Themed collection Analyst HOT Articles 2021
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The dynamicity of light-up aptamers in one-pot in vitro diagnostic assays
The direct modulation of a light-up aptamer that engenders an analyte-specific aptamer-light-up aptamer chimera is readily applicable in any diagnostic assay for a targeted detection.
Analyst, 2022,147, 10-21
https://doi.org/10.1039/D1AN01690C
Nanowire-based sensor electronics for chemical and biological applications
Detection and recognition of chemical and biological species via sensor electronics are important not only for various sensing applications but also for fundamental scientific understanding.
Analyst, 2021,146, 6684-6725
https://doi.org/10.1039/D1AN01096D
Application of centrifugal microfluidics in immunoassay, biochemical analysis and molecular diagnosis
Complete layout of a centrifugal microfluidic system.
Analyst, 2021,146, 5800-5821
https://doi.org/10.1039/D1AN00629K
Engineering of nanomaterials for mass spectrometry analysis of biomolecules
We review the endeavors on the compositional and structural engineering of nanomaterials in the MS characterization of biomolecules in terms of enriching targets, enhancing the ionization efficiency and amplifying the ion signals.
Analyst, 2021,146, 5779-5799
https://doi.org/10.1039/D1AN00860A
A cysteine-triggered fluorogenic donor base on native chemical ligation for tracking H2S delivery in vivo
A fluorogenic hydrogen sulfide (H2S) donor is a fundamental molecular tool used as an exogenous source in biological studies and therapies.
Analyst, 2021,146, 7374-7378
https://doi.org/10.1039/D1AN01809D
Detection of the effect of polydopamine (PDA)-coated polydimethylsiloxane (PDMS) substrates on the release of H2O2 from a single HeLa cell
Endogenous H2O2 generated by a single HeLa cell that was adhered on the PDA-coated PDMS substrates under 25 mM glucose culture conditions was detected using a home-built photoelectric dual detection platform.
Analyst, 2021,146, 6445-6449
https://doi.org/10.1039/D1AN01506K
Colorimetric recognition of lanthanide ions with a complexometric indicator array
A colorimetric sensor array based on complexometric indicators is proposed for pattern recognition of 14 lanthanide ions.
Analyst, 2021,146, 4441-4445
https://doi.org/10.1039/D1AN00710F
Phenoxazine pseudonucleotides in DNA i-motifs allow precise profiling of small molecule binders by fluorescence monitoring
A fluorescence-tracking system with phenoxazine pseudonucleotides in loops that do not alter iM unfolding enables precise evaluation of ligand-induced changes of iM stability.
Analyst, 2021,146, 4436-4440
https://doi.org/10.1039/D1AN00660F
Dual-wavelength electrochemiluminescence ratiometry for hydrogen sulfide detection based on Cd2+-doped g-C3N4 nanosheets
A dual-wavelength ECL ratiometry sensing platform was constructed for H2S detection.
Analyst, 2022,147, 247-251
https://doi.org/10.1039/D1AN01873F
Target-driven assembly of DNAzyme probes for simultaneous electrochemical detection of multiplex microRNAs
In this work, we employed target-driven assembly of a Mg2+-dependent DNAzyme to develop an ultrasensitive electrochemical biosensor for the simultaneous detection of miRNA-21 and miRNA-141.
Analyst, 2022,147, 262-267
https://doi.org/10.1039/D1AN02036F
A new metal-free near-infrared fluorescent probe based on nitrofuran for the detection and bioimaging of carbon monoxide releasing molecule-2 in vivo
A new metal-free near-infrared fluorescent probe based on IR-780 is designed and applied for the imaging and detection of carbon monoxide releasing molecule-2 (CORM-2) in paper chips, living cells, zebrafish and mice.
Analyst, 2022,147, 268-273
https://doi.org/10.1039/D1AN01766G
NIR-emitting benzene-fused oligo-BODIPYs for bioimaging
The hexameric and octameric variants of benzene-fused oligo-BODIPYs emit fluorescence in the near-infrared (NIR). Their potential for biophotonics and imaging is reported.
Analyst, 2022,147, 230-237
https://doi.org/10.1039/D1AN01850G
Manganese-doped iron coordination polymer nanoparticles with enhanced peroxidase-like activity for colorimetric detection of antioxidants
The peroxidase-like activity of Fe-based CPNs was enhanced by Mn doping. The optimum Fe5Mn-DHTP was devised for colorimetric detection of AA, Cys and GSH by inhibiting TMB chromogenic reaction in presence of H2O2via different inhibition mechanisms.
Analyst, 2022,147, 238-246
https://doi.org/10.1039/D1AN01953H
A ratiometric ESIPT probe based on 2-aza-Cope rearrangement for rapid and selective detection of formaldehyde in living cells
A ratiometric ESIPT probe, FormAFP, has been developed for rapid, selective and sensitive detection of FA via 2-aza-Cope rearrangement. The probe also showed a fast response (<20 min) to both exogenous and endogenous FA in living cells.
Analyst, 2022,147, 252-261
https://doi.org/10.1039/D1AN01722E
3D imaging of single bacterial cells using surface-enhanced Raman spectroscopy with a multivariate curve resolution model
We proposed a SERS single bacterial cell imaging strategy and integrated use of intracellular biosynthesized Ag NPs and the MCR model.
Analyst, 2022,147, 223-229
https://doi.org/10.1039/D1AN01879E
Copper fumarate with high-bifunctional nanozyme activities at different pH values for glucose and epinephrine colorimetric detection in human serum
A colorimetric sensor based on Cu MOFs with fumaric acid as the ligand shows bifunctional enzyme activities, namely laccase activity at pH = 8 and peroxidase activity at pH = 4.
Analyst, 2022,147, 40-47
https://doi.org/10.1039/D1AN01817E
Multi-tailoring of a modified MOF-derived CuxO electrochemical transducer for enhanced hydrogen peroxide sensing
Reasonable control of the redox states within the catalytic units together with the interconnection degrees of the substrate is of great significance in the modulation of a well-performing transducer.
Analyst, 2022,147, 72-79
https://doi.org/10.1039/D1AN01864G
Biomimetic -mineralized multifunctional nanoflowers for anodic-stripping voltammetric immunoassay of rehabilitation-related proteins
An anodic-stripping voltammetric immunosensing system was innovatively designed for quantitative screening of C-reactive protein using biomimetic-mineralized bifunctional antibody-Cu3(PO4)2 nanoflowers as the molecular tags.
Analyst, 2022,147, 80-86
https://doi.org/10.1039/D1AN01934A
A bifunctional immunosensor based on osmium nano-hydrangeas as a catalytic chromogenic and tinctorial signal output for folic acid detection
Schematic of the bifunctional immunosensor based on osmium nano-hydrangeas as a catalytic chromogenic and tinctorial signal output for folic acid detection.
Analyst, 2022,147, 55-65
https://doi.org/10.1039/D1AN01432C
Halogen-modified carbazole derivatives for lipid droplet-specific bioimaging and two-photon photodynamic therapy
Iodine-modified carbazole derivatives showed two-photon absorption properties, lipid drop specificity and higher anticancer effects.
Analyst, 2022,147, 66-71
https://doi.org/10.1039/D1AN01826D
A gas-pressure-assisted ratiometric atomic flame assay for the point-of-care testing of tumor-cell-derived exosomes
With various flames and a fast color response, an atomic flame was developed for the highly sensitive POCT of tumor cell-derived exosomes.
Analyst, 2022,147, 48-54
https://doi.org/10.1039/D1AN01825F
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Identification of cellulose textile fibers
Near infrared imaging spectroscopy and chemometrics enable reliable identification of natural and regenerated cellulose textile fibers for chemical recycling.
Analyst, 2021,146, 7503-7509
https://doi.org/10.1039/D1AN01794B
Super-assembled silica nanoprobes for intracellular Zn(II) sensing and reperfusion injury treatment through in situ MOF crystallization
A multifunction 2MI-P@MSN nanoparticle was constructed for Zn2+ sensing and reperfusion injury treatment. This strategy highlights the potential for the detection, absorption and assembly of excess zinc ions simultaneously.
Analyst, 2021,146, 6788-6797
https://doi.org/10.1039/D1AN01475G
Protective mechanism of dried blood spheroids: stabilization of labile analytes in whole blood, plasma, and serum
Dried blood spheroid prepared on hydrophobic paper substrate enables the stabilization of red blood cells at room temperature.
Analyst, 2021,146, 6780-6787
https://doi.org/10.1039/D1AN01132D
An electrochemical aptasensor for the milk allergen β-lactoglobulin detection based on a target-induced nicking site reconstruction strategy
A novel electrochemical aptasensor was fabricated for the quantitative detection of β-lactoglobulin, based on target-induced nicking site reconstruction strategy accompanied with nicking enzyme activated hybridization chain reaction amplification.
Analyst, 2021,146, 6808-6814
https://doi.org/10.1039/D1AN01483H
Polymer surface ligand and silica coating induced highly stable perovskite nanocrystals with enhanced aqueous fluorescence for efficient Hg2+ and glutathione detection
Highly stable and enhanced aqueous fluorescent CsPbBr3-mPEG@SiO2 NCs were synthesized through the synergistic effects of polymer surface ligand and silica encapsulation, and used as a novel “on–off–on” fluorescent probe for detection of Hg2+ and GSH.
Analyst, 2021,146, 6798-6807
https://doi.org/10.1039/D1AN01485D
Isotopic trace analysis of water vapor with multipass cavity Raman scattering
Trace isotopologue analysis of evaporated liquid water was carried out using spontaneous Raman scattering. A multimode laser diode receiving feedback from a multipass cavity enabled detection of HDO down to D-H concentration ratios as low as 8 ppm.
Analyst, 2021,146, 6482-6489
https://doi.org/10.1039/D1AN01254A
A double-tetrahedral DNA framework based electrochemical biosensor for ultrasensitive detection and release of circulating tumor cells
An electrochemical biosensor system based on a double-tetrahedral DNA framework for ultrasensitive capture, detection and release of circulating tumor cells. The released cells can be recultured for further clinical research.
Analyst, 2021,146, 6474-6481
https://doi.org/10.1039/D1AN01470F
Visual colorimetric detection of triacetone triperoxide based on a Fe(II)-promoted thermal decomposition process
A visual colorimetric method was developed for the on-site and rapid detection of triacetone triperoxide. This method is applied for analyzing real samples, and a test-paper-based assay was also developed.
Analyst, 2021,146, 6187-6192
https://doi.org/10.1039/D1AN01480C
A feasible self-assembled near-infrared fluorescence sensor for acid phosphatase detection and cell imaging
A feasible self-assembly near-infrared fluorescence sensor for acid phosphatase detection and cell image.
Analyst, 2021,146, 5558-5566
https://doi.org/10.1039/D1AN01218E
Boronate carbon nanoparticles featuring efficient FRET for activatable two-photon fluorescence imaging of sialic acid surface-abundant tumor cells
In situ growth of MnO2 nanosheets on the surface of BCNPs enabled to realize of specific cell-targeted two-photon fluorescence activation imaging.
Analyst, 2021,146, 5567-5573
https://doi.org/10.1039/D1AN01155C
Three dimensionally printed nitrocellulose-based microfluidic platform for investigating the effect of oxygen gradient on cells
The hybrid 3D printed/nitrocellulose-based microfluidic platform analyzed the effect of oxygen gradient on cells with a variety of methods.
Analyst, 2021,146, 5255-5263
https://doi.org/10.1039/D1AN00927C
Single-digit Salmonella detection with the naked eye using bio-barcode immunoassay coupled with recombinase polymerase amplification and a CRISPR-Cas12a system
An ultrasensitive, rapid, and visual detection platform for Salmonella Typhimurium based on the bio-barcode assay and recombinase polymerase amplification (RPA) coupled with a CRISPR-Cas12a cleavage system is presented.
Analyst, 2021,146, 5271-5279
https://doi.org/10.1039/D1AN00717C
A novel p-dimethylaminophenylether-based fluorescent probe for the detection of native ONOO− in cells and zebrafish
A fluorescent probe PDPE-PN with prominent sensitivity and specificity, and a fast response towards ONOO− was synthesized and characterized. The probe with good biocompatibility has been successfully applied in cells and zebrafish.
Analyst, 2021,146, 5264-5270
https://doi.org/10.1039/D1AN00608H
Design of a dual-signal sensing platform for D-penicillamine based on UiO-66-NH2 MOFs and APBA@Alizarin Red
Through the FRET of UiO-66-NH2 and APBA@ARS with the reaction of copper ions, alizarin red and D-PA, fluorescence and colorimetric platform detection are realized. The mobile phone RGB detection are realized owing to the change of solution color.
Analyst, 2021,146, 5280-5286
https://doi.org/10.1039/D1AN01013A
Electrochemiluminescence of water-dispersed nitrogen and sulfur doped carbon dots synthesized from amino acids
A facile one-pot hydrothermal approach for synthesizing water-dispersed nitrogen and sulfur doped carbon dots (NS-CDs) with high luminescence quantum yield and ECL efficiency was explored, using cysteine and tryptophan as precursors.
Analyst, 2021,146, 5287-5293
https://doi.org/10.1039/D1AN00991E
Boosting the peroxidase-like activity of gold nanoclusters for the colorimetric detection of oxytetracycline in rat serum
LTN@AuNCs display peroxidase-like activity in a TMB-H2O2 system. Their catalytic activity was enhanced by oxytetracycline. Using the mechanism, a protocol for highly selective and sensitive monitoring of rat serum drug was constructed.
Analyst, 2021,146, 5061-5066
https://doi.org/10.1039/D1AN01003D
A fluorescence color card for point-of-care testing (POCT) and its application in simultaneous detection
A novel strategy for the POCT of glucose and the simultaneous detection of multiple targets using different fluorescence color cards is developed.
Analyst, 2021,146, 5074-5080
https://doi.org/10.1039/D1AN01035B
Antibody-powered DNA switches to initiate the hybridization chain reaction for the amplified fluorescence immunoassay
Targeted bivalent anti-Dig antibody as an input to power a directional switch of the DNA structure through a specific binding event with two tethered haptens, rationally integrating with the hybridization chain reaction for signal amplification.
Analyst, 2021,146, 5067-5073
https://doi.org/10.1039/D1AN01045J
Immunoassay of SARS-CoV-2 nucleocapsid proteins using novel red emission-enhanced carbon dot-based silica spheres
The fluorescence enhancement of red emissive CDs and the casting of its aggregates were realized, and then, applied to the immunoassay of SARS-CoV-2 nucleocapsid proteins.
Analyst, 2021,146, 5055-5060
https://doi.org/10.1039/D1AN01010G
Deep eutectic solvent decomposition-based microextraction for chromium determination in aqueous environments by atomic absorption spectrometry with electrothermal atomization
A sensitive, rapid, and simple procedure for the determination of traces of chromium species in natural and waste waters using a quasi-hydrophobic deep eutectic solvent was developed for the first time.
Analyst, 2021,146, 5081-5088
https://doi.org/10.1039/D1AN00924A
Exploring the contribution of charged species at the outer surface to the ion current signal of nanopores: a theoretical study
Nanopores attached to charged species realize the artificial regulation of ion transport by the electrostatic effect in nanoconfines, produce a sensitive ion current signal and play a critical role in nanopore-based analyses.
Analyst, 2021,146, 5089-5094
https://doi.org/10.1039/D1AN00826A
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Rapid ultra-sensitive diagnosis of clostridium difficile infection using a SERS-based lateral flow assay
Duplex SERS-based lateral flow testing for C. diff bacterial infection using new biomarker, SlpA, and ToxB within 20 minutes.
Analyst, 2021,146, 4495-4505
https://doi.org/10.1039/D1AN00726B
Expanding current applications and permitting the analysis of larger intact samples by means of a 7 mm CMP–NMR probe
With a larger sample size, 7 mm CMP–NMR can identify and distinguish components in different phases within a softgel capsule of hydroxyzine hydrochloride. The capsule would not fit in a 4 mm probe.
Analyst, 2021,146, 4461-4472
https://doi.org/10.1039/D1AN00809A
Analysis of protein phosphorylation in solution and in cells by using an ATP analogue in combination with fluorescence techniques
We synthesized a new ATP analogue ATP-NB, and a fluorescent probe TZ-Cy3 based on D–A reaction. Using fluorescent techniques, we established an efficient method for studying the phosphorylation of proteins in solution and in living cells.
Analyst, 2021,146, 4506-4514
https://doi.org/10.1039/D1AN00742D
Ultrasensitive photoelectrochemical immunoassay for prostate-specific antigen based on silver nanoparticle-triggered ion-exchange reaction with ZnO/CdS nanorods
A signal-amplified photoelectrochemical immunosensing platform was designed to monitor prostate-specific antigen based on ion-exchange reaction between Zno/CdS and silver nanolabels.
Analyst, 2021,146, 4487-4494
https://doi.org/10.1039/D1AN00822F
Direct analysis of metabolites in the liver tissue of zebrafish exposed to fiproles by internal extractive electrospray ionization mass spectrometry
The process of exploring metabolic disturbance induced by fiproles in zebrafish by iEESI-MS.
Analyst, 2021,146, 4480-4486
https://doi.org/10.1039/D1AN00490E
An electrochemical method for a rapid and sensitive immunoassay on digital microfluidics with integrated indium tin oxide electrodes coated on a PET film
Digital microfluidic with integrated ITO electrodes patterned on ITO-PET film is used to perform automated immunoassay for H5N1. The better electrochemical performance is achieved using square wave voltammetry.
Analyst, 2021,146, 4473-4479
https://doi.org/10.1039/D1AN00513H
About this collection
This themed collection features articles published in Analyst marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.