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Imaging therapeutic peptide transport across intestinal barriers
Jannik Bruun Larsen, Nayere Taebnia, Alireza Dolatshahi-Pirouz, Anne Zebitz Eriksen, Claudia Hjørringgaard, Kasper Kristensen, Nanna Wichmann Larsen, Niels Bent Larsen, Rodolphe Marie, Ann-Kathrin Mündler, Ladan Parhamifar, Andrew James Urquhart, Arjen Weller, Kim I. Mortensen, Henrik Flyvbjerg and Thomas Lars Andresen
RSC Chem. Biol., 2021, 2, 1115
DOI: 10.1039/D1CB00024A

Robust chemical bonding of PMMA microfluidic devices to porous PETE membranes for reliable cytotoxicity testing of drugs
Thao Nguyen, Su Hyun Jung, Min Seok Lee, Tae-Eun Park, Suk-kyun Ahn and Joo H. Kang
Lab Chip, 2019, 19, 3706
DOI: 10.1039/C9LC00338J

Spatial trans-epithelial electrical resistance (S-TEER) integrated in organs-on-chips
Noa Renous, Mark D. Kiri, Ronny A. Barnea, Rossana Rauti, Yael Leichtmann-Bardoogo and Ben M. Maoz
Lab Chip, 2022, 22, 71
DOI: 10.1039/D1LC00789K

Online monitoring of epithelial barrier kinetics and cell detachment during cisplatin-induced toxicity of renal proximal tubule cells
Yuji Takata, Ramin Banan Sadeghian, Kazuya Fujimoto and Ryuji Yokokawa
Analyst, 2024, 149, 3596
DOI: 10.1039/D4AN00267A

Organ-on-a-chip with integrated semitransparent organic electrodes for barrier function monitoring
Denise Marrero, Anton Guimera, Laure Maes, Rosa Villa, Mar Alvarez and Xavi Illa
Lab Chip, 2023, 23, 1825
DOI: 10.1039/D2LC01097F

A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood–retinal barrier
Jose Yeste, Marta García-Ramírez, Xavi Illa, Anton Guimerà, Cristina Hernández, Rafael Simó and Rosa Villa
Lab Chip, 2018, 18, 95
DOI: 10.1039/C7LC00795G

From animal testing to in vitro systems: advancing standardization in microphysiological systems
Darwin R. Reyes, Mandy B. Esch, Lorna Ewart, Rohollah Nasiri, Anna Herland, Kyung Sung, Monica Piergiovanni, Carolina Lucchesi, James T. Shoemaker, Jelena Vukasinovic, Hiroki Nakae, James Hickman, Kapil Pant, Anne Taylor, Niki Heinz and Nureddin Ashammakhi
Lab Chip, 2024, 24, 1076
DOI: 10.1039/D3LC00994G

Membrane-based microfluidic systems for medical and biological applications
Silvia Tea Calzuola, Gwenyth Newman, Thomas Feaugas, Cécile M. Perrault, Jean-Baptiste Blondé, Emmanuel Roy, Constance Porrini, Goran M. Stojanovic and Jasmina Vidic
Lab Chip, 2024, 24, 3579
DOI: 10.1039/D4LC00251B

High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip
Muhammad Asad Ullah Khalid, Kyung Hwan Kim, Abdul Rahim Chethikkattuveli Salih, Kinam Hyun, Sung Hyuk Park, Bohye Kang, Afaque Manzoor Soomro, Muhsin Ali, Yesl Jun, Dongeun Huh, Heeyeong Cho and Kyung Hyun Choi
Lab Chip, 2022, 22, 1764
DOI: 10.1039/D1LC01079D

Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease
Jun Liu, Ronghao Lu, Xiaolin Zheng, Wensheng Hou, Xiaoying Wu, Hezhao Zhao, Guixue Wang and Tian Tian
Biomater. Sci., 2023, 11, 2504
DOI: 10.1039/D2BM01490D

Non-contact monitoring of extra-cellular field potentials with a multi-electrode array
Tal Sharf, Paul K. Hansma, Mukund A. Hari and Kenneth S. Kosik
Lab Chip, 2019, 19, 1448
DOI: 10.1039/C8LC00984H

High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows
H. Azizgolshani, J. R. Coppeta, E. M. Vedula, E. E. Marr, B. P. Cain, R. J. Luu, M. P. Lech, S. H. Kann, T. J. Mulhern, V. Tandon, K. Tan, N. J. Haroutunian, P. Keegan, M. Rogers, A. L. Gard, K. B. Baldwin, J. C. de Souza, B. C. Hoefler, S. S. Bale, L. B. Kratchman, A. Zorn, A. Patterson, E. S. Kim, T. A. Petrie, E. L. Wiellette, C. Williams, B. C. Isenberg and J. L. Charest
Lab Chip, 2021, 21, 1454
DOI: 10.1039/D1LC00067E

Recent advances in microfluidic technologies for cell-to-cell interaction studies
Mario Rothbauer, Helene Zirath and Peter Ertl
Lab Chip, 2018, 18, 249
DOI: 10.1039/C7LC00815E

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy
Marinke W. van der Helm, Olivier Y. F. Henry, Amir Bein, Tiama Hamkins-Indik, Michael J. Cronce, William D. Leineweber, Mathieu Odijk, Andries D. van der Meer, Jan C. T. Eijkel, Donald E. Ingber, Albert van den Berg and Loes I. Segerink
Lab Chip, 2019, 19, 452
DOI: 10.1039/C8LC00129D

Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems
Alisa Ugodnikov, Henrik Persson and Craig A. Simmons
Lab Chip, 2024, 24, 3199
DOI: 10.1039/D3LC01027A

Contact photolithography-free integration of patterned and semi-transparent indium tin oxide stimulation electrodes into polydimethylsiloxane-based heart-on-a-chip devices for streamlining physiological recordings
Joycelyn K. Yip, Debarghya Sarkar, Andrew P. Petersen, Jennifer N. Gipson, Jun Tao, Salil Kale, Megan L. Rexius-Hall, Nathan Cho, Natalie N. Khalil, Rehan Kapadia and Megan L. McCain
Lab Chip, 2021, 21, 674
DOI: 10.1039/D0LC00948B

Real-time cell barrier monitoring by spatial transepithelial electrical resistance measurement on a microelectrode array integrated Transwell
Yimin Shi, Sheng Sun, Hui Liu, Mingda Zhao, Meiyan Qin, Jinlong Liu, Jingfang Hu, Yang Zhao, Mingxiao Li, Lingqian Zhang and Chengjun Huang
Lab Chip, 2025, 25, 253
DOI: 10.1039/D4LC00817K

Heat and pressure-resistant room temperature irreversible sealing of hybrid PDMS–thermoplastic microfluidic devices via carbon–nitrogen covalent bonding and its application in a continuous-flow polymerase chain reaction
Rajamanickam Sivakumar, Kieu The Loan Trinh and Nae Yoon Lee
RSC Adv., 2020, 10, 16502
DOI: 10.1039/D0RA02332A

Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures
Johannes Dornhof, Jochen Kieninger, Harshini Muralidharan, Jochen Maurer, Gerald A. Urban and Andreas Weltin
Lab Chip, 2022, 22, 225
DOI: 10.1039/D1LC00689D

Heart-on-a-chip systems: disease modeling and drug screening applications
Derrick Butler and Darwin R. Reyes
Lab Chip, 2024, 24, 1494
DOI: 10.1039/D3LC00829K

A layered cancer-on-a-chip system for anticancer drug screening and disease modeling
Magdalena Flont, Artur Dybko and Elżbieta Jastrzębska
Analyst, 2023, 148, 5486
DOI: 10.1039/D3AN00959A

Strategies for directing cells into building functional hearts and parts
Mahboubeh Jafarkhani, Zeinab Salehi, Reza Kowsari-Esfahan, Mohammad Ali Shokrgozar, M. Rezaa Mohammadi, Jayakumar Rajadas and Masoud Mozafari
Biomater. Sci., 2018, 6, 1664
DOI: 10.1039/C7BM01176H

Innovative electrode and chip designs for transendothelial electrical resistance measurements in organs-on-chips
Muriel A. Holzreuter and Loes I. Segerink
Lab Chip, 2024, 24, 1121
DOI: 10.1039/D3LC00901G

Online oxygen monitoring using integrated inkjet-printed sensors in a liver-on-a-chip system
A. Moya, M. Ortega-Ribera, X. Guimerà, E. Sowade, M. Zea, X. Illa, E. Ramon, R. Villa, J. Gracia-Sancho and G. Gabriel
Lab Chip, 2018, 18, 2023
DOI: 10.1039/C8LC00456K

Measuring barrier function in organ-on-chips with cleanroom-free integration of multiplexable electrodes
Elsbeth G. B. M. Bossink, Mariia Zakharova, Douwe S. de Bruijn, Mathieu Odijk and Loes I. Segerink
Lab Chip, 2021, 21, 2040
DOI: 10.1039/D0LC01289K

Rapid integration of screen-printed electrodes into thermoplastic organ-on-a-chip devices for real-time monitoring of trans-endothelial electrical resistance
Satoru Kawakita, Shaopei Li, Huu Tuan Nguyen, Surjendu Maity, Reihaneh Haghniaz, Jamal Bahari, Ning Yu, Kalpana Mandal, Praveen Bandaru, Lei Mou, Menekse Ermis, Enam Khalil, Safoora Khosravi, Arne Peirsman, Rohollah Nasiri, Annie Adachi, Aya Nakayama, Remy Bell, Yangzhi Zhu, Vadim Jucaud, Mehmet Remzi Dokmeci and Ali Khademhosseini
Biomed Microdevices, 2023, 25
DOI: 10.1007/s10544-023-00669-9

Complex or not too complex? One size does not fit all in next generation microphysiological systems
Simone Bersini, Chiara Arrigoni, Giuseppe Talò, Christian Candrian and Matteo Moretti
iScience, 2024, 27, 109199
DOI: 10.1016/j.isci.2024.109199

Potential applications of microfluidics based blood brain barrier (BBB)-on-chips for in vitro drug development
Xiaobo Wang, Ya Hou, Xiaopeng Ai, Jiayi Sun, Binjie Xu, Xianli Meng, Yi Zhang and Sanyin Zhang
Biomedicine & Pharmacotherapy, 2020, 132, 110822
DOI: 10.1016/j.biopha.2020.110822

Impedance Spectroscopy as a Tool for Monitoring Performance in 3D Models of Epithelial Tissues
Tatiana Gerasimenko, Sergey Nikulin, Galina Zakharova, Andrey Poloznikov, Vladimir Petrov, Ancha Baranova and Alexander Tonevitsky
Front. Bioeng. Biotechnol., 2020, 7
DOI: 10.3389/fbioe.2019.00474

Advances in TEER measurements of biological barriers in microphysiological systems
Hojjatollah Nazari, Jesus Shrestha, Vahid Yaghoubi Naei, Sajad Razavi Bazaz, Milad Sabbagh, Jean Paul Thiery and Majid Ebrahimi Warkiani
Biosensors and Bioelectronics, 2023, 234, 115355
DOI: 10.1016/j.bios.2023.115355

Sorption of Neuropsychopharmaca in Microfluidic Materials for In Vitro Studies
Thomas E. Winkler and Anna Herland
ACS Appl. Mater. Interfaces, 2021, 13, 45161
DOI: 10.1021/acsami.1c07639

In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential
Stefanie Fuchs, Sofia Johansson, Anders Ø. Tjell, Gabriel Werr, Torsten Mayr and Maria Tenje
ACS Biomater. Sci. Eng., 2021, 7, 2926
DOI: 10.1021/acsbiomaterials.0c01110

Advanced electrochemical and sensor technologies in gastroenterology: Applications of EIS, organ-on-a-chip, and ingestible/wearable devices in chronic disease diagnosis and monitoring
Weitong Hu and Xianmei Lv
International Journal of Electrochemical Science, 2025, 20, 101178
DOI: 10.1016/j.ijoes.2025.101178

Novel design of biplanar electrodes in a multiwell plate for transepithelial electrical resistance measurement in 3D cell cultures
Georges Dubourg, Divyasree Prabhakaran, Harry Dawson, Vasa Radonic, Sara Joksović, Jovana Stanojev and Antoni Homs Corbera
Sensors and Actuators A: Physical, 2025, 387, 116413
DOI: 10.1016/j.sna.2025.116413

Transforming a well into a chip: A modular 3D-printed microfluidic chip
Rossana Rauti, Adi Ess, Baptiste Le Roi, Yevgeniy Kreinin, Mark Epshtein, Netanel Korin and Ben M. Maoz
APL Bioengineering, 2021, 5
DOI: 10.1063/5.0039366

New bioimaging avenues for organs‐on‐chips by integration of bioluminescence
Liliana Moreira Teixeira and Laura Mezzanotte
VIEW, 2021, 2
DOI: 10.1002/VIW.20200177

Towards Cellular Ultrastructural Characterization in Organ-on-a-Chip by Transmission Electron Microscopy
Adrianna Glinkowska Mares, Natalia Feiner-Gracia, Yolanda Muela, Gema Martínez, Lidia Delgado, Lorenzo Albertazzi and Silvia Pujals
Applied Nano, 2021, 2, 289
DOI: 10.3390/applnano2040021

Human Organs-on-Chips for Virology
Huaqi Tang, Yasmine Abouleila, Longlong Si, Ana Maria Ortega-Prieto, Christine L. Mummery, Donald E. Ingber and Alireza Mashaghi
Trends in Microbiology, 2020, 28, 934
DOI: 10.1016/j.tim.2020.06.005

Engineering Organ-on-a-Chip Systems for Cancer Immunotherapy: Strategies and Assay Integration
Jie Wang and Zongjie Wang
Bioengineering, 2026, 13, 492
DOI: 10.3390/bioengineering13050492

Advancing Organ-on-a-Chip Systems: The Role of Scaffold Materials and Coatings in Engineering Cell Microenvironment
Guido Andrés Ramírez-González, Chiara Consumi-Tubito, Ernesto Vargas-Méndez and Carolina Centeno-Cerdas
Polymers, 2025, 17, 1263
DOI: 10.3390/polym17091263

Electrochemical Imaging of Endothelial Permeability Using a Large-Scale Integration-Based Device
Kosuke Ino, Hao-Jen Pai, Kaoru Hiramoto, Yoshinobu Utagawa, Yuji Nashimoto and Hitoshi Shiku
ACS Omega, 2021, 6, 35476
DOI: 10.1021/acsomega.1c04931

Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening
Yvonne Kohl, Margit Biehl, Sarah Spring, Michelle Hesler, Vladimir Ogourtsov, Miomir Todorovic, Joshua Owen, Elisabeth Elje, Kristina Kopecka, Oscar Hernando Moriones, Neus G. Bastús, Peter Simon, Tibor Dubaj, Elise Rundén‐Pran, Victor Puntes, Nicola William, Hagen von Briesen, Sylvia Wagner, Nikil Kapur, Espen Mariussen, Andrew Nelson, Alena Gabelova, Maria Dusinska, Thomas Velten and Thorsten Knoll
Small, 2021, 17
DOI: 10.1002/smll.202006012

Human Organs‐on‐Chips: A Review of the State‐of‐the‐Art, Current Prospects, and Future Challenges
Payam Zarrintaj, Mohammad Reza Saeb, Florian J. Stadler, Mohsen Khodadadi Yazdi, Mojtaba Nasiri Nezhad, Shabnam Mohebbi, Farzad Seidi, Mohammad Reza Ganjali and Masoud Mozafari
Advanced Biology, 2022, 6
DOI: 10.1002/adbi.202000526

Toward continuous monitoring systems: emerging trends of on-chip sensors in organ-on-a-chip
Shuang Ling, Chenrui Xu, Yuqing Jiang, Feng Xu, Hang Jin, Hong Chen, Songyue Chen, Zhengmao Ding and Daoheng Sun
Microsyst Nanoeng, 2026, 12
DOI: 10.1038/s41378-025-01142-8

Microbiota‐gut‐brain axis multi‐organ chip construction and applications in drug evaluation
Yue Tang, Hewen Chen, Ziyue Zhao, Xuesong Kang, Wenxin Wang, Kun Dai, Yufei Guo, Axin Liang, Aiqin Luo and Zikai Hao
iMetaOmics, 2025, 2
DOI: 10.1002/imo2.70065

Revolutionizing Drug Discovery: The Impact of Distinct Designs and Biosensor Integration in Microfluidics-Based Organ-on-a-Chip Technology
Sheng Yuan, Huipu Yuan, David C. Hay, Huan Hu and Chaochen Wang
Biosensors, 2024, 14, 425
DOI: 10.3390/bios14090425

Environmental toxicology wars: Organ-on-a-chip for assessing the toxicity of environmental pollutants
Sheng Yang, Zaozao Chen, Yanping Cheng, Tong Liu, Lihong Yin, Yuepu Pu and Geyu Liang
Environmental Pollution, 2021, 268, 115861
DOI: 10.1016/j.envpol.2020.115861

Measurement of respiration and acidification rates of mammalian cells in thermoplastic microfluidic devices
Bernhard Müller, Philipp Sulzer, Manuel Walch, Helene Zirath, Tomáš Buryška, Mario Rothbauer, Peter Ertl and Torsten Mayr
Sensors and Actuators B: Chemical, 2021, 334, 129664
DOI: 10.1016/j.snb.2021.129664

A method for rapid generation of model intestinal barriers in vitro
SV Nikulin, AA Poloznikov and DA Sakharov
BRSMU, 2020
DOI: 10.24075/brsmu.2020.077

Gut‐on‐chip with integrated sensors: Enables in‐situ monitoring and real‐time evaluation of the chip
Yan Li, Zhiyuan Xiang, Zihong Yuan, Huaping Zhang and Aliu Shi
Electroanalysis, 2024, 36
DOI: 10.1002/elan.202400188

Lung on a Chip Development from Off-Stoichiometry Thiol–Ene Polymer
Roberts Rimsa, Artis Galvanovskis, Janis Plume, Felikss Rumnieks, Karlis Grindulis, Gunita Paidere, Sintija Erentraute, Gatis Mozolevskis and Arturs Abols
Micromachines, 2021, 12, 546
DOI: 10.3390/mi12050546

In vitro electrochemical assays for vascular cells and organs
Yoshinobu Utagawa, Kaoru Hiramoto, Yuji Nashimoto, Kosuke Ino and Hitoshi Shiku
Electrochemical Science Adv, 2022, 2
DOI: 10.1002/elsa.202100089

Organ‐On‐A‐Chip Models of the Blood–Brain Barrier: Recent Advances and Future Prospects
Satoru Kawakita, Kalpana Mandal, Lei Mou, Marvin Magan Mecwan, Yangzhi Zhu, Shaopei Li, Saurabh Sharma, Ana Lopez Hernandez, Huu Tuan Nguyen, Surjendu Maity, Natan Roberto de Barros, Aya Nakayama, Praveen Bandaru, Samad Ahadian, Han‐Jun Kim, Rondinelli Donizetti Herculano, Eggehard Holler, Vadim Jucaud, Mehmet Remzi Dokmeci and Ali Khademhosseini
Small, 2022, 18
DOI: 10.1002/smll.202201401

Nanotechnology-Assisted Microfluidic Systems: From Bench to Bedside
Navid Rabiee, Sepideh Ahmadi, Yousef Fatahi, Mohammad Rabiee, Mojtaba Bagherzadeh, Rassoul Dinarvand, Babak Bagheri, Payam Zarrintaj, Mohammad Reza Saeb and Thomas J Webster
Nanomedicine (Lond.), 2021, 16, 237
DOI: 10.2217/nnm-2020-0353

The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-Chip
Shafaque Rahman, Mohammed Ghiboub, Joanne M. Donkers, Evita van de Steeg, Eric A. F. van Tol, Theodorus B. M. Hakvoort and Wouter J. de Jonge
IJMS, 2021, 22, 13472
DOI: 10.3390/ijms222413472

Advances in the Model Structure of In Vitro Vascularized Organ-on-a-Chip
Hongze Yin, Yue Wang, Na Liu, Songyi Zhong, Long Li, Quan Zhang, Zeyang Liu and Tao Yue
Cyborg Bionic Syst, 2024, 5
DOI: 10.34133/cbsystems.0107

What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?
Haiqing Bai and Donald E. Ingber
Physiology, 2022, 37, 242
DOI: 10.1152/physiol.00012.2022

State of the art in integrated biosensors for organ-on-a-chip applications
Yangzhi Zhu, Kalpana Mandal, Ana Lopez Hernandez, Satoru Kawakita, Wei Huang, Praveen Bandaru, Samad Ahadian, Han-Jun Kim, Vadim Jucaud, Mehmet R. Dokmeci and Ali Khademhosseini
Current Opinion in Biomedical Engineering, 2021, 19, 100309
DOI: 10.1016/j.cobme.2021.100309

Reconstruction of in vivo-like in vitro model: Enabling technologies of microfluidic systems for dynamic biochemical/mechanical stimuli
Sang Min Park, Seongsu Eom, Hyeonjun Hong, Jaeseung Yoon, Seong Jin Lee, Bum Chang Kim, Hyung Woo Kim and Dong Sung Kim
Microelectronic Engineering, 2019, 203-204, 6
DOI: 10.1016/j.mee.2018.10.010

Cytocentric measurement for regenerative medicine
Alicia D. Henn, Taci Pereira, Joshua Hunsberger, Kunal Mitra, Zohreh Izadifar, Sita Somara, Lisa Lindström, Thomas Forest Farb-Horch, Jake Boy, George F. Muschler, Steven R. Bauer and Randy Yerden
Front. Med. Technol., 2023, 5
DOI: 10.3389/fmedt.2023.1154653

Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)
Mridu Malik, Yang Yang, Parinaz Fathi, Gretchen J. Mahler and Mandy B. Esch
Front. Cell Dev. Biol., 2021, 9
DOI: 10.3389/fcell.2021.721338

Comprehending the Membrane Properties for Emulation in Organs‐on‐a‐Chip
Tanmayee Makarand Sathe and Dhananjay Shrikrishna Bodas
Advanced NanoBiomed Research, 2026, 6
DOI: 10.1002/anbr.202500078

Glial cells influence cardiac permittivity as evidenced through in vitro and in silico models
Jonathan R Soucy, Jody Askaryan, David Diaz, Abigail N Koppes, Nasim Annabi and Ryan A Koppes
Biofabrication, 2020, 12, 015014
DOI: 10.1088/1758-5090/ab4c0a

Fusing spheroids to aligned μ-tissues in a heart-on-chip featuring oxygen sensing and electrical pacing capabilities
Oliver Schneider, Alessia Moruzzi, Stefanie Fuchs, Alina Grobel, Henrike S. Schulze, Torsten Mayr and Peter Loskill
Materials Today Bio, 2022, 15, 100280
DOI: 10.1016/j.mtbio.2022.100280

Recent Advances of Biosensor-Integrated Organ-on-a-Chip Technologies for Diagnostics and Therapeutics
Ashwini Shinde, Kavitha Illath, Uvanesh Kasiviswanathan, Shalini Nagabooshanam, Pallavi Gupta, Koyel Dey, Pulasta Chakrabarty, Moeto Nagai, Suresh Rao, Srabani Kar and Tuhin Subhra Santra
Anal. Chem., 2023, 95, 3121
DOI: 10.1021/acs.analchem.2c05036

Challenges in Permeability Assessment for Oral Drug Product Development
Mirko Koziolek, Patrick Augustijns, Constantin Berger, Rodrigo Cristofoletti, David Dahlgren, Janneke Keemink, Pär Matsson, Fiona McCartney, Marco Metzger, Mario Mezler, Janis Niessen, James E. Polli, Maria Vertzoni, Werner Weitschies and Jennifer Dressman
Pharmaceutics, 2023, 15, 2397
DOI: 10.3390/pharmaceutics15102397

Current advancements in the development of bionic organs using regenerative medicine and 3D tissue engineering
Dilip Kumar Shanmugam, Srinidhiy Chittibabu Anitha, Vedhapriya Souresh, Yasasve Madhavan, Shobana Sampath, Divyambika Catakapatri Venugopal and Muthupandian Saravanan
Materials Technology, 2023, 38
DOI: 10.1080/10667857.2023.2242732

Recent Advances in Integrated Organ‐Chip Sensing Toward Robust and User‐Friendly Systems
Bryan G. Schellberg, Ryan A. Koppes and Abigail N. Koppes
J Biomedical Materials Res, 2025, 113
DOI: 10.1002/jbm.a.37876

High-throughput organ-on-a-chip systems: Current status and remaining challenges
Christopher Probst, Stefan Schneider and Peter Loskill
Current Opinion in Biomedical Engineering, 2018, 6, 33
DOI: 10.1016/j.cobme.2018.02.004

A Decade of Organs-on-a-Chip Emulating Human Physiology at the Microscale: A Critical Status Report on Progress in Toxicology and Pharmacology
Mario Rothbauer, Barbara E.M. Bachmann, Christoph Eilenberger, Sebastian R.A. Kratz, Sarah Spitz, Gregor Höll and Peter Ertl
Micromachines, 2021, 12, 470
DOI: 10.3390/mi12050470

Multifunctional 3D electrode platform for real-time in situ monitoring and stimulation of cardiac tissues
Ning Zhang, Flurin Stauffer, Benjamin R. Simona, Feng Zhang, Zhao-Ming Zhang, Ning-Ping Huang and János Vörös
Biosensors and Bioelectronics, 2018, 112, 149
DOI: 10.1016/j.bios.2018.04.037

Glial Cells in the Heart? Replicating the Diversity of the Myocardium with Low-Cost 3D Models
Jonathan R. Soucy, Jody Askaryan, David Diaz, Abigail N. Koppes, Nasim Annabi and Ryan Koppes
SSRN Journal, 2018
DOI: 10.2139/ssrn.3205400

Transendothelial electrical resistance measurement by a microfluidic device for functional study of endothelial barriers in inflammatory bowel disease
Ya Li, Min Xu, Zhu Zhu, Feng Xu and Bing Chen
Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1236610

Flat and microstructured polymeric membranes in organs-on-chips
Thijs Pasman, Dirk Grijpma, Dimitrios Stamatialis and Andreas Poot
J. R. Soc. Interface., 2018, 15, 20180351
DOI: 10.1098/rsif.2018.0351

Airway-On-A-Chip: Designs and Applications for Lung Repair and Disease
Tanya J. Bennet, Avineet Randhawa, Jessica Hua and Karen C. Cheung
Cells, 2021, 10, 1602
DOI: 10.3390/cells10071602

Building Blood Vessel Chips with Enhanced Physiological Relevance
Xuan Mu, Marie Denise Gerhard‐Herman and Yu Shrike Zhang
Adv Materials Technologies, 2023, 8
DOI: 10.1002/admt.202201778

Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes
Jonathan R. Soucy, Adam J. Bindas, Abigail N. Koppes and Ryan A. Koppes
iScience, 2019, 21, 521
DOI: 10.1016/j.isci.2019.10.052

Electrochemical measurement of serotonin by Au-CNT electrodes fabricated on microporous cell culture membranes
Ashley A. Chapin, Pradeep R. Rajasekaran, David N. Quan, Liangbing Hu, Jens Herberholz, William E. Bentley and Reza Ghodssi
Microsyst Nanoeng, 2020, 6
DOI: 10.1038/s41378-020-00184-4

Advancements in modelling human blood brain-barrier on a chip
Vita Guarino, Alessandra Zizzari, Monica Bianco, Giuseppe Gigli, Lorenzo Moroni and Valentina Arima
Biofabrication, 2023, 15, 022003
DOI: 10.1088/1758-5090/acb571

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases
Valentina Paloschi, Maria Sabater-Lleal, Heleen Middelkamp, Aisen Vivas, Sofia Johansson, Andries van der Meer, Maria Tenje and Lars Maegdefessel
Cardiovascular Research, 2021, 117, 2742
DOI: 10.1093/cvr/cvab088

New Endeavors of (Micro)Tissue Engineering: Cells Tissues Organs on-Chip and Communication Thereof
Haysam M.M.A.M. Ahmed and Liliana S. Moreira Teixeira
Cells Tissues Organs, 2022, 211, 721
DOI: 10.1159/000516356

Porous Membrane Electrical Cell–Substrate Impedance Spectroscopy for Versatile Assessment of Biological Barriers In Vitro
Oleg Chebotarev, Alisa Ugodnikov and Craig A. Simmons
ACS Appl. Bio Mater., 2024, 7, 2000
DOI: 10.1021/acsabm.4c00114

Developmentally inspired human ‘organs on chips’
Donald E. Ingber
Development, 2018, 145
DOI: 10.1242/dev.156125

Continuous Monitoring Reveals Protective Effects of N‐Acetylcysteine Amide on an Isogenic Microphysiological Model of the Neurovascular Unit
Isabelle Matthiesen, Dimitrios Voulgaris, Polyxeni Nikolakopoulou, Thomas E. Winkler and Anna Herland
Small, 2021, 17
DOI: 10.1002/smll.202101785

Heart-on-a-chip platforms and biosensor integration for disease modeling and phenotypic drug screening
Joseph Criscione, Zahra Rezaei, Carol M. Hernandez Cantu, Sean Murphy, Su Ryon Shin and Deok-Ho Kim
Biosensors and Bioelectronics, 2023, 220, 114840
DOI: 10.1016/j.bios.2022.114840

Automated Droplet-Based Microfluidic Platform for Multiplexed Analysis of Biochemical Markers in Small Volumes
Diana F. Cedillo-Alcantar, Yong Duk Han, Jonghoon Choi, Jose L. Garcia-Cordero and Alexander Revzin
Anal. Chem., 2019, 91, 5133
DOI: 10.1021/acs.analchem.8b05689

Broadband electrical impedance as a novel characterization of oxidative stress in single L6 skeletal muscle cells
Caroline Ferguson, Niccolo Pini, Xiaotian Du, Marco Farina, James M.C. Hwang, Tiziana Pietrangelo and Xuanhong Cheng
Analytica Chimica Acta, 2021, 1173, 338678
DOI: 10.1016/j.aca.2021.338678

The Exciting Realities and Possibilities of iPS-Derived Cardiomyocytes
Fuga Takahashi, Praneel Patel, Takahiro Kitsuka and Kenichi Arai
Bioengineering, 2023, 10, 237
DOI: 10.3390/bioengineering10020237

Recent advances in blood-brain barrier-on-a-chip models
Johanna Vetter, Ilaria Palagi, Ari Waisman and Andreas Blaeser
Acta Biomaterialia, 2025, 197, 1
DOI: 10.1016/j.actbio.2025.03.041

Electro-metabolic coupling in multi-chambered vascularized human cardiac organoids
Mohammad Ghosheh, Avner Ehrlich, Konstantinos Ioannidis, Muneef Ayyash, Idit Goldfracht, Merav Cohen, Amit Fischer, Yoav Mintz, Lior Gepstein and Yaakov Nahmias
Nat. Biomed. Eng, 2023, 7, 1493
DOI: 10.1038/s41551-023-01071-9

Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems
Erika Ferrari, Cecilia Palma, Simone Vesentini, Paola Occhetta and Marco Rasponi
Biosensors, 2020, 10, 110
DOI: 10.3390/bios10090110

Organ-on-a-Chip: Ubi sumus? Fundamentals and Design Aspects
Ana Sofia Morais, Maria Mendes, Marta Agostinho Cordeiro, João J. Sousa, Alberto Canelas Pais, Silvia M. Mihăilă and Carla Vitorino
Pharmaceutics, 2024, 16, 615
DOI: 10.3390/pharmaceutics16050615

Ultrapliable bioelectronic interface for mechanosensitive cardiac electrophysiology
Jing Yu, Zhi Jiang, Matthew Ackers-Johnson, Guijin Zou, Feilong Zhang, Ming Zhu, Can Cao, Jiaofu Li, Prasanna Vidyasekar, Wenlong Li, Jianwu Wang, Nuan Chen, Pingqiang Cai, Changtai Guo, Jintong Ai, Yulin Zhou, Srinivas Sheshagiri Prabhu, Huajian Gao and Xiaodong Chen
Sci. Adv., 2026, 12
DOI: 10.1126/sciadv.adz1253

Flexible electrode integrated with transwell for in situ monitoring and regulating cardiomyocyte electrophysiology
Ying Chen, Zijie Wang, Qian Liu, Mengqian Zhao, Haihang Ye, Zhiyuan Zheng, Rongyu Tang, Yijun Wang, Tingrui Pan, Xu Zhang, Jianhua Qin and Weihua Pei
Sensors and Actuators B: Chemical, 2025, 426, 136999
DOI: 10.1016/j.snb.2024.136999

Design and Fabrication of Organ-on-Chips: Promises and Challenges
Alireza Tajeddin and Nur Mustafaoglu
Micromachines, 2021, 12, 1443
DOI: 10.3390/mi12121443

Ear-Bot: Locust Ear-on-a-Chip Bio-Hybrid Platform
Idan Fishel, Yoni Amit, Neta Shvil, Anton Sheinin, Amir Ayali, Yossi Yovel and Ben M. Maoz
Sensors, 2021, 21, 228
DOI: 10.3390/s21010228

Sensitivity and Validation of Porous Membrane Electrical Cell Substrate Impedance Spectroscopy (PM-ECIS) for Measuring Endothelial Barrier Properties
Alisa Ugodnikov, Oleg Chebotarev, Henrik Persson and Craig A. Simmons
ACS Biomater. Sci. Eng., 2024, 10, 5327
DOI: 10.1021/acsbiomaterials.3c01898

The microelectrode array technique - a crucial tool for studying excitable tissue disorders and drug testing: an update on recent advances
Andrijana Angelovski and Markéta Bébarová
Progress in Biophysics and Molecular Biology, 2025, 197, 97
DOI: 10.1016/j.pbiomolbio.2025.07.005

Trends in organ-on-a-chip for pharmacological analysis
Xinmei Xu, Suet Cheung, Xiaomeng Jia, Gang Fan, Yongjian Ai, Yi Zhang and Qionglin Liang
TrAC Trends in Analytical Chemistry, 2024, 180, 117905
DOI: 10.1016/j.trac.2024.117905

Microfluidic Organ-on-a-Chip Models of Human Intestine
Amir Bein, Woojung Shin, Sasan Jalili-Firoozinezhad, Min Hee Park, Alexandra Sontheimer-Phelps, Alessio Tovaglieri, Angeliki Chalkiadaki, Hyun Jung Kim and Donald E. Ingber
Cellular and Molecular Gastroenterology and Hepatology, 2018, 5, 659
DOI: 10.1016/j.jcmgh.2017.12.010

A guide to the organ-on-a-chip
Chak Ming Leung, Pim de Haan, Kacey Ronaldson-Bouchard, Ge-Ah Kim, Jihoon Ko, Hoon Suk Rho, Zhu Chen, Pamela Habibovic, Noo Li Jeon, Shuichi Takayama, Michael L. Shuler, Gordana Vunjak-Novakovic, Olivier Frey, Elisabeth Verpoorte and Yi-Chin Toh
Nat Rev Methods Primers, 2022, 2
DOI: 10.1038/s43586-022-00118-6

Modeling the Response of Heart Muscle to Mechanical Stimulation In Vitro
Jingxuan Guo and Nathaniel Huebsch
Curr. Tissue Microenviron. Rep., 2020, 1, 61
DOI: 10.1007/s43152-020-00007-8

Engineered Biomimetic Membranes for Organ-on-a-Chip
Maedeh Rahimnejad, Fariba Rasouli, Sepideh Jahangiri, Sepideh Ahmadi, Navid Rabiee, Marzieh Ramezani Farani, Omid Akhavan, Mohsen Asadnia, Yousef Fatahi, Sanghoon Hong, Jungho Lee, Junmin Lee and Sei Kwang Hahn
ACS Biomater. Sci. Eng., 2022, 8, 5038
DOI: 10.1021/acsbiomaterials.2c00531

Building blocks of microphysiological system to model physiology and pathophysiology of human heart
Hanna Vuorenpää, Miina Björninen, Hannu Välimäki, Antti Ahola, Mart Kroon, Laura Honkamäki, Jussi T. Koivumäki and Mari Pekkanen-Mattila
Front. Physiol., 2023, 14
DOI: 10.3389/fphys.2023.1213959

Online and in situ analysis of organs-on-a-chip
Milou J.C. Santbergen, Meike van der Zande, Hans Bouwmeester and Michel W.F. Nielen
TrAC Trends in Analytical Chemistry, 2019, 115, 138
DOI: 10.1016/j.trac.2019.04.006

The Role of Silicon Technology in Organ‐On‐Chip: Current Status and Future Perspective
Frøydis Sved Skottvoll, Enrique Escobedo‐Cousin and Michal Marek Mielnik
Adv Materials Technologies, 2025, 10
DOI: 10.1002/admt.202401254

Real-time sensors for live monitoring of disease and drug analysis in microfluidic model of proximal tubule
Arun Asif, Kyung Hwan Kim, Faiza Jabbar, Sejoong Kim and Kyung Hyun Choi
Microfluid Nanofluid, 2020, 24
DOI: 10.1007/s10404-020-02347-1

Organ chips with integrated multifunctional sensors enable continuous metabolic monitoring at controlled oxygen levels
Zohreh Izadifar, Berenice Charrez, Micaela Almeida, Stijn Robben, Kanoelani Pilobello, Janet van der Graaf-Mas, Susan L. Marquez, Thomas C. Ferrante, Kostyantyn Shcherbina, Russell Gould, Nina T. LoGrande, Adama M. Sesay and Donald E. Ingber
Biosensors and Bioelectronics, 2024, 265, 116683
DOI: 10.1016/j.bios.2024.116683

Sensitivity Analysis of Localized Electrochemical Impedance Spectroscopy Towards Tomography-on-a-Chip
Lilia Bató, Péter Fürjes, János M. Bozorádi, Vladimir Tadić, Péter Odry and Zoltán Vizvári
Sensors, 2025, 25, 6393
DOI: 10.3390/s25206393

Design strategy of electrode patterns based on finite element analysis in microfluidic device for Trans‐Epithelial Electrical Resistance (TEER) measurement
Takashi Miyazaki, Yoshikazu Hirai, Ken‐ichiro Kamei, Toshiyuki Tsuchiya and Osamu Tabata
Elect Comm in Japan, 2021, 104
DOI: 10.1002/ecj.12296

Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review
Ye Cong, Xiahe Han, Youping Wang, Zongzheng Chen, Yao Lu, Tingjiao Liu, Zhengzhi Wu, Yu Jin, Yong Luo and Xiuli Zhang
Micromachines, 2020, 11, 381
DOI: 10.3390/mi11040381

Electric and Electrochemical Microfluidic Devices for Cell Analysis
Kaoru Hiramoto, Kosuke Ino, Yuji Nashimoto, Kentaro Ito and Hitoshi Shiku
Front. Chem., 2019, 7
DOI: 10.3389/fchem.2019.00396

Sensor‐integrated brain‐on‐a‐chip platforms: Improving the predictive validity in neurodegenerative research
Sarah Spitz, Silvia Schobesberger, Konstanze Brandauer and Peter Ertl
Bioengineering & Transla Med, 2024, 9
DOI: 10.1002/btm2.10604

Continuous contractile force and electrical signal recordings of 3D cardiac tissue utilizing conductive hydrogel pillars on a chip
Feng Zhang, Hongyi Cheng, Kaiyun Qu, Xuetian Qian, Yongping Lin, Yike Zhang, Sichong Qian, Ningping Huang, Chang Cui and Minglong Chen
Materials Today Bio, 2023, 20, 100626
DOI: 10.1016/j.mtbio.2023.100626

Real-time physiological sensor-based liver-on-chip device for monitoring drug toxicity
Hafiz Muhammad Umer Farooqi, Muhammad Asad Ullah Khalid, Kyung Hwan Kim, Sun Ryung Lee and Kyung Hyun Choi
J. Micromech. Microeng., 2020, 30, 115013
DOI: 10.1088/1361-6439/ababf4

Blood brain barrier-on-a-chip to model neurological diseases
S. Reshma, K.B. Megha, S. Amir, S. Rukhiya and P.V. Mohanan
Journal of Drug Delivery Science and Technology, 2023, 80, 104174
DOI: 10.1016/j.jddst.2023.104174

Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?
Donald E. Ingber
Advanced Science, 2020, 7
DOI: 10.1002/advs.202002030

An Improved Vascularized, Dual-Channel Microphysiological System Facilitates Modeling of Proximal Tubular Solute Secretion
Alenka Chapron, Brian D. Chapron, Dale W. Hailey, Shih-Yu Chang, Tomoki Imaoka, Kenneth E. Thummel, Edward Kelly, Jonathan Himmelfarb, Danny Shen and Catherine K. Yeung
ACS Pharmacol. Transl. Sci., 2020, 3, 496
DOI: 10.1021/acsptsci.9b00078

Induced pluripotent stem cell-based organ-on-a-chip as personalized drug screening tools: A focus on neurodegenerative disorders
Francesca Fanizza, Marzia Campanile, Gianluigi Forloni, Carmen Giordano and Diego Albani
J Tissue Eng, 2022, 13
DOI: 10.1177/20417314221095339

Organs-on-chips technologies – A guide from disease models to opportunities for drug development
Anna Grazia Monteduro, Silvia Rizzato, Giusi Caragnano, Adriana Trapani, Gianluigi Giannelli and Giuseppe Maruccio
Biosensors and Bioelectronics, 2023, 231, 115271
DOI: 10.1016/j.bios.2023.115271

Integration of biological systems with electronic-mechanical assemblies
Ning Yi, Haitao Cui, Lijie Grace Zhang and Huanyu Cheng
Acta Biomaterialia, 2019, 95, 91
DOI: 10.1016/j.actbio.2019.04.032

Peripheral nerve sheath tumors-on-a-chip: Next-generation platforms for mechanistic and therapeutic studies
William H. Delaney, Sara A. Faulkner, Wilbur A. Lam, Nicholas M. Boulis, Yongzhi Qiu and Kecheng Lei
Materials Today Advances, 2026, 30, 100770
DOI: 10.1016/j.mtadv.2026.100770

Sensors in heart-on-a-chip: A review on recent progress
Kyoung Won Cho, Wang Hee Lee, Byung-Soo Kim and Dae-Hyeong Kim
Talanta, 2020, 219, 121269
DOI: 10.1016/j.talanta.2020.121269

hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us
Sophie Kussauer, Robert David and Heiko Lemcke
Cells, 2019, 8, 1331
DOI: 10.3390/cells8111331

Conceptual Design of Micro-Bioreactors and Organ-on-Chips for Studies of Cell Cultures
Carl-Fredrik Mandenius
Bioengineering, 2018, 5, 56
DOI: 10.3390/bioengineering5030056

Engineering Neurovascular Unit and Blood–Brain Barrier for Ischemic Stroke Modeling
Ze Liu, Yaohui Tang, Zhijun Zhang, Qianqian Liu, Mian Wang, Wanlu Li and Guo‐Yuan Yang
Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202202638

In situ biosensing technologies for an organ-on-a-chip
Jinyoung Kim, Junghoon Kim, Yoonhee Jin and Seung-Woo Cho
Biofabrication, 2023, 15, 042002
DOI: 10.1088/1758-5090/aceaae

Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery
Arun Sharma, Samuel Sances, Michael J. Workman and Clive N. Svendsen
Cell Stem Cell, 2020, 26, 309
DOI: 10.1016/j.stem.2020.02.011

Engineering biomimetic tissue barrier models on chips: From design and fabrication to applications in disease modeling and drug screening
Rohollah Nasiri, Masoud Madadelahi, Mohammad Reza Nikmaneshi, Begum Gokce, Mohamad Ali Bijarchi, Shilp Shah, Zuzana Tirpáková, Dirkje Van Gastel, Nayere Taebnia, Natan Roberto de Barros, Yangzhi Zhu, Zehra Gul Morcimen, Baris Gulicli, Rouhollah Habibey, Aylin Sendemir, Saumey Jain, Alessandro Enrico, Volker M. Lauschke, Mehmet Remzi Dokmeci, Guillem Pratx, Ali Khademhosseini and Anna Herland
Biomaterials, 2026, 327, 123739
DOI: 10.1016/j.biomaterials.2025.123739

The future of personalized cardiovascular medicine demands 3D and 4D printing, stem cells, and artificial intelligence
Monique Bax, Jordan Thorpe and Valentin Romanov
Front. Sens., 2023, 4
DOI: 10.3389/fsens.2023.1294721

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications
Negar Farhang Doost and Soumya K. Srivastava
Biosensors, 2024, 14, 225
DOI: 10.3390/bios14050225

Microfluidic intestine-on-a-chip: Current progress and further perspectives of probiotic-foodborne pathogen interactions
Xinran Xiang, Xinbin Wang, Yuting Shang and Yu Ding
Trends in Food Science & Technology, 2023, 134, 207
DOI: 10.1016/j.tifs.2023.03.006

Advanced Materials and Sensors for Microphysiological Systems: Focus on Electronic and Electrooptical Interfaces
Hanie Kavand, Rohollah Nasiri and Anna Herland
Advanced Materials, 2022, 34
DOI: 10.1002/adma.202107876

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips
Anna Herland, Ben M. Maoz, Debarun Das, Mahadevabharath R. Somayaji, Rachelle Prantil-Baun, Richard Novak, Michael Cronce, Tessa Huffstater, Sauveur S. F. Jeanty, Miles Ingram, Angeliki Chalkiadaki, David Benson Chou, Susan Marquez, Aaron Delahanty, Sasan Jalili-Firoozinezhad, Yuka Milton, Alexandra Sontheimer-Phelps, Ben Swenor, Oren Levy, Kevin K. Parker, Andrzej Przekwas and Donald E. Ingber
Nat Biomed Eng, 2020, 4, 421
DOI: 10.1038/s41551-019-0498-9

Micro-patterned SU-8 cantilever integrated with metal electrode for enhanced electromechanical stimulation of cardiac cells
Nomin-Erdene Oyunbaatar, Arunkumar Shanmugasundaram, Yun-Jin Jeong, Bong-Kee Lee, Eung-Sam Kim and Dong-Weon Lee
Colloids and Surfaces B: Biointerfaces, 2020, 186, 110682
DOI: 10.1016/j.colsurfb.2019.110682

Heart-on-a-Chip Model with Integrated Extra- and Intracellular Bioelectronics for Monitoring Cardiac Electrophysiology under Acute Hypoxia
Haitao Liu, Olurotimi A. Bolonduro, Ning Hu, Jie Ju, Akshita A. Rao, Breanna M. Duffy, Zhaohui Huang, Lauren D. Black and Brian P. Timko
Nano Lett., 2020, 20, 2585
DOI: 10.1021/acs.nanolett.0c00076

Microfluidic Gut-on-a-Chip: Fundamentals and Challenges
Dimple Palanilkunnathil Thomas, Jun Zhang, Nam-Trung Nguyen and Hang Thu Ta
Biosensors, 2023, 13, 136
DOI: 10.3390/bios13010136

Recapitulating essential pathophysiological characteristics in lung-on-a-chip for disease studies
Yanning Zhang, Xuejiao Wang, Yaoqing Yang, Jing Yan, Yanlu Xiong, Wenchen Wang, Jie Lei and Tao Jiang
Front. Immunol., 2023, 14
DOI: 10.3389/fimmu.2023.1093460

“Lung-on-a-chip” as an instrument for studying the pathophysiology of human respiration
Oksana A. Zhukova, Iuliia V. Ozerskaya, Dmitry V. Basmanov, Vsevolod Yu. Stolyarov, Vladimir G. Bogush, Vladimir V. Kolesov, Kirill A. Zykov, Gaukhar M. Yusubalieva and Vladimir P. Baklaushev
Journal of Clinical Practice, 2024, 15, 70
DOI: 10.17816/clinpract637140

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation
DoYeun Park, Jaeseo Lee, Justin J. Chung, Youngmee Jung and Soo Hyun Kim
Trends in Biotechnology, 2020, 38, 99
DOI: 10.1016/j.tibtech.2019.06.006

Multi‐Sensor Origami Platform: A Customizable System for Obtaining Spatiotemporally Precise Functional Readouts in 3D Models
Noam Rahav, Denise Marrero, Adi Soffer, Emma Glickman, Megane Beldjilali‐Labro, Yakey Yaffe, Keshet Tadmor, Yael Leichtmann‐Bardoogo, Uri Ashery and Ben M. Maoz
Advanced Science, 2024, 11
DOI: 10.1002/advs.202305555

Bone-on-a-chip platforms and integrated biosensors: Towards advanced in vitro bone models with real-time biosensing
Yang Zhang, Taozhao Yu, Jingyi Ding and Zida Li
Biosensors and Bioelectronics, 2023, 219, 114798
DOI: 10.1016/j.bios.2022.114798

A lung cancer-on-chip platform with integrated biosensors for physiological monitoring and toxicity assessment
Muhammad Asad Ullah Khalid, Young Soo Kim, Muhsin Ali, Byung Gul Lee, Young-Jae Cho and Kyung Hyun Choi
Biochemical Engineering Journal, 2020, 155, 107469
DOI: 10.1016/j.bej.2019.107469

Advanced Organ-on-a-Chip Devices to Investigate Liver Multi-Organ Communication: Focus on Gut, Microbiota and Brain
Lucia Boeri, Luca Izzo, Lorenzo Sardelli, Marta Tunesi, Diego Albani and Carmen Giordano
Bioengineering, 2019, 6, 91
DOI: 10.3390/bioengineering6040091

Extracellular Vesicles in Cardiac Regeneration: Potential Applications for Tissues-on-a-Chip
Karl T. Wagner, Trevor R. Nash, Bohao Liu, Gordana Vunjak-Novakovic and Milica Radisic
Trends in Biotechnology, 2021, 39, 755
DOI: 10.1016/j.tibtech.2020.08.005

Recent Advances in Body-on-a-Chip Systems
Jong Hwan Sung, Ying I. Wang, Narasimhan Narasimhan Sriram, Max Jackson, Christopher Long, James J. Hickman and Michael L. Shuler
Anal. Chem., 2019, 91, 330
DOI: 10.1021/acs.analchem.8b05293

Integrating mechanical sensor readouts into organ-on-a-chip platforms
Ingrid Anaya Morales, Christina-Marie Boghdady, Benjamin E. Campbell and Christopher Moraes
Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.1060895

Building Biomimetic Potency Tests for Islet Transplantation
Aaron L. Glieberman, Benjamin D. Pope, Douglas A. Melton and Kevin Kit Parker
Diabetes, 2021, 70, 347
DOI: 10.2337/db20-0297

Systematic characterization of cleanroom-free fabricated macrovalves, demonstrating pumps and mixers for automated fluid handling tuned for organ-on-chip applications
Elsbeth G. B. M. Bossink, Anke R. Vollertsen, Joshua T. Loessberg-Zahl, Andries D. van der Meer, Loes I. Segerink and Mathieu Odijk
Microsyst Nanoeng, 2022, 8
DOI: 10.1038/s41378-022-00378-y

Photoelectrochemical bioimaging of redox events for 3D cultured cells via hematite-based light-addressable electrodes
Tomoyuki Ogawa, Ryo Yamatake, Yusuke Kanno, Takasi Nisisako, Yuvaraj M. Hunge, Kosuke Ino, Shan Liu, Chen-Zhong Li, Tatsuo Yoshinobu, Hitoshi Shiku and Hiroya Abe
Biosensors and Bioelectronics, 2026, 298, 118414
DOI: 10.1016/j.bios.2026.118414

Integrated Electrochemical and Optical Biosensing in Organs‐on‐Chip
Pratik Tawade and Massimo Mastrangeli
ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202300560

Recent progress in translational engineeredin vitromodels of the central nervous system
Polyxeni Nikolakopoulou, Rossana Rauti, Dimitrios Voulgaris, Iftach Shlomy, Ben M Maoz and Anna Herland
Brain, 2020, 143, 3181
DOI: 10.1093/brain/awaa268

Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier
Nina Truong, Abir Zahra, Ryan C. V. Lintao, Rahul Chauhan, Giovana Fernanda Bento, Manuel Vidal Jr., Sungjin Kim, Po Yi Lam, Thomas Conrads, Kelly Conrads, Arum Han, Ramkumar Menon and Lauren S. Richardson
Front. Bioeng. Biotechnol., 2025, 13
DOI: 10.3389/fbioe.2025.1568389

In Vitro Modeling of Interorgan Crosstalk: Multi-Organ-on-a-Chip for Studying Cardiovascular-Kidney-Metabolic Syndrome
Cody Juguilon, Ramak Khosravi, Milica Radisic and Joseph C. Wu
Circulation Research, 2025, 136, 1476
DOI: 10.1161/CIRCRESAHA.125.325497

Liver–Heart on chip models for drug safety
Erika Ferrari and Marco Rasponi
APL Bioengineering, 2021, 5
DOI: 10.1063/5.0048986

Modelling Neuromuscular Diseases in the Age of Precision Medicine
Alfina A. Speciale, Ruth Ellerington, Thomas Goedert and Carlo Rinaldi
JPM, 2020, 10, 178
DOI: 10.3390/jpm10040178

Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research
Kalina Andrysiak, Jacek Stępniewski and Józef Dulak
Pflugers Arch - Eur J Physiol, 2021, 473, 1061
DOI: 10.1007/s00424-021-02536-z

Skin-on-a-Chip: Transepithelial Electrical Resistance and Extracellular Acidification Measurements through an Automated Air-Liquid Interface
Frank A. Alexander, Sebastian Eggert and Joachim Wiest
Genes, 2018, 9, 114
DOI: 10.3390/genes9020114

Real-time quantitative monitoring of in vitro nasal drug delivery by a nasal epithelial mucosa-on-a-chip model
Hanieh Gholizadeh, Hui Xin Ong, Peta Bradbury, Agisilaos Kourmatzis, Daniela Traini, Paul Young, Ming Li and Shaokoon Cheng
Expert Opinion on Drug Delivery, 2021, 18, 803
DOI: 10.1080/17425247.2021.1873274

Heart on a chip: Micro-nanofabrication and microfluidics steering the future of cardiac tissue engineering
Maria Kitsara, Dimitrios Kontziampasis, Onnik Agbulut and Yong Chen
Microelectronic Engineering, 2019, 203-204, 44
DOI: 10.1016/j.mee.2018.11.001

Engineering cardiac microphysiological systems to model pathological extracellular matrix remodeling
Nethika R. Ariyasinghe, Davi M. Lyra-Leite and Megan L. McCain
American Journal of Physiology-Heart and Circulatory Physiology, 2018, 315, H771
DOI: 10.1152/ajpheart.00110.2018

Organ-on-a-chip technology for the study of the female reproductive system
Rachel E. Young and Dan Dongeun Huh
Advanced Drug Delivery Reviews, 2021, 173, 461
DOI: 10.1016/j.addr.2021.03.010

Pannexin1 Channel-Mediated Inflammation in Acute Ischemic Stroke
Yubing Huang, Yutong Shi, Mengmeng Wang, Bingyi Liu, Xueqin Chang, Xia Xiao, Huihui Yu, Xiaodie Cui and Ying Bai
Aging and disease, 2023, 0
DOI: 10.14336/AD.2023.0303

Standardizing designed and emergent quantitative features in microphysiological systems
Dennis M. Nahon, Renée Moerkens, Hande Aydogmus, Bas Lendemeijer, Adriana Martínez-Silgado, Jeroen M. Stein, Milica Dostanić, Jean-Philippe Frimat, Cristina Gontan, Mees N. S. de Graaf, Michel Hu, Dhanesh G. Kasi, Lena S. Koch, Kieu T. T. Le, Sangho Lim, Heleen H. T. Middelkamp, Joram Mooiweer, Paul Motreuil-Ragot, Eva Niggl, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Nele Revyn, José M. Rivera-Arbelaez, Jelle Slager, Laura M. Windt, Mariia Zakharova, Berend J. van Meer, Valeria V. Orlova, Femke M. S. de Vrij, Sebo Withoff, Massimo Mastrangeli, Andries D. van der Meer and Christine L. Mummery
Nat. Biomed. Eng, 2024, 8, 941
DOI: 10.1038/s41551-024-01236-0

Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine
Fahad Alghannam, Mrwan Alayed, Salman Alfihed, Mahmoud A. Sakr, Dhaifallah Almutairi, Naif Alshamrani and Nojoud Al Fayez
Biosensors, 2025, 15, 76
DOI: 10.3390/bios15020076

Developing organs‐on‐chips for biomedical applications
Lingyu Sun, Hanxu Chen, Dongyu Xu, Rui Liu and Yuanjin Zhao
Smart Medicine, 2024, 3
DOI: 10.1002/SMMD.20240009

Microfluidic platforms for monitoring cardiomyocyte electromechanical activity
Wei Wang, Weiguang Su, Junlei Han, Wei Song, Xinyu Li, Chonghai Xu, Yu Sun and Li Wang
Microsyst Nanoeng, 2025, 11
DOI: 10.1038/s41378-024-00751-z

Recent technological advances in lab-on-a-chip for bone remodeling
Seoyeon Kim, Arun Kumar Rajendran, Sivashanmugam Amirthalingam, Jung Hun Kim, Kyoung-Ha So and Nathaniel S. Hwang
Biosensors and Bioelectronics: X, 2023, 14, 100360
DOI: 10.1016/j.biosx.2023.100360

Super-Resolution-Chip: an in-vitro platform that enables super-resolution microscopy of co-cultures and 3D systems
Ofir Sade, Ronja Boneberg, Yifat Weiss, Megane Beldjilali-Labro, Yael Leichtmann-Bardoogo, Itay Talpir, Irit Gottfried, Uri Ashery, Rossana Rauti and Ben M. Maoz
Biomed. Opt. Express, 2023, 14, 5223
DOI: 10.1364/BOE.498038

Advances in sensor integration for real-time monitoring of joint-on-chips
A. Mantegazza, S. Materne, M. Rasponi and P. Occhetta
Biophysics Reviews, 2026, 7
DOI: 10.1063/5.0287852

Tunable Microstructured Membranes in Organs-on-Chips to Monitor Transendothelial Hydraulic Resistance
Pritam Das, Andries D. van der Meer, Aisen Vivas, Yusuf B. Arik, Jean-Christophe Remigy, Jean-François Lahitte, Rob G.H. Lammertink and Patrice Bacchin
Tissue Engineering Part A, 2019, 25, 1635
DOI: 10.1089/ten.tea.2019.0021

Biomedical Application of Functional Materials in Organ-on-a-Chip
Chizhu Ding, Xiang Chen, Qinshu Kang and Xianghua Yan
Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00823

Integrated technologies for continuous monitoring of organs-on-chips: Current challenges and potential solutions
Jonathan Sabaté del Río, Jooyoung Ro, Heejeong Yoon, Tae-Eun Park and Yoon-Kyoung Cho
Biosensors and Bioelectronics, 2023, 224, 115057
DOI: 10.1016/j.bios.2022.115057

Construction, evaluation, and applications of renal barrier-on-a-chip system
Tuya Naren, Weikang Lv, Abdellah Aazmi, Yujun Wang, Haoran Yu, Jie Ying Lee, Huixiang Yang, Mengfei Yu, Xiuxiu Jiang, Huayong Yang and Liang Ma
Bioactive Materials, 2026, 59, 421
DOI: 10.1016/j.bioactmat.2025.12.032

Intelligent organ-on-chip platforms: Machine learning in predictive and personalized drug delivery
Tanishq Khurana, Sourav Ganguly and Kiran Raj M
Biomicrofluidics, 2026, 20
DOI: 10.1063/5.0306883

Latest Trends in Biosensing for Microphysiological Organs-on-a-Chip and Body-on-a-Chip Systems
Sebastian Kratz, Gregor Höll, Patrick Schuller, Peter Ertl and Mario Rothbauer
Biosensors, 2019, 9, 110
DOI: 10.3390/bios9030110

Advancement of Sensor Integrated Organ-on-Chip Devices
Gabriel A. Clarke, Brenna X. Hartse, Amir Ehsan Niaraki Asli, Mehrnoosh Taghavimehr, Niloofar Hashemi, Mehran Abbasi Shirsavar, Reza Montazami, Nima Alimoradi, Vahid Nasirian, Lionel J. Ouedraogo and Nicole N. Hashemi
Sensors, 2021, 21, 1367
DOI: 10.3390/s21041367

Organs-on-chips: into the next decade
Lucie A. Low, Christine Mummery, Brian R. Berridge, Christopher P. Austin and Danilo A. Tagle
Nat Rev Drug Discov, 2021, 20, 345
DOI: 10.1038/s41573-020-0079-3

In VitroModels of the Small Intestine: Engineering Challenges and Engineering Solutions
Sarah A. Hewes, Reid L. Wilson, Mary K. Estes, Noah F. Shroyer, Sarah E. Blutt and K. Jane Grande-Allen
Tissue Engineering Part B: Reviews, 2020, 26, 313
DOI: 10.1089/ten.teb.2019.0334

Gut-on-a-chip: Current progress and future opportunities
Nureddin Ashammakhi, Rohollah Nasiri, Natan Roberto de Barros, Peyton Tebon, Jai Thakor, Marcus Goudie, Amir Shamloo, Martin G. Martin and Ali Khademhosseini
Biomaterials, 2020, 255, 120196
DOI: 10.1016/j.biomaterials.2020.120196

Review of Design Considerations for Brain-on-a-Chip Models
Tiffany Cameron, Tanya Bennet, Elyn Rowe, Mehwish Anwer, Cheryl Wellington and Karen Cheung
Micromachines, 2021, 12, 441
DOI: 10.3390/mi12040441

Microphysiological stem cell models of the human heart
Ulgu Arslan, Alessia Moruzzi, Joanna Nowacka, Christine L. Mummery, Dominik Eckardt, Peter Loskill and Valeria V. Orlova
Materials Today Bio, 2022, 14, 100259
DOI: 10.1016/j.mtbio.2022.100259

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa and Angel Raya
Adv Healthcare Materials, 2026
DOI: 10.1002/adhm.202505524

Application of Micro-Engineered Kidney, Liver, and Respiratory System Models to Accelerate Preclinical Drug Testing and Development
Hanieh Gholizadeh, Shaokoon Cheng, Agisilaos Kourmatzis, Hanwen Xing, Daniela Traini, Paul M. Young and Hui Xin Ong
Bioengineering, 2022, 9, 150
DOI: 10.3390/bioengineering9040150

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications
Gad D. Vatine, Riccardo Barrile, Michael J. Workman, Samuel Sances, Bianca K. Barriga, Matthew Rahnama, Sonalee Barthakur, Magdalena Kasendra, Carolina Lucchesi, Jordan Kerns, Norman Wen, Weston R. Spivia, Zhaohui Chen, Jennifer Van Eyk and Clive N. Svendsen
Cell Stem Cell, 2019, 24, 995
DOI: 10.1016/j.stem.2019.05.011

Vascularisation of pluripotent stem cell–derived myocardium: biomechanical insights for physiological relevance in cardiac tissue engineering
Oisín King, Ilona Sunyovszki and Cesare M. Terracciano
Pflugers Arch - Eur J Physiol, 2021, 473, 1117
DOI: 10.1007/s00424-021-02557-8

Heart-on-a-chip using human iPSC-derived cardiomyocytes with an integrated vascular endothelial layer based on a culture patch as a potential platform for drug evaluation
Yadong Tang, Feng Tian, Xiaomin Miao, Dianqi Wu, Yaqi Wang, Han Wang, Kai You, Qinglan Li, Suqing Zhao and Wenlong Wang
Biofabrication, 2023, 15, 015010
DOI: 10.1088/1758-5090/ac975d

Microfluidic Systems to Mimic the Blood–Brain Barrier: from Market to Engineering Challenges and Perspectives
Gabriela Gomes da Silva, Daniel Pereira Sacomani, Bruna Gregatti de Carvalho, Marimélia Aparecida Porcionatto, Angelo Gobbi, Renato Sousa Lima and Lucimara Gaziola de la Torre
ACS Biomater. Sci. Eng., 2025, 11, 3789
DOI: 10.1021/acsbiomaterials.4c02221

Trans-epithelial/endothelial electrical resistance (TEER): Current state of integrated TEER measurements in organ-on-a-chip devices
Mridu Malik, Stecia A. Steele, Deepshikha Mitra, Christopher J. Long and James J. Hickman
Current Opinion in Biomedical Engineering, 2025, 34, 100588
DOI: 10.1016/j.cobme.2025.100588

Step-by-step fabrication of heart-on-chip systems as models for cardiac disease modeling and drug screening
Sara Deir, Yasaman Mozhdehbakhsh Mofrad, Shohreh Mashayekhan, Amir Shamloo and Amirreza Mansoori-Kermani
Talanta, 2024, 266, 124901
DOI: 10.1016/j.talanta.2023.124901

Advances in organ-on-a-chip engineering
Boyang Zhang, Anastasia Korolj, Benjamin Fook Lun Lai and Milica Radisic
Nat Rev Mater, 2018, 3, 257
DOI: 10.1038/s41578-018-0034-7

The promise of Synovial Joint-on-a-Chip in rheumatoid arthritis
Xin Zhang, Rui Su, Hui Wang, Ruihe Wu, Yuxin Fan, Zexuan Bin, Chong Gao and Caihong Wang
Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1408501

Low-Impedance PEDOT:PSS MEA Integrated in a Stretchable Organ-on-Chip Device
Affan K. Waafi, Nikolas Gaio, William F. Quiros-Solano, Paul Dijkstra, Pasqualina M. Sarro and Ronald Dekker
IEEE Sensors J., 2020, 20, 1150
DOI: 10.1109/JSEN.2019.2946854

Bioelectronic tools for understanding the universal language of electrical signaling across species and kingdoms
Shivani Shukla, Colin J. Comerci, Gürol M. Süel and Zeinab Jahed
Biosensors and Bioelectronics, 2025, 267, 116843
DOI: 10.1016/j.bios.2024.116843

Intervertebral Disc-on-a-Chip as Advanced In Vitro Model for Mechanobiology Research and Drug Testing: A Review and Perspective
Andrea Mainardi, Elena Cambria, Paola Occhetta, Ivan Martin, Andrea Barbero, Stefan Schären, Arne Mehrkens and Olga Krupkova
Front. Bioeng. Biotechnol., 2022, 9
DOI: 10.3389/fbioe.2021.826867

Advances in Multidimensional Cardiac Biosensing Technologies: From Electrophysiology to Mechanical Motion and Contractile Force
Xinwei Wei, Liujing Zhuang, Hongbo Li, Chuanjiang He, Hao Wan, Ning Hu and Ping Wang
Small, 2020, 16
DOI: 10.1002/smll.202005828

Chips for Biomaterials and Biomaterials for Chips: Recent Advances at the Interface between Microfabrication and Biomaterials Research
Alexander P. M. Guttenplan, Zeinab Tahmasebi Birgani, Stefan Giselbrecht, Roman K. Truckenmüller and Pamela Habibović
Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202100371

Progress and Challenges in the Use of a Liver-on-a-Chip for Hepatotropic Infectious Diseases
Kasem Kulkeaw and Worakamol Pengsart
Micromachines, 2021, 12, 842
DOI: 10.3390/mi12070842

Human mini-brain models
Hsih-Yin Tan, Hansang Cho and Luke P. Lee
Nat Biomed Eng, 2020, 5, 11
DOI: 10.1038/s41551-020-00643-3

A novel multi-frequency trans-endothelial electrical resistance (MTEER) sensor array to monitor blood-brain barrier integrity
Maider Badiola-Mateos, Davide Di Giuseppe, Roberto Paoli, Maria Jose Lopez-Martinez, Arianna Mencattini, Josep Samitier and Eugenio Martinelli
Sensors and Actuators B: Chemical, 2021, 334, 129599
DOI: 10.1016/j.snb.2021.129599

Kidney-on-a-chip: untapped opportunities
Nureddin Ashammakhi, Katherine Wesseling-Perry, Anwarul Hasan, Elmahdi Elkhammas and Yu Shrike Zhang
Kidney International, 2018, 94, 1073
DOI: 10.1016/j.kint.2018.06.034

Engineered models of the human heart: Directions and challenges
Jeroen M. Stein, Christine L. Mummery and Milena Bellin
Stem Cell Reports, 2021, 16, 2049
DOI: 10.1016/j.stemcr.2020.11.013

Microfluidics in biomedicine: Heart-on-chip platforms for cardiovascular disease modeling and therapeutic innovation
Vasudeva Reddy Netala, Tianyu Hou and Zhijun Zhang
Journal of Drug Delivery Science and Technology, 2025, 111, 107171
DOI: 10.1016/j.jddst.2025.107171

Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system
Hafiz Muhammad Umer Farooqi, Bohye Kang, Muhammad Asad Ullah Khalid, Abdul Rahim Chethikkattuveli Salih, Kinam Hyun, Sung Hyuk Park, Dongeun Huh and Kyung Hyun Choi
Nano Convergence, 2021, 8
DOI: 10.1186/s40580-021-00253-y

Advances in microfluidic in vitro systems for neurological disease modeling
Paul M. Holloway, Sandrine Willaime‐Morawek, Richard Siow, Melissa Barber, Róisín M. Owens, Anup D. Sharma, Wendy Rowan, Eric Hill and Michele Zagnoni
J of Neuroscience Research, 2021, 99, 1276
DOI: 10.1002/jnr.24794

Recent Advances in Microfluidic Platforms for Programming Cell‐Based Living Materials
Pengchao Zhang, Ning Shao and Lidong Qin
Advanced Materials, 2021, 33
DOI: 10.1002/adma.202005944