Themed collection 2019 Organic Chemistry Frontiers Review-type Articles

Ni-Catalyzed reductive cross-coupling of two electrophiles has evolved into a powerful means for building diverse carbon-carbon bonds in an enantioselective manner. Here we summarize the recent progress in Ni-catalyzed enantioselective electroreductive coupling reactions.

This review summarizes recent advances in micro/nanoscale photonic barcodes based on organic materials from the aspects of diverse optical encoding techniques.

N-Heterocyclic Carbene (NHC)-catalyzed umpolung reactions of aldimines are highlighted in this article, with a special emphasis on the corresponding enantioselective transformations developed by the research groups of Lupton and Biju.

Aminoboronic acids and their derivatives are particularly useful as drugs, probes and synthons. Recent developments in their synthesis are highlighted.

GEST NMR provides dynamic information on host–guest systems. It allows signal amplification of low concentrated complexes, detection of intermolecular interactions and quantification of guest exchange rates.

The key learnings of the utilization of sulfoximines, sulfondiimines and sulfonimidamides in drug discovery at Bayer AG are shared.

This review describes recent developments in enantioselective imine reduction, including related substrates in which a CN bond is the target for reduction, and in situ methods.

The first review article summarizing known methodologies for the preparation of (4H)-imidazol-4-ones and their application in the total synthesis of imidazol-4-one containing natural products.

In this review, we summarized recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions.

This review summarized the enzymatic and non-enzymatic crosslinks found in collagen and elastin and their organic synthesis.

Novel synthesis of selenium containing polymers with pre-determined structures and applications thereof.

This review describes cavity-based applications of cage-like SCCs such as molecular recognition and separation, stabilization of reactive species by encapsulation, as drug delivery systems and as molecular flasks.

Significant progress in the chemistry of nitro radicals has been witnessed in the past decades, providing efficient and rapid access to nitro-containing compounds. This review describes recent advances in nitro-involved radical reactions, and summarizes various transformations.

A number of novel methodologies concerning the chemical, biological and medicinal applications of sulfuryl fluoride (SO₂F₂) gas have dramatically improved year by year.

This review presents the construction of C–X bonds (X = O/N/S) by using intramolecular C–H functionalization for the synthesis of heterocyclic compounds.

Selenium-based catalysts, including organo- and inorganoselenium ones, in organic synthesis in the recent decade are reviewed.

A number of methods have been adopted for the synthesis of amides; among these methods, the oxidation of an amine to an amide is growing in interest as a means to prepare this imperative functional group.

Fragmentation reactions that generate alkynes in conjunction with C–C bond cleavage require special considerations but can produce high-value alkyne building blocks for organic synthesis.

Recent advances in the metal-catalyzed radical-type transformation of unactivated alkyl halides with C–C bond formation under photoinduced conditions are summarized. Usually, a broad reaction scope is observed including tertiary, secondary, and primary alkyl halides, with good functional group compatibility.

α-Amido sulfones can be directly used as N-acylimine or N-acyliminium ion precursors in several synthetic processes aimed at the preparation of nitrogen containing compounds. This review collects the most relevant and practical utilizations of α-amido sulfones appeared in the literature after 2005.

This review focuses on the synthesis of N-heterocycles using amidines as starting materials, with an emphasis on the mechanisms of these reactions via C–N/C–C bond formation.

A selection of supramolecular ligands designed to extract f-elements.

Synthetic methodologies can be easily compared using the Cost of Academic Methodologies (CAM) parameter, which estimates the cost of making a mole of a product.

In this review, we have focused on the recent advances in photocatalytic C–S/P–S bond formation via the generation of thioyl/sulfonyl radicals and further functionalization.

The application of dialkyl azodicarboxylates as versatile reagents in Mitsunobu, oxidation, electrophilic, amination and carbonylation reactions is reviewed.

The use of diffusion NMR in studying calixarenes and other arene-based supramolecular systems is described, emphasizing the pivotal role played by the calixarene community in transforming the methods into a routine tool used in supramolecular chemistry.

This review reports a comprehensive compilation of gold-catalyzed heterocyclic synthesis by using α-imino gold carbene complexes as the proposed intermediates.

Rapid progress in the synthesis of perylene bisimide dyes gave an old scaffold new life.