Issue 6, 2015

An evolutionary perspective on zinc uptake by human fungal pathogens

Abstract

The mammalian immune system has evolved sophisticated mechanisms to withhold essential micronutrients from invading pathogens. These processes, collectively known as nutritional immunity serve to limit microbial proliferation and bolster killing of the invader. Successful pathogens, therefore, have developed strategies to counteract nutritional immunity and acquire essential micronutrients in the restrictive environment of the infected host. Here I take advantage of the now large number of sequenced fungal genomes to explore the zinc acquisition strategies of human fungal pathogens and reflect on the evolutionary context of these uptake pathways.

Graphical abstract: An evolutionary perspective on zinc uptake by human fungal pathogens

Supplementary files

Article information

Article type
Perspective
Submitted
15 Гру 2014
Accepted
26 Січ 2015
First published
26 Січ 2015
This article is Open Access
Creative Commons BY license

Metallomics, 2015,7, 979-985

Author version available

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