Issue 42, 2024

Organophotoelectrocatalytic C(sp2)–H alkylation of heteroarenes with unactivated C(sp3)–H compounds

Abstract

An organophotoelectrocatalytic method for the C(sp2)–H alkylation of heteroarenes with unactivated C(sp3)–H compounds through dehydrogenation cross-coupling has been developed. The C(sp2)–H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions.

Graphical abstract: Organophotoelectrocatalytic C(sp2)–H alkylation of heteroarenes with unactivated C(sp3)–H compounds

Supplementary files

Article information

Article type
Communication
Submitted
23 Бер 2024
Accepted
25 Кві 2024
First published
26 Кві 2024

Chem. Commun., 2024,60, 5502-5505

Organophotoelectrocatalytic C(sp2)–H alkylation of heteroarenes with unactivated C(sp3)–H compounds

Q. Wan, X. Wu, Z. Hou, Y. Ma and L. Wang, Chem. Commun., 2024, 60, 5502 DOI: 10.1039/D4CC01335B

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