Lu and Guan-Yu Chen

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00519

Next‐generation preclinical models of lung development, physiology and disease

Kimia Asadi Jozani, Sonya Kouthouridis, Jeremy Alexander Hirota and Boyang Zhang

Can J Chem Eng, 2023, 101, 18
DOI: 10.1002/cjce.24581

Engineering in vitro vascular microsystems

Qiao Liu, Guoliang Ying, Chenyan Hu, Lingyu Du, Huaiyi Zhang, Zhenye Wang, Hongyan Yue, Ali K. Yetisen, Guixue Wang, Yang Shen and Nan Jiang

Microsyst Nanoeng, 2025, 11
DOI: 10.1038/s41378-025-00956-w

Nanoadhesive Layer to Prevent Protein Absorption in a Poly(dimethylsiloxane) Microfluidic Device

Jae Bem You, Byungjin Lee, Yunho Choi, Chang-Soo Lee, Matthias Peter, Sung Gap Im and Sung Sik Lee

BioTechniques, 2020, 69, 46
DOI: 10.2144/btn-2020-0025

Microfluidic devices for the detection of disease-specific proteins and other macromolecules, disease modelling and drug development: A review

S. Amir, A. Arathi, S. Reshma and P.V. Mohanan

International Journal of Biological Macromolecules, 2023, 235, 123784
DOI: 10.1016/j.ijbiomac.2023.123784

What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?

Haiqing Bai and Donald E. Ingber

Physiology, 2022, 37, 242
DOI: 10.1152/physiol.00012.2022

Alternative lung cell model systems for toxicology testing strategies: Current knowledge and future outlook

Joana A. Moura, Kirsty Meldrum, Shareen H. Doak and Martin J.D. Clift

Seminars in Cell & Developmental Biology, 2023, 147, 70
DOI: 10.1016/j.semcdb.2022.12.006

Cell-contact-mediated assembly of contractile airway smooth muscle rings

Jonathan Tjong, Stefan Pendlmayr, Jena Barter, Julie Chen, Geoffrey N Maksym, T Alexander Quinn and John P Frampton

Biomed. Mater., 2023, 18, 025025
DOI: 10.1088/1748-605X/acbd09

Application and prospects of lung organ-on-a-chip in the development of new drugs

Jun Su, Jingjing Qiu, Jiaxu Meng, Yi Gong, Yichun Xu and Junsong Han

BioMed Eng OnLine, 2025, 25
DOI: 10.1186/s12938-025-01497-z

Rapid prototyping of PMMA-based microfluidic spheroid-on-a-chip models using micromilling and vapour-assisted thermal bonding

Monieb A. M. Ahmed, Klaudia M. Jurczak, N. Scott Lynn, Jean-Paul S. H. Mulder, Elisabeth M. J. Verpoorte and Anika Nagelkerke

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-53266-y

Organ-on-a-chip: recent breakthroughs and future prospects

Qirui Wu, Jinfeng Liu, Xiaohong Wang, Lingyan Feng, Jinbo Wu, Xiaoli Zhu, Weijia Wen and Xiuqing Gong

BioMed Eng OnLine, 2020, 19
DOI: 10.1186/s12938-020-0752-0

Advanced In Vitro Lung Models for Drug and Toxicity Screening: The Promising Role of Induced Pluripotent Stem Cells

Anabela Moreira, Michelle Müller, Pedro F. Costa and Yvonne Kohl

Advanced Biology, 2022, 6
DOI: 10.1002/adbi.202101139

Modelling Human Physiology on-Chip: Historical Perspectives and Future Directions

Sirjana Pun, Li Cai Haney and Riccardo Barrile

Micromachines, 2021, 12, 1250
DOI: 10.3390/mi12101250

Emerging toolset of three-dimensional pulmonary cell culture models for simulating lung pathophysiology towards mechanistic elucidation and therapeutic treatment of SARS-COV-2 infection

Kai Ni, Bo Che, Chongxin Yang, Youyuan Qin, Rong Gu, Chunhong Wang, Mingzhi Luo and Linhong Deng

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.1033043

Microfluidic strategies for biomimetic lung chip establishment and SARS-CoV2 study

Hui Wang, Tingqing Wen, Wan Zhu, Keke Li, Xiaojie Gong and Zhongyu Li

Materials Today Bio, 2024, 24, 100905
DOI: 10.1016/j.mtbio.2023.100905

Muscarinic receptor antagonists and airway inflammation: A systematic review on pharmacological models

Luigino Calzetta, Elena Pistocchini, Beatrice Ludovica Ritondo, Francesco Cavalli, Francesca Camardelli and Paola Rogliani

Heliyon, 2022, 8, e09760
DOI: 10.1016/j.heliyon.2022.e09760

Biomedical Application of Functional Materials in Organ-on-a-Chip

Chizhu Ding, Xiang Chen, Qinshu Kang and Xianghua Yan

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00823

Recent advances in lung-on-a-chip models

Isabella Francis, Jesus Shrestha, Keshav Raj Paudel, Philip M. Hansbro, Majid Ebrahimi Warkiani and Suvash C. Saha

Drug Discovery Today, 2022, 27, 2593
DOI: 10.1016/j.drudis.2022.06.004

Suspended Tissue Open Microfluidic Patterning (STOMP)

Amanda J. Haack, Lauren G. Brown, Alex J. Goldstein, Priti Mulimani, Jean Berthier, Asha R. Viswanathan, Irina Kopyeva, Jamison M. Whitten, Ariel Lin, Serena H. Nguyen, Thomas P. Leahy, Ella E. Bouker, Ruby M. Padgett, Natalie A. Mazzawi, Jodie C. Tokihiro, Ross C. Bretherton, Aaliyah Wu, Stephen J. Tapscott, Cole A. DeForest, Tracy E. Popowics, Erwin Berthier, Nathan J. Sniadecki and Ashleigh B. Theberge

Advanced Science, 2025, 12
DOI: 10.1002/advs.202501148

A guide to the organ-on-a-chip

Chak Ming Leung, Pim de Haan, Kacey Ronaldson-Bouchard, Ge-Ah Kim, Jihoon Ko, Hoon Suk Rho, Zhu Chen, Pamela Habibovic, Noo Li Jeon, Shuichi Takayama, Michael L. Shuler, Gordana Vunjak-Novakovic, Olivier Frey, Elisabeth Verpoorte and Yi-Chin Toh

Nat Rev Methods Primers, 2022, 2
DOI: 10.1038/s43586-022-00118-6

Open Microfluidic Capillary Systems

Erwin Berthier, Ashley M. Dostie, Ulri N. Lee, Jean Berthier and Ashleigh B. Theberge

Anal. Chem., 2019, 91, 8739
DOI: 10.1021/acs.analchem.9b01429

The VersaLive platform enables microfluidic mammalian cell culture for versatile applications

Giovanni Marco Nocera, Gaetano Viscido, Stefania Criscuolo, Simona Brillante, Fabrizia Carbone, Leopoldo Staiano, Sabrina Carrella and Diego di Bernardo

Commun Biol, 2022, 5
DOI: 10.1038/s42003-022-03976-8

3D Microphysiological System‐Inspired Scalable Vascularized Tissue Constructs for Regenerative Medicine

Seokyoung Bang, Dongha Tahk, Young Hwan Choi, Somin Lee, Jungeun Lim, Seung‐Ryeol Lee, Byung‐Soo Kim, Hong Nam Kim, Nathaniel S. Hwang and Noo Li Jeon

Adv Funct Materials, 2022, 32
DOI: 10.1002/adfm.202105475

Emerging Technologies for In Vitro Inhalation Toxicology

Ajay Vikram Singh, Anthony Romeo, Kassandra Scott, Sandra Wagener, Lars Leibrock, Peter Laux, Andreas Luch, Pranali Kerkar, Shidin Balakrishnan, Sarada Prasad Dakua and Byung‐Wook Park

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202100633

PDMS Organ-On-Chip Design and Fabrication: Strategies for Improving Fluidic Integration and Chip Robustness of Rapidly Prototyped Microfluidic In Vitro Models

Tiffany C. Cameron, Avineet Randhawa, Samantha M. Grist, Tanya Bennet, Jessica Hua, Luis G. Alde, Tara M. Caffrey, Cheryl L. Wellington and Karen C. Cheung

Micromachines, 2022, 13, 1573
DOI: 10.3390/mi13101573

Organs on chips: fundamentals, bioengineering and applications

Nasser K. Awad

J Artif Organs, 2025, 28, 110
DOI: 10.1007/s10047-024-01460-0

Microfluidic platforms integrated with nano-sensors for point-of-care bioanalysis

Hamed Tavakoli, Samayeh Mohammadi, Xiaochun Li, Guanglei Fu and XiuJun Li

TrAC Trends in Analytical Chemistry, 2022, 157, 116806
DOI: 10.1016/j.trac.2022.116806

Application of Micro-Engineered Kidney, Liver, and Respiratory System Models to Accelerate Preclinical Drug Testing and Development

Hanieh Gholizadeh, Shaokoon Cheng, Agisilaos Kourmatzis, Hanwen Xing, Daniela Traini, Paul M. Young and Hui Xin Ong

Bioengineering, 2022, 9, 150
DOI: 10.3390/bioengineering9040150

Organs-on-Chips Platforms Are Everywhere: A Zoom on Biomedical Investigation

Mohamed Zommiti, Nathalie Connil, Ali Tahrioui, Anne Groboillot, Corinne Barbey, Yoan Konto-Ghiorghi, Olivier Lesouhaitier, Sylvie Chevalier and Marc G. J. Feuilloley

Bioengineering, 2022, 9, 646
DOI: 10.3390/bioengineering9110646

Physiological and Disease Models of Respiratory System Based on Organ-on-a-Chip Technology

Di Wang, Ye Cong, Quanfeng Deng, Xiahe Han, Suonan Zhang, Li Zhao, Yong Luo and Xiuli Zhang

Micromachines, 2021, 12, 1106
DOI: 10.3390/mi12091106

3D Inkjet-Bioprinted Lung-on-a-Chip

Wookyeom Kim, Yunji Lee, Dayoon Kang, Taejeong Kwak, Hwa-Rim Lee and Sungjune Jung

ACS Biomater. Sci. Eng., 2023, 9, 2806
DOI: 10.1021/acsbiomaterials.3c00089

Co-cultured microfluidic model of the airway optimized for microscopy and micro-optical coherence tomography imaging

Zhongyu Liu, Stephen Mackay, Dylan M. Gordon, Justin D. Anderson, Dustin W. Haithcock, Charles J. Garson, Guillermo J. Tearney, George M. Solomon, Kapil Pant, Balabhaskar Prabhakarpandian, Steven M. Rowe and Jennifer S. Guimbellot

Biomed. Opt. Express, 2019, 10, 5414
DOI: 10.1364/BOE.10.005414

Recent advances in the understanding of alveolar flow

Jun Dong, Yue Yang and Yonggang Zhu

Biomicrofluidics, 2022, 16
DOI: 10.1063/5.0084415

Cells in the 3D biomatrix on-chip: better mimicking the real micro-physiological system

Michele D’Orazio, Joanna Filippi, Gianni Antonelli, Giorgia Curci, Paola Casti, Arianna Mencattini, Gianluca Cidonio and Eugenio Martinelli

Next Materials, 2024, 5, 100229
DOI: 10.1016/j.nxmate.2024.100229

Hydrogel membranes in organ-on-a-chip devices: A review

Przemysław Gnatowski, Maryam Ansariaghmiuni, Edyta Piłat, Maryam Poostchi, Justyna Kucińska-Lipka, Mohsen Khodadadi Yazdi, Jacek Ryl, Milad Ashrafizadeh, Fatemeh Mottaghitalab, Mehdi Farokhi, Mohammad Reza Saeb, Tomasz Bączek, Chu Chen and Qi Lu

Colloids and Surfaces B: Biointerfaces, 2025, 251, 114591
DOI: 10.1016/j.colsurfb.2025.114591

Vascularized Lower Respiratory-Physiology-On-A-Chip

Hyoryung Nam, Yoo-mi Choi and Jinah Jang

Applied Sciences, 2020, 10, 900
DOI: 10.3390/app10030900

Modeling organ-specific vasculature with organ-on-a-chip devices

Dawn S Y Lin, Feng Guo and Boyang Zhang

Nanotechnology, 2019, 30, 024002
DOI: 10.1088/1361-6528/aae7de

Inkjet-based bioprinting for tissue engineering

Ju An Park, Yunji Lee and Sungjune Jung

Organoid, 2023, 3, e12
DOI: 10.51335/organoid.2023.3.e12

Advancing human in vitro pulmonary disease models in preclinical research: opportunities for lung-on-chips

Arbel Artzy-Schnirman, Claus-Michael Lehr and Josué Sznitman

Expert Opinion on Drug Delivery, 2020, 17, 621
DOI: 10.1080/17425247.2020.1738380

Recent advances in microfluidic technologies for organ-on-a-chip

Chang Tian, Qin Tu, Wenming Liu and Jinyi Wang

TrAC Trends in Analytical Chemistry, 2019, 117, 146
DOI: 10.1016/j.trac.2019.06.005

The emergence of 3D bioprinting in organ-on-chip systems

Kirsten Fetah, Peyton Tebon, Marcus J Goudie, James Eichenbaum, Li Ren, Natan Barros, Rohollah Nasiri, Samad Ahadian, Nureddin Ashammakhi, Mehmet R Dokmeci and Ali Khademhosseini

Prog. Biomed. Eng., 2019, 1, 012001
DOI: 10.1088/2516-1091/ab23df

Organ‐On‐A‐Chip Devices: Technology Progress and Challenges

Pierre J. Obeid, Paolo Yammine, Hanna El‐Nakat, Rima Kassab, Tony Tannous, Zeina Nasr, Therese Maarawi, Norma Dahdah, Ali El Safadi, Agapy Mansour and Ayman Chmayssem

ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400580

Organ-on-a-Chip for Drug Screening: A Bright Future for Sustainability? A Critical Review

Jéssica F. Feitor, Laís C. Brazaca, Amanda M. Lima, Vinícius G. Ferreira, Giulia Kassab, Vanderlei S. Bagnato, Emanuel Carrilho and Daniel R. Cardoso

ACS Biomater. Sci. Eng., 2023, 9, 2220
DOI: 10.1021/acsbiomaterials.2c01454

Microfluidic high-throughput 3D cell culture

Jihoon Ko, Dohyun Park, Jungseub Lee, Sangmin Jung, Kyusuk Baek, Kyung E. Sung, Jeeyun Lee and Noo Li Jeon

Nat Rev Bioeng, 2024, 2, 453
DOI: 10.1038/s44222-024-00163-8

Fallopian tube rheology regulates epithelial cell differentiation and function to enhance cilia formation and coordination

Melati S. Abdul Halim, Jennifer M. Dyson, Max M. Gong, Moira K. O’Bryan and Reza Nosrati

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-51481-9

The promise of Synovial Joint-on-a-Chip in rheumatoid arthritis

Xin Zhang, Rui Su, Hui Wang, Ruihe Wu, Yuxin Fan, Zexuan Bin, Chong Gao and Caihong Wang

Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1408501

Organ-on-a-chip: Quo vademus? Applications and regulatory status

Maria Mendes, Ana Sofia Morais, Ana Carlos, João José Sousa, Alberto Canelas Pais, Silvia M. Mihăilă and Carla Vitorino

Colloids and Surfaces B: Biointerfaces, 2025, 249, 114507
DOI: 10.1016/j.colsurfb.2025.114507

Microfluidics in biomedical research and its application in orthopedics: a perspective review

Hemalatha Kanniyappan, Mareeswari Paramasivan, Vanaja Narayanaswamy, Rucha Konety, Govindaraj Perumal, Yang Lin, Ravindra V. Badhe and Mathew T. Mathew

Microfluid Nanofluid, 2026, 30
DOI: 10.1007/s10404-025-02856-x

3D (bio)printing of lungs: past, present, and future

Mohammadhossein Dabaghi, Mabel Barreiro Carpio, Jose Manuel Moran-Mirabal and Jeremy Alexander Hirota

Eur Respir J, 2023, 61, 2200417
DOI: 10.1183/13993003.00417-2022

Bioengineering the Blood‐gas Barrier

Katherine L. Leiby, Micha Sam Brickman Raredon and Laura E. Niklason

Comprehensive Physiology, 2020, 10, 415
DOI: 10.1002/j.2040-4603.2020.tb00124.x

Building Blood Vessel Chips with Enhanced Physiological Relevance

Xuan Mu, Marie Denise Gerhard‐Herman and Yu Shrike Zhang

Adv Materials Technologies, 2023, 8
DOI: 10.1002/admt.202201778

Advances and challenges in organ-on-chip technology: toward mimicking human physiology and disease in vitro

Dhiraj Kumar, Rahul Nadda and Ramjee Repaka

Med Biol Eng Comput, 2024, 62, 1925
DOI: 10.1007/s11517-024-03062-7

Microphysiological Systems: A Pathologist’s Perspective

Radhakrishna Sura, Terry Van Vleet and Brian R. Berridge

Vet Pathol, 2020, 57, 358
DOI: 10.1177/0300985820908794

In situ-Like Aerosol Inhalation Exposure for Cytotoxicity Assessment Using Airway-on-Chips Platforms

Shani Elias-Kirma, Arbel Artzy-Schnirman, Prashant Das, Metar Heller-Algazi, Netanel Korin and Josué Sznitman

Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00091

A human airway-on-a-chip microphysiological system for modeling chlorine gas toxicity

Sean V Murphy, Shiny A P Rajan, Kevin Lindert, Tracey Young, Yan Jiao, Yu Zhou, Oula Khoury, Malcolm McSwain, Sivanandane Sittadjody, Zeeshan Hamid, Phillip W Clapp, Timothy S Leach, Timothy C Orr, Douglas Shankle, Emily Whitaker, Khiry Sutton, Steven E Albertson, Kristina Stumpf, Lysette Mutkus, Trang Simon, Gauri Kulkarni, Jeannie Chan, Jingyun Lee, Laura A Cox, Ge Li, Charity Campbell, Michael Olivier, Sobha Puppala, Tony E Reeves, Carl D Langefeld, Hannah C Ainsworth, Julie Ziegler, Amy Zinnia, Mohammad S Khan, Frank C Marini, Stephen J Walker, Thomas D Shupe, Alan Jacobson, Cristina M Furdui, Andrew C Bishop, Adam R Hall, Michael C Seeds, Kimberly D Reeves and Anthony Atala

Toxicological Sciences, 2026, 209
DOI: 10.1093/toxsci/kfaf179

Organ-On-A-Chip Technology: An In-depth Review of Recent Advancements and Future of Whole Body-on-chip

Rishab Driver and Shweta Mishra

BioChip J, 2023, 17, 1
DOI: 10.1007/s13206-022-00087-8

A Microfluidic Organ-On-A-Chip: Into the Next Decade of Bone Tissue Engineering Applied in Dentistry

Muhammad Hidayat Syahruddin, Rahmi Anggraeni and Ika Dewi Ana

Future Sci. OA, 2023, 9
DOI: 10.2144/fsoa-2023-0061

Bronchial epithelial and airway smooth muscle cell interactions in health and disease

Reshed Abohalaka

Heliyon, 2023, 9, e19976
DOI: 10.1016/j.heliyon.2023.e19976

Investigation of the role of the autophagic protein LC3B in the regulation of human airway epithelium cell differentiation in COPD using a biomimetic model

Shiue-Luen Chen, Hsiao-Chun Chou, Kuan-Chen Lin, Jia-Wei Yang, Ren-Hao Xie, Chong-You Chen, Xin-Yi Liu, Johnson H.Y. Chung and Guan-Yu Chen