Hao Wang, Zhongyu Li, Xiangyang Chen, Jonathan Wong, Tongyu Bi, Xiankun Tong, Zhongliang Xu, Mingyue Zheng, Yunhui Wan, Li Tang, Bo Liu, Xinlei Zong, Jianping Zuo, Li Yang, Wei Huang, Kendall N. Houk and Weibo Yang

SSRN Journal, 2022
DOI: 10.2139/ssrn.4138710

Transition-Metal-Catalyzed C–C Bond Macrocyclization via Intramolecular C–H Bond Activation

Xiao Wang, Ming-Zhu Lu and Teck-Peng Loh

Catalysts, 2023, 13, 438
DOI: 10.3390/catal13020438

Recent Progress in Transition Metal-Catalyzed C—H Bond Activation of N-Aryl Phthalazinones

Haichun Gu, Xinxin Jin, Jiaqi Li, He Li and Jinglin Liu

Chinese Journal of Organic Chemistry, 2022, 42, 2682
DOI: 10.6023/cjoc202204056

Synthesis of 3-benzoylisoxazolines by copper(Ⅰ) bromide-catalyzed 1,3-dipolar cycloaddition of nitroketones with dipolarophiles

Xiaoyu Liao, Zhiyun Zhao, Jiyi Lv, Xiling Deng, Xinrun Zhao, Yangzi Chen, Wei Zhang, Pinghua Sun and Xinhui Pan

Tetrahedron, 2026, 192, 135088
DOI: 10.1016/j.tet.2025.135088

Chemoselective Synthesis of δ-Amino Alcohols from Chiral 1,4-Diols Catalyzed by an NHC–Ir(III) Complex

Emanuele Silvi, Aitor Bermejo-López, Sarko Jabbari, Mariell Pettersson, Magnus J. Johansson and Belén Martín-Matute

Org. Lett., 2026, 28, 628
DOI: 10.1021/acs.orglett.5c04592

Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines

Isaac J. Knudson, Taylor L. Dover, Diondra A. Dilworth, Cameron Paloutzian, Orel Paz, Jieye Lin, Hannah Cho, Tamir Gonen, Alanna Schepartz and Scott J. Miller

Nat. Chem., 2026, 18, 61
DOI: 10.1038/s41557-025-01935-4

Biocatalytic synthesis of peptidic natural products and related analogues

Dake Liu, Garret M. Rubin, Dipesh Dhakal, Manyun Chen and Yousong Ding

iScience, 2021, 24, 102512
DOI: 10.1016/j.isci.2021.102512

Trinuclear gold-catalyzed site-selective alkylation of peptides

Qing-Yun Fang, Chengyihan Gu, Yinghan Chen, Wencheng Yan, Yong Liang, Weipeng Li, Chengjian Zhu, Jie Han and Jin Xie

Sci. China Chem., 2025, 68, 249
DOI: 10.1007/s11426-024-2169-4

Solid Phase Synthesis of Thioether‐linked Peptide Macrocycles via Palladium‐Catalyzed Intramolecular S‐Arylation and S‐Alkenylation

Peng Yang, Chao Zhang, Bo Li, Gang He and Gong Chen

Asian J Org Chem, 2021, 10, 2888
DOI: 10.1002/ajoc.202100561

Teraryl Braces in Macrocycles: Synthesis and Conformational Landscape Remodeling of Peptides

Peng Yang, Martynas J. Širvinskas, Bo Li, Nicholas W. Heller, Hua Rong, Gang He, Andrei K. Yudin and Gong Chen

J. Am. Chem. Soc., 2023, 145, 13968
DOI: 10.1021/jacs.3c03512

Rh(III)-Catalyzed Double C–H Activation toward Peptide–Benzazepine Conjugates

Qi Quan, Yan Li, Zhefan Zhang, Erik V. Van der Eycken, Lingchao Cai and Liangliang Song

Org. Lett., 2025, 27, 482
DOI: 10.1021/acs.orglett.4c04498

Reactivity-Controlling Factors in Carboxylate-Assisted C–H Activation under 4d and 3d Transition Metal Catalysis

Torben Rogge, João C. A. Oliveira, Rositha Kuniyil, Lianrui Hu and Lutz Ackermann

ACS Catal., 2020, 10, 10551
DOI: 10.1021/acscatal.0c02808

Mizoroki‐Heck Macrocyclization Reactions at 1 M Concentration Catalyzed by Sub‐nanometric Palladium Clusters

Francisco Garnes‐Portolés, Estíbaliz Merino and Antonio Leyva‐Pérez

ChemSusChem, 2023, 16
DOI: 10.1002/cssc.202300200

Crafting Unnatural Peptide Macrocycles via Rh(III)-Catalyzed Carboamidation

Christopher W. Lamartina, Cassandra A. Chartier, Jillian M. Hirano, Neel H. Shah and Tomislav Rovis

J. Am. Chem. Soc., 2024, 146, 20868
DOI: 10.1021/jacs.4c05248

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization

Xing-Yu Liu, Wei Cai, Nathan Ronceray, Aleksandra Radenovic, Beat Fierz and Jerome Waser

J. Am. Chem. Soc., 2023, 145, 26525
DOI: 10.1021/jacs.3c09261

Macrolactonization Reactions Driven by a Pentafluorobenzoyl Group**

Guillaume Force, Anna Perfetto, Robert J. Mayer, Ilaria Ciofini and David Lebœuf

Angew Chem Int Ed, 2021, 60, 19843
DOI: 10.1002/anie.202105882

Ungesättigte Phosphinoxide für modulares Antikörper‐Rebridging und Einkomponenten Peptid‐Zyklisierung‐Biokonjugation

Christian E. Stieger, Alastair J. McMillan, Mark A. R. de Geus, Jan Vincent V. Arafiles, Luise Franz and Christian P. R. Hackenberger

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202508656

4-Aminobenzotriazole (ABTA) as a Removable Directing Group for Palladium-Catalyzed Aerobic Oxidative C–H Olefination

Zhuo Wang, Xiaohan Ye, Meina Jin, Qi Tang, Shengyu Fan, Zhiguang Song and Xiaodong Shi

Org. Lett., 2022, 24, 3107
DOI: 10.1021/acs.orglett.2c00285

Macrocyclic Aromatic Amide Foldamer: Synthesis, Twisted‐to‐Boxlike Conformational Switching, and Molecular Recognition

Dongyao Li, Tian Qin, Xinlu Liu, Boyuan Zhang, Fangrui Zhong, Chunmiao Ma and Quan Gan

ChemPlusChem, 2021, 86, 920
DOI: 10.1002/cplu.202100193

Hypervalent Iodine Amino Acid Building Blocks for Bioorthogonal Peptide Macrocyclization

Xing‐Yu Liu, Olha Mykhailenko, Adriana Faraone and Jerome Waser

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202404747

Peptide Boronic Acids by Late‐Stage Hydroboration on the Solid Phase

Marius Werner, Julian Brinkhofer, Leon Hammermüller, Thomas Heim, Truc Lam Pham, Jonas Huber, Christian Klein and Franziska Thomas

Advanced Science, 2024, 11
DOI: 10.1002/advs.202400640

On-Resin Synthesis of Linear Aryl Thioether Containing Peptides and in-Solution Cyclization via Cysteine SNAr Reaction

Jian Li, Weihong Lai, Ao Pang, Lu Liu, Lianbao Ye and Xiao-Feng Xiong

Org. Lett., 2022, 24, 1673
DOI: 10.1021/acs.orglett.2c00234

A General Medium-to-Large Sized Ring Synthesis Enabled by Copper-Catalyzed Difluoroalkylamidation Cyclization of Alkynes

Jing Ren, Linfeng He, Jinlong Li, Ning Wang, Xinyu Long, Jiayin Yang and Kaizhi Li

Org. Lett., 2025, 27, 5253
DOI: 10.1021/acs.orglett.5c01459

Aza-Oxa-Triazole Based Macrocycles with Tunable Properties: Design, Synthesis, and Bioactivity

Subba Rao Cheekatla, Liya Thurakkal, Anna Jose, Debashis Barik and Mintu Porel

Molecules, 2022, 27, 3409
DOI: 10.3390/molecules27113409

Exploring Macrocyclic Chemical Space: Strategies and Technologies for Drug Discovery

Taegwan Kim, Eunbee Baek and Jonghoon Kim

Pharmaceuticals, 2025, 18, 617
DOI: 10.3390/ph18050617

Photochemical Methods for Peptide Macrocyclisation

Laetitia Raynal, Nicholas C. Rose, James R. Donald and Christopher D. Spicer

Chemistry A European J, 2021, 27, 69
DOI: 10.1002/chem.202003779

Developing New Strategies to Construct Pseudo-natural Macrocycles for Undruggable Targets

Han Wang, Tongyu Bi and Weibo Yang

Acc. Chem. Res., 2025, 58, 3096
DOI: 10.1021/acs.accounts.5c00524

On the scope of the double Ugi multicomponent stapling to produce helical peptides

Manuel G. Ricardo, Yadiel Vázquéz-Mena, Yuleidys Iglesias-Morales, Ludger A. Wessjohann and Daniel G. Rivera

Bioorganic Chemistry, 2021, 113, 104987
DOI: 10.1016/j.bioorg.2021.104987

Catalytic macrocyclization of unactivated C(sp3)-H bond in natural product synthesis

Zhuo Wang

Tetrahedron Green Chem, 2025, 5, 100064
DOI: 10.1016/j.tgchem.2025.100064

Synthesis and Diversification of Macrocyclic Alkynediyl Sulfide Peptides

Éric Godin, Sacha Nguyen Thanh, Javier Guerrero‐Morales, Jeffrey Santandrea, Antoine Caron, Clémentine Minozzi, Noémie Beaucage, Bastien Rey, Mathieu Morency, Xavier Abel‐Snape and Shawn K. Collins

Chemistry A European J, 2020, 26, 14575
DOI: 10.1002/chem.202003655

Unsaturated Phosphine Oxides for Modular Antibody Rebridging and Single Reagent Peptide‐Cyclization‐Bioconjugation

Christian E. Stieger, Alastair J. McMillan, Mark A. R. de Geus, Jan Vincent V. Arafiles, Luise Franz and Christian P. R. Hackenberger

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202508656

Tuning Cyclometalated Gold(III) for Cysteine Arylation and Ligand-Directed Bioconjugation

Sailajah Gukathasan, Sean Parkin, Esther P. Black and Samuel G. Awuah

Inorg. Chem., 2021, 60, 14582
DOI: 10.1021/acs.inorgchem.1c01517

Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles

Mengran Wang, Chao Wang, Yumei Huo, Xiaobo Dang, Hongxiang Xue, Liangyu Liu, Hongli Chai, Xiuling Xie, Zhixuan Li, Doudou Lu and Zhaoqing Xu

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-27086-x

Synthesis and Applications of Peptides and Peptidomimetics in Drug Discovery

Ravikumar Jimmidi

Eur J Org Chem, 2023, 26
DOI: 10.1002/ejoc.202300028

Macrocyclizations toward the Assembly of Tyr-Linked Cyclopeptides

Arkaitz Correa

Tetrahedron, 2026, 135290
DOI: 10.1016/j.tet.2026.135290

Pd(I)-catalyzed ring-opening arylation of cyclopropyl-α-aminoamides: Access to α-ketoamide peptidomimetics

Yue Sun, Liming Yang, Yaohang Cheng, Guanghui An and Guangming Li

Chinese Chemical Letters, 2024, 35, 109250
DOI: 10.1016/j.cclet.2023.109250

Trifluoroacetic Acid Mediated Additive-Free Late-Stage Native Peptide Cyclization to Form Disulfide Mimetics via Thioketalization with Ketones

Yisa Xiao, Haiyan Zhou, Han Liu and Xuechen Li

Org. Lett., 2024, 26, 6512
DOI: 10.1021/acs.orglett.4c02464

Eco-Friendly Cellulose-Supported Nickel Complex as an Efficient and Recyclable Heterogeneous Catalyst for Suzuki Cross-Coupling Reaction

Zhanyu Li, Guohao Zhou, Yu Sun, Yingning Mao, Fanxiang Zeng, Zhihui Wang, Yuanyuan Zhang and Bin Li

Molecules, 2024, 29, 4525
DOI: 10.3390/molecules29194525

Unnatural Cyclopeptide Synthesis via Cu-Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides

Enrique Gallent, Inés Alonso, Juan C. Carretero, Nuria Rodríguez and Javier Adrio

Org. Lett., 2024, 26, 10394
DOI: 10.1021/acs.orglett.4c04036

Importance of additive effects on the reactivity of Ag catalyzed domino cyclization: a computational chemistry survey

Yunhe Li, Jie Zhang and Xiang Zhao

Molecular Catalysis, 2022, 524, 112287
DOI: 10.1016/j.mcat.2022.112287

Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization

Chuan Dai, Chenshan Lian, Huilong Fang, Qinhong Luo, Junrong Huang, Min Yang, Heng Yang, Lizhi Zhu, Jinqiang Zhang, Feng Yin and Zigang Li

Org. Lett., 2022, 24, 3532
DOI: 10.1021/acs.orglett.2c01239

Synthesis of highly strained para-cyclophanes via ring-expansion [5,5]-sigmatropic rearrangement reaction

Zhonghong Chen, Weihao Yang, Maomao Jia, Jiarong Shi, Jiyang Li, Haohua Chen and Yang Li

Nat. Chem., 2025, 17, 1169
DOI: 10.1038/s41557-025-01878-w

Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction

Yue Wu, Ho‐Fai Chau, Waygen Thor, Kaitlin Hao Yi Chan, Xia Ma, Wai‐Lun Chan, Nicholas J. Long and Ka‐Leung Wong

Angewandte Chemie, 2021, 133, 20463
DOI: 10.1002/ange.202108885

PIII‐Directed Late‐Stage Ligation and Macrocyclization of Peptides with Olefins by Rhodium Catalysis

Lei Liu, Xinlong Fan, Boning Wang, Hong Deng, Tianhang Wang, Jie Zheng, Jun Chen, Zhuangzhi Shi and Huan Wang

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202206177

Advances in Hydrocarbon Stapled Peptides via Ring‐Closing Metathesis: Synthetic Strategies, Structural Diversity, and Therapeutic Applications

Linji Li, Rong Li, Yanan Jiang, Jingru Chao, Si Chen, Hongli Liao and Xiang Li

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202500527

Exploring a Non-Comfort Zone: Central Chirality-Generating Macrocyclizations

Kuan Zheng and Ran Hong

J. Org. Chem., 2024, 89, 7355
DOI: 10.1021/acs.joc.4c00030

Tunable Electrochemical Peptide Modifications: Unlocking New Levels of Orthogonality for Side‐Chain Functionalization

Dhanya Karipal Padinjare Veedu, Luke A. Connal and Lara R. Malins

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202215470

Peptide synthesis: a review of classical and emerging methods

Zhangping Cai, Liheng Liu, Chang Zou, Xin Jiang, Gang Wang, Xun He, Weihua Zhuang, Chengli Yang, Yongchao Yao, Xuping Sun, Chun Ye and Wenchuang (Walter) Hu

Biofabrication, 2026, 18, 012001
DOI: 10.1088/1758-5090/ae1bdc

Macrolactam Synthesis via Ring-Closing Alkene–Alkene Cross-Coupling Reactions

Manikantha Maraswami, Jeffrey Goh and Teck-Peng Loh

Org. Lett., 2020, 22, 9724
DOI: 10.1021/acs.orglett.0c03801

Late-Stage Functionalization and Diversification of Peptides by Internal Thiazole-Enabled Palladium-Catalyzed C(sp3)–H Arylation

Zengbing Bai, Qingqing Chen, Jun Gu, Chuangxu Cai, Jie Zheng, Wangjian Sheng, Shandong Yi, Fang Liu and Huan Wang

ACS Catal., 2021, 11, 15125
DOI: 10.1021/acscatal.1c05030

Modern Macrolactonization Techniques

Max Van Hoof, Guillaume Force and David Lebœuf

Synthesis, 2024, 56, 714
DOI: 10.1055/a-2181-9800

Triple C–H Activation/Annulation: In Situ Construction of Fluorescent Peptides

Zhefan Zhang, Tianyan Wan, Qi Quan, Yiqi Zang, Jinyuan Xu, Shuo Tang, Nanxi Wang, Lingchao Cai and Liangliang Song

Org. Lett., 2024, 26, 10915
DOI: 10.1021/acs.orglett.4c04081

Macrolactonization Reactions Driven by a Pentafluorobenzoyl Group**

Guillaume Force, Anna Perfetto, Robert J. Mayer, Ilaria Ciofini and David Lebœuf

Angewandte Chemie, 2021, 133, 19996
DOI: 10.1002/ange.202105882

Gold‐Based Pharmacophore Inhibits Intracellular MYC Protein

Samuel Ofori, Sailajah Gukathasan and Samuel G. Awuah

Chemistry A European J, 2021, 27, 4168
DOI: 10.1002/chem.202004962

Site‐Selective Trifluoromethylation Reactions of Oligopeptides

Itziar Guerrero and Arkaitz Correa

Asian J Org Chem, 2020, 9, 898
DOI: 10.1002/ajoc.202000170

PICKAPEP: An application for parameter calculation and visualization of cyclized and modified peptidomimetics

Vanessa Erckes, Mattis Hilleke, Clemens Isert and Christian Steuer

Journal of Peptide Science, 2024, 30
DOI: 10.1002/psc.3646

Construction of Peptide Macrocycles via Palladium-Catalyzed Multiple S-Arylation: An Effective Strategy to Expand the Structural Diversity of Cross-Linkers

Xin Chu, Linhua Shen, Bo Li, Peng Yang, Chengzhuo Du, Xiaoye Wang, Gang He, Samir Messaoudi and Gong Chen

Org. Lett., 2021, 23, 8001
DOI: 10.1021/acs.orglett.1c03003

Controlled reversible methionine-selective sulfimidation of peptides

Zeyuan He, Xiufang Zhao, Wen-Yan Gao, Guangjun Bao, Yiping Li, Quan Zuo, Xinyi Song, Ling-Yun Mou, Wangsheng Sun and Rui Wang

Sci. Adv., 2025, 11
DOI: 10.1126/sciadv.adv8712

Peptide-based drug discovery: Current status and recent advances

Komal Sharma, Krishna K. Sharma, Anku Sharma and Rahul Jain

Drug Discovery Today, 2023, 28, 103464
DOI: 10.1016/j.drudis.2022.103464

Fluorous Tagged Peptides for Intracellular Delivery and Biomedical Imaging

Lei Ding, Guangyu Rong and Yiyun Cheng

Macromolecular Bioscience, 2023, 23
DOI: 10.1002/mabi.202300048

Metal‐Catalyzed C(sp2)−H Functionalization Processes of Phenylalanine‐ and Tyrosine‐Containing Peptides

Arkaitz Correa

Eur J Inorg Chem, 2021, 2021, 2928
DOI: 10.1002/ejic.202100374

Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction

Yue Wu, Ho‐Fai Chau, Waygen Thor, Kaitlin Hao Yi Chan, Xia Ma, Wai‐Lun Chan, Nicholas J. Long and Ka‐Leung Wong

Angew Chem Int Ed, 2021, 60, 20301
DOI: 10.1002/anie.202108885

Constructions of Biaryl‐Bridged Macrocycles Through Phosphine‐Ligand‐Controlled Switch of Selectivity Between Intra‐ and Intermolecular Cyclizations

Xin Lou, Xiaofeng Zhang, Shijun Huang, Xi Deng, Xiaoming Jie and Weiping Su

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202505591

Unnatural Amino Acids: Strategies, Designs, and Applications in Medicinal Chemistry and Drug Discovery

Krishna K. Sharma, Komal Sharma, Kamya Rao, Anku Sharma, Gajanan K. Rathod, Shams Aaghaz, Naina Sehra, Rajesh Parmar, Brett VanVeller and Rahul Jain

J. Med. Chem., 2024, 67, 19932
DOI: 10.1021/acs.jmedchem.4c00110

Selective Deprotonated Amide Activation of Dehydroalanine for Peptide Modification

Pengxin Wang, Jinyuan Gong, Yuntao Shi, Luping Liu and Rui Wang

Org. Lett., 2026, 28, 2889
DOI: 10.1021/acs.orglett.6c00048

Constructions of Biaryl‐Bridged Macrocycles Through Phosphine‐Ligand‐Controlled Switch of Selectivity Between Intra‐ and Intermolecular Cyclizations

Xin Lou, Xiaofeng Zhang, Shijun Huang, Xi Deng, Xiaoming Jie and Weiping Su

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202505591

Synthesis of Bis-urea-Bridged Cyclopeptides via Stapling of Unprotected Peptides

Wenfang Xiong, Peiru Chen, Jinyao Liu, Yixin Liao, Meilin Tang and Jinwu Zhao

Org. Lett., 2025, 27, 14230
DOI: 10.1021/acs.orglett.5c04412

Peptide Diversification through Addition Reaction of Free Carboxylic Acids to Ynamides

Zhefan Zhang, Lingchao Cai and Liangliang Song

Processes, 2023, 11, 2262
DOI: 10.3390/pr11082262

Recent Progress on Transition Metal Catalyzed Macrocyclizations Based on C−H Bond Activation at Heterocyclic Scaffolds

Sarbojit Das, Tapan Kumar Pradhan and Rajarshi Samanta

Chemistry An Asian Journal, 2024, 19
DOI: 10.1002/asia.202400397

Recent Advances in Late‐Stage Construction of Stapled Peptides via C−H Activation

Jiang Liu, Peng Wang, Zhengqing Yan, Jiahui Yan, Kenry and Qing Zhu

ChemBioChem, 2021, 22, 2762
DOI: 10.1002/cbic.202100044

Palladium(II)-Catalyzed Site-Selective C(sp3)–H Alkenylation of Oligopeptides

Bing-Tong Li, Xing-Xing Ding and Lin Dong

Org. Lett., 2024, 26, 9455
DOI: 10.1021/acs.orglett.4c03365

The recent advance of Interleukin-1 receptor associated kinase 4 inhibitors for the treatment of inflammation and related diseases

Yi-Ru Bai, Wei-Guang Yang, Xue-Hui Hou, Dan-Dan Shen, Sheng-Nan Zhang, Yan Li, Yan-Yan Qiao, Sai-Qi Wang, Shuo Yuan and Hong-Min Liu

European Journal of Medicinal Chemistry, 2023, 258, 115606
DOI: 10.1016/j.ejmech.2023.115606

Multicomponent coupling and macrocyclization enabled by Rh(III)-catalyzed dual C–H activation: Macrocyclic oxime inhibitor of influenza H1N1

Hao Wang, Zhongyu Li, Xiangyang Chen, Jonathan J. Wong, Tongyu Bi, Xiankun Tong, Zhongliang Xu, Mingyue Zhen, Yunhui Wan, Li Tang, Bo Liu, Xinlei Zong, Dandan Xu, Jianping Zuo, Li Yang, Wei Huang, Kendall N. Houk and Weibo Yang

Chem, 2023, 9, 607
DOI: 10.1016/j.chempr.2022.10.019

In Cellulo Peptide Cyclization via Gene‐Encoded Proximity‐Induced Proline‐Isothiocyanate Crosslinking

Zhifen Huang, Shuai Jiang, Jiaying Ren, Lei Zhao, Zhuo Zhang, Hongqiang Qin, Gong Chen and Weimin Xuan

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202517565

Importance of Counterions in Gold‐hydrogen Bonding Cooperative Catalytic Approach to Spirocyclic Rings: Insights on Mechanism and Origins

Yunhe Li and Xiang Zhao

ChemCatChem, 2020, 12, 6265
DOI: 10.1002/cctc.202001303

Tunable Electrochemical Peptide Modifications: Unlocking New Levels of Orthogonality for Side‐Chain Functionalization

Dhanya Karipal Padinjare Veedu, Luke A. Connal and Lara R. Malins

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202215470

Intramolecular Cobalt Porphyrin-Catalyzed Alkylation of 1-Isoindolinones by Site-Selective Insertion into a C(sp3)–H Bond

Christoph Buchelt, Julian Zuber and Thorsten Bach

Org. Lett., 2024, 26, 7302
DOI: 10.1021/acs.orglett.4c02270

Macrocyclic polymers: Synthesis, purification, properties and applications

Jordan Ochs, Carlo Andrea Pagnacco and Fabienne Barroso-Bujans

Progress in Polymer Science, 2022, 134, 101606
DOI: 10.1016/j.progpolymsci.2022.101606

Pyridyloxy-Directed, Pd(II)-Catalyzed Late-Stage C(sp2)–H Alkynylation and Olefination of Tyrosine Oligopeptides

Qing-Sheng Zhao, Shu Yang, Ting-Ting Guo, Jian-Bo Ma, Xiao-Hong Cheng and Sheng-Jiao Yan

J. Org. Chem., 2025, 90, 6910
DOI: 10.1021/acs.joc.5c00118

Tools and new metric (Macrocyclization Environmental Impact - MEI) to tackle the sustainability of macrocyclization reactions

Ferran Esteve, Belén Altava, Santiago V. Luis and Eduardo García-Verdugo

Catalysis Today, 2024, 426, 114407
DOI: 10.1016/j.cattod.2023.114407

Gold(III) Aryl Complexes as Reagents for Constructing Hybrid Peptide-Based Assemblies via Cysteine S-Arylation

Julia M. Stauber, Arnold L. Rheingold and Alexander M. Spokoyny

Inorg. Chem., 2021, 60, 5054
DOI: 10.1021/acs.inorgchem.1c00087

Practical Enzymatic Production of Carbocycles

Weijin Wang, Douglass F. Taber and Hans Renata

Chemistry A European J, 2021, 27, 11773
DOI: 10.1002/chem.202101232

Synthesis of Peptide N-Acylpyrroles via Anodically Generated N,O-Acetals

Yutong Lin and Lara R. Malins

Synthesis, 2022, 54, 3558
DOI: 10.1055/s-0041-1737411

Cu-Catalyzed C–H Phenothiazination toward the Assembly of Cyclopeptides

Iván Pérez-Cubero, Paula Andrade-Sampedro, Ibon Sasiain and Arkaitz Correa

ACS Catal., 2025, 15, 10320
DOI: 10.1021/acscatal.5c02350

Chemoselective Peptide Backbone Diversification and Bioorthogonal Ligation by Ruthenium‐Catalyzed C−H Activation/Annulation

Liangliang Song, Gerardo M. Ojeda‐Carralero, Divyaakshar Parmar, David A. González‐Martínez, Luc Van Meervelt, Johan Van der Eycken, Jan Goeman, Daniel G. Rivera and Erik V. Van der Eycken

Adv Synth Catal, 2021, 363, 3297
DOI: 10.1002/adsc.202100323

In Cellulo Peptide Cyclization via Gene‐Encoded Proximity‐Induced Proline‐Isothiocyanate Crosslinking

Zhifen Huang, Shuai Jiang, Jiaying Ren, Lei Zhao, Zhuo Zhang, Hongqiang Qin, Gong Chen and Weimin Xuan

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202517565

Hypervalent Iodine Amino Acid Building Blocks for Bioorthogonal Peptide Macrocyclization

Xing‐Yu Liu, Olha Mykhailenko, Adriana Faraone and Jerome Waser

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202404747

PIII‐Directed Late‐Stage Ligation and Macrocyclization of Peptides with Olefins by Rhodium Catalysis

Lei Liu, Xinlong Fan, Boning Wang, Hong Deng, Tianhang Wang, Jie Zheng, Jun Chen, Zhuangzhi Shi and Huan Wang

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202206177

Ideas Behind the Tryptophan‐Mediated Petasis Reaction (TMPR) Concept for Peptide Stapling

Sona Krajcovicova

ChemMedChem, 2024, 19
DOI: 10.1002/cmdc.202400148

Construction of Peptide–Isoquinolone Conjugates via Rh(III)-Catalyzed C–H Activation/Annulation

Liangliang Song, Zhenwei Lv, Yan Li, Kui Zhang, Erik V. Van der Eycken and Lingchao Cai

Org. Lett., 2023, 25, 2996
DOI: 10.1021/acs.orglett.3c00766

Enhancing Peptide Cyclization: Unveiling the Key Roles of Coupling Reagents and Heat for Optimal Results

Kim Gaudin, Alexie Bobe, Vijay Kumar Pal, Céline Corcelle, Kelton Rodrigues Souza and Cécilia Ménard‐Moyon

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202500375

Designing Short Peptides: A Sisyphean Task?

Héctor M. Pineda-Castañeda, Diego S. Insuasty-Cepeda, Víctor A. Niño-Ramírez, Hernando Curtidor and Zuly J. Rivera-Monroy

COC, 2020, 24, 2448
DOI: 10.2174/1385272824999200910094034

Heterogeneous Catalysis Expands the Toolbox for Chemoselective Peptide Derivatization and Labeling

Leslie Reguera, Aldrin V. Vasco, Javiel F. Marrero, Manuel G. Ricardo, Ludger A. Wessjohann and Daniel G. Rivera

J. Am. Chem. Soc., 2025, 147, 8478
DOI: 10.1021/jacs.4c16754

Demethylative Alkylation of Methionine Residue by Employing the Sulfonium as the Key Intermediate

Qi-Long Hu, Jia-Tian Liu, Jian Li, Yang Ge, Zhendong Song, Albert S. C. Chan and Xiao-Feng Xiong

Org. Lett., 2021, 23, 8543
DOI: 10.1021/acs.orglett.1c03241

Chemoselective, Oxidation-Induced Macrocyclization of Tyrosine-Containing Peptides

E. Dalles Keyes, Marcus C. Mifflin, Maxwell J. Austin, Brighton J. Alvey, Lotfa H. Lovely, Andriea Smith, Tristin E. Rose, Bethany A. Buck-Koehntop, Jyoti Motwani and Andrew G. Roberts

J. Am. Chem. Soc., 2023, 145, 10071
DOI: 10.1021/jacs.3c00210